Uvavanyo lwe-Pharmacogenetic
Umxholo
- Yintoni uvavanyo lwefarmacogenetic?
- Isetyenziselwa ntoni?
- Kutheni ndifuna uvavanyo lwe-pharmacogenetic?
- Kwenzeka ntoni ngexesha lovavanyo lwe-pharmacogenetic?
- Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?
- Ngaba bukhona ubungozi kuvavanyo?
- Zithetha ntoni iziphumo?
- Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lwe-pharmacogenetic?
- Izalathiso
Yintoni uvavanyo lwefarmacogenetic?
I-Pharmacogenetics, ekwabizwa ngokuba yi-pharmacogenomics, luphononongo lwendlela imfuza echaphazela ngayo ukuphendula komzimba kumayeza athile. Imfuza ngamalungu e-DNA agqithiselwe kumama notata wakho. Baphethe ulwazi olumisela iimpawu zakho ezizodwa, ezinjengokuphakama nombala wamehlo. Imfuza yakho inokuchaphazela nokuba inokukhuseleka kwaye isebenze njani ichiza elithile kuwe.
Imfuza inokuba sisizathu sokuba iyeza elifanayo kwidosi efanayo lichaphazele abantu ngeendlela ezahlukeneyo. Imfuza inokuba sesona sizathu sokuba abanye abantu babe neziphumo ebezingalunganga kunyango, ngelixa abanye bengenayo.
Ukuvavanywa kwe-Pharmacogenetic kujonge kwiijethi ezithile ukunceda ukufumanisa iintlobo zamayeza kunye needosi ezinokuthi zikulungele.
Amanye amagama: i-pharmacogenomics, uvavanyo lwe-pharmacogenomic
Isetyenziselwa ntoni?
Uvavanyo lwe-Pharmacogenetic lunokusetyenziselwa:
- Fumanisa ukuba amayeza athile anokukunceda na
- Fumanisa ukuba yeyiphi eyona idosi ibhetele
- Qikelela ukuba ngaba uya kuba neziphumo ebezingalindelekanga ezimandundu ezivela kwiyeza
Kutheni ndifuna uvavanyo lwe-pharmacogenetic?
Umboneleli wakho wezempilo unokuyalela ezi mvavanyo phambi kokuba uqale iyeza elithile, okanye ukuba uthatha iyeza elingasebenziyo kunye / okanye elibangela iziphumo ebezingalindelekanga ezimbi.
Uvavanyo lwe-Pharmacogenetic lufumaneka kuphela kwinani eliqingqiweyo lamayeza. Apha ngezantsi kukho amanye amayeza kunye nemfuza enokuvavanywa. (Amagama eGene ahlala enikwa ngoonobumba kunye namanani.)
Iyeza | Imfuza |
---|---|
IWarfarin: igazi elincinci | CYP2C9 kunye neVKORC1 |
I-Plavix, igazi elincinci | CYP2C19 |
Amayeza okulwa noxinzelelo, amayeza okuxhuzula | Inkcazo: CYP2D6, CYPD6 CYP2C9, CYP1A2, SLC6A4, HTR2A / C |
I-Tamoxifen, unyango lomhlaza webele | CYPD6 |
Iintsholongwane | I-DRD3, CYP2D6, CYP2C19, CYP1A2 |
Unyango lwengxaki yokusilela kwengqwalaselo | D4D4 |
I-Carbamazepine, unyango lwesifo sokuwa | I-HLA-B * 1502 |
Abacavir, unyango lwe-HIV | I-HLA-B * 5701 |
Iipioids | I-OPRM1 |
I-Statins, amayeza anyanga i-cholesterol ephezulu | I-SLCO1B1 |
Unyango lwe-leukemia yobuntwana kunye nokuphazamiseka okuthile okuzenzekelayo | TMPT |
Kwenzeka ntoni ngexesha lovavanyo lwe-pharmacogenetic?
Ukuvavanywa kuhlala kwenziwa egazini okanye kumathe.
Uvavanyo lwegazi, Unonophelo lwempilo uyakuthatha isampulu yegazi kumthambo engalweni yakho, esebenzisa inaliti encinci. Emva kokuba inaliti ifakiwe, inani elincinci legazi liya kuqokelelwa kwityhubhu yovavanyo okanye igutyana. Unokuziva uluma kancinci xa inaliti ingena okanye iphuma. Oku kuhlala kuthatha imizuzu engaphantsi kwesihlanu.
Uvavanyo lwamathe, buza umboneleli wakho wezempilo ukuba ayinikeze njani isampulu yakho.
Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?
Ngokwesiqhelo awudingi malungiselelo akhethekileyo kuvavanyo lwegazi. Ukuba ufumana uvavanyo lwamathe, akufuneki utye, usele, okanye utshaye kangangemizuzu engama-30 ngaphambi kovavanyo.
Ngaba bukhona ubungozi kuvavanyo?
Mncinci kakhulu umngcipheko wokuvavanywa kwegazi. Unokuba nentlungu encinci okanye ukrakra kwindawo apho inaliti yafakwa khona, kodwa uninzi lweempawu zihamba ngokukhawuleza.
Akukho bungozi bokuvavanywa amathe.
Zithetha ntoni iziphumo?
Ukuba ngaba wavavanywa ngaphambi kokuba uqale unyango, uvavanyo lunokubonisa ukuba ngaba iyeza lingasebenza kwaye / okanye ukuba usemngciphekweni weziphumo ebezingalindelekanga ezimandundu. Olunye uvavanyo, olufana nolo lwamachiza athile anyanga isifo sokuwa kunye ne-HIV, lunokubonisa ukuba ingaba usemngciphekweni weziphumo ebezingalindelekanga ezisongela ubomi. Ukuba kunjalo, umboneleli wakho uza kuzama ukufumana olunye unyango.
Uvavanyo olwenzeka ngaphambili kwaye ngelixa ukwonyango lunokunceda umboneleli wakho wezempilo ukuba afumane idosi elungileyo.
Ukuba unemibuzo malunga neziphumo zakho, thetha nomboneleli wakho wezempilo.
Funda ngakumbi malunga novavanyo lwelabhoratri, uluhlu lweereferensi, kunye neziphumo zokuqonda.
Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lwe-pharmacogenetic?
Uvavanyo lwe-Pharmacogenetic lusetyenziswa kuphela ukufumana impendulo yomntu kwiyeza elithile. Ayifani novavanyo lwemfuzo. Uninzi lovavanyo lwemfuza lusetyenziselwa ukunceda ukufumanisa isifo okanye umngcipheko wesifo, ukuchonga ubudlelwane bosapho, okanye ukuchonga umntu kuphando lolwaphulo-mthetho.
Izalathiso
- UHefti E, uBlanco J. Ukubhala uVavanyo lweFarmacogenomic ngoVavanyo lweeKhowudi zeNkqubo yamagama (i-CPT) yangoku, uphononongo lweendlela ezidlulileyo nezangoku. J AHIMA [Intanethi]. I-2016 Jan [icatshulwe ngowama-2018 ngoJuni 1]; 87 (1): 56–9. Ifumaneka kwi: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998735
- Uvavanyo lweLebhu kwi-Intanethi [kwi-Intanethi]. IWashington DC: Umbutho waseMelika weKlinikhi yeKhemistry; c2001–2018. Uvavanyo lwe-Pharmacogenetic; [ihlaziywe ngo-2018 Juni 1; ikhankanywe ngo-2018 Jun 1]; [malunga nezikrini ezi-2]. Ifumaneka kwi: https://labtestsonline.org/tests/pharmacogenetic-tests
- Uvavanyo lweLebhu kwi-Intanethi [kwi-Intanethi]. IWashington DC: Umbutho waseMelika weKlinikhi yeKhemistry; c2001–2018. Umhlaba wovavanyo lweMfuzo; [ihlaziywe ngo-2017 Novemba 6; ikhankanywe ngo-2018 Jun 1]; [malunga nezikrini ezi-2]. Ifumaneka kwi: https://labtestsonline.org/articles/genetic-testing?start=4
- Ikliniki yaseMayo: Iziko lezeMpilo eyahlukeneyo [kwi-Intanethi]. Isiseko seMayo seMfundo yezoNyango noPhando; c1998–2018. Ukuvavanywa kweGene-Gene; [icatshulwe ngo-2018 ngoJuni 1]; [malunga nezikrini ezi-3]. Ifumaneka kwi: http://mayoresearch.mayo.edu/center-for-individualized-medicine/drug-gene-testing.asp
- Ikliniki yaseMayo: Iziko lezeMpilo eyahlukeneyo [kwi-Intanethi]. Isiseko seMayo seMfundo yezoNyango noPhando; c1998–2018. Uvavanyo lweCYP2D6 / Tamoxifen yeFarmacogenomic Lab; [icatshulwe ngo-2018 ngoJuni 1]; [malunga nezikrini ezi-5].Ifumaneka kwi: http://mayoresearch.mayo.edu/center-for-individualized-medicine/cyp2d6-tamoxifen.asp
- Ikliniki yaseMayo: Iziko lezeMpilo eyahlukeneyo [kwi-Intanethi]. Isiseko seMayo seMfundo yezoNyango noPhando; c1998–2018. I-HLA-B 1502 / iCarbamazepine yovavanyo lweLebhu ye-Pharmacogenomic Lab; [icatshulwe ngo-2018 ngoJuni 1]; [malunga nezikrini ezi-4]. Ifumaneka kwi: http://mayoresearch.mayo.edu/center-for-individualized-medicine/hlab1502-carbamazephine.asp
- Ikliniki yaseMayo: Iziko lezeMpilo eyahlukeneyo [kwi-Intanethi]. Isiseko seMayo seMfundo yezoNyango noPhando; c1998–2018. I-HLA-B 5701 / i-Abacavir yeFarmacogenomic Lab yovavanyo; [icatshulwe ngo-2018 ngoJuni 1]; [malunga nezikrini ezi-4]. Ifumaneka kwi: http://mayoresearch.mayo.edu/center-for-individualized-medicine/hlab5701-abacavir.asp
- Ikliniki yaseMayo: Mayo Medical Laboratories [kwi-Intanethi]. Isiseko seMayo seMfundo yezoNyango noPhando; c1995–2018. I-ID yovavanyo: I-PGXFP: Iphaneli egxile kwiFarmacogenomics: Uhlobo; [icatshulwe ngo-2018 ngoJuni 1]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://www.mayomedicallaboratories.com/test-catalog/Specimen/65566
- IZiko leSizwe loMhlaza [kwi-Intanethi]. I-Bethesda (MD): Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu; Isichazi-magama seNCI seMiqathango yoMhlaza: imfuza; [icatshulwe ngo-2018 ngoJuni 1]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q;=gene
- Intliziyo kaZwelonke, iMiphunga, kunye neZiko leGazi [kwi-Intanethi]. I-Bethesda (MD): Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu; Uvavanyo lwegazi; [icatshulwe ngo-2018 ngoJuni 1]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://www.nhlbi.nih.gov/health-topics/blood-tests
- IZiko leSizwe le-NIH lezeNzululwazi ngezoNyango [i-Intanethi]. I-Bethesda (MD): Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu; Pharmacogenomics; [ihlaziyiwe ngo-2017 Okt; ikhankanywe ngo-2018 Jun 1]; [malunga nezikrini ezi-4]. Ifumaneka kwi: https://www.nigms.nih.gov/education/Pages/factsheet-pharmacogenomics.aspx
- I-NIH yeLayibrari yeSizwe yoNyango yezeMpilo: Isalathiso seKhaya leMfuza [kwi-Intanethi]. I-Bethesda (MD): Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu; Yintoni i-pharmacogenomics ?; I-2018 ngoMeyi 29 [icatshulwe ngo-2018 ngoJuni 1]; [malunga nezikrini ezi-4]. Ifumaneka kwi: https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomics
- Impilo ye-UF: iYunivesithi yaseFlorida yezeMpilo [i-Intanethi]. IYunivesithi yaseFlorida; c2018. Imfuza yakho iyiphembelela njani into yokuba amayeza akulungele; Ngo-2016 uJan 11 [uhlaziyiweyo ngo-2018 Jun 1; ikhankanywe ngo-2018 Jun 1]; [malunga nezikrini ezi-2]. Ifumaneka kwi: https://ufhealth.org/blog/how-your-genes-influence-what-medicines-are-right-you
- Isibhedlele se-UW saseMelika seSibhedlele saBantwana [i-Intanethi]. Madison (WI): Izibhedlele zeYunivesithi yaseWisconsin kunye neGunya leKlinikhi; c2018. Impilo yaBantwana: Pharmacogenomics; [icatshulwe ngo-2018 ngoJuni 1]; [malunga nezikrini ezi-4]. Ifumaneka kwi: https://www.uwhealthkids.org/kidshealth/en/parents/pharmacogenomics.html/
Ulwazi olukule ndawo akufuneki lusetyenziswe endaweni yonyango okanye iingcebiso. Nxibelelana nomboneleli wezempilo ukuba unemibuzo malunga nempilo yakho.