Umbhali: Eugene Taylor
Umhla Wokudalwa: 16 Eyethupha 2021
Hlaziya Umhla: 14 Eyenkanga 2024
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How to Inject Taltz
Ividiyo: How to Inject Taltz

Umxholo

Yintoni iTaltz?

I-Taltz ligama lonyango elichaza igama lonyango. Kuvunyiwe ukunyanga le miqathango ilandelayo:

Kwi-plaque psoriasis, iTaltz inokumiselwa abantu abadala kunye nabantwana abaneminyaka emi-6 nangaphezulu. Kodwa kuko konke okunye ukusetyenziswa kwayo okuvunyiweyo, iTaltz inokumiselwa kuphela kubantu abadala.


I-Taltz iqulethe ichiza elisebenzayo ixekizumab. Luhlobo lweziyobisi ze-biologic (ichiza elenziwe ngeeseli eziphilayo) elibizwa ngokuba yi-humanized monoclonal antibody.

I-Taltz iza ngeendlela ezimbini: isirinji ekhethiweyo kunye nepen ye-autoinjector. Iyeza linikwa ngenaliti phantsi kolusu lwakho (inaliti yangaphantsi). Umboneleli wakho wezempilo uya kukunika inaliti ekuqaleni. Emva koko banokukufundisa ngendlela yokuzitofa ngokwakho ekhaya.

Ukusebenza ngempumelelo

Ngolwazi malunga nokusebenza kweTaltz ekuphatheni iimeko ezidweliswe apha ngasentla, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngezantsi.

Taltz generic

I-Taltz ifumaneka kuphela njengeyeza elinegama lophawu. Okwangoku ayifumaneki ngendlela eqhelekileyo. (Ichiza elenza lafana nalawo aveliswe ngumenzi liyikopi ngqo yesiyobisi esisebenzayo kwiyeza elinegama lophawu.)

I-Taltz inesithako esinye esisebenzayo seziyobisi: ixekizumab.

Taltz idosi

Umthamo weTaltz omiselwe ngugqirha wakho uxhomekeke kwimeko yokuphathwa.

Olu lwazi lulandelayo luchaza iidosi eziqhelekileyo ezisetyenziswayo okanye ezicetyiswayo. Nangona kunjalo, qiniseka ukuthatha idosi kwaye ulandele ishedyuli yedosi emiselweyo ngugqirha.


Iifom zamachiza kunye namandla

I-Taltz ifumaneka kumandla omnye: i-80 milligrams nge-milliliter (mg / mL).

Iyeza liza ngeendlela ezimbini: isirinji yokusebenzisa enye kunye nokusetyenziswa okukodwa kwepen ye-autoinjector. Unokufumanisa ukuba enye ifom kulula kuwe ukuba uyisebenzise kunenye. Thetha nogqirha wakho malunga nokuba yeyiphi ifomu ekulungeleyo.

Iyeza linikwa ngenaliti phantsi kolusu lwakho (inaliti yangaphantsi). Umboneleli wakho wezempilo uya kukunika inaliti ekuqaleni. Emva koko banokukufundisa ngendlela yokuzitofa ngokwakho ekhaya.

Isisombululo se-psoriatic arthritis

Kwi-psoriatic arthritis, idosi yakho yokuqala yeTaltz iya kunikwa njengezitofu ezingama-80-mg (iyonke eyi-160 mg) kwangolo suku lunye. Emva koko, idosi yakho yesondlo iya kuba yinaliti enye engama-80-mg kube kanye emva kweeveki ezi-4 okoko ugqirha ekucebisa.

Phawula: Ukuze ufunde okungakumbi malunga ne-psoriatic arthritis, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngezantsi.

Umyinge we-plaque psoriasis

Kwi-plaque psoriasis, idosi yakho yokuqala yeTaltz iya kuba ziinaliti ezimbini ezingama-80-mg (iyonke eyi-160 mg) kwangolo suku lunye. Emva koko, uya kuba nenaliti enye ye-80-mg kanye kwiiveki ezimbini zeeveki ezili-12. Ke umthamo wakho wokugcina uya kuba yinaliti enye kanye kwiiveki ezi-4 okoko ugqirha ekucebisa.


Phawula: Ukufunda ngakumbi nge-plaque psoriasis, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngezantsi.

Umthamo we-psoriatic arthritis kunye nokumodareyitha kwi-plaque psoriasis

Ukuba une-psoriatic arthritis kunye ne-plaque psoriasis, uya kusebenzisa idosi ye-Taltz kunye neshedyuli yokulinganisa i-plaque psoriasis ephakathi. Jonga icandelo elingentla apha ukuze ufumane ulwazi malunga noku.

Phawula: Ukuze ufunde okungakumbi malunga ne-psoriatic arthritis kunye ne-plaque psoriasis, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngezantsi.

Isisombululo se-spondyloarthritis ye-axial non-radiographic

Nge-non-radiographical axial spondyloarthritis (nr-axSpA), uyakufumana inaliti eyi-80-mg yeTaltz kanye kwiiveki ezi-4.

Phawula: Ukuze ufunde okungakumbi malunga ne-nr-axSpA, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngezantsi.

Isisombululo se-ankylosing spondylitis esebenzayo

Kwi-ankylosing spondylitis (AS), idosi yakho yokuqala yeTaltz iya kuba ziinaliti ezimbini ezingama-80-mg (iyonke eyi-160 mg) kwangolo suku lunye. Emva koko, idosi yokugcinwa kwakho iya kuba yinaliti enye engama-80-mg kube kanye kwiiveki ezi-4.

Phawula: Ukufunda ngakumbi nge-AS, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngezantsi.

Kuthekani ukuba ndiphose idosi?

Ukuba uyaphoswa yinaliti, kufuneka ubenayo ngokukhawuleza. Emva koko thatha inaliti yakho elandelayo xa kufanelekile. Kodwa ukuba uphosa inaliti kwaye ayide ibe ingekho de kufike enye elandelayo, cela ingcebiso kugqirha wakho ukuba wenzeni.

Ukukunceda uqiniseke ukuba awuphosi idosi, zama ukuseta isikhumbuzi kwifowuni yakho. Ixesha leyeza linokuba luncedo, nalo.

Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?

I-Taltz yenzelwe ukuba isetyenziswe njengonyango lwexesha elide. Ukuba wena nogqirha wakho uthatha isigqibo sokuba i-Taltz isebenze kakuhle kuwe, kusenokwenzeka ukuba uya kuyisebenzisa ixesha elide.

Iziphumo ebezingalindelekanga zeTaltz

I-Taltz inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha iTaltz. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga zeTaltz, thetha nogqirha wakho okanye usokhemesti. Banokukunika iingcebiso malunga nendlela yokujongana nayo nayiphi na imiphumela emibi enokuthi ikhathaze.

Phawula: Ulawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) umkhondo weziphumo ebezingalindelekanga ezivunyiweyo. Ukuba ungathanda ukunika ingxelo kwi-FDA isiphumo esecaleni obukade unaso ngeTaltz, ungakwenza oko ngeMedWatch.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo eziqhelekileyo zeTaltz zingabandakanya:

  • Ukuphendula kwendawo yenaliti (ububomvu kunye nokukhathazeka okujikeleze indawo yenaliti)
  • izifo eziphezulu zokuphefumula, ezinjengomkhuhlane oqhelekileyo okanye umkhuhlane
  • isicaphucaphu
  • usulelo lomngundo, olufana nonyawo lweembaleki
  • i-conjunctivitis (iliso elipinki)

Uninzi lweziphumo ebezingalindelekanga zinokuhamba zingaphelanga iintsuku okanye iiveki ezimbalwa. Ukuba zinzima kakhulu okanye azihambi, thetha nogqirha wakho okanye usokhemesti.

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ebezingalindelekanga ezimandundu ezivela eTaltz aziqhelekanga, kodwa zinokwenzeka. Shayela ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Iziphumo ebezingalindelekanga ezimandundu, ezichazwe ngakumbi apha ngezantsi "Iinkcukacha zeziphumo ebezingalindelekanga," zibandakanya:

  • negazi kakhulu
  • isifo sesisu sokuvuvukala (IBD), esifana nesifo sikaCrohn okanye isifo sezilonda
  • ukwanda komngcipheko wosulelo, njengesifo sephepha (TB)

Iziphumo ebezingalindelekanga ebantwaneni

Uphononongo lweklinikhi lujonge abantwana abaneminyaka emi-6 ukuya kweli-18 ubudala abane-plaque psoriasis. Kolu phononongo, iintlobo zeziphumo ebezingalindelekanga ezibonwe ebantwaneni kwaye kwenzeka kangaphi ngoku bezifana nezo zibonwa kubantu abadala. Ngaphandle koku, iziphumo ebezingalindelekanga zilandelayo zenzeka rhoqo kubantwana kunakubantu abadala:

  • i-conjunctivitis (iliso elipinki)
  • umkhuhlane
  • imihlathi (ukugqithisa kwesikhumba)

Kwakweso sifundo sinye, isifo sikaCrohn senzeka nge-0.9% rhoqo kubantwana abathatha iTaltz kunokuba kwenzekile kubantwana abathatha indawo ye-placebo. (I-placebo lunyango ngaphandle kwesiyobisi esisebenzayo.)

Iinkcukacha zesiphumo

Unokuzibuza ukuba zenzeka kangaphi iziphumo ebezingalindelekanga ngeli chiza, okanye nokuba ngaba ezinye iziphumo ebezingalindelekanga zinxulumene nalo. Nazi ezinye iinkcukacha kwezinye zeziphumo ebezingalindelekanga ezinokubangelwa okanye ezingabangelwa zezi ziyobisi.

Ukuphendula ngokuchaseneyo

Njengokuba kuninzi lweziyobisi, abanye abantu banokuphendula emva kokuthatha iTaltz. Iimpawu zokuphendula kancinci kunokubandakanya:

  • irhashalala
  • ukucheba
  • ukucoca (ukufudumala nokubomvu kwesikhumba sakho)

Impendulo eyingozi kakhulu inqabile kodwa inokwenzeka. Iimpawu zokungaziphathi kakuhle kunokubandakanya:

  • i-angioedema (ukudumba phantsi kolusu lwakho, ubukhulu becala kwiinkophe zakho, imilebe, okanye izidlele)
  • ukudumba kolwimi lwakho, umlomo, okanye umqala
  • ingxaki yokuphefumla
  • ukuqina kwesifuba
  • ndiziva ndidiniwe

Kwizifundo zeklinikhi, uguquko lwenzeka nge-0.1% okanye ngaphantsi kwabantu abafumana iTaltz. Ezi mpendulo zibangelwa yi-angioedema kunye ne-urticaria (irhashalala elurhawuzayo ekwabizwa ngokuba yimingxuma (hives)

Biza ugqirha wakho ngoko nangoko ukuba uneempendulo eziqatha kuTaltz. Kodwa fowunela i-911 okanye inombolo yakho yongxamiseko yendawo ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unonyango olungxamisekileyo.

Ukuphendula kwendawo yenaliti

Unokuba nokuphendula kwesikhumba kwindawo apho utofa iidosi zeTaltz. Kwaye ezi mpendulo zinokubangela iimpawu ezinje ngokubomvu okanye iintlungu.

Kwizifundo zeklinikhi, iipesenti ezili-17 zabantu abane-plaque psoriasis abafumana i-Taltz babephendula, njengokubomvu okanye iintlungu, kwindawo yenaliti. Uninzi lwezi mpendulo lwaluphakathi okanye luphakathi kwaye aluzange lubangele abantu bayeke unyango.

Qho xa ufaka i-Taltz, kuya kufuneka ukhethe indawo eyahlukileyo emzimbeni wakho kunenaliti yokugqibela. Ukuba unempendulo yesikhumba enzima okanye engahambi ngeentsuku ezimbalwa, jonga ugqirha wakho.

Ukwanda komngcipheko wosulelo

I-Taltz inokuwenza buthathaka amajoni akho omzimba. Xa amajoni akho omzimba engomelelanga ngokwaneleyo ukuba ungalwa neentsholongwane, ungafumana usulelo.

Kwizifundo zeklinikhi, iipesenti ezingama-27 zabantu abane-plaque psoriasis abafumana iTaltz iiveki ezili-12 bafumana usulelo. Nazi ezinye iziphumo zophando:

  • Uninzi lwezi zifo lwalungelulanga. Kuphela yi-0.4% yosulelo oluthathelwa ingqalelo njengolubi, njenge-pneumonia.
  • Ezona zifo zixhaphakileyo zizifo zokuphefumla ezinje ngokukhohlela, ukubanda, okanye usulelo lomqala.
  • Olunye usulelo lubandakanya i-conjunctivitis (iliso elipinki) kunye nosulelo lokungunda, njenge-thrush yomlomo okanye unyawo lwembaleki.
  • Kwezi zifundo, iipesenti ezingama-23 zabantu abafumene i-placebo (unyango ngaphandle kwesiyobisi esisebenzayo) nabo bosulelekile.
  • Kubantu abafumene unyango lwe-Taltz iiveki ezingama-60, iipesenti ezingama-57 bafumana usulelo xa kuthelekiswa nama-32% afumana i-placebo.

Ukubeka iliso nokujonga usulelo

Ukuba unempawu zosulelo, thetha nogqirha wakho okanye usokhemesti. Banokuncoma unyango. Iimpawu zosulelo oluncinci zinokubandakanya:

  • ifiva
  • ukukhohlela
  • umqala obuhkungu
  • ebomvu namehlo abuhlungu
  • iindawo ezibomvu nezibuhlungu zolusu
  • amabala amhlophe emlonyeni wakho
  • ukutshisa okanye iintlungu xa uchama

Kubaluleke kakhulu ukubona ugqirha wakho ukuba usulelo alucaci. Ngaphandle koko, kunokuba kubi ngakumbi.

Ngaphambi kokuba uqale unyango nge-Taltz, ugqirha wakho uya kujonga nasiphi na isifo, esifana nesifo sephepha (i-TB), isifo semiphunga. Ukuba unazo naziphi na iimpawu zeTB ngexesha lonyango lwakho, kubalulekile ukubiza ugqirha wakho ngoko nangoko. Ezi mpawu zibandakanya:

  • ifiva
  • iintlungu zemisipha
  • ukunciphisa umzimba ngaphandle kokuzama
  • ukukhohlela okubi okuhlala iiveki ezintathu okanye nangaphezulu
  • ukukhohlela igazi okanye amafinyila
  • iintlungu esifubeni
  • ukubila ebusuku

Ukuthintela usulelo ngexesha lonyango lweTaltz

Ukunceda ukuthintela usulelo ngelixa uthatha iTaltz, hlamba izandla zakho rhoqo. Kulumkele ukunxibelelana nabantu abanosulelo (ngakumbi ukukhwehlela, ukubanda, okanye umkhuhlane).

Buza ugqirha wakho ukuba ngaba kukho naziphi na izitofu ekufuneka uzifumene ngaphambi kokuba uqale ukuthatha iTaltz. (Jonga "iTaltz kwaye uphile ngokugonya" kwicandelo "lokusebenzisana kweTaltz" apha ngezantsi ukuze ufunde okungakumbi.)

Ukudumba kwesifo

Ukuba uthatha iTaltz, kukho umngcipheko omncinci wokuba uphuhlise isifo samathumbu esivuthayo (IBD). I-IBD liqela lezifo ezibangela ukudumba (ukudumba) kwindawo yakho yokugaya ukutya. Ezi zifo zibandakanya isifo sikaCrohn kunye ne-ulcerative colitis.

Ukuba sele unayo i-IBD, iTaltz inokuyenza mandundu, kodwa oku kunqabile. Kwizifundo zeklinikhi, isifo sikaCrohn senzeka kwi-0.1% yabantu abafumene iTaltz. Kwaye i-0.2% yabantu abafumene i-Taltz babene-colitis entsha okanye eyandayo.

Kuya kufuneka ubone ugqirha wakho ukuba uneempawu ezintsha okanye ezibaxekileyo ze-IBD. Oku kunokubandakanya:

  • iintlungu esiswini sakho (isisu)
  • urhudo, nokuba unegazi
  • ukuhla ukusinda

Ukutyeba okanye ukunciphisa umzimba (hayi isiphumo esisecaleni)

Ukutyeba kunye nokulahleka kobunzima khange kuxelwe kwizifundo zeklinikhi zaseTaltz. Nangona kunjalo, ukunciphisa umzimba kunokuba luphawu lwesifo sephepha (i-TB) okanye isifo sesisu esivuthayo (IBD). Kwaye ezi meko zombini ziziphumo ebezingalindelekanga ezinokubakho zeTaltz. Ke ukuba unciphisa umzimba ngelixa uthatha iTaltz, kubaluleke kakhulu ukubona ugqirha wakho.

Ukuba unayo nayiphi na inkxalabo malunga nokufumana ubunzima okanye ukunciphisa umzimba, thetha nogqirha wakho.

Ukulahleka kweenwele (hayi isiphumo esisecaleni)

Ukulahleka kweenwele akuzange kubonwe kwizifundo zeklinikhi zaseTaltz. Nangona kunjalo, ukulahleka kweenwele kunokuba ngumphumo we-scalp psoriasis, uhlobo lwe-plaque psoriasis olunokunyangwa ngeTaltz. Ngokukrwela isikhumba sakho sasentloko okanye ukukhetha izikali, unokukhupha iinwele zakho.

Ukuba unenkxalabo malunga nokulahleka kweenwele, thetha nogqirha wakho.

Uxinzelelo (hayi isiphumo esisecaleni)

Uxinzelelo aluzange luxelwe njengempembelelo yecala kwizifundo zeklinikhi zaseTaltz. Nangona kunjalo, uxinzelelo luqhelekile kubantu abane-psoriasis okanye i-psoriatic arthritis, esetyenziselwa ukunyanga iTaltz.

Olunye uphononongo luvavanye indlela iTaltz ezichaphazele ngayo iimpawu zoxinzelelo kubantu abane-psoriasis. Abaphandi bafumanise ukuba malunga neepesenti ezingama-40 zabantu abafumene iTaltz iiveki ezili-12 bachacha kwiimpawu zokudakumba.

Izifo zolusu ezifana ne-psoriasis zinokuba nefuthe elibalulekileyo lengqondo. Ukuba uziva uphantsi, uxinezelekile, okanye uxhalabile, qiniseka ukuba uthethe nogqirha wakho ngayo. Ngamanye amaxesha ukuxoxa nje ngezinto ezikuxhalabisayo kunokuba luncedo. Kodwa ukuba ugqirha wakho ucinga ukuba unengxaki yoxinzelelo, unokufuna unyango ngayo. Oku kunokuba luhlobo lonyango lwengqondo okanye amayeza.

Amabala (hayi isiphumo esisecaleni)

Amabala akazange axelwe njengempembelelo yecala kwizifundo zeklinikhi zaseTaltz. Nangona kunjalo, emva kokuba i-Taltz ivunyiwe, abantu abambalwa baxele [KD1] [AK2] ukuba namaqhakuva okanye amaqhuma kulusu. Kodwa la matyala ayenqabile, kwaye akucaci nokuba yiTaltz ebangele induna.

Amayeza e-Psoriasis ngamanye amaxesha asetyenziselwa ukunyanga uhlobo olubi lwe-acne, ebizwa ngokuba yi-acne inversa (okanye i-hidradenitis suppurativa). Kungenxa yokuba i-acne inversa ibandakanya isikhumba esibuhlungu, esidumbileyo, njenge-psoriasis.

Kodwa iTaltz khange ifundelwe abantu abanalo naluphi na uhlobo lwamabala. Okwangoku, iyeza kuphela elamkelweyo ukunyanga i-acne inversa yiHumira (adalimumab).

Ukuba ukhathazekile ngamabala, thetha nogqirha wakho. Banokucebisa ngeendlela zokunceda ukuyinyanga.

Iindleko zeTaltz

Njengawo onke amayeza, iindleko zeTaltz zingahluka. Ukufumana amaxabiso akhoyo ngoku eTaltz kwindawo yakho, jonga WellRx.com. Iindleko ozifumana kwi-WellRx.com yinto onokuyihlawula ngaphandle kwe-inshurensi. Ixabiso langempela oza kulihlawula lixhomekeke kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Uncedo lwezezimali kunye neinshurensi

Ukuba ufuna inkxaso yemali ukuhlawula i-Taltz, okanye ukuba ufuna uncedo lokuqonda i-inshurensi yakho, uncedo luyafumaneka.

U-Eli Lilly kunye neNkampani, umenzi weTaltz, ubonelela ngekhadi lokonga kunye nenkqubo yenkxaso ebizwa ngokuba yiTaltz Ndawonye. Ngolwazi oluthe kratya kunye nokufumanisa ukuba ukulungele na ukufumana uncedo, tsalela umnxeba ku-844-825-8966 okanye undwendwele iwebhusayithi yenkqubo.

Ukusetyenziswa kweTaltz

Ulawulo lokutya kunye neziyobisi (i-FDA) livuma amayeza amiselweyo anje ngeTaltz ukunyanga iimeko ezithile. I-Taltz inokusetyenziselwa ngaphandle kwelebheli kwezinye iimeko. Ukusetyenziswa kwelebula engekho xa kusebenze iyeza elamkelweyo ukunyanga imeko enye lisetyenziselwa ukunyanga imeko eyahlukileyo.

I-Taltz ye-psoriatic arthritis

I-Taltz yamkelwe yi-FDA ukunyanga i-psoriatic arthritis kubantu abadala.

I-Psoriatic arthritis luhlobo lwesifo samathambo apho elinye okanye ngaphezulu kwamalungu adumbayo, abuhlungu, kwaye aqine. Imeko ikhula malunga ne-30% yabantu abane-psoriasis. Kuyenzeka ukuba ube ne-psoriatic arthritis ngaphambi kokuba ube ne-psoriasis kulusu lwakho.

I-Psoriatic arthritis ihlala ichaphazela amalungu akho:

  • iminwe
  • iinzwane
  • amadolo
  • amaqatha
  • izihlahla
  • umva ongezantsi

I-Taltz inciphisa ukudumba (ukudumba) kunye neentlungu kumalungu akho. Iyeza linokukwenza kube lula kuwe ukuba uhambe kwaye wenze imisebenzi yemihla ngemihla, enjengokunxiba, ukuhlamba, ukutya nokuhamba.

Ukusebenza ngempumelelo kwe-psoriatic arthritis

Izifundo zonyango ziye zajonga indlela i-Taltz echaphazele ngayo iimpawu ze-psoriatic arthritis. Abaphandi baqaphele ukuba zininzi kangakanani iintlungu ezixelwe ngabantu kunye nendlela abayigqibe ngayo imisebenzi yemihla ngemihla. Abaphandi baphinde bagweba ukuba mangaphi amalungu abantu athambileyo okanye adumbileyo.

Emva kweeveki ezingama-24, uTaltz waziphucula ezi mpawu ngo:

  • ubuncinci i-20% kwi-53% ukuya kwi-58% yabantu
  • ubuncinci i-50% kwi-35% ukuya kwi-40% yabantu
  • ubuncinci i-70% kwi-22% ukuya kwi-23% yabantu

I-Taltz yokumodareyitha kwi-plaque psoriasis

I-Taltz yamkelwe yi-FDA ukunyanga i-plaque psoriasis ngokulinganayo kubantu abadala nakubantwana abaneminyaka emi-6 nangaphezulu. Kufanelekile kubantu abane-psoriasis abanokuxhamla kunyango lwenkqubo (unyango oluchaphazela umzimba wakho uphela) okanye i-phototherapy (unyango olulula).

I-plaque psoriasis lolona hlobo luqhelekileyo lwepsoriasis. Iyakwazi ukusuka kumnene ukuya kunzima. Ugqirha wakho unokukuxelela ukuba inzima kangakanani i-psoriasis yakho nokuba ingaba iTaltz ilungile na kuwe. I-psoriasis yakho inokulungela unyango kunye neTaltz ukuba:

  • uneeplathi (ezingqindilili, ezibomvu, namabala anamaxolo) ngaphezulu kwe-3% yomzimba wakho
  • uneepleyiti ezandleni zakho, ezinyaweni, okanye kwilungu langasese
  • Psoriasis yakho ichaphazela kakhulu umgangatho wobomi bakho
  • Unyango oluphezulu (olusetyenziswe kulusu lwakho) alukhange luzise i-psoriasis yakho phantsi kolawulo

I-Taltz inceda ukunciphisa inani lamabala e-psoriasis kunye nokuba aqatha kangakanani.

Ukusebenza ngempumelelo kwe-plaque psoriasis kubantu abadala

Izifundo zeklinikhi zijonge indlela iTaltz eyazichaphazela ngayo iimpawu ze-plaque psoriasis kubantu abadala abaneminyaka eli-18 nangaphezulu. Emva kweeveki ezili-12, uTaltz wazikhupha iimpawu ngo:

  • ubuncinci i-75% kwi-87% ukuya kwi-90% yabantu
  • ubuncinci i-90% kwi-68% ukuya kwi-71% yabantu
  • I-100% kwi-35% ukuya kwi-40% yabantu

Abaphandi bajonga indlela esebenza ngayo i-Taltz kubantu abaneempawu ze-psoriasis ezazicacisiwe, okanye zazincinci, emva kweeveki ezili-12 zonyango. Emva kweeveki ezingama-60 zokuthatha i-Taltz, i-75% yaba bantu basenempawu ezincinci okanye ezingekho kwaphela ze-psoriasis.

Kwaye kuvavanyo lweklinikhi ye-psital genital, i-73% yabantu abafumene i-Taltz baneempawu nje ezincinci okanye iimpawu zabo zacaca emva kweeveki ezili-12.

Ukusebenza ngempumelelo kwe-plaque psoriasis ebantwaneni

Isifundo seklinikhi sijonge indlela iTaltz eyazichaphazela ngayo iimpawu zeplace psoriasis kubantwana abaneminyaka emi-6 ukuya kweli-18 ubudala. Emva kweeveki ezili-12, uTaltz wazikhupha iimpawu ngo:

  • ubuncinci i-75% kubantwana abangama-89%
  • ubuncinci i-90% kwi-78% yabantwana
  • I-100% kubantwana abangama-50%

I-Taltz yespondyloarthritis

I-Taltz yamkelwe yi-FDA ukunyanga iindlela ezimbini zespondyloarthritis (SA) kubantu abadala. Ngokukodwa, iTaltz yamkelwe ukuze iphathe ezi ndlela zimbini zilandelayo zoMzantsi Afrika, ezichazwe ngakumbi apha ngezantsi:

  • i-spondyloarthritis engekho kwi-radiographic axial (nr-axSpA)
  • i-ankylosing spondylitis esebenzayo (AS) okanye i-radiographic axial spondyloarthritis (r-axSpA)

I-SA sisifo esidumbisayo kunye nohlobo lwesifo samathambo esibangela ukudumba emqolo. Rhoqo, amalungu akufutshane nawo ayachaphazeleka, ngakumbi la malungu mabini adibanisa umqolo wakho osezantsi kwi-pelvis yakho (amalungu e-sacropelvic). Xa umonakalo kumalungu ungabonakali kwii-X-ray (ii-radiographs), ifom ye-SA ibizwa ngokuba yi-nr-axSpA.

Xa i-SA iqhubeka, ukudumba okungapheliyo (okuhlala ixesha elide) kunokubangela ukuba i-vertebrae kumqolo wakho idibane kunye. Ngenxa yoko, umqolo wakho uba bhetyebhetye. Umqolo obuhlungu nokudinwa ziimpawu eziqhelekileyo zoMzantsi Afrika eziqhubela phambili. Ngolu hlobo lwe-SA, umonakalo odibeneyo unokubonakala kwi-X-ray. Le fomu ye-SA ibizwa ngokuba yi-AS esebenzayo, okanye i-r-axSpA.

Ukusebenza kwe-non-radiographic axial spondyloarthritis

Isifundo seklinikhi sijonge abantu abadala abaneminyaka eli-18 nangaphezulu nge-nr-axSpA. Olu phononongo lujonge unyango nge-Taltz xa kuthelekiswa naleyo ye-placebo (unyango ngaphandle kwesiyobisi esisebenzayo).

Emva kweeveki ezingama-52 zonyango:

  • Ama-30% abantu abasebenzisa iTaltz baneempawu zabo ezincitshiswe ngama-40% okanye nangaphezulu. Ezi mpawu zibandakanya ukuqina kwamalungu kunye nomqolo.
  • Xa kuthelekiswa, i-13% yabantu abasebenzisa i-placebo babeneziphumo ezifanayo.

Ukusebenza ngempumelelo kwe-ankylosing spondylitis

Izifundo ezibini zeklinikhi zijonge abantu abadala abaneminyaka eli-18 okanye ngaphezulu nge-AS esebenzayo. Ezi zifundo zijonge unyango nge-Taltz ngokuthelekiswa naleyo ye-placebo.

Emva kweeveki ezili-16 zonyango:

  • Ama-25% ukuya kuma-48% abantu abasebenzisa iTaltz baneempawu zabo ezincitshiswe ngama-40% okanye nangaphezulu. Ezi mpawu zibandakanya ukuqina kwamalungu kunye nomqolo.
  • Xa kuthelekiswa, i-13% ukuya kwi-18% yabantu abasebenzisa i-placebo babeneziphumo ezifanayo.

Ukongeza, abantu abathathe i-Taltz babeneentlungu ezingaphantsi kwaye ngokwasemzimbeni baziva bhetele xa kuthelekiswa nabantu abathathe i-placebo.

Taltz kunye nabantwana

I-Taltz ivunyiwe yi-FDA ukunyanga i-plaque psoriasis kubantwana abaneminyaka emi-6 nangaphezulu. Ngeenkcukacha malunga nokusetyenziswa, jonga icandelo elingentla elibizwa ngokuba yi "Taltz ngokulinganisela ukuya kwi-plaque psoriasis."

I-Taltz yezinye iimeko

Ukongeza kusetyenziso oludweliswe apha ngasentla, iTaltz inokusetyenziselwa ngaphandle kwelebheli yenye injongo. Ukusetyenziswa kweziyobisi ezingekho kwilebula kuxa iziyobisi ezivunyiweyo zisetyenziselwa ukusetyenziswa kwesinye zisetyenziselwa enye eyahlukileyo engavunyelwanga. Kwaye usenokuzibuza ukuba ingaba iTaltz isetyenziselwa iimeko ezithile kusini na.

I-Taltz yesifo samathambo (ukusetyenziswa kwelebula)

I-Taltz ayivunyelwanga ukunyanga i-rheumatoid arthritis (RA). Nangona kunjalo, ugqirha wakho unokuyalela ukuba ichiza lingabikho kwileyibhile ukuba ezinye iindlela zonyango ezivunyiweyo azikusebenzeli.

I-RA sisifo apho amajoni akho omzimba ahlasela amalungu akho, esenza ukuba adumbe, aqine kwaye abe buhlungu. Izifundo ezininzi zijonge ukuba ngaba iTaltz inganceda na ukunyanga iRA. I-Taltz isebenza kwinxalenye yenkqubo yomzimba yokuzikhusela eyaziwayo ukuba ibangele olu hlaselo ngokudibeneyo (ukudumba).

Uphengululo lwezifundo kugqitywe ekubeni i-Taltz yayisebenza ngokunyanga i-RA.

Ukuba ungathanda ukwazi okungakumbi malunga nokusebenzisa i-Taltz ukunyanga i-RA, thetha nogqirha wakho.

I-Taltz ye-osteoarthritis (ayisebenzisi ngokufanelekileyo)

I-Taltz ayivunyelwanga okanye isetyenzisiwe ngaphandle kwelebula yokunyanga i-osteoarthritis. Olu hlobo lwe-arthritis lubangelwa kukuwohloka kumalungu akho. Ayibangelwa kukudumba. Ke i-osteoarthritis ayinakuncediswa ziziyobisi, ezinje ngeTaltz, ezichaphazela amajoni akho omzimba.

Ukuba unemibuzo malunga nokhetho kunyango lwe-osteoarthritis, thetha nogqirha wakho.

Taltz kunye notywala

Utywala abuchaphazeli ngokuthe ngqo indlela iTaltz esebenza ngayo, ngoko akukho zilumkiso ezithile malunga nokuphepha utywala ngexesha lonyango lweTaltz.

Nangona kunjalo, ukusela utywala kunokuba mandundu i-psoriasis, esetyenziselwa ukunyanga iTaltz.Ukongeza, utywala bunokwenza ukuba unyango lwe-psoriasis lungasebenzi kakuhle kwaye lunokwenza amajoni akho omzimba angakwazi ukulwa ulosuleleko.

Izikhokelo zangoku zokunyanga nokulawula i-psoriasis zincoma ukunciphisa umlinganiselo wobungakanani botywala obuselayo.

Ukuba usela utywala, buza ugqirha wakho ukuba kukhuseleke kangakanani ukuba ungatya ngelixa uthatha iTaltz.

Eminye indlela eya kwiTaltz

Amanye amachiza akhoyo anokuyinyanga imeko yakho. Abanye banokukulungela ngcono kunabanye. Ukuba unomdla ekufumaneni enye i-Taltz, thetha nogqirha wakho. Banokukuxelela ngamanye amayeza anokukusebenzela.

Phawula: Amanye amachiza adweliswe apha asetyenziswa ngaphandle kwelebheli ukunyanga le miqathango.

Olunye unyango lwe-psoriatic arthritis

Imizekelo yezinye iziyobisi ezingasetyenziselwa ukunyanga i-psoriatic arthritis zibandakanya:

  • imethotrexate (iOtrexup, iRasuvo, iTrexall)
  • I-apremilast (i-Otezla)
  • infliximab (I-Remicade)
  • adalimumab (Humira)
  • I-etanercept (i-Enbrel)
  • Tofacitinib (Xeljanz)
  • igolimumab (iSimponi)
  • isatifikethi (Cimzia)
  • secukinumab (iCosentyx)
  • ustekinumab (uStelara)
  • brodalumab (uSiliq)
  • guselkumab (Tremfya)
  • sulfasalazine (Azulfidine)

Phawula: Ukuze ufunde okungakumbi malunga ne-psoriatic arthritis, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngasentla.

Enye indlela yokumodareyitha kwi-plaque psoriasis

Imizekelo yezinye iziyobisi ezingasetyenziselwa ukunyanga i-plaque psoriasis ngokuqatha zibandakanya:

  • I-apremilast (i-Otezla)
  • infliximab (I-Remicade)
  • adalimumab (Humira)
  • I-etanercept (i-Enbrel)
  • isatifikethi (Cimzia)
  • ustekinumab (uStelara)
  • secukinumab (iCosentyx)
  • brodalumab (uSiliq)
  • guselkumab (Tremfya)
  • igolimumab (iSimponi)
  • imethotrexate (iOtrexup, iRasuvo, iTrexall)
  • sulfasalazine (Azulfidine)

Phawula: Ukufunda ngakumbi nge-plaque psoriasis, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngasentla.

Olunye uhlobo lwe-ankylosing spondylitis

Imizekelo yezinye iziyobisi ezingasetyenziselwa ukunyanga i-ankylosing spondylitis (AS) ibandakanya:

  • infliximab (I-Remicade)
  • adalimumab (Humira)
  • I-etanercept (i-Enbrel)
  • secukinumab (iCosentyx)
  • isatifikethi (Cimzia)
  • igolimumab (iSimponi)
  • ustekinumab (uStelara)
  • brodalumab (uSiliq)
  • imethotrexate (iOtrexup, iRasuvo, iTrexall)
  • sulfasalazine (Azulfidine)

Phawula: Ukuze ufunde okungakumbi nge-AS, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngasentla.

Olunye uhlobo lwe-non-radiographic axial spondyloarthritis

Imizekelo yezinye iziyobisi ezinokusetyenziselwa ukunyanga i-non-radiographic axial spondyloarthritis (nr-axSpA) ibandakanya:

  • isatifikethi (Cimzia)
  • adalimumab (Humira)
  • secukinumab (iCosentyx)
  • imethotrexate (iOtrexup, iRasuvo, iTrexall)
  • sulfasalazine (Azulfidine)

Phawula: Ukuze ufunde okungakumbi malunga ne-nr-axSpA, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngasentla.

Taltz vs Cosentyx

Usenokuzibuza ukuba iTaltz ithelekisa njani namanye amayeza anikwe ukusetyenziswa okufanayo. Apha sijonga indlela iTaltz kunye neCosentyx ezifanayo kunye ezahlukeneyo.

Malunga

I-Taltz kunye neCosentyx zombini amachiza e-biologic (amachiza enziwe ngezinto eziphilayo). Basebenza ngokujolisa kwicandelo elithile lamajoni akho omzimba.

I-Taltz iqulethe ichiza ixekizumab, ngelixa i-Cosentyx iqulethe ichiza secukinumab. La machiza mabini abizwa ngokuba zii-antibodies ze-monoclonal. Bavimba umsebenzi weprotein kwinkqubo yakho yomzimba ebizwa ngokuba yi-interleukin-17. I-Interleukin-17 ibangela ukuba amajoni akho omzimba ahlasele iiseli zolusu kunye namalungu akho. Oku kubangela ukudumba okubonakalayo ngezifo ezinje nge-plaque psoriasis, i-psoriatic arthritis, kunye ne-spondyloarthritis.

Sebenzisa

Ulawulo lwezoKutya kunye neDrug (i-FDA) luvumile zombini i-Taltz kunye neCosentyx ukunyanga i-plaque psoriasis ngokuphakathi. La machiza afanele abantu abane-psoriasis abanokuxhamla kunyango lwenkqubo (unyango oluchaphazela umzimba wakho uphela) okanye i-phototherapy (unyango olulula).

I-plaque psoriasis, iTaltz ivunyiwe ukuba isetyenziswe kubantu abadala kunye nabantwana abaneminyaka emi-6 nangaphezulu. Nangona kunjalo, iCosentyx yamkelwe kuphela ukuba isetyenziswe kubantu abadala abanale meko.

Zombini i-Taltz kunye neCosentyx nazo zivunyiwe yi-FDA ukunyanga i-psoriatic arthritis kubantu abadala. ("Ukusebenza" kuthetha ukuba okwangoku uneempawu.)

Ukongeza, zombini i-Taltz kunye neCosentyx zivunyiwe ukunyanga i-non-radiographic axial spondyloarthritis kunye ne-ankylosing spondylitis kubantu abadala.

Phawula: Ngolwazi oluthe kratya malunga neemeko ezichazwe apha, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngasentla.

Iifom zeziyobisi kunye nolawulo

Zombini i-Taltz kunye neCosentyx zinikwa ngenaliti phantsi kolusu lwakho (inaliti yangaphantsi). Umboneleli wakho wezempilo uya kukunika inaliti ekuqaleni. Emva koko banokukufundisa ukuba ungazinika njani inaliti ekhaya.

I-Taltz iza ngeendlela ezimbini: isirinji esetyenzisiweyo esetyenzisiweyo kunye nepeni yokusetyenziswa kwe-autoinjector.

ICosentyx iza ngeendlela ezintathu:

  • Usetyenziso olunye lokuloba
  • isirinji esetyenziselwa ukusetyenziswa kube kanye
  • igutyana elisebenzisa ibenye unikwe inaliti ngumboneleli wakho wokhathalelo lwempilo

Iziphumo kunye neengozi

I-Taltz kunye neCosentyx zinokubangela iziphumo ezifanayo ebezingalunganga kwaye ezinye zahlukile. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho kunye neTaltz, neCosentyx, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Ngaba kunokwenzeka ngeTaltz:
    • Ukuphendula kwendawo yenaliti (ububomvu kunye nokukhathazeka okujikeleze indawo yenaliti)
    • i-conjunctivitis (iliso elipinki)
  • Ngaba kunokwenzeka ngeCosentyx:
    • urhudo
    • izilonda zomlomo
    • irhashalala
  • Ngaba kunokwenzeka ngeTaltz kunye neCosentyx:
    • usulelo lomngundo, olufana nonyawo lweembaleki
    • izifo eziphezulu zokuphefumula, ezifana nokubanda okuqhelekileyo
    • isicaphucaphu

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeTaltz kunye neCosentyx (xa zithathwa ngokwahlukeneyo).

  • ukwanda kwengozi yosulelo olunokuba lubi, njengesifo sephepha (TB)
  • isifo esitsha okanye esiba mandundu sokudumba kwamathumbu (IBD), esifana nesifo sikaCrohn okanye isifo sokulunywa sisilonda
  • negazi kakhulu

Ukusebenza ngempumelelo

I-Taltz kunye neCosentyx zinokusetyenziswa okuvunyiweyo kwe-FDA, kodwa zombini zisetyenziselwa ukunyanga le miqathango ilandelayo:

  • ukumodareyitha ukuya kwi-plaque psoriasis
  • i-psoriatic arthritis esebenzayo (ebangela iimpawu ngoku)
  • i-spondyloarthritis engeyiyo radiographic
  • i-ankylosing spondylitis esebenzayo

La machiza khange athelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Nangona kunjalo, uphononongo olunye lophando lwe-plaque psoriasis lufumanise ukuba iTaltz yayisebenza ngakumbi kuneCosentyx ekunciphiseni iimpawu ze-psoriasis.

Izikhokelo zonyango ukusuka ngo-2018 no-2019 zincoma zombini iziyobisi njengezinto ezinokukhetha kubantu abafuna unyango lwebhayoloji ye-psoriasis okanye i-psoriatic arthritis. I-Biologics luhlobo lonyango olujolise kumalungu omzimba wakho abandakanyeka kwi-psoriasis kunye ne-psoriatic arthritis.

Ugqirha wakho unokucebisa nge-biologic ukuba ezinye iindlela zonyango azisebenzi kakuhle ngokwaneleyo. Umzekelo, i-biologic inokuba ilungile kuwe ukuba:

  • une-plaque psoriasis kunye nonyango olulula okanye unyango olusetyenzisiweyo kulusu lwakho alusebenzanga
  • une-psoriatic arthritis kunye nonyango lokuchasana (okunceda ukunciphisa ukudumba) njengokuthomalalisa iintlungu okanye ii-steroids azisebenzi

ICosentyx ingangcono kuneTaltz yeplque psoriasis echaphazela iinzipho. I-Taltz inokuba lukhetho olungcono lwe-erythrodermic psoriasis, uhlobo olunqabileyo lwepsoriasis.

Iindleko

I-Taltz kunye neCosentyx zombini zinegama lophawu lweziyobisi. Okwangoku azikho iintlobo zohlobo oluthile lwamayeza. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo kwi-WellRx.com, iTaltz kunye neCosentyx ngokubanzi zibiza malunga nokufanayo. Elona xabiso uzakuhlawula ngalo naliphi na ichiza lixhomekeke kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

I-Taltz vs Humira

Ukongeza kwiCosentyx (ngasentla), uHumira lelinye ichiza elinokusetyenziswa okufana noko kweTaltz. Apha sijonga indlela iTaltz kunye neHumira ezifanayo kunye ezahlukeneyo.

Malunga

I-Taltz ne-Humira zombini iziyobisi ze-biologic (iziyobisi ezenziwe kwiindawo zezinto eziphilayo). Zisebenza nganye ngokujolisa kwiindawo ezahlukeneyo, kodwa ezithile, kumajoni akho omzimba.

I-Taltz iqulethe i-ixekizumab, eluhlobo lwesiyobisi ekuthiwa yi-monoclonal antibody. Ibhloka umsebenzi weprotein kwinkqubo yomzimba ebizwa ngokuba yi-interleukin-17. I-Interleukin-17 ibangela ukuba amajoni omzimba ahlasele iiseli zolusu kunye namalungu. Oku kubangela ukudumba okubonakalayo kwizifo ezinje nge-plaque psoriasis, i-psoriatic arthritis, kunye ne-spondyloarthritis.

I-Humira iqulethe i-adalimumab, eluhlobo lweziyobisi ekuthiwa yi-tumor necrosis factor-alpha (TNF-α) blocker. Ibhloka umsebenzi weprotein ebizwa ngokuba yi-TNF-α. Le proteni ibandakanyeka ekubangeleni ukudumba kwiimeko ezahlukeneyo, kubandakanya i-psoriasis kunye ne-psoriatic arthritis.

Sebenzisa

Ulawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) luvumile zombini i-Taltz ne-Humira ukunyanga i-plaque psoriasis ngokulinganayo. Ugqirha wakho unokumisela elinye lala machiza ukuba i-psoriasis inokuzuza kunyango lwenkqubo (unyango oluchaphazela umzimba wakho uphela) okanye i-phototherapy (unyango olulula).

I-plaque psoriasis, iTaltz ivunyiwe ukuba isetyenziswe kubantu abadala kunye nabantwana abaneminyaka emi-6 nangaphezulu. Nangona kunjalo, i-Humira ivunyiwe kuphela ukuba isetyenziswe kubantu abadala abanale meko.

Zombini i-Taltz kunye neHumira nazo zivunyiwe yi-FDA ukunyanga i-psoriatic arthritis kubantu abadala. ("Ukusebenza" kuthetha ukuba okwangoku uneempawu.)

Ukongeza, zombini i-Taltz ne-Humira zivunyiwe ngokunyanga i-ankylosing spondylitis esebenzayo kubantu abadala. Kodwa yi-Taltz kuphela evunyiweyo yokunyanga i-non-radiographic axial spondyloarthritis kubantu abadala.

U-Humira naye unemvume ye-FDA yokunyanga le miqathango ilandelayo:

  • isifo samathambo (RA)
  • ukumodareyitha ukuya kubunzima be-juvenile idiopathic arthritis
  • Isifo sikaCrohn
  • ukumodareyitha ukuya kubunzima besilonda esibuhlungu
  • i-hidradenitis suppurativa, imeko ebuhlungu yesikhumba ekwabizwa ngokuba ngamabala anversa
  • ezinye iintlobo ze-uveitis engosuleliyo (uhlobo lokudumba kwamehlo), kubandakanya u-uveitis ophakathi, u-posterior uveitis, kunye ne-panuveitis

Phawula: Ukufunda ngakumbi malunga nemeko iTaltz evunyiweyo ukunyanga, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngasentla.

Iifom zeziyobisi kunye nolawulo

Zombini i-Taltz ne-Humira zinikwa ngenaliti phantsi kolusu lwakho (inaliti yangaphantsi). Umboneleli wakho wezempilo uya kukunika inaliti ekuqaleni. Emva koko banokukufundisa ukuba ungazinika njani inaliti ekhaya.

I-Taltz iza ngeendlela ezimbini: isirinji esetyenzisiweyo esetyenzisiweyo kunye nepeni yokusetyenziswa kwe-autoinjector.

I-Humira iza ngeendlela ezintathu:

  • usiba olunye olusetyenzisiweyo
  • isirinji esetyenziselwa ukusetyenziswa kube kanye
  • igutyana elisebenzisa ibenye unikwe inaliti ngumboneleli wakho wokhathalelo lwempilo

Iziphumo kunye neengozi

I-Taltz ne-Humira inokubangela iziphumo ebezingalindelekanga ezifanayo kwaye ezinye zahlukile. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho kunye neTaltz, neHumira, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Ngaba kunokwenzeka ngeTaltz:
    • usulelo lwe-tinea fungal, njengonyawo lwembaleki
    • i-conjunctivitis (iliso elipinki)
  • Ngaba kunokwenzeka ngeHumira:
    • intloko ebuhlungu
    • irhashalala
  • Inokwenzeka kunye neTaltz kunye neHumira:
    • ukusabela kwendawo yenaliti, njengokubomvu kunye nokukhathazeka okujikeleze indawo yenaliti
    • izifo eziphezulu zokuphefumula, ezifana nokubanda okuqhelekileyo
    • isicaphucaphu

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho kunye neTaltz, kunye neHumira, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Ngaba kunokwenzeka ngeTaltz:
    • isifo esitsha okanye esiba mandundu sokudumba kwamathumbu (IBD), esifana nesifo sikaCrohn okanye isifo sesilonda esibuhlungu
  • Ngaba kunokwenzeka ngeHumira:
    • iingxaki zesibindi, ezinje ngokusilela kwesibindi
    • iingxaki zenkqubo ye-nervous, njenge-multiple sclerosis (MS)
    • iingxaki zegazi, ezinje ngokuncitshiswa kwamanani eeseli ezibomvu zegazi, iiseli ezimhlophe zegazi, okanye iiplatelets
    • ukumelwa yintliziyo
    • izifo zokungunda, ezinje nge-histoplasmosis
    • Ukwanda komngcipheko kwezinye zomhlaza, njengomhlaza wolusu, i-leukemia, kunye ne-lymphoma
    • i-psoriasis entsha okanye eyandayo
  • Inokwenzeka kunye neTaltz kunye neHumira:
    • ukwanda kwengozi yosulelo olunokuba lubi, njengesifo sephepha (TB)
    • negazi kakhulu

Ukusebenza ngempumelelo

I-Taltz ne-Humira banezinto ezahlukileyo ezamkelweyo ze-FDA, kodwa zombini zisetyenziselwa ukunyanga le miqathango ilandelayo:

  • ukumodareyitha ukuya kwi-plaque psoriasis
  • i-psoriatic arthritis esebenzayo
  • i-ankylosing spondylitis esebenzayo

La machiza awathelekiswanga ngokuthe ngqo kubantu abane-plaque psoriasis, kodwa izifundo zifumanise ukuba zombini i-Taltz ne-Humira ziyasebenza ekunyangeni le meko.

Olunye uphononongo lweklinikhi lujonge zombini iTaltz kunye neHumira kubantu abane-psoriatic arthritis esebenzayo. Emva kweeveki ezingama-24, iimpawu ze-psoriatic arthritis zancitshiswa ubuncinci ngama-20% kwi-58% ukuya kuma-62% abantu abathathe iTaltz. Oku kwafaniswa ne-57% yabantu abathathe i-Humira kunye ne-30% abathathe indawo ye-placebo (akukho nyango).

Izikhokelo zonyango ukusuka ngo-2018 no-2019 zincoma zombini iziyobisi njengezinto ezinokukhetha kubantu abafuna unyango lwe-biologic ye-psoriasis okanye i-psoriatic arthritis. I-Biologics luhlobo lonyango olujolise kumalungu omzimba wakho abandakanyeka kwi-psoriasis kunye ne-psoriatic arthritis.

Ugqirha wakho unokucebisa nge-biologic ukuba ezinye iindlela zonyango azisebenzi kakuhle ngokwaneleyo. Umzekelo, i-biologic inokuba ilungile kuwe ukuba:

  • une-plaque psoriasis kunye nonyango olulula okanye unyango olusetyenzisiweyo kulusu lwakho alusebenzanga
  • une-psoriatic arthritis kunye nonyango lokuchasana (okunceda ukunciphisa ukudumba) njengokuthomalalisa iintlungu okanye ii-steroids azisebenzi

Kubantu abaninzi abaqala unyango lwe-psoriatic arthritis esebenzayo, izikhokelo ze-2018 zincomela ukusebenzisa i-TNF-alpha blockers (njengeHumira) ngaphezulu kwe-interleukin-17 blockers (ezinje ngeTaltz). Izikhokelo ze-2019 zichaza ukuba uHumira unokulunge ngakumbi kuneTaltz ye-plaque psoriasis echaphazela ulusu kunye ne-erythrodermic psoriasis (uhlobo olunqabileyo lwepsoriasis).

Uphononongo lweklinikhi luthelekisa indlela esebenza ngayo i-Taltz ne-Humira kunyango lwe-psoriatic arthritis kunye ne-plaque psoriasis. Uphononongo lubike ukuba ngaphezulu kweeveki ezingama-24 zonyango, ama-36% abantu abathathe iTaltz baneempawu zabo eziphuculweyo okungenani ngama-50%. Xa kuthelekiswa, iipesenti ezingama-28 zabantu abathathe uHumira baneempawu zabo eziphuculweyo ubuncinci ngama-50%.

Iindleko

I-Taltz ne-Humira bobabini bangamagama egama lophawu. Okwangoku azikho iintlobo zohlobo oluthile lwamayeza. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo kwi-WellRx.com, iTaltz neHumira ngokubanzi zibiza malunga nokufanayo. Elona xabiso uzakuhlawula ngalo naliphi na ichiza lixhomekeke kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Unxibelelwano lweTaltz

I-Taltz inokusebenzisana namanye amayeza. Unxibelelwano olwahlukileyo kunokubangela iziphumo ezahlukeneyo. Umzekelo, unxibelelwano oluthile lunokuphazamisa ukusebenza kakuhle kwesiyobisi. Olunye unxibelelwano lunokunyusa iziphumo ebezingalindelekanga okanye lubenze bube nzima ngakumbi.

Taltz kunye namanye amayeza

Apha ngezantsi kukho uluhlu lwamayeza anokusebenzisana neTaltz. Olu luhlu alunazo zonke iziyobisi ezinokusebenzisana neTaltz.

Ngaphambi kokuba uthathe iTaltz, thetha nogqirha wakho kunye nosokhemesti. Baxelele ngawo onke amayeza kagqirha, ekhawuntareni, kunye nezinye iziyobisi ozithathayo. Baxelele malunga nazo naziphi na iivithamini, amayeza esintu kunye nezixhasi ozisebenzisayo. Ukwabelana ngolu lwazi kunokukunceda uphephe unxibelelwano olunokubakho.

Ukuba unemibuzo malunga nokunxibelelana kweziyobisi okunokuchaphazela, buza ugqirha wakho okanye usokhemesti.

I-Taltz kunye ne-warfarin

IWarfarin (Coumadin, Jantoven) luhlobo lwegazi elincinci, ichiza elinceda ukuthintela amahlwili egazi. Ukuthatha iTaltz nge-warfarin kunokwenza ukuba i-warfarin yakho ingasebenzi kakuhle.

Ukuba uthatha i-warfarin, ugqirha wakho unokufuna ukubeka esweni ukuba kuthatha ixesha elingakanani ukuba igazi lakho lijiye emva kokuba uqale i-Taltz, ngexesha lonyango lwakho, kwaye ukuba uyeka iTaltz. Banokuhlengahlengisa idosi yakho yewarfarin xa kufuneka.

Taltz kunye cyclosporine

I-cyclosporine sisiyobisi esingaxutywanga. Uyithatha ukunciphisa umsebenzi wamajoni akho omzimba. Ukuthatha iTaltz nge-cyclosporine kunokwenza ukuba i-cyclosporine yakho ingasebenzi kakuhle.

Ukuba uthatha i-cyclosporine, ugqirha wakho unokufuna ukujonga inqanaba leziyobisi egazini lakho emva kokuba uqale iTaltz, ngexesha lonyango lwakho kwaye ukuba uyeka iTaltz. Banokuhlengahlengisa idosi yakho yecyclosporine ukuba iyafuneka.

ICyclosporine ikwafumaneka njengala magama alandelayo:

  • Cequa
  • IGengraf
  • Ukudibana
  • Ukuphumla
  • Isandimmune

Taltz kwaye ugonyo

Ukufumana isitofu sokugonya esiphilayo ngelixa uthatha iTaltz kunokubangela usulelo olubi.

Amayeza okugonya aphilayo aneentlobo ezibuthathaka zeentsholongwane okanye iintsholongwane, kodwa azibangeli zintsholongwane kubantu abanamajoni omzimba asempilweni. Nangona kunjalo, izitofu zokugonya eziphilayo zinokubangela usulelo kubantu abanamajoni omzimba achaphazeleka ngonyango ngeTaltz.

Ngelixa uthatha iTaltz, akufuneki ufumane izitofu zokugonya ezifana ne:

  • iqhwiqhwi
  • umkhuhlane omthubi
  • isifo sephepha (TB)
  • imasisi, uqwilikana, kunye nerubella (MMR)

Kulungile ukufumana izitofu ezingasebenziyo (ezingaphiliyo), ezinje ngomkhuhlane, ngexesha lonyango lwakho lweTaltz. Nangona kunjalo, izitofu ezingasebenziyo zinokungasebenzi njengokuba zihlala zisenza. (Amachiza asebenza ngokubangela amajoni omzimba wakho ukuba avelise izilwa-buhlungu ezinceda ukulwa izifo. ITaltz ingenza ukuba amajoni akho omzimba angakwazi ukuvelisa izilwa-buhlungu.)

Ukuba ugqirha wakho ufuna ukuba uthathe i-Taltz, cela ukuba unolwazi ngazo zonke izitofu zokugonya ezicetyiswayo.

Taltz kunye nemifuno kunye nezongezelelo

Akukho zityalo okanye izongezo ezichazwe ngokukodwa ukuba zisebenzisane neTaltz. Kodwa qiniseka ukuba ujonga kwikhemesti yakho ngaphambi kokusebenzisa nayiphi na.

Uyithatha njani iTaltz

Iyeza linikwa ngenaliti phantsi kolusu lwakho (inaliti yangaphantsi). Umboneleli wakho wezempilo uya kukunika inaliti ekuqaleni. Emva koko banokukufundisa ukuba ungazinika njani inaliti ekhaya. Unokuthatha inaliti yakho yeTaltz ngalo naliphi na ixesha losuku ngemini efanelekileyo.

I-Taltz iza njengethamo elinye lesirinji elichongiweyo kunye nokusetyenziswa okukodwa kwepen ye-autoinjector. Buza ugqirha wakho okulungeleyo. Zombini ezi fom zinedosi enye. Utofa idosi epheleleyo emva koko ulahle isirinji okanye ipeni ye-autoinjector.

Nini ukuthatha

Xa uza kudinga ukuthatha idosi yeTaltz kuxhomekeke kwimeko yokuphathwa. Ngokwesiqhelo, uya kufumana idosi yakho yokuqala yeTaltz kwiofisi kagqirha wakho. Emva koko uya kuba nakho ukunika ii-injection ezilandelayo kuwe.

Apha ngezantsi, sichaza iishedyuli zokulinganisa i-Taltz ngokusetyenziswa kwayo okuvunyiweyo.

  • Ukuba unayo i-psoriasis: Kwidosi yakho yokuqala yeTaltz, uyakufumana iinaliti ezimbini ngemini enye. Emva kwethamo lokuqala leTaltz, uya kuba nenaliti enye rhoqo kwiiveki ezi-2 kwiiveki ezili-12. Oku kuya kulandelwa ngenaliti enye rhoqo kwiiveki ezi-4 okoko ugqirha ekucebisa.
  • Ukuba une-psoriatic arthritis: Kwidosi yakho yokuqala yeTaltz, uyakufumana iinaliti ezimbini ngemini enye. Emva kwethamo lokuqala leTaltz, uya kuba nenaliti enye rhoqo kwiiveki ezi-4 okoko ugqirha ekucebisa.
  • Ukuba une-psoriasis kunye ne-psoriatic arthritis: Uya kufumana iidosi zeTaltz ngokusekwe kucwangciso lwedosi olucetyiswayo lwepsoriasis, oluchazwe apha ngasentla.
  • Ukuba une-non-radiographic axial spondyloarthritis (nr-axSpA): Emva kwedosi yakho yokuqala yeTaltz, uya kuba nenaliti enye qho kwiiveki ezi-4.
  • Ukuba une-ankylosing spondylitis (AS) esebenzayo: Kwidosi yakho yokuqala yeTaltz, uyakufumana iinaliti ezimbini ngemini enye. Emva kwethamo lokuqala leTaltz, uya kuba nenaliti enye qho kwiiveki ezi-4.

Ukuze i-Taltz isebenze kakuhle, kubalulekile ukuyithatha njengoko ugqirha wakho ekuyalela. Ukuqinisekisa ukuba uyakhumbula ukuthatha iyeza, licebo elihle ukubhala ishedyuli yakho yenaliti kwikhalenda. Unokusebenzisa isixhobo sokukhumbuza amayeza ukuze ungalibali.

Phawula: Ngolwazi oluthe kratya malunga neemeko ezidweliswe apha, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngasentla.

Ungayifaka njani inaliti

Umboneleli wakho wezempilo uya kukuyalela indlela yokusebenzisa isirinji okanye ipeni ye-autoinjector. Ngolwazi oluthe kratya, iividiyo, kunye nemifanekiso yemiyalelo yenaliti, jonga iwebhusayithi yomenzi.

Gcina ukhumbula ukuba iisayithi ezifanelekileyo zokufaka i-Taltz zingaphambi kwamathanga akho okanye isisu sakho (isisu). Unokusebenzisa umva weengalo zakho ezingasentla, kodwa unokufuna omnye umntu ukuba akunike inaliti.

Isebenza njani iTaltz

I-Psoriasis, i-psoriatic arthritis, kunye ne-spondyloarthritis ziimeko ezizimeleyo. Zenza ukuba amajoni akho omzimba (ukuzikhusela komzimba wakho kwizifo) ahlasele iiseli eziphilileyo ngempazamo.

Ngolwazi oluthe kratya malunga nale miqathango, jonga icandelo elithi "Ukusetyenziswa kweTaltz" apha ngasentla.

Amacandelo ahlukeneyo amajoni omzimba ayabandakanyeka kwezi meko. Inkqubo ethile inento yokwenza neprotein ebizwa ngokuba yi-interleukin-17A. Le proteni ixelela amajoni akho omzimba ukuba ahlasele iiseli kulusu nakumalungu akho.

I-Taltz iqulethe i-ixekizumab, eluhlobo lweziyobisi olubizwa ngokuba yi-humanized monoclonal antibody. Isebenza ngokubopha (ngokudibanisa) kwi-interleukin-17A. Ngokwenza oku, i-Taltz ibhloka isenzo seprotein. Iyayeka ukuxelela amajoni akho omzimba ukuba ahlasele iiseli zolusu kunye namalungu akho.

Ngokuthintela amajoni akho omzimba ekuhlaseleni iiseli, iTaltz iyanceda:

  • ukunciphisa ukwenziwa kwamacwecwe esikhumbeni sakho kwi-plaque psoriasis
  • ukunciphisa ukudumba (ukudumba) kwamalungu akho kwi-psoriatic arthritis, i-non-radiographic axial spondyloarthritis, kunye ne-ankylosing spondylitis esebenzayo

Kuthatha ixesha elingakanani ukusebenza?

I-Taltz iqala ukusebenza ngokukhawuleza xa uqala unyango. Nangona kunjalo, kuya kuthatha iiveki ezimbalwa ukuba uqaphele naluphi na utshintsho.

Kwizifundo zeklinikhi, uninzi lwabantu abane-plaque psoriasis lwalucacile okanye lucacile ulusu kwiiveki ezili-12 emva kokuba beqale unyango okanye kwangoko. Kwaye malunga nesiqingatha sabantu abane-psoriatic arthritis abathathe i-Taltz babeneempawu ezinzima kunye nokusebenza okungcono komzimba kwiiveki ezili-12 emva kokuqala konyango.

Isifundo seklinikhi sabantu abadala abane-non-radiographic axial spondyloarthritis bajonge kunyango nge-Taltz kunye nonyango nge-placebo. (I-placebo lunyango olungenachiza lisebenzayo.) Emva kweeveki ezingama-52 zonyango, ama-30% abantu abasebenzisa iTaltz iimpawu zabo zancitshiswa ngama-40% ngaphezulu. Xa kuthelekiswa, i-13% yabantu abasebenzisa i-placebo babeneziphumo ezifanayo.

Izifundo ezibini zeklinikhi zabantu abadala abane-ankylosing spondylitis esebenzayo bajonge kunyango nge-Taltz xa kuthelekiswa naleyo ye-placebo. Emva kweeveki ezili-16 zonyango, ama-25% ukuya kuma-48% abantu abasebenzisa iTaltz zaye zancitshiswa iimpawu zabo ngama-40% okanye nangaphezulu. Xa kuthelekiswa, i-13% ukuya kwi-18% yabantu abasebenzisa i-placebo babeneziphumo ezifanayo.

Taltz kunye nokukhulelwa

I-Taltz khange ifundwe kwabasetyhini abakhulelweyo, ke ayaziwa ukuba ichiza likhuselekile na ngexesha lokukhulelwa.

Qinisekisa ukuxelela ugqirha wakho ukuba ukhulelwe okanye uceba ukukhulelwa ngaphambi kokuba uqale unyango. Ukuba ucinga ukuba unokukhulelwa ngelixa uthatha iTaltz, thetha nogqirha wakho kwangoko.

I-Taltz kunye nolawulo lokuzalwa

Ayaziwa ukuba i-Taltz ikhuselekile ukuthatha ngexesha lokukhulelwa. Ukuba usebenza ngokwesondo kwaye wena okanye iqabane lakho unokukhulelwa, thetha nogqirha wakho malunga neemfuno zakho zolawulo lokuzalwa ngelixa usebenzisa iTaltz.

Ngolwazi oluthe kratya malunga nokuthatha iTaltz ngexa lokukhulelwa, jonga kwicandelo "iTaltz kunye nokukhulelwa" apha ngasentla.

Taltz kunye nokuncancisa

Ayaziwa ukuba i-Taltz idlula kubisi lwebele lomntu okanye ukuba iyayichaphazela indlela umzimba wakho owenza ngayo ubisi lwebele. I-Taltz yafunyanwa kubisi lwebele kwizifundo zezilwanyana, kodwa izifundo kwizilwanyana azihlali zibonisa into eza kwenzeka ebantwini.

Ukuba uncelisa kwaye ucinga ukuthatha iTaltz, thetha nogqirha wakho. Banokuthetha nawe ngomngcipheko onokubakho kunye nezibonelelo zamachiza.

Imibuzo eqhelekileyo malunga neTaltz

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga neTaltz.

Ngaba iTaltz yi-biologic?

Ewe. I-Taltz yonyango lwe-biologic. Oku kuthetha ukuba sisiyobisi esenziwe kwiiproteni hayi kwiikhemikhali (njengoko uninzi lweziyobisi lukhona). Iziyobisi zebhayoloji ziveliswa elebhu kusetyenziswa iiseli zezilwanyana.

Ngaba ndisafuna ukusebenzisa iikhrimu ze-psoriasis ngelixa ndisebenzisa iTaltz?

Ingayiyo. Kodwa kuya kufuneka ulandele imiyalelo kagqirha wakho malunga noku.

Ukuba ulusu lwakho luyacoca ngokupheleleyo emva kokuba uthathe i-Taltz, ngekhe kungafuneki ukuba uqhubeke usebenzisa unyango lwesihloko. Kodwa kwezinye iimeko, usenokuba namacwecwe e-psoriasis (ashinyeneyo, abomvu, amabala anamaxolo kulusu lwakho). Ukuba oku kwenzekayo, ugqirha wakho unokucebisa ukuba uqhubeke usebenzisa i-moisturizers okanye ezinye iindlela zonyango njengoko kufuneka. Soloko ulandela ingcebiso akunikwa ngugqirha wakho.

Ngaba ukusebenzisa i-Taltz kunokubangela isifo sesibindi esitsha okanye esibi?

Ewe unako, nangona oku kunqabile. Isifo samathumbu esivuthayo (IBD) liqela lezifo ezibangela ukudumba (ukudumba) kwindawo yakho yokwetyisa. Ezi zifo zibandakanya isifo sikaCrohn kunye ne-ulcerative colitis.

Kwizifundo zeklinikhi, isifo sikaCrohn senzeka kwi-0.1% yabantu abane-plaque psoriasis abafumana iTaltz. I-ulcerative colitis yenzeke kwi-0.2% yabantu abane-plaque psoriasis abafumana iTaltz.

Ukuba unempawu ezintsha okanye ezibi kakhulu ze-IBD, jonga ugqirha wakho. Iimpawu zinokubandakanya iintlungu esiswini sakho (isisu), urhudo kunye okanye ngaphandle kwegazi, kunye nokwehla kobunzima.

Ndingenza ntoni ukuthintela usulelo ngelixa ndithatha iTaltz?

I-Taltz inokunciphisa amandla omzimba wakho, ngoko ke ichiza linokunyusa umngcipheko wokufumana izifo. Nazi ezinye zeengcebiso zokunceda ukugcina amajoni akho omzimba omelele kwaye akuncede uphephe izifo:

  • Ngaphambi kokuba uqale unyango, thetha nogqirha wakho malunga nokufumana umhla kunye naziphi na izitofu zokugonya ezicetyiswayo.
  • Hlamba izandla zakho rhoqo, ngakumbi ukuba ubukwindawo yoluntu.
  • Zama ukuphepha ukunxibelelana nabantu abanesifo, ngakumbi ukukhwehlela, ukubanda, okanye umkhuhlane.
  • Gwema ukwabelana ngeetawuli okanye amalaphu okuhlamba nawuphina umntu onesifo sokungunda kolusu okanye ukubanda.
  • Yitya ukutya okusempilweni.
  • Lala ngokwaneleyo.
  • Musa ukutshaya.

Ngaba i-Taltz iphilisa i-plaque psoriasis okanye i-psoriatic arthritis?

Hayi, iTaltz ayizinyangi ezi meko. Okwangoku akukho lunyango lwe-plaque psoriasis okanye i-psoriatic arthritis. Kodwa unyango lwexesha elide kunye neTaltz lunokunceda ukulawula iimpawu zezi meko.

Izifundo zonyango ziye zavavanya abantu abane-plaque psoriasis abathathe iTaltz. Ezinye iimpawu zabantu zicocwe ngokupheleleyo okanye zaba zincinci emva kweeveki ezili-12. Isiqingatha seli qela emva koko sithathe iTaltz ezinye iiveki ezingama-48. Esinye isiqingatha seqela sithathe i-placebo (akukho lonyango) kwiiveki ezingama-48.

Kubantu abaqhubeka nokuthatha iTaltz, iipesenti ezingama-75 babengenazo okanye iimpawu nje ezincinci ekupheleni kwesifundo. Kuninzi lwabantu abathathe indawo ye-placebo, iimpawu zabo ziye zaphinda zaya zisiba mandundu. Kuphela yi-7% yeqela le-placebo ebengenazo okanye zincinci iimpawu. Ixesha eliqhelekileyo elithathiweyo lokuba iimpawu ziye zisiba mbi kubantu abathathe indawo ye-placebo ibiziintsuku ezili-164. Kodwa xa beqala kwakhona ukuthatha i-Taltz, i-66% yaba bantu, i-psoriasis yabo icociwe ngaphakathi kweeveki ezili-12.

Izikhuselo zeTaltz

Ngaphambi kokuba uthathe i-Taltz, thetha nogqirha wakho malunga nembali yakho yezempilo. I-Taltz isenokungakulungeli ukuba uneemeko ezithile zonyango. Oku kubandakanya:

  • Naluphi na usulelo, kodwa isifo sephepha ngokukodwa. I-Taltz ingenza ukuba amajoni akho omzimba angakwazi ukulwa iintsholongwane, kungoko usulelo olunjengesifo sephepha (i-TB) lunokuba mandundu.
    • Ukuba ngaba une-TB okanye ubunayo i-TB ngaphambili, kungafuneka uthathe amayeza ukuze unyange. Nje ukuba inyangwe i-TB, unganakho ukuqala ukuthatha i-Taltz.
    • Ukuba uneempawu zolunye usulelo, ezinje ngomkhuhlane, okanye ukuba ufumana usulelo oluhlala lubuya, xelela ugqirha wakho. Ezi zifo zingafuna ukunyangwa ngaphambi kokuba uqale unyango ngeTaltz.
  • Ukudumba kwesifo. Kwiimeko ezinqabileyo, i-Taltz inokuzenza mandundu ngakumbi iimpawu zesifo sokuqaqamba kwamathumbu (IBD). I-IBD liqela lezifo ezibandakanya isifo sikaCrohn kunye ne-ulcerative colitis. Ukuba unayo i-IBD, thetha nogqirha wakho. Banokujonga iimpawu zakho ngelixa uthatha iTaltz. Ukuba i-IBD yakho iya isiba mandundu, unokufuna ukumisa iTaltz. Kukho amanye amayeza e-biologic angonakalisi i-IBD onokuthi uzame.

Phawula: Ngolwazi oluthe kratya malunga neziphumo ezibi ezinokubakho zeTaltz, jonga icandelo leziphumo ebezingalindelekanga zeTaltz.

Ukugqithisa kweTaltz

Isirinji nganye kunye nepen ye-autoinjector iqulethe inani elifanelekileyo lamayeza edosi enye. Ukugqithisa kunokwenzeka kuphela xa unika ii-injection ezininzi okanye ukuba uthatha iTaltz rhoqo.

Iimpawu libanda

Iimpawu zokudlula ngaphezulu zinokubandakanya iziphumo ebezingalindelekanga eziba rhoqo okanye zibenzima, ezinje:

  • izifo eziphezulu zokuphefumula, ezifana nokubanda okuqhelekileyo
  • isicaphucaphu
  • usulelo lomngundo, olufana nonyawo lweembaleki
  • negazi kakhulu
  • isifo sesisu sokuvuvukala (IBD), esifana nesifo sikaCrohn okanye isifo sezilonda
  • ukwanda komngcipheko wosulelo, njengesifo sephepha (TB)

Kufuneka wenze ntoni xa uthe wagqithisa?

Ukuba ucinga ukuba uthathe kakhulu eli chiza, tsalela ugqirha wakho. Ungabiza uMbutho waseMelika wamaZiko oLawulo lweTyhefu ku-800-222-1222 okanye usebenzise isixhobo esikwi-Intanethi. Kodwa ukuba iimpawu zakho zinzima, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko.

Ukuphelelwa yisikhathi kweTaltz, ukugcinwa kunye nokulahlwa

Xa ufumana i-Taltz kwikhemesti, usokhemesti uya kongeza umhla wokuphelelwa kwileyibhile esebhotileni. Lo mhla uqhele ukuba ngunyaka omnye ukusukela kumhla wokuhambisa kwabo amayeza.

Umhla wokuphelelwa unceda ekuqinisekiseni ukusebenza kwamayeza ngeli xesha. Isimo sangoku soLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) kukuphepha ukusebenzisa amayeza aphelelwe lixesha. Ukuba awusebenzisanga amayeza adlulileyo kumhla wokuphelelwa, cela usokhemesti wakho ukuba usenako na ukusebenzisa.

Ukugcina

Ukuhlala ixesha elingakanani iyeza lihlala lilungile kunokuxhomekeka kwizinto ezininzi, kubandakanya ukuba uligcina phi kwaye phi na iyeza.

Iisirinji ezizalisiweyo zeTaltz kunye neepeni ze-autoinjector kufuneka zigcinwe kwifriji kwi-36 ° F ukuya kwi-46 ° F (2 ° C ukuya kwi-8 ° C). Qinisekisa ukuba bafikelele ebantwaneni. Musa ukumisa umkhenkce iTaltz. Kwaye musa ukusebenzisa iyeza ukuba liye labanda.

Ngamanye amaxesha, unokufuna ukuthatha iTaltz ngaphandle kwefriji ngaphambi kokuyisebenzisa. Umzekelo, ukuba uyahamba iintsuku ezimbalwa kwaye uyakufuna inaliti ngelo xesha. Yazi ukuba ungayigcina iTaltz kubushushu begumbi ukuya kuthi ga kwi-86 ° F (30 ° C) ukuya kuthi ga kwiintsuku ezintlanu.

Qiniseka ukuba ugcina isirinji okanye ipeni ye-autoinjector kwibhokisi yayo yoqobo ukuyikhusela ekukhanyeni. Ukuba awusebenzisi isirinji okanye usiba kwiintsuku ezintlanu, kuya kufuneka uyilahle ngokukhuselekileyo. Akufanele ubeke iTaltz kwakhona kwifriji emva kokuba igcinwe kubushushu begumbi.

Ukulahla

Emva kokuba usebenzise isirinji ekhethiweyo ye-Taltz okanye ipeni ye-autoinjector, yibeke kwindawo yokulahla izixhobo evunyiweyo ye-FDA. Oku kunceda ukuthintela abanye, kubandakanya abantwana kunye nezilwanyana zasekhaya, ekubeni bathathe iyeza ngengozi. Kuyanceda ukugcina ichiza lingonzakalisi okusingqongileyo.

Ukuba awunaso isikhongozeli esibukhali, ungathenga enye kwi-intanethi kwikhemesti yakho yasekuhlaleni.

Unokufumana iingcebiso ezifanelekileyo ngokulahla amayeza apha. Unokucela ikhemesti yakho ukuba ikunike iingcebiso malunga nendlela yokulahla amayeza akho.

Ulwazi lobungcali lweTaltz

Olu lwazi lulandelayo lubonelelwe ngoochwephesha kunye nabanye abaqeqeshi bezempilo.

Iimpawu

Ulawulo lokutya kunye neziyobisi (i-FDA) yamkele iTaltz ukuba inyange:

  • ukumodareyitha ukuya kwi-plaque psoriasis efanelekileyo kunyango lwenkqubo okanye kwi-phototherapy; ukulungiselela oku kusetyenziswa, ichiza linokumiselwa abantu abadala kunye nabantwana abaneminyaka emi-6 nangaphezulu
  • i-psoriatic arthritis esebenzayo kubantu abadala
  • i-non-radiographic axial spondyloarthritis (nr-axSpA) kubantu abadala
  • i-ankylosing spondylitis esebenzayo (AS), ekwabizwa ngokuba yi-radiographic axial spondyloarthritis (r-axSpA); ukulungiselela oku kusetyenziswa, ichiza linokumiselwa abantu abadala

Indlela yokusebenza

I-Taltz iqulethe i-ixekizumab, eyi-anti-IgG monoclonal antibody. Ixekizumab ikhetha iithagethi kwaye ibophelela kwi-interleukin-17A (IL-17A). I-IL-17A yenye yee-cytokines ezivuthayo ezaziwa ukuba ziyabandakanyeka ekuveliseni iimpendulo zokukrala kunye nokuzivikela komzimba ezibangela isifo se-psoriatic kunye ne-ankylosing spondylitis. Ngokuzibophelela kwi-IL-17A, ixekizumab iyeka ukusebenzisana ne-IL-17A receptor kwaye ke inqanda ezi mpendulo.

I-Pharmacokinetics kunye ne-metabolism

Ixekizumab bioavailability isusela kwi-60% ukuya kwi-81% kulandela inaliti engaphantsi kwizifundo ze-plaque psoriasis. Ukufumaneka okuphezulu kwe-bioavailability kufezekisiwe ngenaliti ethangeni xa kuthelekiswa nezinye iindawo zenaliti ezinje ngengalo kunye nesisu.

Kuthetha ukuba isiqingatha sobomi yayiziintsuku ze-13 kwizifundo ezine-plaque psoriasis.

Indlela yokuphelisa metabolic ayichongwanga, kodwa kulindeleke ukuba ifane naleyo ye-IgG engapheliyo kunye neendlela zokwenza izinto ezivelisa iipeptides ezincinci kunye neeamino acid.

Ukungqinelana

I-Taltz iyaphikiswa kubantu abanempendulo engathandekiyo yangaphambili, njenge-anaphylaxis, kwi-ixekizumab okanye izinto zayo.

Ukugcina

I-Taltz autoinjector kunye nesirinji ekhethiweyo kufuneka igcinwe kwifriji kwi-36 ° F ukuya kwi-46 ° F (2 ° C ukuya kwi-8 ° C).

Musa ukubanda. Khusela ekukhanyeni. Musa ukungcangcazela. I-Taltz inokugcinwa kubushushu begumbi ukuya kuma-86 ° F (30 ° C) ukuya kwiintsuku ezintlanu. Nje ukuba igcinwe kubushushu begumbi, akufuneki ibuyiselwe kwifriji.

Iphepha elichazayo ukuba awusenanto oyifunayo: Iindaba zezoNyango namhlanje zenze zonke iinzame zokuqinisekisa ukuba zonke iinkcukacha zichanekile, zibanzi kwaye zihlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.

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