Yintoni iMethotrexate?

Umxholo

• Yenzelwe ntoni
• Kusetyenziswa kwanjani
• 1. Isifo samathambo
• 2. Psoriasis
• 3. Umhlaza
• Iziphumo ebezingalindelekanga ezinokwenzeka
• Ngubani ongafanele asebenzise

Ithebhulethi yeMethotrexate sisixhobo esibonisiweyo kunyango lwe-rheumatoid arthritis kunye ne-psoriasis eqatha engaphenduliyo kwezinye iindlela zonyango. Ukongeza, i-methotrexate ikwakhona njenge-inaliti, esetyenziswa kwi-chemotherapy kunyango lomhlaza.

Esi sixhobo siyafumaneka ngohlobo lwepilisi okanye inaliti kwaye sinokufumaneka ezikhemesti phantsi kwegama leTecnomet, Enbrel kunye ne-Endofolin, umzekelo.

Yenzelwe ntoni

I-Methotrexate kumacwecwe ibonakalisiwe kunyango lwe-rheumatoid arthritis, kuba inefuthe kwinkqubo yamajoni omzimba, ukunciphisa ukudumba, isenzo sayo siqwalaselwa kwiveki yesi-3 yonyango.Kunyango lwe-psoriasis, i-methotrexate inciphisa ukwanda kunye nokudumba kweeseli zolusu kunye neziphumo zayo ziyaqapheleka kwiiveki ezi-1 ukuya kwezi-4 emva kokuqala konyango.

Imethotrexate enesitofu ibonakalisiwe ukunyanga i-psoriasis ebukhali kunye nezi ntlobo zilandelayo zomhlaza:

• Iipropu ze-Gestational trophoblastic neoplasms;
• Leukemias lymphocytic Acute;
• Umhlaza omncinci wesifo somhlaza;
• Intloko kunye nentamo yomhlaza;
• Umhlaza webele;
• Osteosarcoma;
• Unyango kunye neprophylaxis ye-lymphoma okanye i-lecinemia ye-meningeal;
• Unyango lokuthambisa ngamathumba aqinileyo angenakusebenza;
• I-non-Hodgkin's lymphomas kunye neBurkitt's lymphoma.

Kusetyenziswa kwanjani

1. Isifo samathambo

Umthamo womlomo ocetyiswayo unokuba yi-7.5 mg, kanye ngeveki okanye nge-2.5 mg, rhoqo kwiiyure ze-12, ngeedosi ezintathu, ezilawulwa njengomjikelo, kanye ngeveki.

Imilinganiselo yerejimeni nganye kufuneka ihlengahlengiswe ngokuthe ngcembe ukufezekisa impendulo efanelekileyo, kodwa akufuneki idlule idosi eyi-20 mg yeveki.

2. Psoriasis

Idosi yomlomo ekhuthazwayo yi-10-25 mg ngeveki, de kube kufezekiswe impendulo eyoneleyo okanye, kungenjalo, i-2.5 mg, rhoqo kwiiyure ezili-12, ngeedosi ezintathu.

Idosi kwirejimeni nganye inokuhlengahlengiswa ngokuthe ngcembe ukufezekisa impendulo efanelekileyo yeklinikhi, kuthintelwe ukugqitha idosi ye-30 mg ngeveki.

Kwiimeko ze-psoriasis eqatha, apho kusetyenziswa i-methotrexate enesitofu, idosi enye ye-10 ukuya kuma-25 mg ngeveki kufuneka ilawulwe de kufumaneke impendulo eyoneleyo. Funda ukuchonga iimpawu ze-psoriasis kunye nokhathalelo olubalulekileyo ekufuneka uluthathile.

3. Umhlaza

Uluhlu lwethamo lonyango lwe-methotrexate yesalathiso se-oncological lubanzi kakhulu, kuxhomekeke kuhlobo lomhlaza, ubunzima bomzimba kunye neemeko zesigulana.

Iziphumo ebezingalindelekanga ezinokwenzeka

Iziphumo eziqhelekileyo ezinokubakho ngexesha lonyango ngamacwecwe e-methotrexate yintloko ebuhlungu, ukuqina kwentamo, ukugabha, umkhuhlane, ukuba bomvu kwesikhumba, ukonyusa i-uric acid kunye nokunciphisa inani lesidoda, ukubonakala kwezilonda zomlomo, ukudumba kolwimi kunye iintsini, urhudo, ukunciphisa iiseli ezimhlophe zegazi kunye nokubala kweplatelet, ukusilela kwezintso kunye ne-pharyngitis.

Ngubani ongafanele asebenzise

Ithebhulethi yeMethotrexate iyaphikiswa kwizigulana ezinesifo sokungabikho komzimba kwi-methotrexate okanye naliphi na icandelo lokwenziwa, abasetyhini abakhulelweyo, abasetyhini abancancisayo, abantu abanamajoni omzimba abuthathaka, isibindi esibi okanye ukungasebenzi kakuhle kwezintso kunye notshintsho kwiiseli zegazi ezinje ngokunciphisa iiseli zegazi ezimhlophe iiseli zegazi kunye neeplatelets.