Ngaba iMethotrexate iyasebenza kwiRheumatoid Arthritis?

Umxholo

• Ukunyanga i-RA nge-methotrexate
• Ukusebenza ngempumelelo
• Ngokudibana namanye amachiza
• Iziphumo ebezingalindelekanga ze-methotrexate
• Thetha nogqirha wakho

I-rheumatoid arthritis (RA) sisifo esingapheliyo sokuzimela. Ukuba unale meko, uqhelene nokudumba kunye namalungu abuhlungu abangela oko. Ezi iintlungu kunye neentlungu azibangelwa kukunxiba kwendalo kunye neenyembezi ezenzeka ngokuguga. Endaweni yoko, amajoni akho omzimba enza iimpazamo kumalungu akho abahlaseli bangaphandle emva koko ahlasele umzimba wakho. Akukho mntu uyazi ngokuqinisekileyo ukuba kutheni oku kusenzeka okanye kutheni abanye abantu benesi sifo.

Okwangoku alukho unyango lweRA, kodwa kukho iindlela zokuyinyanga. Ugqirha wakho unokukunika amayeza acothisa ukuqhubela phambili kwesi sifo okanye acinezele amajoni akho omzimba. Banokukunika iziyobisi ezinciphisa ukudumba kunye nentlungu kumalungu akho.

Ingcebiso yangoku yonyango lokuqala lwe-RA inesifo esiguqula i-antirheumatic drug (DMARDs). Elinye lala machiza yi-methotrexate. Jonga ukuba lisebenza njani eli yeza, kubandakanya nokuba lisebenza njani kunyango lwe-RA.

Ukunyanga i-RA nge-methotrexate

IMethotrexate luhlobo lweDMARD. Ii-DMARD ziludidi lwamayeza ahlala esetyenziswa kumanqanaba okuqala e-RA. Amachiza ambalwa kwiklasi ye-DMARD ayenzelwe ngokukodwa unyango lwe-RA, kodwa i-methotrexate yaphuhliswa ngesizathu esahlukileyo. Ekuqaleni yayenzelwe ukunyanga umhlaza, kodwa kwafunyaniswa ukuba isebenzela iRA. Ithengiswa phantsi kwegama lophawu lweRheumatrex kunye neTrxall. Iza njengecwecwe lomlomo kunye nesisombululo ngenaliti.

I-Methotrexate kunye nezinye ii-DMARD zisebenza ukunciphisa ukudumba. Benza oku ngokucinezela amajoni akho omzimba. Kukho umngcipheko onxulunyaniswa nokugcina amajoni akho omzimba ejonge ngale ndlela, nangona kunjalo, kubandakanya ukwanda komngcipheko wosulelo.

Ngelixa i-methotrexate iza nethuba leziphumo ebezingalindelekanga, ikwabonelela ngezibonelelo ezinkulu kubantu abane-RA. Ii-DMARD zinokuthintela umonakalo odibeneyo ukuba uzisebenzisa kwangoko ngokwaneleyo emva kokuba iimpawu zakho ze-RA ziqale zavela. Banokucothisa ukuqhubekeka nokudibana kunye nokunciphisa iimpawu zeRA. Uninzi loogqirha nabantu abane-RA bacinga ukuba izibonelelo zeli yeza zikufanele umngcipheko.

IMethotrexate sisiyobisi sexesha elide xa sisetyenziselwa iRA. Uninzi lwabantu luyayithatha lude lungasebenzi kubo okanye de bangabinako ukunyamezela iziphumo zayo kumajoni omzimba.

Ukusebenza ngempumelelo

IMethotrexate sisiyobisi esigqibeleleyo sonyango lwe-RA. Oku kungenxa yokuba isebenza kakuhle kangakanani. NgokukaJohn Hopkins, uninzi lwabantu luthatha i-methotrexate ixesha elide xa kuthelekiswa nezinye ii-DMARD ukuya kuthi ga kwiminyaka emihlanu. Oku kubonisa ukuba kusebenza njani ekunyangeni le meko kwaye uninzi lwabantu luyinyamezele.

Amanani abonisa ukuba i-methotrexate inceda abantu abaninzi abane-RA. Ngokwe-National Rheumatoid Arthritis Society, ngaphezulu kwesiqingatha sabantu abayithathayo babona ukuphuculwa kwipesenti ezingama-50 kwisifo sabo. Kwaye ngaphezu kwesinye kwisithathu sabantu babona ukuphuculwa kweepesenti ezingama-70. Asinguye wonke umntu oya kufumana isiqabu nge-methotrexate, kodwa isebenza ngcono kubantu abaninzi kunezinye ii-DMARD.

Ukuba unyango lwe-methotrexate aluzange lusebenzele i-RA yakho okokuqala, kusekho ithemba. A

Ngokudibana namanye amachiza

I-Methotrexate ihlala isetyenziswa kunye nezinye ii-DMARD okanye amanye amayeza entlungu kunye nokudumba. Kubonakalisile ukuba liqabane elihle. Ukudityaniswa okuthile kwe-DMARDs ezimbini okanye nangaphezulu-ihlala i-methotrexate njengecandelo elinye-lisebenza ngcono kune-methotrexate yodwa. Gcina oku engqondweni ukuba awuphenduli kwi-methotrexate ngokwayo. Unokuthetha nogqirha wakho malunga nonyango oludibeneyo.

Iziphumo ebezingalindelekanga ze-methotrexate

Ngaphandle kwento yokuba isebenza kubantu abaninzi, oogqirha bayathanda ukusebenzisa i-methotrexate kuba iziphumo ebezingalindelekanga ezinzulu aziqhelekanga. Kodwa njengawo onke amayeza, i-methotrexate inokubangela iziphumo ebezingalindelekanga. Iziphumo eziqhelekileyo zinokubandakanya:

• isisu esimoshakele
• ukudinwa
• ukucheba iinwele

Unokwazi ukunciphisa umngcipheko wale miphumo emibi xa uthatha isongezelelo se-folic acid. Buza ugqirha wakho ukuba ngaba oku kulungileyo kukulungele.

Thetha nogqirha wakho

Ukuba unayo i-RA, thetha nogqirha wakho malunga ne-methotrexate. Eli chiza libonakalisiwe ukuba lisebenza kakuhle ngaphandle kokubangela iziphumo ebezingalindelekanga ezininzi kubantu abaneRA. Ukuba i-methotrexate ayisebenzi ukunyanga iimpawu zakho ze-RA, ugqirha wakho unokukunika idosi ephezulu okanye elinye ichiza oza kuhamba nalo kunye ne-methotrexate.