Umbhali: Peter Berry
Umhla Wokudalwa: 14 Eyekhala 2021
Hlaziya Umhla: 23 Isilimela 2024
Anonim
Izibonelelo ezi-9 zezeMpilo zeVitamin B6 (Pyridoxine) - Isondlo
Izibonelelo ezi-9 zezeMpilo zeVitamin B6 (Pyridoxine) - Isondlo

Umxholo

I-Vitamin B6, ekwabizwa ngokuba yi-pyridoxine, yivitamin enyibilikayo yamanzi efunwa ngumzimba wakho kwimisebenzi eliqela.

Kubalulekile kwiprotein, fat and carbohydrate metabolism kunye nokudala iiseli ezibomvu zegazi kunye nee-neurotransmitters (1).

Umzimba wakho awunako ukuvelisa ivithamin B6, ke kuya kufuneka uyifumane ekutyeni okanye kwizongezo.

Uninzi lwabantu lufumana i-vitamin B6 eyaneleyo ngokutya kwabo, kodwa abantu abathile banokuba semngciphekweni wokunqongophala.

Ukutya ixabiso elaneleyo levithamini B6 kubalulekile kwimpilo efanelekileyo kwaye kunokuthintela nokunyanga izifo ezinganyangekiyo ().

Nazi izibonelelo zempilo ezili-9 zevithamini B6, exhaswa sisayensi.

1. Ngamana angaphucula iiMood kunye nokuNciphisa iimpawu zoxinzelelo

I-Vitamin B6 idlala indima ebalulekileyo kulawulo lweemood.

Oku kungenxa yokuba le vithamini iyimfuneko ekudaleni ii-neurotransmitters ezilawula iimvakalelo, kubandakanya i-serotonin, i-dopamine kunye ne-gamma-aminobutyric acid (GABA) (3,,).


I-Vitamin B6 inokudlala indima ekunciphiseni amanqanaba aphezulu egazi e-amino acid homocysteine, enxulunyaniswe noxinzelelo kunye neminye imiba yengqondo (,).

Izifundo ezininzi zibonise ukuba iimpawu zoxinzelelo zinxulunyaniswa namanqanaba asezantsi egazi kunye nokutya kwe-vitamin B6, ngakumbi kubantu abadala abadala abasemngciphekweni omkhulu wokunqongophala kwe-Vitamin B (,,).

Olunye uphononongo kubantu abadala abangama-250 bafumanise ukuba amanqanaba egazi anqongopheleyo ngevithamini B6 ephindwe kabini amathuba okudakumba ().

Nangona kunjalo, ukusebenzisa ivithamin B6 ukuthintela okanye ukunyanga uxinzelelo akubonakaliswanga kusebenza (,).

Isifundo seminyaka emibini esilawulwayo kumadoda amadala angama-300 awayengenalo uxinzelelo ekuqaleni afumanisa ukuba abo bathatha isongezelelo nge-B6, folate (B9) kunye ne-B12 babengenamathuba okuba neempawu zokudakumba xa kuthelekiswa neqela le-placebo ().

Isishwankathelo Amanqanaba asezantsi e-vitamin B6 kubantu abadala asebekhulile adibaniswe nokudakumba, kodwa uphando alubonisanga ukuba i-B6 yonyango olusebenzayo lokuphazamiseka kwemood.

2. Ngamana angakhuthaza impilo yeBongo kwaye anciphise umngcipheko we-Alzheimer

I-Vitamin B6 inokudlala indima ekuphuculeni ukusebenza kwengqondo nokukhusela isifo se-Alzheimer's, kodwa uphando luyaphikisana.


Kwelinye icala, i-B6 inokunciphisa amanqanaba aphezulu egazi le-homocysteine ​​elinokuthi landise umngcipheko we-Alzheimer's (,,).

Olunye uphononongo kubantu abadala abali-156 abanamanqanaba aphezulu e-homocysteine ​​kunye nokukhubazeka okuphakathi kwengqondo kufumanise ukuba ukuthatha iidosi eziphezulu ze-B6, B12 kunye ne-folate (B9) kunciphise i-homocysteine ​​kunye nokunciphisa ukumosha kwezinye iingingqi zengqondo ezisemngciphekweni we-Alzheimer's ().

Nangona kunjalo, akucaci ukuba ukwehla kwe-homocysteine ​​kuguqulela ekuphuculeni ukusebenza kwengqondo okanye kwinqanaba elincinci lokuphazamiseka kwengqondo.

Isilingo esilawulwa ngokungahleliwe kubantu abadala abangaphezu kwama-400 abane-Alzheimer's mild to moderation yafumanisa ukuba iidosi eziphezulu ze-B6, B12 kunye ne-folate yehlile amanqanaba e-homocysteine ​​kodwa ayithothanga ukwehla ekusebenzeni kwengqondo xa kuthelekiswa ne-placebo ().

Ukongeza, uphononongo lwezifundo ezili-19 zigqibe kwelokuba ukongeza nge-B6, B12 kunye nefolate yodwa okanye ngokudibeneyo ayikhange iphucule ukusebenza kwengqondo okanye inciphise umngcipheko we-Alzheimer's ().

Olunye uphando olujonga isiphumo sevithamini B6 kuphela kumanqanaba e-homocysteine ​​kunye nokusebenza kwengqondo kuyafuneka ukuqonda ngcono indima yale vithamini ekuphuculeni impilo yengqondo.


Isishwankathelo I-Vitamin B6 inokuthintela ukwehla kokusebenza kwengqondo ngokunciphisa amanqanaba e-homocysteine ​​enxulunyaniswa nesifo se-Alzheimer kunye nokuphazamiseka kwememori. Nangona kunjalo, izifundo azibonisanga kusebenza kwe-B6 ekuphuculeni impilo yengqondo.

3. Ngamana angathintela kwaye anyange iAnemia ngokunceda ukuveliswa kwehemoglobin

Ngenxa yendima yayo kwimveliso yehemoglobin, ivithamin B6 inokuba luncedo ekuthinteleni nasekunyangeni i-anemia ebangelwa kukusilela ().

IHemoglobin yiprotein ehambisa ioksijini kwiiseli zakho. Xa unehemoglobin esezantsi, iiseli zakho azifumani oksijini yaneleyo. Ngenxa yoko, unokuhlakulela i-anemia kwaye uzive ubuthathaka okanye udiniwe.

Izifundo zidibanise amanqanaba asezantsi e-vitamin B6 kunye ne-anemia, ngakumbi kwabasetyhini abakhulelweyo nakwabasetyhini abaneminyaka yobudala bokuzala (,).

Nangona kunjalo, ukunqongophala kukavithamini B6 kucingelwa ukuba kunqabile kuninzi lwabantu abadala abasempilweni, ngenxa yoko kukho uphando olulinganiselweyo ekusebenziseni i-B6 ukunyanga i-anemia.

Isifundo esenziwe kumfazi oneminyaka engama-72 ubudala one-anemia ngenxa ye-B6 esezantsi wafumanisa ukuba unyango lolona hlobo lusebenzayo lwe-vitamin B6 luphuculo lweempawu ().

Olunye uphononongo lufumanise ukuba ukuthatha i-75 mg ye-vitamin B6 yonke imihla ngexesha lokukhulelwa kunciphise iimpawu ze-anemia kwi-56 yabasetyhini abakhulelweyo abangaphendulanga kunyango nge-iron ().

Uphando oluthe kratya luyafuneka ukuqonda ukusebenza kwe vithamin B6 ekunyangeni i-anemia kubantu ngaphandle kwalabo basemngciphekweni wokonyuka kwe-vitamin B, njengabafazi abakhulelweyo kunye nabantu abadala.

Isishwankathelo Ukungafumani vithamini B6 ngokwaneleyo kungakhokelela kwi-hemoglobin esezantsi kunye ne-anemia, ke ukuxhasa le vithamini kunokuthintela okanye kunyange le micimbi.

4. Unokuba Ncedo Ekunyangeni Iimpawu ze-PMS

I-Vitamin B6 isetyenziselwe ukunyanga iimpawu ze-premenstrual syndrome, okanye i-PMS, kubandakanya uxinzelelo, uxinzelelo kunye nokucaphuka.

Abaphandi bakrokrela ukuba i-B6 iyanceda ngeempawu zeemvakalelo ezinxulumene ne-PMS ngenxa yendima yayo ekudaleni ii-neurotransmitters ezilawula imeko.

Isifundo seenyanga ezintathu ngaphezulu kwabasetyhini abangama-60 be-premenopausal bafumanise ukuba ukuthatha i-50 mg ye-vitamin B6 imihla ngemihla kuphucule iimpawu ze-PMS zoxinzelelo, ukucaphuka nokudinwa ngama-69% ().

Nangona kunjalo, abasetyhini abafumene indawo ye-placebo bakwachaza neempawu eziphuculweyo ze-PMS, ebonisa ukuba ukusebenza kwesongezelelo se-vitamin B6 kunokuba kubangelwe yinxalenye yesiphumo se-placebo ().

Olunye uphononongo oluncinci lufumanise ukuba i-50 mg ye-vitamin B6 kunye ne-200 mg ye-magnesium ngemini iyazinciphisa kakhulu iimpawu ze-PMS, kubandakanya ukutshintsha kwemozulu, ukuba nochuku kunye noxinzelelo, ngexesha lokuya exesheni ().

Ngelixa ezi ziphumo zithembisa, zinqunyelwe kwisayizi encinci yesampulu kunye nexesha elifutshane. Olunye uphando malunga nokhuseleko kunye nokusebenza kwe-vitamin B6 ekuphuculeni iimpawu ze-PMS ziyafuneka ngaphambi kokuba kwenziwe iingcebiso ().

Isishwankathelo Olunye uphando lubonakalisile ukuba iidosi eziphezulu zevithamini B6 zinokusebenza ekunciphiseni uxinzelelo kunye neminye imiba yeemvakalelo enxulunyaniswa ne-PMS ngenxa yendima yayo ekudaleni ii-neurotransmitters.

5. Ngamana unokunceda ukunyanga isicaphucaphu ngexa lokukhulelwa

I-Vitamin B6 isetyenziselwe amashumi eminyaka ukunyanga isicaphucaphu kunye nokugabha ngexesha lokukhulelwa.

Ngapha koko, sisithako kwiDiclegis, iyeza eliqhele ukusetyenziselwa ukunyanga ukugula kwasekuseni ().

Abaphandi abaqinisekanga ngokupheleleyo ukuba kutheni ivithamin B6 inceda ekuguleni kwasekuseni, kodwa kunokuba kungenxa yokuba i-B6 eyoneleyo idlala indima ebalulekileyo ekuqinisekiseni ukukhulelwa okunempilo ().

Isifundo kwabasetyhini abangama-342 kwiiveki zabo zokuqala ezili-17 bekhulelwe bafumanisa ukuba ukongezwa kwemihla ngemihla kwama-30 mg wevithamini B6 kunciphise imvakalelo yokuba nesicaphucaphu emva kweentsuku ezintlanu zonyango, xa kuthelekiswa ne-placebo ().

Olunye uphononongo luthelekise ifuthe lejinja kunye nevithamini B6 ekunciphiseni iziqendu zesicaphucaphu kunye nokugabha kwabasetyhini abakhulelweyo abali-126. Iziphumo zibonise ukuba ukuthatha i-75 mg ye-B6 yonke imihla kunciphise isicaphucaphu kunye neempawu zokugabha nge-31% emva kweentsuku ezine ().

Olu phononongo lubonisa ukuba ivithamini B6 iyasebenza ekunyangeni ukugula kwasekuseni nakumaxesha angaphantsi kweveki enye.

Ukuba unomdla wokuthatha i-B6 yokugula kwasekuseni, thetha nogqirha wakho ngaphambi kokuqala naziphi na izongezo.

Isishwankathelo I-Vitamin B6 isongezelelo kwiidosi ze-30-75 mg ngosuku zisetyenziswe njengonyango olusebenzayo lokunyanzelisa nokugabha ngexesha lokukhulelwa.

6. Ngamana angathintela imithambo evalekileyo nokunciphisa ubungozi besifo sentliziyo

I-Vitamin B6 inokuthintela imithambo evalekileyo kunye nokunciphisa umngcipheko wesifo sentliziyo.

Uphando lubonisa ukuba abantu abanamanqanaba asezantsi egazi e-vitamin B6 phantse babe semngciphekweni wokufumana isifo sentliziyo xa kuthelekiswa nalawo anamanqanaba aphezulu e-B6 ().

Oku kunokwenzeka ngenxa yendima ye-B6 ekwehliseni amanqanaba aphezulu e-homocysteine ​​ahambelana neenkqubo ezininzi zesifo, kubandakanya isifo sentliziyo (,,).

Olunye uphononongo lufumanise ukuba iigundane ezingenayo i-vitamin B6 zinamanqanaba aphezulu egazi e-cholesterol kwaye zavelisa izilonda ezinokubangela ukubhloka kwemithambo emva kokuvezwa kwi-homocysteine, xa kuthelekiswa neempuku ezinamanqanaba aneleyo e-B6 ().

Uphando lomntu lukwabonisa isiphumo esihle se-B6 ekuthinteleni isifo sentliziyo.

Isilingo esilawulwa ngokungahleliwe kubantu abadala abasempilweni abali-158 ababenabantakwabo abanesifo sentliziyo abohlule abathathi-nxaxheba baba ngamaqela amabini, elinye lafumana i-250 mg ye-vitamin B6 kunye ne-5 mg ye-folic acid yonke imihla kangangeminyaka emibini kwaye enye yafumana i-placebo ().

Iqela elithathe i-B6 kunye ne-folic acid lalinamanqanaba asezantsi e-homocysteine ​​kunye nokuvavanywa kwentliziyo okungaqhelekanga ngexesha lokuzilolonga kuneqela le-placebo, elibabeka kumngcipheko ophantsi wesifo sentliziyo ().

Isishwankathelo I-Vitamin B6 inokunceda ukunciphisa amanqanaba aphezulu e-homocysteine ​​akhokelela ekunciphiseni kwemithambo. Oku kunokunciphisa ingozi yesifo senhliziyo.

7. Ngamana unokunceda ukukhusela umhlaza

Ukufumana i-vitamin B6 eyaneleyo kunokunciphisa umngcipheko wokuphuhlisa iintlobo ezithile zomhlaza.

Isizathu sokuba i-B6 inokunceda ukuthintela umhlaza asikacaci, kodwa abaphandi bakrokrela ukuba inxulumene nokukwazi kwayo ukulwa nokudumba okunokuba negalelo kumhlaza nakwezinye iimeko ezingapheliyo (,).

Ukuphononongwa kwezifundo ezili-12 kufumanise ukuba zombini ukutya okwaneleyo kokutya kunye namanqanaba egazi e-B6 ayayanyaniswa nemingcipheko esezantsi yomhlaza ongalunganga. Abantu abanamanqanaba aphezulu egazi e-B6 babenomngcipheko ophantsi wama-50% wokuphuhlisa olu hlobo lomhlaza ().

Uphando malunga nevithamin B6 kunye nomhlaza webele ukwabonisa unxibelelwano phakathi kwamanqanaba egazi afanelekileyo e-B6 kunye nokwehla kwengozi yesi sifo, ngakumbi kubafazi abasele besemva kokuya esikhathini ().

Nangona kunjalo, olunye uphononongo kumanqanaba e-vitamin B6 kunye nomngcipheko womhlaza alufumananga nhlangano (,).

Olunye uphando olubandakanya izilingo ezingahleliyo kwaye hayi nje kuphela izifundo zokujonga ziyafuneka ukuvavanya eyona ndima ye-vitamin B6 kuthintelo lomhlaza.

Isishwankathelo Olunye uphononongo lokujonga lubonisa unxibelelwano phakathi kokutya okwaneleyo kokutya kunye namanqanaba egazi e-vitamin B6 kunye nokwehla komngcipheko weentlobo ezithile zomhlaza, kodwa uphando olungakumbi luyafuneka.

8. Ngamana angakhuthaza impilo yamehlo kwaye athintele izifo zamehlo

I-Vitamin B6 inokudlala indima ekuthinteleni izifo zamehlo, ngakumbi uhlobo lokulahleka kombono okuchaphazela abantu abadala ababizwa ngokuba kukudibana kwe-macular degeneration (AMD).

Izifundo zidibanise amanqanaba aphezulu egazi ekujikelezeni i-homocysteine ​​kunye nomngcipheko owandayo we-AMD (,).

Kuba ivithamin B6 inceda ukunciphisa amanqanaba egazi aphezulu e-homocysteine, ukufumana i-B6 eyaneleyo kunokunciphisa umngcipheko kwesi sifo ().

Isifundo seminyaka esixhenxe ngaphezulu kwe-5,400 yabasetyhini abaqeqeshiweyo bezempilo bafumanisa ukuba ukuthatha isongezelelo semihla ngemihla se-vitamin B6, B12 kunye ne-folic acid (B9) kunciphise umngcipheko we-AMD ngama-35-40%, xa kuthelekiswa ne-placebo ().

Ngelixa ezi ziphumo zibonisa ukuba i-B6 ingadlala indima ekuthinteleni i-AMD, kunzima ukuxela ukuba ngaba i-B6 iyodwa inganikezela ngezibonelelo ezifanayo.

Uphando luye lwadibanisa amanqanaba egazi asezantsi e-vitamin B6 kwimeko zamehlo ezithintela imithambo edibanisa kwi-retina. Uphononongo olulawulwayo kubantu abangaphezulu kwama-500 bafumanise ukuba amanqanaba egazi asezantsi e-B6 ayanyaniswa kakhulu nokuphazamiseka kwithumbu ().

Isishwankathelo Izongezo zeVitamin B6 zinokunciphisa umngcipheko wokudodobala okunxulumene nobudala be-macular (AMD). Ukongeza, amanqanaba egazi afanelekileyo e-B6 anokuthintela imiba echaphazela i-retina. Nangona kunjalo, uphando olongezelelweyo luyafuneka.

9. Ngamana anganyanga ukudumba okunxulunyaniswa neRheumatoid Arthritis

Vitamin B6 inokunceda ukunciphisa iimpawu ezinxulumene nesifo samathambo.

Amanqanaba aphezulu okudumba emzimbeni okubangelwa sisifo samathambo kunokukhokelela kumanqanaba asezantsi evithamini B6 (,).

Nangona kunjalo, akucaci ukuba ukongeza nge-B6 kunciphisa ukuvuvukala kubantu abakule meko.

Isifundo seentsuku ezingama-30 kubantu abadala abangama-36 abane-rheumatoid arthritis bafumanisa ukuba i-50 mg ye-vitamin B6 mihla le ilungisa amanqanaba egazi asezantsi e-B6 kodwa khange inciphise ukuveliswa kweemolekyuli ezivuthayo emzimbeni ().

Kwelinye icala, uphononongo kubantu abadala abangama-43 abane-rheumatoid arthritis ethathe i-5 mg ye-folic acid yodwa okanye i-100 mg ye-vitamin B6 ene-5 mg ye-folic acid mihla le ibonakalise ukuba abo bafumana i-B6 banamanqanaba asezantsi kakhulu eemolekyuli ezinokutsha Iiveki ezili-12 ().

Iziphumo eziphikisanayo zezi zifundo zinokubangelwa ngumahluko kwithamo le-vitamin B6 kunye nobude bokufunda.

Ngelixa kubonakala ngathi iidosi eziphezulu zevithamini B6 zokuncedisa zinokubonelela ngezibonelelo ezichasene nokuvuvukala kwabantu abane-rheumatoid arthritis ekuhambeni kwexesha, uphando olongezelelweyo luyafuneka.

Isishwankathelo Ukudumba okunxulunyaniswa ne-rheumatoid arthritis kunganciphisa amanqanaba egazi e-vitamin B6. Ukongezwa ngamanani aphezulu e-B6 kunokunceda ukulungisa iziphene kunye nokunciphisa ukuvuvukala, kodwa uphando olongezelelweyo lufunekayo ukuqinisekisa ezi ziphumo.

I-Vitamin B6 Imithombo yokutya kunye neziXhobo

Unokufumana ivithamini B6 kukutya okanye kwizongezo.

Inani elinconywayo langoku (RDA) le-B6 yi-1.3-1.7 mg yabantu abadala abangaphezulu kwe-19. Uninzi lwabantu abadala abasempilweni banokufumana le mali ngokutya okunezakha-mzimba okubandakanya ukutya okune-vitamin-B6-okunje nge-turkey, i-chickpeas, ityhuna, isalmon, iitapile kunye iibhanana (1).

Izifundo eziqaqambisa ukusetyenziswa kwevithamini B6 ukuthintela nokunyanga imiba yezempilo kugxile kwizongezelelo kunakwimithombo yokutya.

Imithamo ye-30-250 mg ye-vitamin B6 ngosuku isetyenzisiwe kuphando lwe-PMS, ukugula kwasekuseni kunye nesifo sentliziyo (,,).

Ezi zixa ze-B6 ziphezulu kakhulu kune-RDA kwaye ngamanye amaxesha zidityaniswa nezinye iivithamini ze-B. Kunzima ukuvavanya ukuba ukonyuka kokungenisa i-B6 kwimithombo yokutya kunezibonelelo ezifanayo kwiimeko ezithile ezinokubonelela ngezibonelelo.

Ukuba unomdla wokuthatha izongezo ze-vitamin B6 ukuthintela okanye ukulungisa ingxaki yezempilo, thetha nomboneleli wakho wezempilo malunga nokhetho olufanelekileyo kuwe. Ukongeza, jonga isongezelelo esivavanyelwe umgangatho ngumntu wesithathu.

Isishwankathelo Uninzi lwabantu lunokufumana i-vitamin B6 eyaneleyo ngokutya kwabo. Ngamanye amaxesha, ukuthatha isixa esiphakamileyo sevithamini B6 kwizongezo phantsi kweliso likagqirha kunokuba luncedo.

Iziphumo ebezingalindelekanga ezinokubakho zeVitamin B6 eninzi kakhulu

Ukufumana ivithamini B6 eninzi kwizongezo kunokubangela iziphumo ebezingalindelekanga.

I-Vitamin B6 ityhefu ayinakulindeleka ukuba ivela kwimithombo yokutya ye-B6. Kuya kuba nzima ukuchitha isixa esongezwayo kwisondlo kuphela.

Ukuthatha ngaphezulu kwe-1,000 mg ye-B6 eyongezelelweyo ngosuku kunokubangela ukonakala kwentliziyo kunye nentlungu okanye ukuphazamiseka ezandleni okanye ezinyaweni. Ezinye zeziphumo ebezingalindelekanga ziye zabhalwa nasemva nje kwe-100-300 mg ye-B6 ngosuku ().

Ngenxa yezi zizathu, umda ongaphezulu wokunyamezeleka wevithamini B6 yi-100 mg ngosuku kubantu abadala (3,).

Isixa se-B6 esisetyenziselwa ukulawula iimeko ezithile zempilo kunqabile ukuba sigqithe kule mali. Ukuba unomdla wokuthatha ngaphezulu komda ongaphezulu onokunyamezeleka, nxibelelana nogqirha wakho.

Isishwankathelo I-vitamin B6 eninzi evela kwizongezelelo inokubangela ukonakala kwimithambo-luvo kunye neempembelelo ngokuhamba kwexesha. Ukuba unomdla wokuthatha isongezelelo se-B6, thetha nomboneleli wakho wezempilo malunga nokhuseleko kunye nedosi.

Umgca osezantsi

Vitamin B6 iivithamini ezinyibilikayo emanzini ezifumaneka ekutyeni okanye kwizongezo.

Iyadingeka kwiinkqubo ezininzi emzimbeni wakho, kubandakanya ukudala ii-neurotransmitters kunye nokulawula amanqanaba e-homocysteine.

Iidosi eziphezulu ze-B6 zisetyenziselwe ukukhusela okanye ukunyanga iimeko ezithile zempilo, kubandakanya i-PMS, i-macular degeneration (AMD) enxulumene nobudala kunye nesicaphucaphu kunye nokugabha ngexesha lokukhulelwa.

Ukufumana i-B6 eyaneleyo ngokutya okanye isongezelelo kubalulekile ukuze uhlale usempilweni kwaye unokuba nezinye izibonelelo zempilo ezinomtsalane ngokunjalo.

Amanqaku Amatsha

Ungalikhetha njani ikhaya labongikazi

Ungalikhetha njani ikhaya labongikazi

Kwikhaya lokugcina abantu abalupheleyo, aba ebenzi abanezakhono kunye nabanikezela ngononophelo lwempilo banikela ngononophelo lwexe ha lonke. Amakhaya abantu abadala angabonelela ngeenkonzo ezahluken...
Ukulungiswa kweMeningocele

Ukulungiswa kweMeningocele

Ukulungi wa kweMeningocele (ekwabizwa ngokuba kukulungi wa kwe-myelomeningocele) lutyando ukulungi a iziphene zokuzalwa komqolo kunye neembambo zomqolo. I-Meningocele kunye ne-myelomeningocele ziindid...