Izizathu ezi-6 zokuzama i-Biologics yeSifo sakho seCrohn

Umxholo

• 1. Awuphenduli kunyango lwesifo sikaCrohn esiqhelekileyo
• 2. Unesifo esitsha
• 3. Uhlangabezana nengxaki eyaziwa ngokuba yifistula
• 4. Ufuna ukugcina uxolelo
• 5. Umthamo unokuba kube kanye ngenyanga
• 6. I-Biologics inokuba neziphumo ebezingalindelekanga ezimbalwa kunee-steroids
• Ukoyisa ukuthandabuza kwakho
• Ukukhetha i-biologic

Njengomntu ophila nesifo sikaCrohn, kusenokwenzeka ukuba uvile nge-biologics kwaye usenokucinga nokuzisebenzisa ngokwakho. Ukuba kukho into ekubambayo, ufike kwindawo efanelekileyo.

Nazi izizathu ezintandathu onokufuna ukuphinda uziqwalasele olu hlobo lonyango luqhubayo, kunye neengcebiso zokwenza njalo.

1. Awuphenduli kunyango lwesifo sikaCrohn esiqhelekileyo

Mhlawumbi uthathe amayeza ahlukeneyo eCrohn's disease, anje ngee-steroids kunye nee-immunomodulators, okwethutyana ngoku. Nangona kunjalo, usenazo i-flare-ups amatyeli aliqela ngonyaka.

Izikhokelo zeAmerican College of Gastroenterology (ACG) zicebisa ukuba uthathe iarhente ye-biologic ukuba unesifo sikaCrohn esisemgangathweni esinganyangekiyo kwi-steroids okanye kwi-immunomodulators. Ugqirha wakho unokujonga ngokudibanisa i-biologic kunye ne-immunomodulator, nokuba awuzange uzame la machiza ngokwahlukeneyo okwangoku.

2. Unesifo esitsha

Ngokwesiko, izicwangciso zonyango zesifo sikaCrohn zibandakanya indlela yokunyusa. Amachiza abiza kakhulu, njengee-steroids, azanywa kuqala, ngelixa i-biologics ebiza kakhulu yazama ukugqibela.

Kutshanje, izikhokelo zithethelela indlela ephezulu yonyango, njengoko ubungqina bukhombisile kwiziphumo eziphumeleleyo zonyango lwe-biologic kwizigulana ezisandula ukufunyanwa.

Umzekelo, olunye uphononongo olukhulu lwedatha yamabango onyango yafumanisa ukuba ukuqala ngebhayoloji ekuqaleni kwonyango lwesifo sikaCrohn kuphucula impendulo kunyango.

Iqela lokufunda eliqale ngokuchasene ne-TNF biologics kwangoko lalinamazinga asezantsi kakhulu okufuna i-steroids yokunyanga i-flare-ups kunamanye amaqela okufunda. Baye benza utyando ezimbalwa ngenxa yesifo sikaCrohn.

3. Uhlangabezana nengxaki eyaziwa ngokuba yifistula

Iifistula ziindawo zonxibelelwano ezingaqhelekanga phakathi kwamalungu omzimba. Kwisifo sikaCrohn, i-fistula inokwenzeka xa isilonda sisolulela kudonga lwakho lwamathumbu, oludibanisa amathumbu kunye nolusu, okanye amathumbu akho kunye nelinye ilungu.

Ukuba i-fistula iyosuleleka, inokubusongela ubomi. I-Biologics eyaziwa ngokuba yi-TNF inhibitors inokumiselwa ngugqirha wakho ukuba une-fistula kuba iyasebenza.

I-FDA ivume i-biologics ngokukodwa ukunyanga isifo se-Crohn kunye nokugcina ukuvalwa kwe-fistula.

4. Ufuna ukugcina uxolelo

Iicorticosteroids ziyaziwa ngokuzisa uxolelo kodwa azikwazi ukugcina olo xolelo. Ukuba uthathe i-steroids iinyanga ezintathu okanye nangaphezulu, ugqirha wakho unokukuqala kwi-biologic endaweni yoko. Izifundo zonyango zibonisa ukuba i-anti-TNF biologics iyakwazi ukugcina ukuxolelwa kwizigulana ezinesifo esiqatha sikaCrohn.

I-ACG igqibe ekubeni izibonelelo zala machiza ukugcina ukuxolelwa zingaphezulu kobubi kwizigulana ezininzi.

5. Umthamo unokuba kube kanye ngenyanga

Ingcinga yenaliti inokothusa, kodwa emva kwedosi ezimbalwa zokuqala, uninzi lweebhayoloji zenziwa kube kanye ngenyanga. Ngaphezulu koku, inaliti incinci kakhulu, kwaye iyeza lifakwa phantsi kolusu lwakho.

Uninzi lwee-biologics zikwanikezelwa ngohlobo lwe-auto-injakor-oku kuthetha ukuba ungafumana iinaliti ngaphandle kokuyibona inaliti. Unokude uzinike i-biologics ethile ekhaya emva kokuba uqeqeshwe ngokufanelekileyo ukuba ungakwenza njani oko.

6. I-Biologics inokuba neziphumo ebezingalindelekanga ezimbalwa kunee-steroids

ICorticosteroids esetyenziselwa ukunyanga isifo sikaCrohn, esifana ne-prednisone okanye i-budesonide, isebenza ngokucinezela amajoni omzimba onke.

I-Biologics, ngakolunye uhlangothi, isebenza ngendlela ekhethiweyo ngokujolisa kwiiprotheni ezithile kwi-immune system yakho esele ibonakaliswe ukuba idibene nokuvuvukala kukaCrohn. Ngesi sizathu, baneziphumo ebezingalindelekanga ezimbalwa kune-corticosteroids.

Phantse zonke iziyobisi zithwala umngcipheko weziphumo ebezingalindelekanga. Kwi-biologics, iziphumo eziqhelekileyo ezichaphazelekayo zihambelana nendlela ezilawulwa ngayo. Unokufumana ukucaphuka okuncinci, ukuba bomvu, iintlungu, okanye impendulo kwindawo yenaliti.

Kukho umngcipheko ophakamileyo wosulelo, kodwa umngcipheko awukho phezulu njengezinye iziyobisi, ezinje nge-corticosteroids.

Ukoyisa ukuthandabuza kwakho

I-biologic yokuqala yesifo sikaCrohn yavunywa ngo-1998, ngoko i-biologics inamava kunye nokuvavanya ukhuseleko ukuzibonisa. Unokuba mathidala ukuzama unyango lwe-biologic kuba uvile ukuba "banamandla" amachiza okanye woyika iindleko eziphezulu.

Ngelixa kuyinyani ukuba i-biologics ithathwa njengonyango olunobundlongondlongo ngakumbi, i-biologics ikwajolise ngakumbi kwiziyobisi, kwaye zisebenza kakuhle kakhulu.

Ngokungafaniyo nezinye iindlela zonyango lwakudala lwesifo sikaCrohn esenza buthathaka amajoni omzimba, iziyobisi ze-biologic zijolise kwiiproteni ezithile ezitshisayo ezaziwayo ukuba ziyabandakanyeka kwisifo sikaCrohn. Ngokwahlukileyo, iziyobisi ze-corticosteroid ziyayicinezela yonke inkqubo yomzimba yokuzikhusela.

Ukukhetha i-biologic

Ngaphambi kwe-biologics, zazimbalwa iindlela zokonyango ngaphandle kotyando kubantu abanesifo sikaCrohn. Ngoku kukho iindlela ezininzi:

• i-adalimumab (Humira, Exemptia)
• isatifikethi sepgol (Cimzia)
• infliximab (Remicade, Remsima, Inflectra)
• natalizumab (iTysabri)
• ustekinumab (uStelara)
• vedolizumab (Entyvio)

Kuya kufuneka usebenze nenkampani yeinshurensi yakho ukufumana ukuba ngaba i-biologic ethile igutyungelwe phantsi kwesicwangciso sakho.

Kucacile ukuba amayeza e-biologic aphucule imeko yamathuba okunyanga isifo sikaCrohn kunye nezinye iingxaki zokuzimela. Uphando luyaqhubeka nokukhula kwi-biologics, eyenza ukuba kunokwenzeka ukuba unyango oluninzi ngakumbi unokufumaneka kwixa elizayo.

Ekugqibeleni, isicwangciso sakho sonyango sisigqibo esenziwe kakuhle nogqirha wakho.