Iiproton Pump Inhibitors

Umxholo

• Isebenza njani iProton Pump Inhibitors?
• Ngaba zikho iindidi ezahlukeneyo zeProton Pump Inhibitors?
• Zeziphi iingozi zokusebenzisa iProton Pump Inhibitors?
• Amanyathelo alandelayo

Unyango lwesifo se-reflux se-gastroesophageal (GERD) sihlala sinezigaba ezithathu. Amanqanaba amabini okuqala abandakanya ukuthatha amayeza kunye nokwenza ukutya kunye nokutshintsha indlela ophila ngayo. Inqanaba lesithathu lutyando. Ugqirha luqhele ukusetyenziswa kuphela njengendawo yokugqibela enokusetyenziselwa iimeko ezinzima kakhulu ze-GERD ezibandakanya iingxaki.

Uninzi lwabantu luya kuxhamla kunyango lwenqanaba lokuqala ngokulungisa indlela, nini kunye nento abayityayo. Nangona kunjalo, ukutya kunye nohlengahlengiso kwindlela yokuphila kuphela ayinakusebenza kwabanye. Kwiimeko ze-theses, oogqirha banokucebisa ukuba basebenzise amayeza acothisa okanye ayeke ukuveliswa kweasidi esiswini.

Iiproton pump inhibitors (ii-PPIs) lolunye uhlobo lwamayeza anokusetyenziselwa ukunciphisa isisu kunye neempawu zeGERD. Olunye unyango olunokunyanga i-acid engaphezulu kwesisu kubandakanya i-H2 receptor blockers, efana ne-famotidine (Pepcid AC) kunye ne-cimetidine (Tagamet). Nangona kunjalo, ii-PPIs zihlala zisebenza ngakumbi kune-H2 receptor blocker kwaye zinokunciphisa iimpawu kuninzi lwabantu abane-GERD.

Isebenza njani iProton Pump Inhibitors?

Ii-PPI zisebenza ngokuthintela kunye nokunciphisa ukuveliswa kwesisu esiswini. Oku kunika naliphina ixesha leethishu elonakeleyo lokuphola. Ii-PPI zikwanceda ukunqanda ukutsha kwentliziyo, imvakalelo evuthayo ehlala ihamba ne-GERD. Ii-PPI lelinye lawona mayeza anamandla okuphelisa iimpawu ze-GERD kuba ne-asidi encinci inokubangela iimpawu ezibonakalayo.

Ii-PPI zinceda ukunciphisa isisu esiswini ngaphezulu kweeveki ezine ukuya kwezili-12. Eli xesha lexesha livumela ukuphiliswa okufanelekileyo kwezicubu zomqala. Kungathatha ixesha elide kwi-PPI ukunciphisa iimpawu zakho kune-H2 receptor blocker, edla ngokuqala ukunciphisa isisu esiswini kwiyure enye. Nangona kunjalo, ukukhululeka kweempawu kwii-PPIs kuya kuhlala ixesha elide. Ke amayeza e-PPI athambekele ekubeni afanelekileyo kwabo bane-GERD.

Ngaba zikho iindidi ezahlukeneyo zeProton Pump Inhibitors?

Ii-PPIs ziyafumaneka kokubini ngaphandle kwekhawuntari nangemigqaliselo. Ii-PPIs ezingaphezulu kwe-counter zibandakanya:

• I-lansoprazole (Prevacid 24 HR)
• omeprazole (Prilosec)
• esomeprazole (Nexium)

I-Lansoprazole kunye ne-omeprazole nazo ziyafumaneka ngommiselo, njengoko kunjalo ngee-PPI zilandelayo:

• I-dexlansoprazole (Ukunyibilikisa, iKapidex)
• I-pantoprazole sodium (iProtonix)
• irabeprazole sodium (Aciphex)

Elinye iyeza likagqirha elaziwa njengeVimovo likwafumaneka kunyango lwe-GERD. Inomdibaniso we-esomeprazole kunye ne-naproxen.

Amandla-amayeza kunye namandla ee-counter-counter-counter-PPI zibonakala zisebenza ngokulinganayo ekukhuseleni iimpawu zeGERD.

Thetha nogqirha wakho ukuba iimpawu ze-GERD aziphucuki kwi-counter-counter okanye i-PPIs ye-prescription kwiiveki ezimbalwa. Unokuba nefayile ye- Helicobacter pylori (H. pyloriusulelo lwebacteria. Olu hlobo losulelo lufuna unyango olunzima ngakumbi. Nangona kunjalo, usulelo alusoloko lubangela iimpawu. Xa iimpawu zikhula, ziyafana kakhulu neempawu zeGERD. Oku kwenza ukuba kube nzima ukwahlula phakathi kwezi meko zimbini. Iimpawu ze H. pylori Usulelo lunokubandakanya:

• isicaphucaphu
• ukuqhekeza rhoqo
• Ukuphelelwa ngumdla wokutya
• ukudumba

Ukuba ugqirha wakho ukrokrela ukuba une H. pylori usulelo, baya kuqhuba iimvavanyo ezahlukeneyo ukuqinisekisa isifo. Emva koko baya kugqiba ngesicwangciso sonyango esisebenzayo.

Zeziphi iingozi zokusebenzisa iProton Pump Inhibitors?

Ii-PPIs ngokwesiko zithathwa njengezikhuselekileyo kunye namayeza anyamezelwayo. Nangona kunjalo, uphando ngoku lubonisa ukuba umngcipheko othile unokubandakanyeka ekusetyenzisweni kwexesha elide kwala machiza.

Uphononongo lwakutsha nje lufumanise ukuba abantu abasebenzisa ii-PPIs ixesha elide banokungafani okuncinci kwi-gut gut bacteria. Oku kungabikho kokwahluka kubabeka emngciphekweni wokonyuka kosulelo, ukwaphuka kwamathambo, kunye nokusilela kweevithamini kunye nezamaminerali. Amathumbu akho aneebhiliyoni zeebacteria. Ngelixa ezinye zezi ntsholongwane “zimbi,” uninzi lwazo alunabungozi kwaye lunceda kuyo yonke into ukusukela ekwetyisweni nasekuzinziseni imeko. Ii-PPIs zinokuphazamisa ibhalansi yeebhaktiriya ngokuhamba kwexesha, zibangele iibhaktheriya "ezimbi" ukuba zigqithise iibacteria "ezilungileyo". Oku kunokubangela ukugula.

Ukongeza, i-US Food and Drug Administration (i-FDA) yakhupha ngo-2011 eyathi ukusetyenziswa kwexesha elide kwemithi ye-PPIs kunokunxulunyaniswa namanqanaba asezantsi e-magnesium. Oku kunokubangela iingxaki zempilo ezinzulu, kubandakanya ukuphazamiseka kwemisipha, ukubetha kwentliziyo ngendlela engaqhelekanga, kunye nokuxhuzula. Malunga neepesenti ezingama-25 zamatyala apho i-FDA ihlaziyeyo, ukuxhaswa kwe-magnesium kuphela akuzange kuphucule amanqanaba e-serum magnesium asezantsi. Ngenxa yoko, ii-PPIs kuye kwafuneka ziyekwe.

Nangona kunjalo i-FDA igxininisa ukuba akukho mngcipheko mncinci wokuphucula amanqanaba e-magnesium asezantsi xa usebenzisa ii-PPI ezingaphezulu kwekhawuntari njengoko kuyalelwe. Ngokungafaniyo nokuchazwa kwee-PPI, iinguqulelo ezingaphezulu kwee-counter zithengiswa ngeedosi ezisezantsi. Zikwenzelwe ngokubanzi ukuba zenziwe iikhosi zeeveki ezimbini zonyango ezingekho ngaphezulu kwesithathu ngonyaka.

Ngaphandle kweziphumo ebezingalindelekanga ezinokubakho, ii-PPIs zihlala zilunyango olusebenzayo lwe-GERD. Wena kunye nogqirha wakho unokuxoxa ngemingcipheko enokubakho kwaye unqume ukuba ngaba ii-PPIs zezona zilungileyo kuwe.

Amanyathelo alandelayo

Xa uyeka ukuthatha ii-PPIs, unokufumana ukwanda kwimveliso yeasidi. Olu konyuka lungahlala iinyanga ezininzi. Ugqirha wakho unokukuncancisa la machiza ukukunceda ukuthintela oku ukuba kungenzeki. Banokucebisa ngokuthatha la manyathelo alandelayo ukunciphisa ukungonwabi kwakho nakweyiphi na impawu zeGERD:

• ukutya iziqwenga ezincinci
• Ukutya amanqatha amancinci
• ukunqanda ukubeka phantsi ubuncinci iiyure ezimbini emva kokutya
• ukunqanda amashwamshwam phambi kokulala
• unxibe impahla ekhululekileyo
• ukuphakamisa intloko yebhedi malunga nee-intshi ezintandathu
• ukunqanda utywala, icuba, kunye nokutya okubangela iimpawu

Qinisekisa ukubonisana nogqirha wakho ngaphambi kokuba uyeke ukuthatha nawaphi na amayeza amiselweyo.