I-Tecfidera (i-dimethyl fumarate)

Umxholo

• Yintoni iTecfidera?
• Tecfidera igama eliqhelekileyo
• Iziphumo ebezingalindelekanga zeTecfidera
• Iziphumo eziqhelekileyo ezichaphazelekayo
• Iziphumo ebezingalindelekanga ezimandundu
• I-PML
• Ukuhluza
• KwiLymphopenia
• Iziphumo zesibindi
• Impendulo enamandla kakhulu
• Irhashalala
• Ukulahleka kweenwele
• Ukutyeba / ukuthoba ubunzima
• Ukudinwa
• Intlungu yesisu
• Urhudo
• Iziphumo kwisidoda okanye ukuchuma kwendoda
• Intloko ebuhlungu
• Ukurhawuzelela
• Uxinzelelo
• Izibophelelo
• Umhlaza
• Isicaphucaphu
• Ukuqunjelwa
• Ukuqhawula
• Ukuphuthelwa
• Ukuthuthuzela
• Intlungu edibeneyo
• Umlomo owomileyo
• Iziphumo emehlweni
• Iimpawu ezinjengomkhuhlane
• Iziphumo ebezingalindelekanga zexesha elide
• I-Tecfidera isebenzisa
• I-Tecfidera ye-MS
• I-Tecfidera ye-psoriasis
• Ezinye iindlela zeTecfidera
• I-Tecfidera vs ezinye iziyobisi
• I-Tecfidera vs. Aubagio
• Tecfidera vs.Copaxone
• Tecfidera vs. Ocrevus
• I-Tecfidera vs. iTysabri
• Tecfidera vs.Gilenya
• I-Tecfidera vs interferon (Avonex, Rebif)
• I-Tecfidera vs. iProtandim
• Umlinganiselo weTecfidera
• Isisombululo se-multiple sclerosis
• Kuthekani ukuba ndiphose idosi?
• Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?
• Uyithatha njani iTecfidera
• Ixesha
• Ukuthatha iTecfidera ngokutya
• Ngaba iTecfidera inokutyunyuzwa?
• Ukukhulelwa kunye neTecfidera
• Ukuncancisa kunye neTecfidera
• Isebenza njani iTecfidera
• Kuthatha ixesha elingakanani ukusebenza?
• Tecfidera kunye notywala
• Ukusebenzisana kweTecfidera
• Tecfidera kunye ne-ocrelizumab (Ocrevus)
• Tecfidera kunye ibuprofen
• Tecfidera kunye neasprini
• Imibuzo eqhelekileyo malunga neTecfidera
• Kutheni iTecfidera ibangela ukugungxula?
• Ungakuthintela njani ukugungxula kwiTecfidera?
• Ngaba iTecfidera ikwenza udinwe?
• Ngaba iTecfidera i-immunosuppressant?
• Ngaba kufuneka ndikhathazeke ngokuvezwa lilanga ngelixa ndithatha iTecfidera?
• Isebenza njani iTecfidera?
• Kutheni le nto ndineendlela ezahlukeneyo zedosi emva kweveki yokuqala?
• Ngaba ndifuna ukufumana uvavanyo lwegazi ngelixa ndikwiTecfidera?
• Ukugqithisa kweTecfidera
• Iimpawu libanda
• Kufuneka wenze ntoni xa uthe wagqithisa?
• Izilumkiso zeTecfidera
• Ukuphelelwa kweTecfidera
• Ulwazi lobungcali lweTecfidera
• Indlela yokusebenza
• I-Pharmacokinetics kunye ne-metabolism
• Ukungqinelana
• Ukugcina
• Ukumisela ulwazi

Yintoni iTecfidera?

I-Tecfidera (i-dimethyl fumarate) liyeza lonyango elinegama lebrendi. Isetyenziselwa ukunyanga iifom ezibuyayo ze-multiple sclerosis (MS).

I-Tecfidera ihlelwa njengonyango lokuguqula isifo kwi-MS. Iyanciphisa umngcipheko wokuphinda ubuye kwi-MS ukuya kuthi ga kwiipesenti ezingama-49 ngaphezulu kweminyaka emibini. Iyanciphisa nomngcipheko wokuba neziphene zomzimba eziba mandundu malunga neepesenti ezingama-38.

I-Tecfidera iza njenge-capsule yomlomo ekhawulezileyo. Itholakala kumandla amabini: i-120-mg capsules kunye ne-240-mg capsules.

Tecfidera igama eliqhelekileyo

I-Tecfidera sisiyobisi esinegama lophawu. Okwangoku ayifumaneki njengechiza eliqhelekileyo.

I-Tecfidera iqulethe i-dimethyl fumarate.

Iziphumo ebezingalindelekanga zeTecfidera

I-Tecfidera inokubangela iziphumo ebezingalindelekanga ezinobuzaza okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha iTecfidera. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga zeTecfidera, okanye iingcebiso ngendlela yokujongana nefuthe elibi, thetha nogqirha wakho okanye usokhemesti.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo eziqhelekileyo zeTecfidera zibandakanya:

• ukugungxula (ukubomvu kobuso nentamo)
• isisu esibuhlungu
• isisu esibuhlungu
• urhudo
• isicaphucaphu
• ukugabha
• ukurhawuzelela ulusu
• irhashalala

Ezi ziphumo zingancipha okanye zihambe kwiiveki ezimbalwa. Ukuba zinzima kakhulu okanye azihambi, thetha nogqirha wakho okanye usokhemesti.

Iziphumo ebezingalindelekanga ezimandundu

Shayela ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka. Iziphumo ebezingalindelekanga ezimandundu zingabandakanya oku kulandelayo:

• ukugungxula okuqatha
• inkqubela phambili ye-leukoencephalopathy (PML)
• ukunciphisa amanqanaba egazi emhlophe (lymphopenia)
• ukulimala kwesibindi
• negazi lakho kakhulu

Jonga apha ngezantsi ngolwazi malunga nefuthe ngalinye elibi.

I-PML

Ukuqhubela phambili kwe-leukoencephalopathy ye-multifocal (PML) sisifo esisongela ubomi bengqondo esibangelwa yintsholongwane ye-JC. Ngokwesiqhelo kwenzeka kuphela kubantu amajoni omzimba wabo angasebenzi ngokupheleleyo. Kunqabile kakhulu, i-PML yenzekile kubantu abane-MS ababethatha iTecfidera. Kule meko, abantu abaphuhlise i-PML nabo banciphisile amanqanaba egazi emhlophe.

Ukukunceda ukukhusela i-PML, ugqirha wakho uya kwenza uvavanyo lwegazi rhoqo ngexesha lonyango lwakho ukujonga amanqanaba eseli amhlophe egazi. Ukuba amanqanaba akho aphantsi kakhulu, ugqirha wakho unokuncoma ukuba uyeke ukuthatha iTecfidera.

Ugqirha wakho uya kujonga kwakhona iimpawu ze-PML ngelixa uthatha iyeza. Iimpawu zingabandakanya:

• ubuthathaka kwelinye icala lomzimba wakho
• iingxaki zombono
• ubuzizi
• iingxaki zememori
• ukudideka

Ukuba unayo le mpawu ngelixa uthatha iTecfidera, biza ugqirha wakho kwangoko. Ugqirha wakho uya kwenza iimvavanyo ukujonga ukuba unayo i-PML, kwaye banokuyeka unyango lwakho ngeTecfidera.

Ukuhluza

Ukutshiza (ukubomvu kobuso bakho okanye intamo) sisiphumo secala esiqhelekileyo seTecfidera. Kwenzeka ukuya kuthi ga kwiipesenti ezingama-40 zabantu abathatha iyeza. Iziphumo zokugungxula kwenzeka emva nje kokuba uqale ukuthatha iTecfidera, emva koko uphucule okanye uhambe ngokupheleleyo ngaphezulu kweeveki ezininzi.

Kwiimeko ezininzi, ukugungxula kubumnene ukumodareyitha ubukhali kwaye iimpawu zibandakanya:

• iimvakalelo zobushushu eluswini
• ubomvu besikhumba
• ukurhawuzelela
• imvakalelo yokutsha

Kweminye, iimpawu zokugungxula zinokuba nzima kwaye zinganyamezeleki. Phantse iipesenti ezi-3 zabantu abathatha iTecfidera baphelisa ukuyeka iziyobisi ngenxa yokugungxula ngamandla.

Ukuthatha iTecfidera ngokutya kunokunceda ukunciphisa ukugungxula. Ukuthatha i-aspirin kwimizuzu engama-30 ngaphambi kokuba uthathe iTecfidera kunokukunceda.

KwiLymphopenia

I-Tecfidera inokubangela i-lymphopenia, inqanaba elinciphileyo leeseli ezimhlophe ezibizwa ngokuba zii-lymphocyte. I-Lymphopenia inokunyusa umngcipheko wosulelo. Iimpawu ze-lymphopenia zingabandakanya:

• ifiva
• ukwandisa ii-lymph node
• amalungu adibeneyo

Ugqirha wakho uya kwenza uvavanyo lwegazi ngaphambi nangexesha lonyango lwakho kunye neTecfidera. Ukuba amanqanaba akho e-lymphocyte aphantsi kakhulu, ugqirha wakho unokucebisa ukuba uyeke ukuthatha iTecfidera ixesha elimiselweyo, okanye ngokusisigxina.

Iziphumo zesibindi

I-Tecfidera inokubangela iziphumo ebezingalindelekanga zesibindi. Inokonyusa amanqanaba e-enzyme ezithile zesibindi ezilinganiswa kuvavanyo lwegazi. Olu konyuka kuhlala kwenzeka kwiinyanga ezintandathu zokuqala zonyango.

Kubantu abaninzi, olu nyuso alubangeli zingxaki. Kodwa kwinani elincinci labantu, banokuba nzima kwaye babonakalise ukonakala kwesibindi. Iimpawu zomonakalo wesibindi zingabandakanya:

• ukudinwa
• Ukuphelelwa ngumdla wokutya
• ubumthubi besikhumba sakho okanye ezimhlophe zamehlo akho

Ngaphambi kunye nonyango lwakho kunye neTecfidera, ugqirha wakho uya kwenza iimvavanyo zegazi ukujonga ukusebenza kwesibindi. Ukuba ii-enzymes zakho zesibindi zanda kakhulu, ugqirha wakho unokuyeka ukuthatha eli chiza.

Impendulo enamandla kakhulu

Impendulo enkulu yokugula, kubandakanya i-anaphylaxis, inokwenzeka kwabanye abantu abathatha iTecfidera. Oku kunokwenzeka nanini na ngexesha lonyango. Iimpawu zokungabikho komzimba zingabandakanya:

• ingxaki yokuphefumla
• irhashalala okanye urticaria
• ukudumba kwemilebe yakho, ulwimi, umqala

Ukuba awunampendulo ayichasanga, biza ugqirha wakho okanye indawo yokulawula ityhefu kwangoko. Ukuba iimpawu zakho zinzima, tsalela umnxeba ku-911 okanye uye kwigumbi elingxamisekileyo elikufutshane.

Ukuba ubukhe wasabela kakubi kakhulu kweli chiza kwixa elidlulileyo, usenokungabi nakho ukulithatha kwakhona. Ukusetyenziswa kwesiyobisi kwakhona kunokuba yingozi. Ukuba ubukhe wasabela kweli yeza ngaphambili, thetha nogqirha wakho ngaphambi kokuba ulithathe kwakhona.

Irhashalala

Phantse iipesenti ezisi-8 zabantu abathatha iTecfidera bafumana ukukhawuleza kwesikhumba emva kokuthatha iTecfidera iintsuku ezimbalwa. Ukukhawuleza kunokuhamba kunye nokusetyenziswa okuqhubekayo. Ukuba ayipheli okanye iya kuba yingxaki, thetha nogqirha wakho.

Ukuba irhashalala ibonakala ngequbuliso emva kokuba uthathe ichiza, kunokuba sisenzo esibi. Ukuba unengxaki yokuphefumla okanye ukudumba kwemilebe okanye ulwimi, oku kunokuba sisenzo esibi se-anaphylactic. Ukuba ucinga ukuba uneempendulo ezigwenxa kwesi siyobisi, tsalela umnxeba ku-911.

Ukulahleka kweenwele

Ukulahleka kweenwele akuyiyo impembelelo ecaleni eyenzekileyo kwizifundo zeTecfidera. Nangona kunjalo, abanye abantu abathatha iTecfidera baye balahleka iinwele.

Kwenye ingxelo, umfazi owaqala ukuthatha iTecfidera waqala ukulahleka iinwele emva kokuthatha iyeza iinyanga ezimbini ukuya kwezintathu. Ukulahleka kweenwele kuye kwacotha emva kokuba eqhubeke nokusela iyeza iinyanga ezimbini, kwaye iinwele zakhe zaqala ukukhula kwakhona.

Ukutyeba / ukuthoba ubunzima

Ukutyeba ngokobunzima okanye ukwehla kobunzima asiyompembelelo esecaleni eye yenzeka kwizifundo zeTecfidera. Nangona kunjalo, abanye abantu abathatha iyeza baye bafumana ubunzima. Abanye baye baphulukana nobunzima ngelixa bethatha iTecfidera. Akucaci ukuba iTecfidera ingunobangela wokufumana ubunzima okanye ilahleko.

Ukudinwa

Abantu abathatha iTecfidera banokudinwa. Kwisifundo esinye, ukudinwa kwenzeke kwiipesenti ezili-17 zabantu abazithathileyo. Iziphumo ebezingalindelekanga zinokwehla okanye ziqhubeke nokusetyenziswa kwesiyobisi.

Intlungu yesisu

Phantse iipesenti ezili-18 zabantu abathatha iTecfidera baneentlungu zesisu. Iziphumo ebezingalindelekanga zixhaphake kakhulu kwinyanga yokuqala yonyango kwaye zihlala zinciphisa okanye zihamba ngokuqhubeka nokusetyenziswa kwesiyobisi.

Urhudo

Phantse iipesenti ezili-14 zabantu abathatha iTecfidera banesifo sohudo. Iziphumo ebezingalindelekanga zixhaphake kakhulu kwinyanga yokuqala yonyango kwaye zihlala zinciphisa okanye zihamba zisetyenziswa ngokuqhubekayo.

Iziphumo kwisidoda okanye ukuchuma kwendoda

Izifundo zabantu azikhange zivavanye umphumo weTecfidera kwisidoda okanye ukuzala kwendoda. Kwizifundo zezilwanyana, iTecfidera khange ichaphazele ukuzala, kodwa izifundo kwizilwanyana azisoloko ziqikelela ukuba kuya kwenzeka ntoni ebantwini.

Intloko ebuhlungu

Abanye abantu abathatha iTecfidera baneentloko. Nangona kunjalo, akucaci ukuba iTecfidera ingunobangela. Kwisifundo esinye, iipesenti ezili-16 zabantu abathathe iTecfidera babenentloko, kodwa iintloko zenzeka rhoqo kubantu abathatha ipilisi ye-placebo.

Ukurhawuzelela

Phantse iipesenti ezi-8 zabantu abathatha iTecfidera banesikhumba esilumkileyo. Esi siphumo sinokuhamba kunye nokuqhubeka nokusebenzisa iziyobisi. Ukuba ayipheli okanye ukuba iya kuba yinkathazo, thetha nogqirha wakho.

Uxinzelelo

Abanye abantu abathatha iTecfidera banexinzelelo. Nangona kunjalo, akucaci ukuba iTecfidera ingunobangela. Kwisifundo esinye, iipesenti ezisi-8 zabantu abathathe iTecfidera babenexinzelelo, kodwa oku kwenzeka kaninzi kubantu abathathe ipilisi ye-placebo.

Ukuba unempawu zokudakumba eziba yingxaki, thetha nogqirha wakho ngeendlela zokuphucula imeko yakho.

Izibophelelo

Kwizifundo zeklinikhi, iTecfidera khange inyuse umngcipheko weesling. Nangona kunjalo, kukho ingxelo ye-shingles kumfazi one-multiple sclerosis owathatha iTecfidera.

Umhlaza

Kwizifundo zeklinikhi, iTecfidera khange inyuse umngcipheko womhlaza.Ngapha koko, abanye abaphandi baphanda ukuba ingaba iTecfidera inokunceda na ukuthintela okanye ukunyanga eminye imihlaza.

Isicaphucaphu

Phantse iipesenti ezili-12 zabantu abathatha iTecfidera banesihlunu. Esi siphumo sinokuhamba kunye nokuqhubeka nokusebenzisa iziyobisi. Ukuba ayipheli okanye ukuba iya kuba yinkathazo, thetha nogqirha wakho.

Ukuqunjelwa

Ukuqunjelwa akuxelwanga kwizifundo zeklinikhi zeTecfidera. Nangona kunjalo, abantu abathatha iTecfidera ngamanye amaxesha banokuqunjelwa. Akucaci ukuba oku kuyimpembelelo yecala leTecfidera.

Ukuqhawula

Ukuqunjelwa akuxelwanga kwizifundo zeklinikhi zeTecfidera. Nangona kunjalo, abantu abathatha iTecfidera ngamanye amaxesha banokudumba. Akucaci ukuba oku kuyimpembelelo yecala leTecfidera.

Ukuphuthelwa

Ukuphuthelwa (ubunzima bokulala okanye ukulala) khange kubikwe kwizifundo zeklinikhi zeTecfidera. Nangona kunjalo, abantu abathatha iTecfidera ngamanye amaxesha banokulala. Akucaci ukuba oku kuyimpembelelo yecala.

Ukuthuthuzela

Kwizifundo zeklinikhi, iTecfidera khange inyuse umngcipheko wokugruzuka. Nangona kunjalo, abantu abaninzi abane-MS bathi bahlala benamanxeba. Isizathu soku asicaci. Iithiyori ezimbalwa zidweliswe apha ngezantsi.

• Njengoko i-MS iqhubeka, ukugcina ibhalansi kunye nokulungelelanisa kunokuba nzima ngakumbi. Oku kunokubangela ukungqubana kwezinto okanye ukuwa, zombini ezinokubangela ukugruzuka.
• Umntu one-MS othatha iTecfidera usenokuthatha i-aspirin ukunceda ukuthintela ukugungxula. I-Aspirin inokunyusa ukutyumka.
• Abantu abathathe i-steroids banokuba nolusu olunciphileyo, olunokubenza batyumke ngokulula. Ke abantu abane-MS abanembali yokusebenzisa i-steroid banokuba namava okugruzuka okungaphezulu.

Ukuba ukhathazekile ngokugruzuka ngelixa uthatha iTecfidera, thetha nogqirha wakho. Ugqirha wakho angenza uvavanyo lwegazi ukukhangela ezinye izizathu.

Intlungu edibeneyo

Intlungu edibeneyo inokwenzeka kubantu abathatha iTecfidera. Kwisifundo esinye, iipesenti ezili-12 zabantu abathathe iTecfidera baneentlungu ezidibeneyo. Enye ingxelo ichaze abantu abathathu ababenomlinganiso wobunzima obuhlangeneyo okanye obuhlungu besisu emva kokuqala iTecfidera.

Iziphumo ebezingalindelekanga zinokwehla okanye ziqhubeke nokusetyenziswa kwesiyobisi. Intlungu edibeneyo inokuphinda iphuculwe xa iTecfidera imisiwe.

Umlomo owomileyo

Umlomo owomileyo awuzange uxelwe kwizifundo zeklinikhi zeTecfidera. Nangona kunjalo, abantu abathatha iTecfidera ngamanye amaxesha banomlomo owomileyo. Akucaci ukuba oku kuyimpembelelo yecala leTecfidera.

Iziphumo emehlweni

Iziphumo ezichaphazelekayo zamehlo azange zichazwe kwizifundo zeklinikhi zeTecfidera. Nangona kunjalo, abanye abantu abathatha iyeza baye bathi baneempawu ezinje:

• amehlo owomileyo
• ukudikiza kwamehlo
• ukungaboni kakuhle

Akucaci ukuba ezi ziphumo zamehlo zibangelwa sisiyobisi okanye yenye into. Ukuba unayo le miphumo kwaye ayiyi kuhamba okanye ibe yinkathazo, thetha nogqirha wakho.

Iimpawu ezinjengomkhuhlane

Umkhuhlane okanye iimpawu ezifana nomkhuhlane zenzekile kwizifundo zabantu abathatha iTecfidera. Kolu phando lunye, iipesenti ezi-6 zabantu abathathe iyeza laba neziphumo, kodwa iziphumo bezisenzeka rhoqo kubantu abathathe ipilisi ye-placebo.

Iziphumo ebezingalindelekanga zexesha elide

Izifundo zokuvavanya iimpembelelo zeTecfidera ziye zahlala ukusuka kwiminyaka emibini ukuya kwemithandathu. Kwisifundo esinye esihlala iminyaka emithandathu, iziphumo ebezingalindelekanga eziqhelekileyo zezi:

• Ukubuyela kwakhona kwi-MS
• umqala obuhlungu okanye impumlo ephumayo
• ukugungxula
• usulelo lokuphefumla
• usulelo lomchamo
• intloko ebuhlungu
• urhudo
• ukudinwa
• isisu esibuhlungu
• iintlungu emqolo, iingalo, okanye imilenze

Ukuba uthatha iTecfidera kwaye uneziphumo ebezingalindelekanga ezingacimekiyo okanye ezomeleleyo okanye eziphazamisayo, thetha nogqirha wakho. Banokucebisa ngeendlela zokunciphisa okanye zokuphelisa iziphumo ebezingalindelekanga, okanye banokucebisa ukuba uyeke ukuthatha ichiza.

I-Tecfidera isebenzisa

I-Tecfidera yamkelwe yi-Food and Drug Administration (FDA) yokunyanga i-multiple sclerosis (MS).

I-Tecfidera ye-MS

I-Tecfidera ivunyiwe ngokunyanga iifom ezibuyela umva ze-MS, ezona ndlela zixhaphakileyo ze-MS. Kwezi fomu, uhlaselo lokonyuka okanye lweempawu ezintsha ezenzekayo (ukubuyela umva), kulandele amaxesha okuphulukana nenxalenye okanye okupheleleyo (uxolelo).

I-Tecfidera inciphisa umngcipheko wokuphinda ubuye kwi-MS ukuya kuthi ga kwiipesenti ezingama-49 ngaphezulu kweminyaka emibini. Iyanciphisa nomngcipheko wokuba neziphene zomzimba eziba mandundu malunga neepesenti ezingama-38.

I-Tecfidera ye-psoriasis

I-Tecfidera isetyenzisiwe ngaphandle kwelebheli ukunyanga i-plaque psoriasis. Ukusetyenziswa kwelebula engekho xa kusebenze iyeza lokunyanga imeko enye kodwa isetyenziselwa ukunyanga imeko eyahlukileyo.

Kwisifundo seklinikhi, malunga neepesenti ezingama-33 zabantu abathatha i-Tecfidera babenamacwecwe acacileyo okanye acace gca emva kweeveki ezili-16 zonyango. Phantse iipesenti ezingama-38 zabantu abathatha ichiza babephucule iipesenti ezingama-75 kwisalathiso sobunzima beplate kunye nendawo echaphazelekayo.

Ezinye iindlela zeTecfidera

Amayeza aliqela ayafumaneka ukunyanga ukubuyela umva kwe-multiple sclerosis (MS). Imizekelo yala mayeza ibandakanya:

• I-interferon beta-1a (iAvonex, iRebif)
• I-interferon beta-1b (iBetaseron)
• I-glatiramer acetate (iCopaxone, iGlatopa)
• IV immunoglobulin (Bivigam, Gammagard, abanye)
• omzimba monoclonal ezifana:
• alemtuzumab (Lemtrada)
• natalizumab (iTysabri)
• rituximab (Rituxan)
• ocrelizumab (Ocrevus)
• fingolimod (iGilenya)
• iteriflunomide (Aubagio)

Qaphela: Amanye amachiza adweliswe apha asetyenziselwa ngaphandle kwelebheli ukunyanga iifom zokubuyela umva ze-MS.

I-Tecfidera vs ezinye iziyobisi

Usenokuzibuza ukuba iTecfidera ithelekiswa njani namanye amayeza anikwe ukusetyenziswa okufanayo. Apha ngezantsi kuthelekiswa phakathi kweTecfidera kunye namayeza aliqela.

I-Tecfidera vs. Aubagio

I-Tecfidera kunye ne-Aubagio (teriflunomide) zozibini zihlelwa njengezonyango zokuguqula izifo. Zombini ziyayinciphisa imisebenzi ethile yomzimba yokuzikhusela, kodwa zisebenza ngeendlela ezahlukeneyo.

Sebenzisa

I-Tecfidera kunye ne-Aubagio zombini zivunyelwe i-FDA ukunyanga iifom ezibuyayo ze-multiple sclerosis (MS).

Iifom zeziyobisi

I-Tecfidera iza njenge-capsule yomlomo ebambezelekileyo ethathwa kabini yonke imihla. I-Aubagio iza njengecwecwe lomlomo elithathwa kanye yonke imihla.

Iziphumo kunye neengozi

I-Tecfidera kunye neAubagio zineziphumo ezifanayo ezifanayo kwaye ezinye zahlukile. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

I-Aubagio ineebhokisi zezilumkiso ezivela kwi-FDA. Esi sisilumkiso esomeleleyo esifunwa yi-FDA. Isilumkiso esinebhokisi silumkisa oogqirha kunye nezigulana malunga neziyobisi ezinokuba yingozi.

Ukusebenza ngempumelelo

Zombini i-Tecfidera kunye neAubagio ziyasebenza kunyango lwe-MS. Ukusebenza kwala machiza akuzange kuthelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Nangona kunjalo, kolunye uhlalutyo, bathelekiswa ngokungangqalanga kwaye kwafunyaniswa ukuba banezibonelelo ezifanayo.

Iindleko

I-Tecfidera kunye neAubagio zifumaneka kuphela njengeziyobisi ezinamagama. Iinguqulelo eziqhelekileyo zala machiza azifumaneki. Iifom zeGeneric zihlala zibiza kakhulu kuneziyobisi.

I-Tecfidera ngokubanzi ixabisa kancinane kune-Aubagio. Nangona kunjalo, elona xabiso uhlawulayo liya kuxhomekeka kwisicwangciso sakho seinshurensi

Tecfidera vs.Copaxone

I-Tecfidera kunye neCopaxone (i-glatiramer acetate) zombini zihlelwa njengezonyango eziguqula izifo. Zombini ziyayinciphisa imisebenzi ethile yomzimba yokuzikhusela, kodwa zisebenza ngeendlela ezahlukeneyo.

Sebenzisa

I-Tecfidera kunye neCopaxone bobabini bavunyelwe yi-FDA ukunyanga iifom ezibuyayo ze-multiple sclerosis (MS).

Iifom zeziyobisi

Enye inzuzo yeTecfidera kukuba ithathwa ngomlomo. Kuza njengokucothiswa kokukhutshwa komlomo othathwa kabini ngemini.

ICopaxone kufuneka itofwe. Kuza njengokuzitofa ngokwakho ngenaliti yangaphantsi. Inganikwa ekhaya kube kanye yonke imihla okanye kathathu ngeveki.

Iziphumo kunye neengozi

I-Tecfidera kunye neCopaxone zineziphumo ezifanayo kwaye ezinye zahlukile. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Ukusebenza ngempumelelo

Zombini i-Tecfidera kunye neCopaxone ziyasebenza kunyango lwe-MS. Ukusebenza kwala machiza akuzange kuthelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Nangona kunjalo, ngokutsho kolunye uhlalutyo, iTecfidera inokusebenza ngakumbi kuneCopaxone yokuthintela ukubuyela umva kunye nokucutha ukwanda kokukhubazeka.

Iindleko

I-Tecfidera ifumaneka kuphela njengesiyobisi esinegama lophawu. ICopaxone iyafumaneka njengechiza elinegama lophawu. Ikwafumaneka ngohlobo oluqhelekileyo olubizwa ngokuba yi-glatiramer acetate.

Ifom yesiqhelo yeCopaxone ibiza kakhulu kuneTecfidera. Igama leBrand Copaxone kunye neTecfidera ngokubanzi lixabisa ngokufanayo. Imali oyihlawulayo iya kuxhomekeka kwisicwangciso sakho seinshurensi.

Tecfidera vs. Ocrevus

I-Tecfidera kunye ne-Ocrevus (ocrelizumab) zozibini zahlulwa njengezonyango eziguqula izifo. Zombini ziyancipha imisebenzi ethile yomzimba yokuzikhusela, kodwa zisebenza ngeendlela ezahlukeneyo.

Sebenzisa

I-Tecfidera kunye ne-Ocrevus bobabini bavunyelwe yi-FDA ukunyanga iifom ezibuyayo ze-multiple sclerosis (MS). I-Ocrevus ikwavunyiwe kunyango lweendlela eziqhubela phambili ze-MS.

Iifom zeziyobisi

Uncedo lweTecfidera kukuba inokuthathwa ngomlomo. Kuza njengokucothiswa kokukhutshwa komlomo othathwa kabini ngemini.

I-Ocrevus kufuneka itofwe kusetyenziswa ukumnika ngaphakathi (IV). Kufuneka yenziwe kwikliniki okanye esibhedlele. Emva kweedosi ezimbini zokuqala, i-Ocrevus inikwa rhoqo kwiinyanga ezintandathu.

Iziphumo kunye neengozi

I-Tecfidera kunye ne-Ocrevus zineziphumo ebezingalindelekanga ezifanayo kwaye ezinye zahlukile. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Ukusebenza ngempumelelo

Zombini i-Tecfidera kunye ne-Ocrevus ziyasebenza ekunyangeni i-MS, kodwa akucaci ukuba enye isebenza bhetele kunenye. Ukusebenza kwala machiza akuzange kuthelekiswe ngokuthe ngqo kwizifundo zeklinikhi.

Iindleko

I-Tecfidera kunye ne-Ocrevus ziyafumaneka njengamayeza egama legama. Azifumaneki kwiifom ze-generic, ezinokubiza kakhulu kuneziyobisi ezinamagama.

I-Ocrevus inokubiza imali encinci kuneTecfidera. Imali oyihlawulayo iya kuxhomekeka kwisicwangciso sakho seinshurensi.

I-Tecfidera vs. iTysabri

I-Tecfidera kunye neTysabri (natalizumab) zozibini zihlelwa njengezonyango ezitshintsha izifo. Omabini la machiza anciphisa imisebenzi ethile yokuzikhusela komzimba, kodwa asebenza ngeendlela ezahlukeneyo.

Sebenzisa

I-Tecfidera kunye neTysabri bobabini bavunyelwe yi-FDA ukunyanga iifom ezibuyayo ze-multiple sclerosis (MS). I-Tysabri ikwavunyiwe ukunyanga isifo sikaCrohn.

Iifom zeziyobisi

Enye inzuzo yeTecfidera kukuba ithathwa ngomlomo. I-Tecfidera iza njenge-capsule yomlomo ebambezelekileyo ethathwa kabini yonke imihla.

I-Tysabri kufuneka ilawulwe njenge-infravenous (IV) infusion enikwe kwiklinikhi okanye esibhedlele. Inikwa kanye ngenyanga.

Iziphumo kunye neengozi

I-Tecfidera kunye neTysabri zineziphumo ebezingalindelekanga ezifanayo kwaye ezinye zahlukile. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Zombini ezi ziyobisi zidityaniswe ne-leukoencephalopathy eqhubekayo (PML), kodwa nguTysabri kuphela onesilumkiso esinebhokisi esivela kwi-FDA. Esi sisilumkiso esomeleleyo esifunwa yi-FDA. Isilumkiso esinebhokisi silumkisa oogqirha kunye nezigulana malunga neziyobisi ezinokuba yingozi.

Ukusebenza ngempumelelo

Zombini i-Tecfidera kunye neTysabri ziyasebenza kunyango lwe-MS. Ukusebenza kwala machiza akuzange kuthelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Nangona kunjalo, ngohlalutyo olunye, iTysabri inokusebenza ngakumbi kuneTecfidera yokuthintela ukubuyela umva.

Kubalulekile ukuba uqaphele ukuba ngenxa yomngcipheko we-PML, iTysabri ayisoloko iyeza lokuqala lokukhetha kwi-MS.

Iindleko

I-Tecfidera kunye neTysabri zifumaneka kuphela njengeziyobisi ezinamagama. Iinguqulelo eziqhelekileyo zala machiza azifumaneki. Iijenerikhi zihlala zibiza imali encinci kunamayeza egama loshicilelo.

I-Tecfidera ngokubanzi ixabisa ngaphezulu kweTysabri. Imali oyihlawulayo iya kuxhomekeka kwisicwangciso sakho seinshurensi.

Tecfidera vs.Gilenya

I-Tecfidera kunye ne-Gilenya (fingolimod) zozibini zihlelwa njengezonyango ezitshintsha izifo. Zombini ziyancipha imisebenzi ethile yomzimba yokuzikhusela, kodwa zisebenza ngeendlela ezahlukeneyo.

Sebenzisa

I-Tecfidera kunye ne-Gilenya bobabini bavunyiwe yi-FDA kunyango lokuphindaphinda kwe-multiple sclerosis (MS).

Iifom zeziyobisi

I-Tecfidera iza njenge-capsule yomlomo ebambezelekileyo ethathwa kabini yonke imihla. I-Gilenya iza njengepilisi yomlomo ethathwa kanye yonke imihla.

Iziphumo kunye neengozi

I-Tecfidera kunye ne-Gilenya zineziphumo ebezingalindelekanga ezifanayo kwaye ezinye zahlukile. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Ukusebenza ngempumelelo

Zombini i-Tecfidera kunye ne-Gilenya ziyasebenza ekunyangeni i-MS. Ukusebenza kwala machiza akuzange kuthelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Nangona kunjalo, ngokutsho kolunye uhlalutyo, iTecfidera kunye ne-Gilenya zisebenza ngokulinganayo ngokufanelekileyo ukuthintela ukubuyela umva.

Iindleko

I-Tecfidera kunye ne-Gilenya zifumaneka kuphela njengeziyobisi ezinamagama. Iinguqulelo eziqhelekileyo zala machiza azifumaneki. Iijenerikhi zihlala zibiza imali encinci kunamayeza egama loshicilelo.

I-Tecfidera kunye ne-Gilenya ngokubanzi zibiza malunga nokufanayo. Imali oyihlawulayo iya kuxhomekeka kwisicwangciso sakho seinshurensi.

I-Tecfidera vs interferon (Avonex, Rebif)

I-Tecfidera kunye ne-interferon (iAvonex, iRebif) zombini zihlelwa njengezonyango ezitshintsha izifo. Zombini ziyancipha imisebenzi ethile yomzimba yokuzikhusela, kodwa zisebenza ngeendlela ezahlukeneyo.

Sebenzisa

I-Tecfidera kunye ne-interferon (iAvonex, iRebif) nganye yamkelwe yi-FDA yokunyanga iindlela zokubuyela umva kwi-multiple sclerosis (MS).

Iifom zeziyobisi

Enye inzuzo yeTecfidera kukuba ithathwa ngomlomo. I-Tecfidera iza njenge-capsule yomlomo ebambezelekileyo ethathwa kabini yonke imihla.

I-Avonex kunye neRebif ngamagama amabini ahlukeneyo e-interferon beta-1a. Zombini ezi fomu kufuneka zitofwe. I-Rebif iza njengenaliti engaphantsi enikezwe phantsi kolusu kathathu ngeveki. I-Avonex iza njengenaliti ye-intramuscular enikwa umsipha kanye ngeveki. Zombini ziyazilawula ekhaya.

Iziphumo kunye neengozi

I-Tecfidera kunye ne-interferon zineziphumo ebezingalindelekanga ezifanayo kwaye ezinye zahlukile. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Ukusebenza ngempumelelo

Zombini i-Tecfidera kunye ne-interferon ziyasebenza ekunyangeni i-MS. Ukusebenza kwala machiza akuzange kuthelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Nangona kunjalo, ngokutsho kolunye uhlalutyo, iTecfidera inokusebenza ngakumbi kune-interferon yokuthintela ukubuyela umva kunye nokucutha ukwanda kokukhubazeka.

Iindleko

I-Tecfidera kunye ne-interferon (i-Rebif, i-Avonex) zifumaneka kuphela njengeziyobisi ezinegama lophawu. Iinguqulelo eziqhelekileyo zala machiza azifumaneki. Iijenerikhi zihlala zibiza imali encinci kunamayeza egama loshicilelo.

I-Tecfidera kunye ne-interferon ngokubanzi zibiza malunga nokufanayo. Imali oyihlawulayo iya kuxhomekeka kwi-inshurensi yakho.

I-Tecfidera vs. iProtandim

I-Tecfidera sisiyobisi esivunyiweyo se-FDA sokunyanga iifom ezibuyayo ze-multiple sclerosis (MS). Izifundo ezininzi zeklinikhi zibonise ukuba inokuthintela ukubuyela umva kwe-MS kunye nokuhamba kancinci kokukhubazeka komzimba.

Iprotandim sisongezelelo sokutya esinezinto ezininzi, kubandakanya:

• inkunkuma yobisi
• ashwagandha
• iti eluhlaza
• I-turmeric
• bacopa

Abanye bathi iProtandim isebenza njengeTecfidera isebenza. I-Protandim ngamanye amaxesha ibizwa ngokuba yi "Tecfidera yendalo."

Nangona kunjalo, iProtandim ayikaze ifundwe kubantu abane-MS. Ke ngoko, akukho phando lonyango luthembekileyo olusebenzayo.

Qaphela: Ukuba ugqirha wakho ukumisele iTecfidera kuwe, sukuyifaka endaweni yeProtandim. Ukuba ungathanda ukuphonononga ezinye iindlela zonyango, thetha nogqirha wakho.

Umlinganiselo weTecfidera

Olu lwazi lulandelayo luchaza iidosi eziqhelekileyo ezisetyenziswayo okanye ezicetyiswayo. Nangona kunjalo, qiniseka ukuthatha idosi ekumisela ugqirha wakho. Ugqirha wakho uya kumisela eyona idosi ilungele iimfuno zakho.

Isisombululo se-multiple sclerosis

Xa iTecfidera iqalile, idosi iyi-120 mg kabini ngemini kwiintsuku ezisixhenxe zokuqala. Emva kwale veki yokuqala, idosi inyuswe yaya kwi-240 mg kabini yonke imihla. Le yidosi yesondlo yexesha elide.

Kubantu abaneziphumo ebezingalindelekanga ezivela kwiTecfidera, idosi yesondlo inokuncitshiswa okwethutyana iye kwi-120 mg kabini yonke imihla. Idosi ephezulu yokugcina i-240 mg kabini yonke imihla kufuneka iqalwe kwakhona kwiiveki ezine.

Kuthekani ukuba ndiphose idosi?

Ukuba uphosa idosi, yithabathe kwangoko xa ukhumbula. Ukuba phantse lixesha ledosi yakho elandelayo, thatha nje idosi enye. Ungazami ukubamba ngokuthatha iidosi ezimbini ngexesha elinye.

Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?

Ewe, eli yeza lenzelwe ukuba lithathwe ixesha elide.

Uyithatha njani iTecfidera

Thatha iTecfidera ngokuchanekileyo ngokwemiyalelo kagqirha wakho.

Ixesha

I-Tecfidera ithathwa kabini imihla ngemihla. Ngokuqhelekileyo kuthathwa kunye nesidlo sasekuseni kunye nesidlo sangokuhlwa.

Ukuthatha iTecfidera ngokutya

I-Tecfidera kufuneka ithathwe kunye nokutya. Oku kunokunceda ukunciphisa isiphumo secala lokugungxula. Ukugungxula kunokuncitshiswa ngokuthatha i-325 mg ye-aspirin kwimizuzu engama-30 ngaphambi kokuba uthathe iTecfidera.

Ngaba iTecfidera inokutyunyuzwa?

I-Tecfidera akufanele ichithwe, okanye ivulwe kwaye ifafazwe ngokutya. Iifomsile zeTecfidera kufuneka ziginywe ziphelele.

Ukukhulelwa kunye neTecfidera

Izifundo zezilwanyana zibonisa ukuba iTecfidera inokuba yingozi kwimveku kwaye ayinakukhuseleka ukuyithatha ngexesha lokukhulelwa. Nangona kunjalo, izifundo zezilwanyana azihlali ziqikelela ukuba kuya kwenzeka ntoni ebantwini.

Izifundo azikhange zivavanye iziphumo zeTecfidera ngokubhekisele ekukhulelweni okanye kwiziphene zokuzalwa ebantwini.

Ukuba ukhulelwe okanye uceba ukukhulelwa, thetha nogqirha wakho malunga nokuba kufuneka uthathe iTecfidera.

Ukuba ukhulelwa ngelixa uthatha iTecfidera, ungathatha inxaxheba kwiRejista yokuKhulelwa kweTecfidera. Irejista yokukhulelwa inceda ukuqokelela ulwazi ngendlela amachiza athile anokuchaphazela ngayo ukukhulelwa. Ukuba ungathanda ukujoyina irejista, cela ugqirha wakho, tsalela umnxeba ku-866-810-1462, okanye undwendwele iwebhusayithi yobhaliso.

Ukuncancisa kunye neTecfidera

Khange kubekho zifundo zaneleyo zokubonisa ukuba ingaba iTecfidera ibonakala kubisi lwebele.

Ezinye iingcali zicebisa ukunqanda ukuncancisa ngelixa uthatha eli chiza. Nangona kunjalo, abanye abenzi njalo. Ukuba uthatha iTecfidera kwaye ungathanda ukuncancisa umntwana wakho, thetha nogqirha wakho malunga neengozi ezinokubakho kunye nezibonelelo.

Isebenza njani iTecfidera

I-Multiple sclerosis (MS) sisifo esizimele. Ngolu hlobo lweemeko, amajoni omzimba, alwa nezifo, iimpazamo iiseli ezisempilweni zabahlaseli botshaba kwaye zibahlasele. Oku kunokubangela ukudumba okungapheliyo.

Nge-MS, oku kudumba okungapheliyo kucingelwa ukuba kunokubangela ukonakala kwemithambo-luvo, kubandakanya nokushenxiswa emzimbeni okubangela iimpawu ezininzi ze-MS. Uxinzelelo lwe-oxidative (OS) lukwacingelwa ukuba lungadala lo monakalo. I-OS kukungalingani kweemolekyuli ezithile emzimbeni wakho.

I-Tecfidera icingelwa ukuba iyanceda ukunyanga i-MS ngokubangela ukuba umzimba uvelise iprotein ebizwa ngokuba yi-Nrf2. Le protein icingelwa ukuba inokunceda ukuphinda ibhalansi yomzimba. Esi siphumo, naso, sinceda ukunciphisa umonakalo obangelwe kukukrala kunye ne-OS.

Ukongeza, iTecfidera iguqula ezinye zeeseli zomzimba zomzimba ukunciphisa iimpendulo ezithile zokuvuvukala. Ikwanokuthintela umzimba ekusebenzeni kweeseli ezithile zomzimba. Ezi ziphumo zinokunceda ukunciphisa iimpawu ze-MS.

Kuthatha ixesha elingakanani ukusebenza?

I-Tecfidera iya kuqala ukusebenza emzimbeni wakho ngoko nangoko, kodwa ingathatha iiveki ezininzi ukufikelela kwisiphumo sayo.

Ngelixa kusetyenzwa, ngekhe uqaphele ukuphucuka okukhulu kwiimpawu zakho. Kungenxa yokuba ikakhulu ijolise ekuthinteleni ukubuyela umva.

Tecfidera kunye notywala

I-Tecfidera ayinxibelelani notywala. Nangona kunjalo, utywala bunokuba mandundu kwiziphumo ezithile zeTecfidera, ezinje:

• urhudo
• isicaphucaphu
• ukugungxula

Gwema ukusela utywala kakhulu ngelixa uthatha iTecfidera.

Ukusebenzisana kweTecfidera

I-Tecfidera inokusebenzisana namanye amayeza. Apha ngezantsi luluhlu lwamayeza anokusebenzisana neTecfidera. Olu luhlu alunakuba nazo zonke iziyobisi ezinokuthi zinxibelelane neTecfidera.

Ukudibana kweziyobisi ezahlukeneyo kunokubangela iziphumo ezahlukeneyo. Umzekelo, ezinye zinokuphazamisa ukusebenza kakuhle kwesiyobisi, ngelixa ezinye zinokubangela ukwanda kweempembelelo.

Ngaphambi kokuba uthathe iTecfidera, qiniseka ukuxelela ugqirha wakho kunye nosokhemesti ngayo yonke into emiselweyo, ekhawuntareni, kunye nezinye iziyobisi ozithathayo. Baxelele malunga nazo naziphi na iivithamini, amayeza esintu kunye nezixhasi ozisebenzisayo. Ukwabelana ngolu lwazi kunokukunceda uphephe unxibelelwano olunokubakho.

Ukuba unemibuzo malunga nokunxibelelana kweziyobisi okunokuchaphazela, buza ugqirha wakho okanye usokhemesti.

Tecfidera kunye ne-ocrelizumab (Ocrevus)

Ukuthatha i-Tecfidera nge-ocrelizumab kunokunyusa umngcipheko wokucinezelwa komzimba kunye nesifo esibi. Ukuzikhusela komzimba kuxa amajoni omzimba ebuthathaka.

Tecfidera kunye ibuprofen

Akukho nxibelelwano lwaziwayo phakathi kwe-ibuprofen kunye neTecfidera.

Tecfidera kunye neasprini

Akukho nxibelelwano lwaziwayo phakathi kweasprini kunye neTecfidera. I-Aspirin isetyenziswa rhoqo kwimizuzu engama-30 ngaphambi kokuthatha iTecfidera ukuthintela ukugungxula.

Imibuzo eqhelekileyo malunga neTecfidera

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga neTecfidera.

Kutheni iTecfidera ibangela ukugungxula?

Akucaci kakuhle ukuba kutheni iTecfidera ibangela ukugungxulwa. Nangona kunjalo, kusenokwenzeka ukuba inento yokwenza nokwanda (ukwandisa) kwemithambo yegazi ebusweni apho kwenzeka khona ukugungxula.

Ungakuthintela njani ukugungxula kwiTecfidera?

Awungekhe ukwazi ukuthintela ukugungxula okubangelwa yiTecfidera, kodwa zimbini izinto onokuzenza ukunceda ukunciphisa:

• Thatha iTecfidera ngokutya.
• Thatha i-325 mg ye-aspirin kwimizuzu engama-30 ngaphambi kokuba uthathe iTecfidera.

Ukuba la manyathelo awancedi kwaye usenengxaki yokugungxula, thetha nogqirha wakho.

Ngaba iTecfidera ikwenza udinwe?

Abanye abantu abathatha iTecfidera bathi baziva bediniwe. Nangona kunjalo, iimvakalelo zokudinwa okanye ukulala azizizo iziphumo ebezingalindelekanga eziye zafunyanwa kwizifundo zeklinikhi zeTecfidera.

Ngaba iTecfidera i-immunosuppressant?

I-Tecfidera ichaphazela amajoni omzimba. Iyanciphisa imisebenzi ethile yamajoni omzimba ukunciphisa iimpendulo ezivuthayo. Inokunciphisa ukwenziwa kweeseli ezithile zomzimba.

Nangona kunjalo, i-Tecfidera ayisoloko ihlelwe njenge-immunosuppressant. Ngamanye amaxesha ibizwa ngokuba yi-immunomodulator, oko kuthetha ukuba ichaphazela eminye imisebenzi yamajoni omzimba.

Ngaba kufuneka ndikhathazeke ngokuvezwa lilanga ngelixa ndithatha iTecfidera?

I-Tecfidera ayenzi ulusu lwakho lubonakale ngakumbi elangeni njengezinye iziyobisi. Nangona kunjalo, ukuba uziva ugungxulwa yiTecfidera, ukubonakaliswa lilanga kunokuba nzima kukuziva ugungxule.

Isebenza njani iTecfidera?

I-Tecfidera ifunyenwe ukunciphisa ukubuyela umva kwe-MS ukuya kuthi ga kwiipesenti ezingama-49 ngaphezulu kweminyaka emibini. Kufunyenwe ukunciphisa umngcipheko wokuba nesiphene ngokwasemzimbeni malunga neepesenti ezingama-38.

Kutheni le nto ndineendlela ezahlukeneyo zedosi emva kweveki yokuqala?

Kuqhelekile ukuba amayeza aqaliswe kumthamo osezantsi emva koko anyuswe kamva. Oku kuvumela umzimba wakho ukuba uqhubekise idosi esezantsi njengoko uhlengahlengisa amayeza.

KwiTecfidera, uqala ngedosi esezantsi ye-120 mg kabini yonke imihla ngeentsuku ezisixhenxe zokuqala. Emva koko, idosi inyuswe yaya kwi-240 mg kabini yonke imihla, kwaye le yidosi onokuhlala kuyo. Nangona kunjalo, ukuba uneziphumo ebezingalindelekanga ezininzi kunye nedosi ephezulu, ugqirha wakho unokunciphisa idosi yakho ixesha.

Ngaba ndifuna ukufumana uvavanyo lwegazi ngelixa ndikwiTecfidera?

Ewe. Ngaphambi kokuba uqale ukuthatha iTecfidera, ugqirha wakho uya kwenza iimvavanyo zegazi ukujonga ukubalwa kweeseli zegazi kunye nokusebenza kwesibindi. Ezi mvavanyo ziya kuphinda ziphindwe ngexesha lonyango kunye neziyobisi. Kunyaka wokuqala wonyango, olu vavanyo lwenziwa ubuncinci rhoqo kwiinyanga ezintandathu.

Ukugqithisa kweTecfidera

Ukuthatha kakhulu la mayeza kunokunyusa umngcipheko weziphumo ebezingalindelekanga ezibi.

Iimpawu libanda

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• urhudo
• isicaphucaphu
• ukugungxula
• ukugabha
• irhashalala
• isisu esimoshakele
• intloko ebuhlungu

Kufuneka wenze ntoni xa uthe wagqithisa?

Ukuba ucinga ukuba uthathe kakhulu eli chiza, biza ugqirha wakho okanye ufune isikhokelo kuMbutho waseMelika wamaZiko oLawulo lweTyhefu e800-222-1222 okanye ngesixhobo sabo se-Intanethi. Kodwa ukuba iimpawu zakho zinzima, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko.

Izilumkiso zeTecfidera

Ngaphambi kokuba uthathe iTecfidera, thetha nogqirha wakho malunga nayo nayiphi na imeko yonyango onayo. I-Tecfidera isenokungakulungeli ukuba uneemeko ezithile zonyango. Ezi meko zibandakanya:

• Ukucinezelwa kwenkqubo yomzimba yokuzikhusela: Ukuba amajoni akho omzimba acinezelwe, iTecfidera inokuyenza mandundu le meko. Esi siphumo sinokunyusa umngcipheko wosulelo olubi.
• Isifo sesibindi: I-Tecfidera inokubangela ukonakala kwesibindi. Ukuba sele unesifo sesibindi, inokuba mandundu imeko yakho.

Ukuphelelwa kweTecfidera

Xa iTecfidera ikhutshwa kwikhemesti, usokhemesti uya kongeza umhla wokuphelelwa kwileyibhile esebhotileni. Lo mhla uqhele ukuba ngunyaka omnye ukusukela kumhla wokukhutshwa kwamayeza.

Injongo yale mihla yokuphelelwa lixesha kukuqinisekisa ukusebenza kweyeza ngeli xesha. Isimo sangoku soLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) kukuphepha ukusebenzisa amayeza aphelelwe lixesha. Nangona kunjalo, uphononongo lwe-FDA lubonise ukuba amayeza amaninzi anokulunga ngaphaya komhla wokuphelelwa kuluhlu oludweliswe kwibhotile.

Kuhlala ixesha elingakanani iyeza lihlala lilungile kunokuxhomekeka kwizinto ezininzi, kubandakanya nokuba ligcinwa njani kwaye liphi iyeza. I-Tecfidera kufuneka igcinwe kubushushu begumbi kwisingxobo sokuqala kwaye ikhuselwe ekukhanyeni.

Ukuba awusebenzisanga iyeza elidlulileyo kumhla wokuphelelwa kwalo, thetha nosokhemesti wakho malunga nokuba unganako na ukuyisebenzisa.

Ulwazi lobungcali lweTecfidera

Olu lwazi lulandelayo lubonelelwe ngoochwephesha kunye nabanye abaqeqeshi bezempilo.

Indlela yokusebenza

Indlela yokusebenza kweTecfidera inzima kwaye ayiqondakali ngokupheleleyo. Isebenza nge-multiple sclerosis (MS) ngefuthe lokuchasana nokudumba kunye nefuthe le-antioxidant. Ukudumba kunye noxinzelelo lwe-oxidative kucingelwa ukuba kubalulekile kwiinkqubo zophendlo lwezifo kwizigulana ezine-MS.

I-Tecfidera inducus inyukliya 1 factor (erythroid-derived 2) -like 2 (Nrf2) antioxidant pathway, ekhusela ngokuchasene nomonakalo we-oxidative kwinkqubo ye-nervous system kunye nokunciphisa ukudanjiswa kwemithambo-luvo.

I-Tecfidera ikwathintela iindlela ezininzi zokuzikhusela komzimba ezinxulumene ne-toll-like receptors, ecutha ukuvuvukala kwemveliso yecytokine. I-Tecfidera ikwanciphisa ukusebenza kweeseli zomzimba ze-T.

I-Pharmacokinetics kunye ne-metabolism

Emva kokulawulwa ngomlomo kweTecfidera, inyanzeliswa ngokukhawuleza ngama-esterase kwimetabolite yayo esebenzayo, i-monomethyl fumarate (MMF). Ke ngoko, i-dimethyl fumarate ayinakulinganiswa kwi-plasma.

Ixesha lokugcina ubuninzi be-MMF (Tmax) ziiyure ezingama-2-2.5.

Umphunga wekharbhon diokside unoxanduva lokuphelisa iipesenti ezingama-60 zeziyobisi. Ukupheliswa kwe-renal kunye ne-fecal ziindlela ezincinci.

Isiqingatha sobomi be-MMF malunga neyure e-1.

Ukungqinelana

I-Tecfidera iyaphikiswa kwizigulana ezine-hypersensitivity eyaziwayo kwi-dimethyl fumarate okanye nayiphi na into eyenye.

Ukugcina

I-Tecfidera kufuneka igcinwe kubushushu begumbi, i-59 ° F ukuya kwi-86 ° F (15 ° C ukuya kwi-30 ° C). Kufuneka igcinwe kwisitya sokuqala kwaye ikhuselwe ekukhanyeni.

Ukumisela ulwazi

I-Tecfidera epheleleyo echaza ulwazi inokufumaneka apha.

Ukuziphendulela: I-MedicalNewsToday yenze yonke imizamo yokuqinisekisa ukuba yonke ingcaciso ichanekile, ibanzi kwaye ihlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.