Ithetha ukuthini i-SVR kubantu abaneHepatitis C?

Umxholo

• Ezinye iimpendulo ze-virologic
• Uyenza njani i-SVR
• Ngaba i-genotypes ihambelana njani ne-SVR?
• Amayeza anamhlanje e-HCV
• Kuthekani ukuba awuyiphumeleli i-SVR?
• Imbonakalo
• Yakha inethiwekhi yenkxaso

Yintoni i-SVR?

Injongo yonyango lwe-hepatitis C kukususa igazi lakho kwintsholongwane ye-hepatitis C (HCV).Ngexesha lonyango, ugqirha wakho uza kubeka iliso kwinqanaba lentsholongwane egazini lakho (umthwalo wentsholongwane). Xa intsholongwane ingasakwazi ukubonwa, ibizwa ngokuba yimpendulo ye-virologic, oko kuthetha ukuba unyango lwakho luyasebenza.

Uya kuqhubeka kuvavanyo lwegazi rhoqo ukukhangela nayiphi na i-RNA ebonakalayo, izinto zemvelo zentsholongwane ye-hepatitis C. Impendulo ye-virologic (SVR) eqhubekayo iqhubeka xa iimvavanyo zegazi ziqhubeka zingabonakali i-RNA kwiiveki ezili-12 okanye ngaphezulu emva kokunyanga.

Kutheni i-SVR inqweneleka? Ngenxa yokuba iipesenti ezingama-99 zabantu abafezekisa i-SVR bahlala bengenayo intsholongwane ubomi kwaye banokuqwalaselwa njengonyango.

Xa uyiphumezile i-SVR, awusenayo intsholongwane kwinkqubo yakho, ke awunakukhathazeka ngokudlulisela intsholongwane kuye nakubani na. Emva kwe-SVR, isibindi sakho asisahlaselwa. Kodwa ukuba sele ugcinile umonakalo wesibindi, unokufuna unyango olongezelelweyo.

Igazi lakho liya kuhlala linee-antibodies ze-hepatitis C. Oko akuthethi ukuba awunakuphinda usuleleke. Kuya kufuneka uthathe amanyathelo othintelo ukunqanda ukubonwa ziintlobo ezininzi zeHCV.

Ezinye iimpendulo ze-virologic

Ukuvavanywa kwegazi rhoqo kuya kuvavanya ukusebenza konyango. Amagama asetyenziselwa ukuchaza iimpendulo ze-virologic anokudideka kancinci.

Nalu uluhlu lwamagama aqhelekileyo kunye neentsingiselo zawo:

• I-SVR12. Yilapho iimvavanyo zakho zegazi zibonisa impendulo eqhubekayo ye-virologic (SVR), okanye akukho mali ifumanekayo ye-HCV, emva kweeveki ezili-12 zonyango. Okwangoku, uthathwa njengonyango lwe-hepatitis C. Isiphawuli sonyango esasisebenzisa ukuba yi-SVR24, okanye akukho mali ifumanekayo ye-HCV egazini lakho emva kweeveki ezingama-24 zonyango. Kodwa ngamayeza anamhlanje, i-SVR12 ngoku ithathwa njengophawu lokunyanga.
• I-SVR24. Yilapho iimvavanyo zakho zibonisa impendulo eqhubekayo ye-virologic (SVR), okanye akukho mali ifumanekayo ye-HCV egazini lakho, emva kweeveki ezingama-24 zonyango. Le nto yayikade ingumgangatho wokunyanga, kodwa ngamayeza amatsha anamhlanje, i-SVR12 ngoku ihlala ithathwa njengophawu lokunyanga.
• Impendulo ekhethekileyo. Amanqanaba akho e-HCV ehle ngexesha lonyango, kodwa intsholongwane isabonakala kwigazi lakho.
• Ukungaphenduli okanye ukuphendula okungalunganga. Akukho lutshintsho okanye akukho lutshintsho kumthwalo wakho weHCV ngenxa yonyango.
• Buyela umva. Le ntsholongwane ibingabonakali egazini lakho okwexeshana, kodwa iphinde yafunyanwa kwakhona. Ukubuya kwayo kunokwenzeka nokuba emva okanye emva konyango. Ugqirha wakho uya kukunceda uthathe isigqibo malunga nolunye unyango.

Uyenza njani i-SVR

Zininzi iindlela zokwenza unyango. Iya kubandakanya indibaniselwano yamachiza, uninzi lwazo ngoku oludityaniswe neepilisi enye. Kungafuneka uthathe ipilisi enye ngosuku.

Ugqirha wakho uya kuncoma irejimeni esekwe kwi:

• ubudala kunye nempilo iyonke
• uhlobo lwe-hepatitis genotype
• ubungakanani bomonakalo wesibindi, ukuba bukhona
• ukukwazi ukulandela izikhokelo zonyango
• iziphumo ebezingalindelekanga ezinokubakho

Ukuqaliswa kwamachiza antiviral asebenzayo ngokuthe ngqo (i-DAAs) ngo-2011 kutshintshe ngokupheleleyo unyango lwe-hepatitis C.

Ngaphambi koko, unyango lwalubandakanya ikakhulu inaliti yamachiza abizwa ngokuba yi-interferon kunye ne-ribavirin, kunye namanye amayeza akwipilisi. Unyango lwalusoloko lungasebenzi, kwaye iziphumo ebezingalindelekanga, kubandakanya ukudakumba, isicaphucaphu, kunye neanemia, zazinzulu.

Ngo-2014, kwaziswa igagasi lesibini le-DAA esebenzayo ngakumbi. La machiza amatsha antiviral sele engoyena ndoqo kunyango lwangoku lwe-hepatitis C engapheliyo e-United States. Bahlasela intsholongwane ngokuthe ngqo kwaye basebenza ngakumbi kunamayeza angaphambili.

IiDAA ezintsha zinokuthathwa ngomlomo, rhoqo kwipilisi enye yonke imihla. Zineziphumo ebezingalindelekanga ezimbalwa, ukonyuka kwamanqanaba onyango, kunye nokunciphisa ixesha lonyango kwiinkqubo ezithile zamachiza kwiminyaka emihlanu eyadlulayo.

I-DAAs yesibini-wave iyakwazi ukunyanga uluhlu olubanzi lwezixhenxe zehepatitis C ezaziwayo, okanye iintlobo zemfuza. Ezinye ze-DAA ezintsha zinokunyanga zonke ii-genotypes ngokudibanisa amayeza ahlukeneyo kwiipilisi ukujolisa kwi-genotypes ezahlukeneyo.

Ezinye ii-DAA zamaza okuqala zisasetyenziswa ngokudibanisa ne-interferon kunye neeroburin, kodwa uninzi lwee-DAA zamaza wesibini zisetyenziswa zodwa.

Umyinge wokunyanga, okanye i-SVR, yerejimeni ze-DAA zangoku ngoku zimalunga neepesenti ezingama-95 ngokubanzi. Eli nqanaba lihlala likhulu kakhulu kubantu abangenayo i-cirrhosis, okanye i-scarring, yesibindi kwaye abazange bafumane unyango lwangaphambili lwe-hepatitis C.

Ukusukela ukongezwa kwee-DAA ezisebenza ngakumbi ukusukela ngo-2014, ezinye ii-DAA zamaza okuqala zaphelelwa lixesha, kwaye abavelisi bazo bazikhupha kwintengiso.

Oku kubandakanya ichiza i-Olysio (simeprevir), eyekile ngoMeyi 2018, kunye neziyobisi iTevivie (ombitasvir / paritaprevir / ritonavir) kunye neViekira Pak (ombitasvir / paritaprevir / ritonavir kunye nedasabuvir), eyekile ngoJanuwari 1, 2019.

Zonke iiDAA zizidibanisi zamachiza. Oososayensi bafumanise ukuba ukudibanisa amayeza ajolise kwintsholongwane ngokwahlukileyo kunokonyusa ithuba lokunyanga. Abantu abafumana unyango bahlala bethatha iipilisi ezahlukeneyo, nangona uninzi lonyango ngoku lubandakanya ipilisi enye edibanisa amayeza ahlukeneyo. Bahlala bethatha amayeza iiveki ezili-12 ukuya kwezi-24, okanye ngaphezulu.

Ugqirha wakho uya kukunceda uthathe isigqibo malunga nerejimeni yonyango lwakho, kuxhomekeke kwimbali yakho yezonyango kwaye yeyiphi i-hepatitis C onayo. Alikho iyeza lokufumana i-hepatitis C njengoko kukho i-hepatitis A kunye no-B.

Ngaba i-genotypes ihambelana njani ne-SVR?

Amayeza e-Hepatitis C ahlala ahlelwa ngohlobo lwe-virus olwenzelwe ukunyanga. Uhlobo lwe-genotype luhlobo oluthile lwentsholongwane olwenziwe njengoko intsholongwane iguquka.

Okwangoku zisixhenxe ii-HCV genotypes ezaziwayo, kunye nee-subtypes ezaziwayo ngaphakathi kwezo genotypes.

I-Genotype 1 yinto exhaphakileyo e-United States, ichaphazela malunga neepesenti ezingama-75 zabantu baseMelika abane-HCV. I-Genotype 2 yinto yesibini exhaphakileyo, echaphazela ama-20 ukuya kuma-25 ekhulwini kumaMerika ane-HCV. Abantu abanesivumelwano se-genotypes 3 ukuya ku-7 bahlala bengaphandle kwe-United States.

Amanye amayeza aphatha zonke okanye ezininzi zeHCV genotypes, kodwa ezinye iziyobisi zijolise kuhlobo olunye kuphela. Ukulinganisa ngononophelo amayeza akho kwi-genotype yosulelo lwakho lwe-HCV kunokukunceda ufezekise i-SVR.

Ugqirha wakho uya kuvavanya ukufumanisa uhlobo lwakho losulelo lwe-HCV, olubizwa ngokuba yi-genotyping. Iirejimeni zamayeza kunye neeshedyuli zeedosi zahlukile kwiindidi ezahlukeneyo zohlobo lwendalo.

Amayeza anamhlanje e-HCV

Oku kulandelayo luluhlu lwezinye zeyeza zangoku zokulwa intsholongwane ezisetyenziselwa ukunyanga i-hepatitis C, ezilungelelaniswe ngokulandelelana kwealfabhethi. Unokufumana ulwazi oluthe kratya malunga namayeza e-HCV akhoyo apha.

Ulwazi oluluhlu olungezantsi luthathwe kumachiza e-hepatitis C avunyiweyo. Igama lophawu lwechiza ngalinye lilandelwa ngamagama aqhelekileyo ezithako zalo.

Abavelisi bala mayeza bahlala benika ulwazi oluneenkcukacha kunye namabango okusebenza kwee-genotypes ezongezelelweyo kwiiwebhusayithi zabo. Ugqirha wakho unokukunceda uvavanye olu lwazi. Ezinye zazo zinokusebenza, ngelixa ezinye zazo zinokubaxwa okanye ngaphandle komxholo kuwe.

Qiniseka ukuba uyaxoxa nodokotela wakho ukuba ngawaphi amayeza afanelekileyo ukuze akuncede ufike kwi-SVR.

• IDaklinza (daclatasvir). Ngokwesiqhelo idityaniswa nesofosbuvir (Sovaldi). Kwavunywa ngo-2015 ukunyanga i-genotype 3. Unyango luhlala luneeveki ezili-12.

• Kuthekani ukuba awuyiphumeleli i-SVR?

  Ayinguye wonke umntu ofikelela kwi-SVR. Iziphumo ebezingalindelekanga ezimandundu zinokubangela ukuba uyeke unyango kwangoko. Kodwa abanye abantu abaphenduli ngokulula, kwaye akusoloko kucacile ukuba kutheni. Ugqirha wakho unokucebisa ukuba uzame indibaniselwano eyahlukileyo yamachiza.

  Nokuba awufiki kwi-SVR, olu nyango lunokunceda ukucothisa intsholongwane kwaye lube luncedo kwisibindi sakho.

  Ukuba awuyi kuzama ukusebenzisa iyeza lokulwa intsholongwane ngenxa yaso nasiphi na isizathu, awuzukufuna ngaphezulu kovavanyo lomthwalo wentsholongwane. Kodwa usenosulelo olufuna ingqalelo. Oku kuthetha ukubalwa kwegazi rhoqo kunye novavanyo lomsebenzi wesibindi. Ngokusebenza ngokusondeleyo nogqirha wakho, unokukhawulezisa ukulungisa naziphi na iingxaki ezinokuvela.

  Ukuba uzame iindlela ezininzi zonyango ngaphandle kwempumelelo, unokufuna ukuqwalasela ukufaka isicelo solingo lweklinikhi. Olu vavanyo ngamanye amaxesha lukuvumela ukuba uzame amachiza amatsha akwisigaba sokuvavanya. Uvavanyo lweklinikhi luthanda ukuba neendlela ezingqongqo, kodwa ugqirha wakho kufuneka akwazi ukubonelela ngolwazi oluthe kratya.

  Imbonakalo

  Nokuba awunazo iimpawu ezininzi ngoku, i-hepatitis C sisifo esinganyangekiyo. Ke kubalulekile ukuba ukhathalele impilo yakho iphela, uhlawula ikakhulu isibindi sakho. Yenza impilo yakho ibe kwindawo ephambili.

  Kufuneke u:

  • Gcina ubudlelwane obuhle kunye nogqirha wakho. Xela iimpawu ezintsha kwangoko, kubandakanya uxinzelelo kunye noxinzelelo. Jonga ugqirha wakho ngaphambi kokuba uthathe amayeza amatsha okanye amayeza, njengoko ezinye zinokuba yingozi kwisibindi sakho. Ugqirha wakho unokugcina ulwazi malunga nenkqubela phambili yonyango.
  • Yitya ukutya okunezondlo. Ukuba unengxaki noku, cela ugqirha wakho ukuba akucebise ngengcali yesondlo ukuba ikukhokele kwicala elifanelekileyo.
  • Yenza umthambo rhoqo. Ukuba i-gym ayiyiyo yakho, nokuba ukuhamba kwansuku zonke kunceda. Kungaba lula ukuba ufumana umhlobo wokuzilolonga.
  • Fumana ubuthongo obuzeleyo. Ukutshisa ikhandlela kwiziphelo zombini kuthabatha umthwalo omkhulu emzimbeni wakho.
  • Musa ukusela. Utywala buyingozi kwisibindi sakho, ngoko ke kungcono ukubuphepha.
  • Musa ukutshaya. Kulumkele iimveliso zecuba kuba ziyingozi kwimpilo yakho iyonke.

  Yakha inethiwekhi yenkxaso

  Ukuphila nemeko engapheliyo kunokuzama ngamanye amaxesha. Nokuba usapho olusondeleyo kunye nabahlobo basenokungazazi izinto ezikukhathazayo. Okanye basenokungazi ukuba mabathini. Zithathele ngokwakho ukuvula amajelo onxibelelwano. Cela inkxaso yemvakalelo kunye noncedo olusebenzayo xa ulufuna.

  Kwaye khumbula, awukude wedwa. Abantu abangaphezu kwezigidi ezi-3 eUnited States baphila nesifo sesibindi esinganyangekiyo uC.

  Cinga ngokujoyina i-intanethi okanye iqela lenkxaso lomntu ukuze ukwazi ukunxibelelana nabanye abayiqondayo into ohamba kuyo. Amaqela enkxaso anokukunceda uhambe ngolwazi kunye nezixhobo ezinokwenza umahluko obonakalayo ebomini bakho.

  Banokukhokelela kubudlelwane obuhlala buhleli, obuzuzisayo macala. Ungaqala ngokufuna inkxaso kwaye kungekudala uzakufumana ukwimeko yokunceda abanye.