Yintoni eyenza ingubo yeseli yeLymphoma yahlukile kwezinye iiLymphomas?

Umxholo

• I-MCL yi-B-cell non-Hodgkin's lymphoma
• I-MCL ihlala ichaphazela amadoda amadala
• I-MCL inqabile ngokubanzi
• Isasazeka kwindawo yengubo
• Inxulumene notshintsho oluthile lwemfuza
• Inoburharha kwaye kunzima ukuyinyanga
• Inokunyangwa ngonyango ekujoliswe kulo
• Ukuthatha

I-Lymphoma ngumhlaza wegazi okhula kwii-lymphocyte, uhlobo lweseli emhlophe yegazi. IiLymphocyte zidlala indima ebalulekileyo kumajoni akho omzimba. Xa benomhlaza, bande ngokungalawulekiyo kwaye bakhule babe ngamathumba.

Kukho iintlobo ezininzi ze-lymphoma. Izinketho zonyango kunye nembono ziyahluka ukusuka kuhlobo olunye ukuya kolunye. Thatha umzuzwana ukuba ufunde indlela yokunxiba iseli lymphoma (MCL) xa ithelekiswa nezinye iintlobo zesi sifo.

I-MCL yi-B-cell non-Hodgkin's lymphoma

Zimbini iintlobo eziphambili ze-lymphoma: iHodgkin's lymphoma kunye ne-non-Hodgkin's lymphoma. Kukho ngaphezulu kwe-60 subtypes ye-non-Hodgkin's lymphoma. I-MCL yenye yazo.

Zimbini iintlobo zeelymphocyte: T ii-lymphocyte (T iiseli) kunye nee-lymphocyte ze-B (iiseli ze-B). I-MCL ichaphazela iiseli ze-B.

I-MCL ihlala ichaphazela amadoda amadala

Ngokwe-American Cancer Society, iHodgkin's lymphoma ihlala ichaphazela abantu abadala abancinci, ngakumbi abantu abakwiminyaka ye-20. Ngokuthelekisa, i-MCL kunye nezinye iintlobo ze-non-Hodgkin's lymphoma zixhaphake kakhulu kubantu abadala. ILymphoma Research Foundation inika ingxelo yokuba uninzi lwabantu abane-MCL ngamadoda angaphezu kweminyaka engama-60.

Ngokubanzi, i-lymphoma yenye yeendlela eziqhelekileyo zomhlaza ezichaphazela abantwana kunye nolutsha. Kodwa ngokungafaniyo nezinye iintlobo ze-lymphoma, i-MCL inqabile kubantu abancinci.

I-MCL inqabile ngokubanzi

I-MCL ixhaphake kakhulu kunezinye iintlobo ze-lymphoma. Ibalelwa malunga neepesenti ezintlanu zazo zonke iimeko ze-lymphoma, ngokwe-American Cancer Society. Oku kuthetha ukuba i-MCL imele malunga ne-1 kwi-20 ye-lymphomas.

Ngokwahlukileyo, uhlobo oluqhelekileyo lwe-non-Hodgkin's lymphoma lusasaza i-B-cell lymphoma enkulu, ebala malunga ne-1 kwii-3 ze-lymphomas.

Ngenxa yokuba kunqabile, oogqirha abaninzi banokungaqheleki ngophando lwamva nje kunye neendlela zonyango ze-MCL. Xa kunokwenzeka, kungcono ukutyelela i-oncologist egxile kwi-lymphoma okanye kwi-MCL.

Isasazeka kwindawo yengubo

I-MCL ifumana igama layo kwinto yokuba yenzeka kwindawo yengubo ye-lymph node. Indawo yengubo yiringi yee-lymphocyte ejikeleze iziko le-lymph node.

Ngexesha lokuchongwa, i-MCL ihlala isasazeka kwezinye ii-lymph node, kunye nezinye izicwili kunye namalungu. Umzekelo, inokusasazeka kumongo wakho wethambo, udakada, kunye namathumbu. Kwiimeko ezinqabileyo, inokuchaphazela ingqondo yakho kunye nentambo yomgogodla.

Inxulumene notshintsho oluthile lwemfuza

I-lymph nodes ezidumbileyo zizimpawu eziqhelekileyo ze-MCL kunye nezinye iintlobo ze-lymphoma. Ukuba ugqirha wakho ukrokrela ukuba une-lymphoma, baya kuthatha isampuli yethishu kwi-lymph node edumbileyo okanye amanye amalungu omzimba wakho ukuba awuhlole.

Ngaphantsi kwemicroscope, iiseli ze-MCL zijongeka njengezinye iintlobo ze-lymphoma. Kodwa kwiimeko ezininzi, iiseli zinophawu lwemfuza olunokunceda ugqirha wakho ukuba afunde ukuba loluphi uhlobo lwe-lymphoma. Ukuze ufumane ukuxilongwa, ugqirha wakho uya ku-oda iimvavanyo ukujonga iimpawu zokumakisha kunye neeprotheni.

Ugqirha wakho unokuyalela ezinye iimvavanyo, ezinje nge-CT scan, ukuze afunde ukuba umhlaza usasazekile. Banokuyalela kwakhona i-biopsy yomongo wethambo, amathumbu, okanye ezinye izicwili.

Inoburharha kwaye kunzima ukuyinyanga

Ezinye iintlobo ze-non-Hodgkin's lymphoma zikumgangatho ophantsi okanye zinevila. Oko kuthetha ukuba bahlala bekhula kancinci, kodwa kwiimeko ezininzi abanyangeki. Unyango lunokunceda ukunciphisa umhlaza, kodwa i-lymphoma ekumgangatho ophantsi ihlala ibuyela umva, okanye ibuye.

Ezinye iintlobo ze-non-Hodgkin's lymphoma ziphezulu okanye zihlasele. Zidla ngokukhula ngokukhawuleza, kodwa zihlala zinyangeka. Xa unyango lokuqala luphumelele, i-lymphoma ekumgangatho ophakamileyo ayihlali iphinda ibuye.

I-MCL ayiqhelekanga kuba ibonisa amanqaku omabini amanqanaba aphezulu kunye nee-lymphomas eziphantsi. Njengamanye ama-lymphomas aphezulu, ihlala ikhula ngokukhawuleza. Kodwa njengee-lymphomas ezikumgangatho osezantsi, zihlala zinganyangeki. Uninzi lwabantu abane-MCL baya kuxolelwa emva konyango lwabo lokuqala, kodwa umhlaza phantse uhlala ubuyela kwisithuba seminyaka embalwa.

Inokunyangwa ngonyango ekujoliswe kulo

Njengezinye iintlobo ze-lymphoma, i-MCL inokunyangwa ngenye yeendlela ezilandelayo:

• ukulinda ukulinda
• iziyobisi chemotherapy
• omzimba monoclonal
• indibaniselwano ichemotherapy kunye nonyango lomzimba olubizwa ngokuba yi-chemoimmunotherapy
• unyango lwemitha
• Ukufakelwa kweseli

Ulawulo lokutya kunye neziyobisi (i-FDA) ikwamkele amayeza amane ajolise ngqo kwi-MCL:

• ibortezomib (Velcade)
• lenalidomide (ihlaziyiweyo)
• ibrutinib (Imbruvica)
• I-acalabrutinib (iCalquence)

Onke la mayeza avunyiwe ukuba asetyenziswe ngexesha lokuphinda ubuye, emva kokuba olunye unyango sele luzanyiwe. IBortezomib ikwamkelwe njengonyango lodidi lokuqala, olunokusetyenziswa ngaphambi kwezinye iindlela. Izilingo ezininzi zeklinikhi ziyaqhubeka ukufundisisa ukusetyenziswa kwe-lenalidomide, ibrutinib, kunye ne-acalabrutinib njengonyango lodidi lokuqala, kananjalo.

Ukuze ufunde okungakumbi ngonyango lwakho, thetha nogqirha wakho. Isicwangciso sabo sonyango esinconywayo siya kuxhomekeka kubudala bakho nakwimpilo iyonke, kunye nalapho umhlaza ukhula khona emzimbeni wakho.

Ukuthatha

I-MCL inqabile kwaye icelomngeni ukunyanga. Kodwa kule minyaka idlulileyo, iindlela zonyango ezintsha ziye zaphuhliswa kwaye zamkelwa ukuba zijolise kolu hlobo lomhlaza. Olu nyango lutsha luye lwandisa kakhulu ubomi babantu abane-MCL.

Ukuba kunokwenzeka, kungcono ukutyelela ingcali yomhlaza enamava okunyanga i-lymphoma, kubandakanya ne-MCL. Le ngcali inokukunceda uqonde kwaye ulinganise ukhetho lwakho lonyango.