I-TRT: Ukwahlula iNyani kwiFiction

Umxholo

• Yintoni iTRT?
• Kutheni le nto T incipha ngokuguga?
• Ndazi njani ukuba ndine T ephantsi?
• Ilawulwa njani i-TRT?
• I-TRT isetyenziswa njani kwezonyango?
• Zeziphi izinto ezingezizo ezonyango ze-TRT?
• Ixabisa malini iTRT?
• Yigcine isemthethweni (kwaye ikhuselekile)
• Ngaba bukhona ubungozi obunxulunyaniswa ne-TRT?
• Umgca wezantsi

Yintoni iTRT?

I-TRT sisifinyezo sonyango olubuyisayo lwe-testosterone, ngamanye amaxesha olubizwa ngokuba yi-androgen endaweni yonyango. Isetyenziselwa ukunyanga amanqanaba asezantsi e-testosterone (T), anokubakho ngenxa yobudala okanye ngenxa yemeko yonyango.

Kodwa iya isiba yinto eyandayo ngokungasetyenziswanga kwezonyango, kubandakanya:

• ukuphucula ukusebenza ngokwesondo
• ukufikelela kwinqanaba eliphezulu lamandla
• ukwakha ubunzima bemisipha yokwakha umzimba

Olunye uphando lubonisa ukuba i-TRT inokukunceda ukufezekisa ezinye zeenjongo. Kodwa kukho imiqolomba. Masingene nzulu kwinto eyenzeka ngokwenyani kumanqanaba akho e-T njengoko usiya ukhula kwaye yintoni onokuyilindela ngokwenyani kwi-TRT.

Kutheni le nto T incipha ngokuguga?

Umzimba wakho ngokwendalo uvelisa i-T encinci njengoko uneminyaka yobudala. Ngokwenqaku kwiAmerican Family Physician, umndilili we-T yemveliso yehla nge-1 ukuya kwi-2 yepesenti ngonyaka.

Yonke le yinxalenye yenkqubo yendalo epheleleyo eqala kwiminyaka yakho yama-20 okanye eyi-30s yokuqala:

1. Njengoko uneminyaka yobudala, amasende akho avelisa i-T encinci.
2. Amatyhalarha athotyiweyo abangela ukuba i-hypothalamus ivelise i-hormone encinci yokukhupha i-gonadotropin (GnRH).
3. Ukuthoba i-GnRH kubangela ukuba i-pituitary gland yakho yenze i-hormone encinci ye-luteinizing (LH).
4. Ukuthoba i-LH kubangela ukuhla kwemveliso yeT yonke.

Oku kuncipha ngokuthe ngcembe kwi-T kuhlala kungabangeli zimpawu zibonakalayo. Kodwa ukwehla okukhulu kumanqanaba e-T kunokubangela:

• isini esisezantsi
• ukulungiswa okuthe ngqo
• Ukungasebenzi kakuhle kwe-erectile
• ukuthoba inani lobudoda okanye ivolumu
• ingxaki yokulala
• ukulahleka okungaqhelekanga kwemisipha kunye nokuxinana kwethambo
• ukuzuza ubunzima obungachazwanga

Ndazi njani ukuba ndine T ephantsi?

Ekuphela kwendlela yokwazi ukuba ngaba ngokwenene une-T esezantsi kukubona umboneleli wezempilo kuvavanyo lwenqanaba le testosterone. Olu luvavanyo lwegazi olulula, kwaye uninzi lwababoneleli balufuna ngaphambi kokumisela i-TRT.

Kuya kufuneka wenze uvavanyo amaxesha ngamaxesha kuba amanqanaba e-T achaphazeleka zizinto ezahlukeneyo, ezinje:

• ukutya
• inqanaba lokomelela komzimba
• ixesha losuku uvavanyo lwenziwe
• amayeza athile, njenge-anticonvulsants kunye ne-steroids

Nalu ulwahlulo lwamanqanaba aqhelekileyo eT kumadoda amadala aqala kwiminyaka engama-20:

Ukuba amanqanaba akho e-T aphantsi kancinci kubudala bakho, mhlawumbi awuyidingi i-TRT.Ukuba ziphantsi kakhulu, umboneleli wakho uya kuthi enze uvavanyo olongezelelweyo ngaphambi kokucebisa i-TRT.

Ilawulwa njani i-TRT?

Zininzi iindlela zokwenza i-TRT. Olona khetho lwakho luya kuxhomekeka kwiimfuno zakho zonyango kunye nendlela ophila ngayo. Ezinye iindlela zifuna ukulawulwa kwemihla ngemihla, ngelixa ezinye zifuna ukwenziwa kuphela ngenyanga.

Iindlela ze-TRT zibandakanya:

• amayeza omlomo
• inaliti intramuscular
• Amachaphaza atshintshayo
• Iikhrim zentloko

Kukho uhlobo lwe-TRT olubandakanya ukuhlikihla i-testosterone kwiintsini zakho kabini yonke imihla.

I-TRT isetyenziswa njani kwezonyango?

I-TRT ngokwesiko isetyenziselwa ukunyanga i-hypogonadism, eyenzeka xa iimvavanyo zakho (zikwabizwa ngokuba ziigonads) azivelisi testosterone eyaneleyo.

Zimbini iintlobo zehypogonadism:

• Hypogonadism yaseprayimari. Iziphumo eziphantsi ze-T kwimicimbi enegonads yakho. Bafumana imiqondiso evela kwingqondo yakho yokwenza i-T kodwa ayinakuyivelisa.
• I-hypogonadism esembindini (yesibini). Iziphumo eziphantsi ze-T ezivela kwimicimbi kwi-hypothalamus okanye kwi-pituitary gland.

I-TRT isebenza ukwenza i-T engaveliswanga ziimvavanyo zakho.

Ukuba une-hypogonadism yokwenyani, i-TRT inako:

• ukuphucula ukusebenza kwakho ngokwesondo
• yonyusa inani lobudoda bakho kunye nevolumu
• yandisa amanqanaba ezinye iihomoni ezinxibelelana no-T, kubandakanya iprolactin

I-TRT inokukunceda ukulinganisa amanqanaba T angaqhelekanga abangelwa:

• iimeko ezizimeleyo
• ukuphazamiseka kwemfuza
• usulelo olonakalisa amalungu akho esini
• amasende angafunwanga
• unyango lwemitha kumhlaza
• uqhaqho lwamalungu esini

Zeziphi izinto ezingezizo ezonyango ze-TRT?

Amazwe amaninzi, kubandakanya neMelika, abavumeli abantu ukuba bathenge ngokusemthethweni izongezo ze-T ze-TRT ngaphandle kommiselo.

Okwangoku, abantu bafuna i-TRT ngohlobo lwezizathu ezingezizo ezonyango, ezinje:

• ukunciphisa umzimba
• ukwandisa amanqanaba amandla
• ukonyusa ukuqhuba ngokwesondo okanye ukusebenza
• ukuphakamisa unyamezelo kwimidlalo yeembaleki
• ukufumana ubunzima obongezelelekileyo bemisipha yokwakha umzimba

Ngokwenene i-TRT ibonakalisiwe inezinye zezi zibonelelo. Umzekelo, kugqityiwe ukuba yonyusa amandla emisipha kumadoda aphakathi nangaphezulu kunye nabesilisa.

Kodwa i-TRT inezibonelelo ezimbalwa eziqinisekisiweyo zabantu, ngakumbi abesilisa abancinci, abanamanqanaba aqhelekileyo okanye aphezulu eT. Kwaye umngcipheko unokugqitha izibonelelo. Isifundo esincinci sika-2014 sifumene ikhonkco phakathi kwamanqanaba aphezulu eT kunye nokuveliswa kwesidoda okuphantsi.

Ngaphezulu, ukusebenzisa i-TRT ukufumana ukhuphiswano kumdlalo kuthathwa njenge "doping" yimibutho emininzi yobungcali, kwaye uninzi lukujonga njengendawo yokupheliswa kwezemidlalo.

Endaweni yoko, cinga ukuzama ezinye iindlela zokonyusa T. Nazi iingcebiso ezisibhozo zokuba uqalise.

Ixabisa malini iTRT?

Iindleko ze-TRT ziyahluka ngokusekwe kuhlobo olumiselweyo. Ukuba unayo i-inshurensi yezempilo kwaye ufuna i-TRT ukunyanga imeko yezempilo, ngekhe uhlawule iindleko ezipheleleyo. Ixabiso lokwenyani linokwahluka ngokuxhomekeke kwindawo okuyo kunye nokuba kukho uhlobo oluqhelekileyo olukhoyo.

Ngokubanzi, unokulindela ukuhlawula naphi na ukusuka kwi- $ 20 ukuya kwi- $ 1,000 ngenyanga. Ixabiso langempela lixhomekeke kuluhlu lwezinto, kubandakanya:

• indawo okuyo
• uhlobo lwamayeza
• indlela yolawulo
• nokuba ngaba kukho uhlobo oluqhelekileyo olukhoyo

Xa ujonga iindleko, gcinani engqondweni ukuba i-TRT inyusa nje amanqanaba akho e-T. Ayizukunyanga oyena nobangela we-T yakho ephantsi, ngenxa yoko unokufuna unyango lwempilo yonke.

Yigcine isemthethweni (kwaye ikhuselekile)

Khumbula, akukho semthethweni ukuthenga i-T ngaphandle kommiselo kumazwe amaninzi. Ukuba ubhaqiwe usenza njalo, unokujongana neziphumo ezibi zomthetho.

Kwaye, kuthengiswa ngaphandle kweekhemesti ezisemthethweni akulawulwa. Oku kuthetha ukuba unokuthenga i-T exutywe nezinye izinto ezingadweliswanga kwileyibhile. Oku kunokuba yingozi okanye kusongele ubomi ukuba uxabisa nasiphi na kwezi zithako.

Ngaba bukhona ubungozi obunxulunyaniswa ne-TRT?

Iingcali zisazama ukuqonda ngokupheleleyo ubungozi kunye neziphumo ebezingalindelekanga ze-TRT. NgokweMpilo yeHarvard, uninzi lwezifundo esele zikhona zinemiqobo, ezinje ngobuncinci besayizi okanye ukusebenzisa iidosi ezinkulu kunezo ziqhelekileyo zeT.

Ngenxa yoko, kusekho impikiswano malunga nezibonelelo kunye nemingcipheko enxulumene ne-TRT. Umzekelo, kuye kwathiwa zombini zonyusa kwaye zinciphise umngcipheko weentlobo ezithile zomhlaza.

A kwiphephancwadi i-Therapeutic Advances in Urology icebisa ukuba ezinye zeembono eziphikisanayo sisiphumo sokusasazwa ngokugqithiseleyo kweendaba, ngakumbi eMelika.

Ngaphambi kokuzama i-TRT, kubalulekile ukuba uhlale phantsi nomboneleli wakho wezempilo kwaye uhambe phezu kwazo zonke iziphumo ebezingalindelekanga kunye neengozi. Oku kunokubandakanya:

• iintlungu zesifuba
• ubunzima bokuphefumla
• ubunzima bokuthetha
• ubalo oluphantsi lobudoda
• polycythemia vera
• yehlisa i-HDL ("elungileyo") cholesterol
• ukuhlaselwa yintliziyo
• ukudumba ezandleni okanye emilenzeni
• ukubetha
• i-benign prostatic hyperplasia (iprostate eyandisiweyo)
• ubuthongo bokulala
• amabala okanye uqhekeko olufanayo lolusu
• i-vein thrombosis enzulu
• Ukunyanzelwa kwemiphunga

Akufanele ungene kwi-TRT ukuba sele usemngciphekweni wazo naziphi na iimeko ezidweliswe apha ngasentla.

Umgca wezantsi

I-TRT kudala ilukhetho lonyango kubantu abane-hypogonadism okanye iimeko ezinxulumene nokuncitshiswa kwemveliso ye-T. Kodwa izibonelelo zayo kwabo bangenayo imeko engaphantsi azicacanga, ngaphandle kwalo lonke uhanahaniso.

Thetha nogqirha wakho ngaphambi kokuba uthathe naziphi na izongezo ze-T okanye amayeza. Banokukunceda ubone ukuba ngaba iinjongo zakho nge-TRT zikhuselekile kwaye ziyinyani.

Kubalulekile ukuba ujongwe yingcali yezonyango njengoko uthatha izongezo ze-T ukuqaphela naziphi na iimpawu ezingafunekiyo okanye iziphumo ebezingalindelekanga ezinokuthi zenzeke ngexesha lonyango.