I-Biologics kunye neCrohn's Disease Remission: Into ekufuneka uyazi

Umxholo

• Njani i-biologics ekujolise kuyo ukudumba
• Uxela njani ukuba uxolelwe
• Njani i-biologics ikugcina uxolelo
• Ziziphi ii-biosimilars?
• Unyango ngelixa uxolelwe
• Ukuthatha

Ushwankathelo

Ngo-1932, uGqirha Burrill Crohn kunye noogxa bakhe ababini bazisa iphepha kuMbutho Wezonyango WaseMelika echaza iinkcukacha zento esiyibiza ngoku ngokuba sisifo sikaCrohn.

Ukusukela ngoko, iinketho zonyango ziye zavela ukuba zibandakanye i-biologics, ezingamachiza enziwe kwiiseli eziphilayo eziyilelwe ukujolisa.

Ukudumba ngoyena nobangela weempawu zesifo sikaCrohn kunye neengxaki. Xa ukhululiwe, ukudumba kwakho kuyaphela. Xa ujongene ne-Crohn's flare, ukubuyela kwakho ekuvukeleni.

Ngelixa lungekho unyango lweCrohn's, injongo yonyango ukunciphisa ukudumba ukubeka esi sifo kuxolelo, kwaye sisigcine apho.

Njani i-biologics ekujolise kuyo ukudumba

I-tumor necrosis factor, okanye i-TNF, yiprotein ebangela ukudumba njengenxalenye yempendulo yenkqubo yomzimba yokuzikhusela. Umsebenzi we-anti-TNF biologics usebenza ngokujolisa kule protein ukunciphisa iipropathi zayo zokuvuvukala.

Ukuba uthatha i-Remicade (infliximab), Humira (adalimumab), Cimzia (certolizumab), okanye iSimponi (golimumab), uthatha i-anti-TNF biologic.

Ngesifo sikaCrohn, amajoni akho omzimba athumela iiseli ezimhlophe zegazi ezininzi kwithumbu lesisu (GI), ebangela ukudumba. Enye indlela i-biologics ejolise kuyo ukudumba kukusombulula umba wokuba neeseli ezimhlophe zegazi kakhulu kwitrone ye-GI.

I-Entyvio (vedolizumab) kunye neTysabri (natalizumab) isebenza ngale ndlela. Banqanda iiseli ezimhlophe zegazi zingangeni esiswini. Eli nyathelo lokuvimba ligcina iiseli ezimhlophe zegazi kude namathumbu, apho zinokuthi zibangele ukudumba. Emva koko, oku kuvumela indawo ukuba iphilise.

I-Biologics inokujolisa kwezinye iindlela emzimbeni ezikhokelela kukudumba. UStelara (ustekinumab) sisithinteli se-interleukin. Ijolise kwiiproteni ezimbini ezithile ekucingelwa ukuba zibangela ukudumba. Abantu abaneCrohn's banamanqanaba aphezulu ezi proteni emzimbeni wabo.

Ngokujolisa kwezi proteni, uStelara uvimba ukuvuvukala kwiphecana le-GI kunye nokunciphisa iimpawu zesifo sikaCrohn.

Uxela njani ukuba uxolelwe

Kuqhelekile ukuba neentsuku ezintle kunye neentsuku ezimbi xa uneCrohn's, ke uyazi njani ukuba uxolelwe kwaye awunayo nje imihla elungileyo?

Zimbini izinto zokuxolelwa. Ukuxolelwa kwezonyango kuthetha ukuba awunazo iimpawu ezibonakalayo. Ukuxolelwa kwamathambo kuthetha ukuba iimvavanyo zibonisa ukuba izilonda zakho ziyaphilisa kwaye igazi lakho linamanqanaba aqhelekileyo okuvuvukala.

Ugqirha wakho usebenzisa into ebizwa ngokuba sisalathiso somsebenzi wesifo sikaCrohn (CDAI) ukulinganisa inqanaba apho iCrohn yakho isebenza khona okanye kuxolelo. I-CDAI ithathela ingqalelo iimpawu zakho, njengenani lokuhamba kwamathumbu kunye nendlela oziva ngayo.

Ikwaqwalasele iingxaki zesifo sikaCrohn kunye neziphumo zovavanyo lwakho.

Naxa uxolelwe, kuqhelekile ukuba i-biopsy ibonakalise utshintsho oluncinci kwimisipha yakho ebonisa ukudumba kwangaphambili. Ngamanye amaxesha, kwimeko yokuxolelwa ixesha elide kunye nobunzulu, iziphumo ze-biopsy ziqhelekile, kodwa oku akuhlali kunjalo.

Njani i-biologics ikugcina uxolelo

I-Biologics ikugcina uxolelwe ngokuthintela impendulo yomzimba wakho yokukhusela. Ukuba uyeka iyeza lakho ngelixa uxolelwe, usemngciphekweni wokuphendula kwi-trigger kunye ne-flare.

Ngamanye amaxesha izinto ezinokubangela kube nzima ukuziqikelela. Ezinye, ezinje ngezi zilandelayo, kulula ukuzibona:

• utshintsho kwindlela otya ngayo
• ukutshaya icuba
• amayeza atshintsha
• uxinzelelo
• ukumoshwa komoya

Ukuba usebenzisa amayeza ngelixa uchazwa zizinto ezibangela, isifo sakho seCrohn akunakufane sisebenze.

Ziziphi ii-biosimilars?

I-Biosimilars ziinguqulelo zamva nje zebhayoloji ezinesakhiwo esifanayo, ukhuseleko kunye nokusebenza. Ayizizo iinguqulelo eziqhelekileyo ze-biologics yoqobo. Endaweni yoko, ziikopi ze-biologics yoqobo eziphelelwe lixesha.

Zixabisa ngokubanzi iindleko kwaye ziyasebenza ukugcina uxolelo.

Unyango ngelixa uxolelwe

Nje ukuba uxole, unokuhendeka ukuba uyeke unyango. Ukuba wenzayo, usengozini yokufumana ulusu olutsha.

Ukuba uyeka ukuthatha amayeza akho, kunokwenzeka ukuba isenokungasebenzi ngexesha elizayo xa usiva. Kungenxa yokuba xa uyeka ukuthatha i-biologic, umzimba wakho unokukhulisa ii-antibodies ngokuchasene neziyobisi, ezenza ukuba zingasebenzi kakuhle kwixa elizayo.

Inokude ikhokelele ekuphenduleni okungalunganga.

I-Biologics icinezela amajoni akho omzimba, okubeka emngciphekweni wosulelo. Ngenxa yoku, kukho iimeko ezithile apho ugqirha anokukucebisa ukuba uthathe ikhefu lonyango. Oku kubandakanya:

• utyando
• izitofu
• ukukhulelwa

Ngaphandle koko, isenzo esinconywayo kukuhlala kumayeza nokuba uxolile.

Izifundo zibonise ukuba kuphela malunga nesiqingatha sabantu abayeka ukusebenzisa i-anti-TNF biologic yabo ngelixa bekhululiwe bahlala ekuxolelweni ixesha elingaphezulu kweminyaka emibini, kwaye elo nani liyancipha ngokuhamba kwexesha.

Ukuthatha

Injongo yonyango lwakho lweCrohn kukufumana kunye nokugcina uxolelo. Ukuphulukana namayeza kungakhokelela kumlilo. Kubalulekile ukusebenza nogqirha wakho ukuseka esona sicwangciso silungileyo sokuhlala uxolelo. Oku kubandakanya ukujongwa rhoqo kunye nokugcina irejimeni yamayeza akho.