Uvavanyo lwePyruvate Kinase

Umxholo

• Kutheni uVavanyo lwePyruvate Kinase luyalelwa?
• Ulawulwa njani uVavanyo?
• Zithini iingozi zovavanyo?
• Ukuqonda iZiphumo zakho

Uvavanyo lwePyruvate Kinase

Iiseli ezibomvu zegazi (RBCs) zithwala ioksijini kuwo wonke umzimba wakho. I-enzyme eyaziwa ngokuba yi-pyruvate kinase iyimfuneko kumzimba wakho ukwenza ii-RBCs kunye nokusebenza ngokufanelekileyo. I-pyruvate kinase testis kuvavanyo lwegazi olusetyenziselwa ukulinganisa amanqanaba epyruvate kinase emzimbeni wakho.

Xa une-pyruvate kinase encinci, ii-RBCs zakho ziyehla ngokukhawuleza kunesiqhelo. Oku kunciphisa inani lee-RBCs ezikhoyo ukuhambisa ioksijini kwizitho ezibalulekileyo, izicwili kunye neeseli. Imeko ekhokelela kuyo yaziwa ngokuba yi-hemolytic anemia kwaye inokuba neziphumo ezibonakalayo kwezempilo.

Iimpawu ze-hemolytic anemia zibandakanya:

• i-jaundice (ukutyheli kolusu)
• ukwandiswa kwepeni (umsebenzi oyintloko wepeni kukucoca igazi kunye nokutshabalalisa ii-RBCs ezindala nezonakalisiweyo)
• i-anemia (ukunqongophala kwee-RBCs ezisempilweni)
• ulusu oluthuthu
• ukudinwa

Ugqirha wakho unokumisela ukuba ngaba une-pyruvate kinase defence esekwe kwiziphumo zolu kunye nolunye uvavanyo lokuqonda isifo.

Kutheni uVavanyo lwePyruvate Kinase luyalelwa?

Ukusilela kwePyruvate kinase sisifo semfuza esiguqula i-autosomal recessive. Oku kuthetha ukuba umzali ngamnye uphethe ufuzo olungalunganga kwesi sifo. Nangona ufuzo lungakhange lubonakaliswe komnye wabazali (oko kuthetha ukuba akukho ntsilelo ye-pyruvate kinase), uphawu oluphindaphindeneyo lunethuba le-1-in-4 lokuvela kubo nabaphi na abantwana abanabazali kunye.

Abantwana abazelwe ngabazali abanesiphene semfuza ye-pyruvate kinase baya kuvavanywa kuphazamiso kusetyenziswa uvavanyo lwe-pyruvate kinase. Ugqirha wakho unokuyalela uvavanyo ekuchongeni iimpawu zokusilela kwepyruvate kinase. Idatha eqokelelwe kuvavanyo lomzimba, uvavanyo lwe-pyruvate kinase, kunye nolunye uvavanyo lwegazi oluya kunceda ukuqinisekisa isifo.

Ulawulwa njani uVavanyo?

Awudingi ukwenza nantoni na ethile ukulungiselela uvavanyo lwe-pyruvate kinase. Nangona kunjalo, uvavanyo luhlala luqhutywa kubantwana abancinci, ke abazali banokufuna ukuthetha nabantwana babo malunga nokuba uvavanyo luza kuziva njani. Ungabonisa uvavanyo kunodoli ukunceda ukunciphisa uxinzelelo lomntwana wakho.

Uvavanyo lwe-pyruvate kinase lwenziwa kwigazi elithathiweyo ngexesha lokutsalwa kwegazi okuqhelekileyo. Umboneleli wezempilo uyakuthatha isampulu yegazi engalweni okanye esandleni sakho esebenzisa inaliti encinci okanye iblade ebizwa ngokuba yi-lancet.

Igazi liya kuqokelela liye kumbhobho lize liye elabhoratri ukuze lihlalutywe. Ugqirha wakho uya kuba nakho ukukunika ulwazi malunga neziphumo kunye nokuba zithetha ntoni.

Zithini iingozi zovavanyo?

Izigulana ezenza uvavanyo lwe-pyruvate kinase zinokufumana ukungonwabi ngexesha lokutsalwa kwegazi. Kunokubakho iintlungu kwindawo yenaliti evela kwiintonga zenaliti. Emva koko, abaguli banokufumana iintlungu, ukugruzuka, okanye ukubetha kwindawo yenaliti.

Imingcipheko yovavanyo incinci. Ubungozi obunokubakho nakuphi na ukuzoba kwegazi kubandakanya:

• ubunzima bokufumana isampulu, okukhokelela kwiinti ezininzi zeenaliti
• ukopha kakhulu kwindawo yenaliti
• ukuwa isiqaqa ngenxa yokulahleka kwegazi
• ingqokelela yegazi phantsi kolusu, eyaziwa ngokuba yihematoma
• ukukhula kosulelo apho ulusu lwaphuke khona ngenaliti

Ukuqonda iZiphumo zakho

Iziphumo zovavanyo lwe-pyruvate kinase ziya kwahluka ngokusekwe kwilabhoratri ehlalutya isampulu yegazi. Ixabiso eliqhelekileyo lovavanyo lwe-pyruvate kinase li-179 ngokudibanisa okanye thabatha iiyunithi ezili-16 zepyruvate kinase nge-100 milliliters yee-RBCs. Amanqanaba asezantsi e-pyruvate kinase abonisa ubukho bokusilela kwe-pyruvate kinase.

Akukho lunyango lokusilela kwe-pyruvate kinase. Ukuba ufumanisa ukuba unale meko, ugqirha wakho unokucebisa ngeendlela ezahlukeneyo zonyango. Kwiimeko ezininzi, abaguli abanesiphene se-pyruvate kinase kuya kufuneka batofelwe igazi ukuze babuyisele ii-RBCs ezonakeleyo. Utofelo-gazi ngenaliti yegazi evela kulowo unikele ngayo.

Ukuba iimpawu zesifo zinzima kakhulu, ugqirha wakho unokucebisa nge-splenectomy (ukususwa kwepeni). Ukususa udakada kunokunceda ukunciphisa inani lee-RBCs ezitshatyalaliswayo. Nokuba udakada ususwe, iimpawu zokuphazamiseka zisenokuhlala. Iindaba ezimnandi zezokuba unyango ngokuqinisekileyo luya kunciphisa iimpawu zakho kunye nokuphucula umgangatho wobomi.