Imibuzo eli-9 malunga neWaldenstrom Macroglobulinemia

Umxholo

• 1. Ngaba i-Waldenstrom macroglobulinemia iyanyangeka?
• 2. Ngaba iWaldenstrom macroglobulinemia inokuxolelwa?
• 3. Inqabile kangakanani iWaldenstrom macroglobulinemia?
• 4. Iqhuba njani iWaldenstrom macroglobulinemia?
• 5. Ngaba iWaldenstrom macroglobulinemia isebenza kwiintsapho?
• 6. Yintoni ebangela iWaldenstrom macroglobulinemia?
• 7. Unokuhlala ixesha elingakanani kunye neWaldenstrom macroglobulinemia?
• 8. Ngaba iWaldenstrom macroglobulinemia metastasize?
• 9. Iphathwa njani i-Waldenstrom macroglobulinemia?
• Ukuthatha

IWaldenstrom macroglobulinemia (WM) yindlela enqabileyo ye-non-Hodgkin's lymphoma ebonakaliswa kukuveliswa kakhulu kweeseli ezimhlophe ezingaqhelekanga.

Luhlobo olukhula kancinci lomhlaza weseli yegazi echaphazela abantu abathathu kwisigidi esinye e-United States minyaka le, ngokwe-American Cancer Society.

I-WM ngamanye amaxesha ibizwa ngokuba:

• Isifo sikaWaldenstrom
• I-lymphoplasmacytic lymphoma
• iiprayimari ze-macroglobulinemia

Ukuba ufumene ukuba une-WM, unokuba nemibuzo emininzi ngesi sifo. Ukufunda kangangoko unako malunga nomhlaza kunye nokuphonononga ukhetho kunyango kunokukunceda ujongane nale meko.

Nazi iimpendulo kwimibuzo esithoba enokukunceda uyiqonde ngcono iWM.

1. Ngaba i-Waldenstrom macroglobulinemia iyanyangeka?

I-WM okwangoku ayinalo unyango olwaziwayo. Nangona kunjalo, iindlela ezahlukeneyo zonyango ziyafumaneka ukukunceda ulawule iimpawu zakho.

Umbono wabantu abafunyaniswe bene-WM uphuculile kule minyaka idlulileyo. Iingcali zenzululwazi ziphinda ziphonononge izitofu zokunceda ukunyusa amajoni omzimba ukwala olu hlobo lomhlaza kunye nokuphuhlisa iindlela ezintsha zonyango.

2. Ngaba iWaldenstrom macroglobulinemia inokuxolelwa?

Kukho ithuba elincinci lokuba i-WM ingene kuxolelo, kodwa ayiqhelekanga. Oogqirha babone kuphela ukuxolelwa okupheleleyo kwesi sifo kubantu abambalwa. Unyango lwangoku alukuthinteli ukubuyela umva.

Ngelixa kungekho datha ininzi kumanani oxolelo, isifundo esinye esincinci esivela ku-2016 safumanisa ukuba nge-WM yangena kuxolelo olupheleleyo emva kokuphathwa ngerejimeni ye "R-CHOP."

Inkqubo yeR-CHOP ibandakanya ukusetyenziswa kwe:

• yitshba
• cyclophosphamide
• vincristine
• yomsoxin
• ubume

Abanye abathathi-nxaxheba abangama-31 baphumelele uxolelo.

Thetha nogqirha wakho ukuze ubone ukuba olu nyango, okanye enye irejimeni, ikulungele na.

3. Inqabile kangakanani iWaldenstrom macroglobulinemia?

Oogqirha bafumanisa i-1,000 ukuya kwi-1,500 yabantu e-United States nge-WM minyaka le, ngokwe-American Cancer Society. Umbutho weSizwe weZinto eziNqabileyo uzithatha njengeyona nto inqabileyo.

I-WM idla ngokuchaphazela amadoda aphindwe kabini kunabafazi. Esi sifo asixhaphakanga kubantu abamnyama kunabantu abamhlophe.

4. Iqhuba njani iWaldenstrom macroglobulinemia?

I-WM ithanda ukuqhubela phambili ngokuthe chu. Idala ukugqitha kweentlobo ezithile zeeseli ezimhlophe zegazi ezibizwa ngokuba ziiB lymphocyte.

Ezi seli zenza ukugqitha kwintsholongwane ebizwa ngokuba yi-immunoglobulin M (IgM), ebangela imeko yokuqina kwegazi ekuthiwa yi-hyperviscosity. Oku kwenza ukuba kube nzima kumalungu akho kunye nezicubu ukuba zisebenze ngokufanelekileyo.

Ukugqitha kwee-lymphocyte ze-B kunokushiya igumbi elincinci kumongo wethambo kwiiseli zegazi ezisempilweni. Unokuphuhlisa i-anemia ukuba ukubala kweeseli ezibomvu kwehla kakhulu.

Ukunqongophala kweeseli ezimhlophe zegazi kunokwenza ukuba kube nzima kumzimba wakho ukulwa nezinye iintlobo zosulelo. Iiplatelet zakho zinokuhla, ezinokukhokelela ekopheni nasekukruqukeni.

Abanye abantu abafumani zimpawu kwiminyaka eliqela emva kokuxilongwa.

Iimpawu zokuqala zibandakanya ukudinwa kunye namandla asezantsi ngenxa ye-anemia. Unokuba neminwe eminwe kunye neenzwane kunye nokuphuma kwempumlo nakwiintsini.

I-WM inokuchaphazela ekugqibeleni amalungu, ekhokelela ekudumbeni kwesibindi, udakada, kunye ne-lymph node. Ukunyanzeliswa sisifo kungakhokelela kumbono omdaka okanye iingxaki zokuhamba kwegazi ukuya kwi-retina.

Umhlaza ekugqibeleni unokubangela iimpawu ezinjenge-stroke ngenxa yokuhamba gazi okungalunganga kwingqondo, kunye nemicimbi yentliziyo nezintso.

5. Ngaba iWaldenstrom macroglobulinemia isebenza kwiintsapho?

Izazinzulu zisafunda iWM, kodwa zikholelwa ekubeni izakhi zofuzo ezinokuzuzwa zinokwandisa amathuba abanye abantu okuphuhlisa esi sifo.

Phantse iipesenti ezingama-20 zabantu abanolu hlobo lomhlaza banxulumene ngokusondeleyo nomntu one-WM okanye esinye isifo esibangela iiseli ze-B ezingaqhelekanga.

Uninzi lwabantu abafunyaniswe ukuba bane-WM abanayo imbali yosapho yokuphazamiseka. Ihlala isenzeka njengesiphumo sokutshintsha kweseli, esingazuzwanga njengelifa, kubo bonke ubomi bomntu.

6. Yintoni ebangela iWaldenstrom macroglobulinemia?

Izazinzulu kusafuneka zichaze ukuba yintoni kanye kanye ebangela iWM. Ubungqina bucebisa ukuba ukudityaniswa kwemfuza, okusingqongileyo, kunye neentsholongwane kubomi bomntu kunokukhokelela kuphuhliso lwesifo.

Utshintsho kuhlobo lwe-MYD88 lwenzeka malunga neepesenti ezingama-90 zabantu abane-Waldenstrom macroglobulinemiaemia, ngokwe-International Waldenstrom's Macroglobulinemia Foundation (IWMF).

Olunye uphando lufumene unxibelelwano phakathi kwe-hepatitis C engapheliyo kunye ne-WM kwezinye (kodwa ayizizo zonke) abantu abanesifo.

Ukuvezwa kwezinto ezenziwe ngesikhumba, irabha, izinyibilikisi, idayi, kunye neepeyinti kunokuba yinto ebalulekileyo kwezinye iimeko zeWM. Uphando malunga nonobangela weWM luyaqhubeka.

7. Unokuhlala ixesha elingakanani kunye neWaldenstrom macroglobulinemia?

Izifundo zamva nje zibonisa ukuba isiqingatha sabantu abane-WM kulindeleke ukuba baphile iminyaka eli-14 ukuya kweli-16 emva kokuchongwa kwabo, ngokwe-IWMF.

Umbono wakho unokwahluka ngokuxhomekeke ku:

• iminyaka yakho
• impilo iyonke
• sihamba ngokukhawuleza kangakanani isifo

Ngokungafaniyo nezinye iintlobo zomhlaza, i-WM ayifumaneki ngokwamanqanaba. Endaweni yoko, oogqirha basebenzisa iNkqubo yokuHlola amaZwe ngamaZwe kwiWaldenstrom Macroglobulinemia (ISSWM) ukuvavanya umbono wakho.

Le nkqubo ithathela ingqalelo izinto ezahlukeneyo, kubandakanya eyakho:

• ubudala
• inqanaba legazi lehemoglobin
• ubalo lweplatelet
• inqanaba le-beta-2 microglobulin
• Inqanaba le-IgM ye-monoclonal

Ngokusekwe kumanqaku akho kwezi zinto zinomngcipheko, ugqirha wakho angakubeka kwiqela eliphantsi, eliphakathi-, okanye elinomngcipheko ophezulu, onokukunceda uqonde ngcono umbono wakho.

Ireyithi yokusinda yeminyaka emi-5 yabantu abakwicandelo elinomngcipheko ophantsi ngama-87 eepesenti, iqela eliphakathi komngcipheko liipesenti ezingama-68, kwaye iqela elinomngcipheko omkhulu ngama-36 epesenti, ngokwe-American Cancer Society.

Ezi nkcukacha-manani zisekwe kwidatha evela kubantu abangama-600 abafunyaniswe bene-WM kwaye banyangwa ngaphambi kukaJanuwari 2002.

Unyango olutsha lunokunika umbono oqinisekileyo.

8. Ngaba iWaldenstrom macroglobulinemia metastasize?

Ewe. I-WM ichaphazela izicubu ze-lymphatic, ezifumaneka kwiindawo ezininzi zomzimba. Ngexesha umntu esiba nesi sifo, sele sele sifunyenwe egazini nakumongo wethambo.

Ingasasazeka kwii-lymph nodes, isibindi kunye ne-spleen. Kwiimeko ezinqabileyo, i-WM inokuphinda isisu esiswini, isifo se-thyroid, isikhumba, imiphunga kunye namathumbu.

9. Iphathwa njani i-Waldenstrom macroglobulinemia?

Unyango lwe-WM luyahluka ukusuka komnye umntu ukuya komnye kwaye ngokubanzi aluqali de ube ufumana iimpawu zesi sifo. Abanye abantu abanakufuna unyango kude kube yiminyaka embalwa emva kokufunyaniswa.

Ugqirha wakho unokucebisa ukuba uqale unyango xa iimeko ezithile ezibangelwa ngumhlaza zikhona, kubandakanya:

• isifo sentsholongwane
• ianemia
• umonakalo wemithambo-luvo
• iingxaki zomzimba
• amyloidosis
• cryoglobulins

Zininzi iindlela zonyango ezikhoyo zokukunceda ulawule iimpawu. Unyango oluqhelekileyo lwe-WM lubandakanya:

• Unokhenketho
• ichemotherapy
• unyango ekujoliswe kulo
• Unyango lokuzikhusela

Kwiimeko ezinqabileyo, ugqirha wakho unokucebisa unyango olungaqhelekanga, olufana:

• ukususwa kwepeni
• Ukufakelwa kweseli
• unyango lwemitha

Ukuthatha

Ukufumanisa ukuba unomdlavuza onqabileyo njenge-WM kunokuba ngamava anzima.

Nangona kunjalo, ukufumana ulwazi lokukunceda uyiqonde ngcono imeko yakho kunye nokhetho kunyango, kunokukunceda uzive uzithembile malunga nembono yakho.