Into ekufuneka uyazi malunga neMfu ye-MTHFR

Umxholo

• Uhlobo lokwahluka kweMTHFR
• Iimpawu zotshintsho lweMTHFR
• Ukuvavanywa kotshintsho lweMTHFR
• Unyango kwiinkxalabo ezinxulumene nezempilo
• Iingxaki zokukhulelwa
• Uncedo olunokubakho
• Ukuqwalaselwa kokutya
• Ukuthatha

Sibandakanya iimveliso esicinga ukuba ziluncedo kubafundi bethu. Ukuba uthenga amakhonkco kweli phepha, sinokufumana ikhomishini encinci. Nantsi inkqubo yethu.

Yintoni iMTHFR?

Usenokuba usibonile isicatshulwa esithi "MTHFR" sivela kwiindaba zempilo zamva nje. Inokubonakala ngathi lilizwi eliqalekisayo xa ulijonga kuqala, kodwa ibhekisa kuguquko lwemfuza oluqhelekileyo.

I-MTHFR imele methylenetetrahydrofolate ukunciphisa. Kukufumana ingqalelo ngenxa yenguquko yemfuza enokuthi ikhokelele kumanqanaba aphezulu e-homocysteine ​​egazini kunye namanqanaba asezantsi e-folate kunye nezinye iivithamini.

Kukho inkxalabo yokuba imicimbi ethile yezempilo inxulunyaniswa notshintsho lwe-MTHFR, ke ukuvavanywa kuye kwaba yinto engaphaya kwiminyaka edlulileyo.

Uhlobo lokwahluka kweMTHFR

Unokuba nolunye okanye ezimbini utshintsho-okanye hayi-kwi-gene ye-MTHFR. Olu tshintsho luhlala lubizwa ngokuba ziiyantlukwano. Ukwahluka yinxalenye ye-DNA yemfuza eyahluka ngokwesiqhelo, okanye iyahluka, ukusuka komnye umntu ukuya komnye.

Ukuba neyantlukwano-heterozygous- akunakufane kube negalelo kwimicimbi yezempilo. Abanye abantu bakholelwa ukuba ukuguquka kwezinto ezimbini-i-homozygous-kunokukhokelela kwiingxaki ezinzulu. Kukho iintlobo ezimbini, okanye iifom, zokuguquka ezinokuthi zenzeke kwi-MTHFR gene.

Umahluko okhethekileyo zezi:

• C677T. Phantse ama-30 ukuya kuma-40 ekhulwini labantu baseMerika banokuthi batshintshe kwisimo somzimba C677T. Phantse iipesenti ezingama-25 zabantu abavela kwi-Hispanic, kunye ne-10 ukuya kwi-15 yeepesenti yemvelaphi yaseCaucasus, ba-homozygous kokwahluka.
• I-A1298C. Kukho uphando olulinganiselweyo malunga noku kwahluka. Izifundo ezikhoyo ngokubanzi ngokwejografi okanye ngokobuhlanga. Umzekelo, uphononongo luka-2004 lujolise kubanikeli begazi abali-120 belifa lemveli laseIreland. Kwabaxhasi, i-56, okanye iipesenti ezingama-46.7, yayiyi-heterozygous kolu luhlu, kwaye i-11, okanye iipesenti ezili-14.2, zazingumntu onehomozygous.
• Kuyenzeka ukuba ufumane zombini utshintsho lwe-C677T kunye ne-A1298C, eyikopi nganye nganye.

Ukutshintsha kwemfuza kuzuzwe njengelifa, oko kuthetha ukuba uzifumana kubazali bakho. Ekukhulelweni, ufumana ikopi enye yohlobo lweMTHFR kumzali ngamnye. Ukuba bobabini baneenguqulelo, umngcipheko wokuba nenguquko kwi-homozygous uphezulu.

Iimpawu zotshintsho lweMTHFR

Iimpawu ziyahluka ukusuka komnye umntu ukuya emntwini nakumahluko okwahlukileyo. Ukuba wenza uphando olukhawulezayo kwi-intanethi, uya kufumana uninzi lwewebhusayithi ezibanga ukuba iMTHFR ibanga ngokuthe ngqo iimeko ezininzi.

Gcina ukhumbula ukuba uphando malunga ne-MTHFR kunye neziphumo zalo ziyaqhubeka. Ubungqina obudibanisa uninzi lwezi meko zempilo kwi-MTHFR okwangoku abukho okanye abuchangekanga.

Ngaphezulu kokunokwenzeka, ngaphandle kokuba uneengxaki okanye uvavanyiwe, awusoze wazi imeko yakho yokuguquka kweMTHFR.

Imiqathango ecetywayo ukuba inxulunyaniswe neMTHFR ibandakanya:

• izifo zentliziyo kunye ne-thromboembolic (ngakumbi amahlwili egazi, ukubetha, ukubola, kunye nentliziyo)
• ukudakumba
• ixhala
• ukuxhuzula
• schizophrenia
• umhlaza wamathumbu
• leukemia etsolo
• iintlungu ezingapheliyo nokudinwa
• iintlungu zemithambo-luvo
• migraines
• Ukuphuma kwesisu rhoqo kwabasetyhini abaneminyaka yobudala bokuzala
• ukukhulelwa ngeziphene zetyhubhu ye-neural, njenge-spina bifida kunye ne-anencephaly

Funda kabanzi malunga nokukhulelwa ngempumelelo kunye ne-MTHFR.

Umngcipheko unokunyuka xa umntu eneentlobo ezimbini zofuzo okanye i-homozygous yenguqu ye-MTHFR.

Ukuvavanywa kotshintsho lweMTHFR

Imibutho eyahlukeneyo yezempilo-kubandakanya i-American College of Obstetricians kunye ne-Gynecologists, i-College of American Pathologists, i-American College ye-Medical Genetics, kunye ne-American Heart Association - musa ukucebisa ukuvavanywa okwahlukileyo ngaphandle kokuba umntu abe namanqanaba aphezulu kakhulu e-homocysteine ​​okanye ezinye izinto ezibonisa impilo.

Okwangoku, unokuba nomdla wokufumanisa imeko yakho ye-MTHFR. Cinga ukutyelela ugqirha wakho kwaye uxoxe ngeenzuzo kunye neengozi zokuvavanywa.

Gcina ukhumbula ukuba uvavanyo lwemfuzo alunakugqitywa yi-inshurensi yakho. Fowunela umphathi wakho ukuba ucinga ukuvavanywa ukuze ubuze malunga neendleko.

Ezinye iikiti zokuvavanya izakhi zofuzo ekhaya zinika ukuhlolwa kwe-MTHFR ngokunjalo. Imizekelo ibandakanya:

• 23andMe lukhetho oludumileyo olunikezela ngookhokho bemfuza kunye nolwazi ngezempilo. Kukwabiza kakhulu ($ 200). Ukwenza olu vavanyo, ufaka amathe kumbhobho kwaye uwuthumele ngeposi kwilebhu. Iziphumo zithatha iiveki ezintandathu ukuya kwezisibhozo.
• Ikhaya lam MTHFR ($ 150) lolunye ukhetho olugxile ikakhulu kuguquko. Uvavanyo lwenziwa ngokuqokelela i-DNA ngaphakathi kwesidlele sakho ngee-swabs. Emva kokuhambisa isampuli, iziphumo zithatha iiveki enye ukuya kwezimbini.

Unyango kwiinkxalabo ezinxulumene nezempilo

Ukuba ne-MTHFR eyahlukileyo akuthethi ukuba ufuna unyango. Ingathetha nje ukuba kufuneka uthathe isongezelelo se-vitamin B.

Unyango luyafuneka xa unamanqanaba aphezulu e-homocysteine, phantse lonke ixesha elingaphezulu kwenqanaba elibangelwa kukuhluka kwe-MTHFR. Ugqirha wakho kufuneka akhuphe ezinye izizathu ezinokubangela ukunyuka kwe-homocysteine, enokuthi yenzeke kunye okanye ngaphandle kwe-MTHFR.

Ezinye izizathu ze-homocysteine ​​ephezulu zibandakanya:

• hypothyroidism
• iimeko ezifana neswekile, icholesterol ephezulu, kunye noxinzelelo lwegazi oluphezulu
• ukutyeba kakhulu nokungasebenzi
• amayeza athile, njenge-atorvastatin, i-fenofibrate, i-methotrexate, kunye ne-nicotinic acid

Ukusuka apho, unyango luya kuxhomekeka kwisizathu kwaye aluthatheli ngqalelo i-MTHFR. Ngaphandle koku xa ufunyenwe unazo zonke ezi meko zilandelayo ngaxeshanye:

• amanqanaba aphezulu e-homocysteine
• uguquko oluqinisekisiweyo lweMTHFR
• ukusilela kweevithamini kwi-folate, choline, okanye iivithamini B-12, B-6, okanye riboflavin

Kule meko, ugqirha wakho unokucebisa ukongezwa ukujongana nokusilela kunye namayeza okanye unyango ukujongana nemeko ethile yezempilo.

Abantu abaneenguqu ze-MTHFR banokunqwenela ukuthatha amanyathelo okuthintela ukunciphisa amanqanaba abo e-homocysteine. Elinye inyathelo lokuthintela kukutshintsha iindlela ezithile zokuphila, ezinokukunceda ngaphandle kokusebenzisa amayeza. Imizekelo ibandakanya:

• ukuyeka ukutshaya, ukuba uyatshaya
• ukufumana umthambo ngokwaneleyo
• ukutya ukutya okusempilweni

Iingxaki zokukhulelwa

Ukuphuphuma kwesisu rhoqo kunye neziphene zetyhubhu ye-neural zinokuthi zinxulunyaniswe neMTHFR. IZiko loLwazi lweZifo zeMfuza kunye noRare lathi uphando lubonisa ukuba abasetyhini abanezinto ezimbini ezahlukileyo ze-C677T basemngciphekweni wokuba nomntwana onesiphene kwi-neural tube.

Uphononongo olwenziwe ngo-2006 lwabasetyhini abanembali yokuphuphuma kwesisu rhoqo. Kufumanise ukuba iipesenti ezingama-59 zazo zinokutshintsha okuninzi kwehomozygous, kubandakanya i-MTHFR, enxulunyaniswa nokuqunjelwa kwegazi, kuthelekiswa neepesenti ze-10 kuphela zabasetyhini kudidi lolawulo.

Thetha nogqirha wakho malunga nokuvavanywa ukuba ngaba kwezi meko zilandelayo zisebenza kuwe:

• Unamava okuphuphuma kwesisu okungachazwanga.
• Unomntwana onesiphene se-neural tube.
• Uyazi ukuba unenguqu ye-MTHFR, kwaye ukhulelwe.

Nangona kungekho bungqina buncinci bokuyixhasa, abanye oogqirha bacebisa ukuthatha amayeza okuvala igazi. Ukongezwa okunyanzelekileyo kwifolthi kunokucetyiswa.

Uncedo olunokubakho

Ukuguqulwa kwemfuza ye-MTHFR kuthintela indlela umzimba oqhuba ngayo i-folic acid kunye nezinye iivithamini ze-B ezibalulekileyo. Ukutshintsha ukuxhaswa kwesi sondlo kukujolisa ekuchaseni iziphumo.

I-acid ye-Folic ngenene yinguqulelo eyenziwe ngumntu, isondlo esivela ngokwendalo esifumaneka kukutya. Ukuthatha uhlobo olungafumanekiyo lwe-folate-methylated folate-kunokunceda umzimba wakho uyifumane ngokulula.

Uninzi lwabantu luyakhuthazwa ukuba luthathe i-multivitamin equlathe ubuncinci i-0.4 milligrams ye-folic acid suku ngalunye.

Abafazi abakhulelweyo abakhuthazwa ukuba batshintshe iivithamini zokubeleka okanye ukhathalelo ngokusekwe kwisimo sabo se-MTHFR kuphela. Oku kuthetha ukuthatha idosi esemgangathweni ye-0.6 milligrams ye-folic acid yonke imihla.

Abasetyhini abanembali yeziphene zetyhubhu ye-neural kufuneka bathethe nogqirha wabo ngezindululo ezithile.

IiVithamini ezininzi ezinee-methylated folate zibandakanya:

• Amanqanaba ezondlo ezisisiseko 2 / Usuku
• Ibhulukhwe eyi-Smarty yabantu abadala igqityiwe
• Umama weentaka zeVithamini zokubeleka

Thetha nogqirha wakho ngaphambi kokutshintsha iivithamini kunye nezongezo. Abanye banokuphazamisa amanye amayeza okanye unyango olufumanayo.

Ugqirha wakho unokucebisa iivithamini kagqirha eziqulathe folate xa kuthelekiswa nefolic acid. Kuxhomekeka kwi-inshurensi yakho, iindleko zolu khetho zinokwahluka ngokuthelekisa iindidi zekhawuntara.

Ukuqwalaselwa kokutya

Ukutya ukutya okunotye ngokutya kunokunceda ngokwendalo ukuxhasa amanqanaba akho kule vithamini ibalulekileyo. Nangona kunjalo, ukongezwa kusenokufuneka.

Ukukhetha ukutya okuhle kubandakanya:

• Iiproteni ezinje ngeembotyi eziphekiweyo, ii-ertyisi kunye neelentile
• Imifuno efana nesipinashi, i-asparagus, i-lettuce, ii-beet, i-broccoli, ingqolowa, ihlumelo lase-Brussels kunye ne-bok choy
• iziqhamo ezinje ngecantaloupe, honeydew, banana, raspberries, grapefruit, kunye nequnube
• iijusi ezinjengeorenji, ipayinapile enkonkxiweyo, iidiliya, itumato, okanye enye incindi yemifuno
• ipeanut butter
• imbewu kajongilanga

Abantu abaneenguqu ze-MTHFR banokufuna ukunqanda ukutya okuqulethe uhlobo lokwenziwa kwe-folate, i-folic acid-nangona ubungqina bungacacanga ukuba buyimfuneko okanye buluncedo.

Qiniseka ukuba ujonga iilebheli, njengoko le vithamini yongezwa kwiinkozo ezininzi ezicebileyo, ezinjengepasta, iisiriyeli, isonka, kunye nomgubo oveliswe ngentengiso.

Funda okungakumbi ngumahluko phakathi kwefolate kunye nefolic acid.

Ukuthatha

Isimo sakho se-MTHFR sinokuthi okanye singachaphazeli impilo yakho. Olunye uphando luyafuneka ukumisela ifuthe lokwenyani, ukuba likho, elinxulunyaniswa nokwahluka.

Kwakhona, imibutho emininzi ehloniphekileyo yezempilo ayikukhuthazi ukuvavanywa kolu tshintsho, ngakumbi ngaphandle kolunye uphawu lwezonyango. Thetha nogqirha wakho malunga nezibonelelo kunye nobungozi bovavanyo, kunye nazo naziphi na ezinye izinto ezinokukhathaza.

Qhubeka nokutya kakuhle, umthambo, kunye nokwenza ezinye iindlela zokuphila ezisempilweni ukuxhasa impilo-ntle yakho iyonke.