UZulresso (ibrexanolone)

Umxholo

• Yintoni iZulresso?
• Ukusebenza ngempumelelo
• Ukuvunywa kwe-FDA
• Ngaba iZulresso yinto elawulwayo?
• Zulresso generic
• Iindleko zeZulresso
• Uncedo lwezezimali kunye neinshurensi
• Iziphumo ebezingalindelekanga zeZulresso
• Iziphumo eziqhelekileyo ezichaphazelekayo
• Iziphumo ebezingalindelekanga ezimandundu
• Iinkcukacha zesiphumo
• Ukuphendula ngokuchaseneyo
• Ukuhlala kunye nokulahleka kwengqondo
• I-Zulresso yoxinzelelo lwasemva kokubeleka
• Umthamo weZulresso
• Iifom zamachiza kunye namandla
• Isisombululo soxinzelelo lwasemva kokubeleka (PPD)
• Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?
• I-Zulresso kunye notywala
• Unxibelelwano lweZulresso
• I-Zulresso kunye namanye amayeza
• I-Zulresso kunye neopioids
• I-Zulresso kunye neyeza ezithile zokuxhalabisa
• I-Zulresso kunye namayeza athile okulala
• I-Zulresso kunye ne-anti-depressants
• Eminye indlela eya kwiZulresso
• I-Zulresso vs. iZoloft
• Sebenzisa
• Iifom zeziyobisi kunye nolawulo
• Iziphumo kunye neengozi
• Iziphumo eziqhelekileyo ezichaphazelekayo
• Iziphumo ebezingalindelekanga ezimandundu
• Ukusebenza ngempumelelo
• Iindleko
• I-Zulresso vs. iLexapro
• Sebenzisa
• Iifom zeziyobisi kunye nolawulo
• Iziphumo kunye neengozi
• Iziphumo eziqhelekileyo ezichaphazelekayo
• Iziphumo ebezingalindelekanga ezimandundu
• Ukusebenza ngempumelelo
• Iindleko
• Inikwa njani iZulresso
• Xa iZulresso inikwa
• Ukuthatha iZulresso ngokutya
• Isebenza njani iZulresso
• Malunga nePPD
• Inokunceda njani iZulresso
• Kuthatha ixesha elingakanani ukusebenza?
• I-Zulresso kunye nokukhulelwa
• I-Zulresso kunye nokuncelisa
• Imibuzo eqhelekileyo malunga neZulresso
• Ngaba iZulresso inokunyanga ezinye iintlobo zoxinzelelo ngaphandle koxinzelelo lwasemva kokubeleka?
• Kutheni iZulresso ifumaneka kuphela kwiziko eliqinisekisiweyo leREMS?
• Ndiza kusafuna ukuthatha iipilisi zokunyanga umlomo emva konyango lweZulresso?
• Ngaba amadoda anokufumana uxinzelelo lwasemva kokubeleka? Ukuba kunjalo, bangayisebenzisa iZulresso?
• Ngaba iZulresso inganyanga isifo sengqondo emva kokubeleka?
• Ngaba iZulresso ingalunyanga uxinzelelo lwasemva kokubeleka kulutsha?
• Izilumkiso zeZulresso
• Isilumkiso se-FDA: Ukudakumba okugqithisileyo kunye nokulahleka ngesiquphe kwengqondo
• Ezinye izilumkiso
• Ulwazi lobungcali lweZulresso
• Iimpawu
• Indlela yokusebenza
• I-Pharmacokinetics kunye ne-metabolism
• Ukungqinelana
• Ukuphathwa gadalala kunye nokuxhomekeka
• Ukugcina

Yintoni iZulresso?

I-Zulresso ligama lonyango elichaza uxinzelelo lwasemva kokubeleka (PPD) kubantu abadala. I-PPD luxinzelelo oluqala kwiiveki ezimbalwa zokubeleka. Kwabanye, ayiqali de kube ziinyanga emva kokuba nomntwana.

I-Zulresso ayinyangi i-PPD, kodwa inokunceda ukukhulula iimpawu ze-PPD. Oku kunokubandakanya ukuziva ulusizi kakhulu, unxunguphalo, kwaye udakumbile I-PPD inokukuthintela ekubeni ukwazi ukukhathalela umntwana wakho, kwaye inokuba neziphumo ezibi kakhulu kuwe nakwintsapho yakho.

I-Zulresso iqulethe i-brexanolone. Inikwa njenge-infravenous (IV) infusion, eya emthanjeni wakho. Uya kufumana ukumiliselwa kwisithuba seeyure ezingama-60 (iintsuku ezi-2.5). Uya kuhlala kwiziko lezempilo eliqinisekisiweyo ngokukodwa ngelixa ufumana iZulresso. (Ngeli xesha, akwaziwa ukuba unyango olungaphezulu kwesinye kunye neZulresso lukhuselekile okanye lusebenza kakuhle.)

Ukusebenza ngempumelelo

Kwizifundo zeklinikhi, iZulresso ikhuphe iimpawu ze-PPD ngaphezulu kwe-placebo (unyango ngaphandle kwesiyobisi esisebenzayo). Izifundo zisebenzise isikali sokuqina koxinzelelo kunye nenqaku eliphezulu lamanqaku e-52. Ngokwezifundo, i-PPD ephakathi ifunyaniswa inamanqaku angama-20 ukuya kuma-25. I-PPD ebukhali ifunyaniswa inamanqaku angama-26 okanye ngaphezulu.

Olunye uphononongo lubandakanya abasetyhini abane-PPD enzima. Emva kokufakwa kwe-Zulresso iiyure ezingama-60, amanqaku oxinzelelo kula mabhinqa aphuculwe ngama-3.7 ukuya kuma-5.5 amanqaku ngakumbi kunamanqaku abasetyhini abathatha indawo ye-placebo.

Kwisifundo esasibandakanya abasetyhini abane-PPD elungeleleneyo, iZulresso iphucule amanqaku oxinzelelo ngamanqaku angama-2.5 ngaphezulu kwe-placebo emva kokufakwa kweyure ezingama-60.

Ukuvunywa kwe-FDA

I-Zulresso yamkelwe yi-Food and Drug Administration (i-FDA) ngo-Matshi 2019. Sisisiyobisi sokuqala nesikuphela kwaso i-FDA evume ukuba inyange ngokukodwa i-PPD. Nangona kunjalo, ayikafumaneki ukuba isetyenziswe (jonga "Ngaba iZulresso yinto elawulwayo?" Apha ngezantsi).

Ngaba iZulresso yinto elawulwayo?

Ewe, iZulresso yinto elawulwayo, oko kuthetha ukuba ukusetyenziswa kwayo kubekwe esweni ngurhulumente womanyano. Into nganye elawulwayo yabelwa ishedyuli esekwe ekusebenziseni kwayo unyango, ukuba ikho, kunye nokusetyenziswa kwayo gwenxa. I-Zulresso ihlelwa njengeshedyuli yesi-4 (IV) yeziyobisi.

I-Zulresso kulindeleke ukuba ifumaneke ngasekupheleni kukaJuni 2019.

Urhulumente wenze imigaqo ekhethekileyo yokuba icandelo ngalinye leziyobisi ezicwangcisiweyo zinokumiselwa kwaye zihanjiswe njani. Ugqirha wakho kunye nosokhemesti banokukuxelela ngakumbi ngale mithetho.

Zulresso generic

I-Zulresso ifumaneka kuphela njengonyango lwegama lophawu. Okwangoku ayifumaneki ngendlela eqhelekileyo.

I-Zulresso iqulethe isithako esisebenzayo seziyobisi i-brexanolone.

Iindleko zeZulresso

Njengawo onke amayeza, iindleko zeZulresso ziyahluka. I-Sage Therapeutics, umvelisi weZulresso, ithi kwingxelo yayo yekota ukuba uluhlu lwamaxabiso yi- $ 7,450 ngebhotile enye. Unyango lufuna umndilili weebhotile ze-4.5, ke iindleko zizonke ziya kuba malunga ne-34,000 yeedola ngaphambi kwezaphulelo. Ixabiso langempela oza kulihlawula lixhomekeke kwisicwangciso sakho seinshurensi.

Uncedo lwezezimali kunye neinshurensi

Ukuba ufuna inkxaso yemali ukuhlawulela iZulresso, uncedo lusendleleni. I-Sage Therapeutics, umenzi weZulresso, uxele ukuba baya kubonelela ngeenkqubo zoncedo lwezezimali kubafazi abafanelekileyo.

Ukufumana ulwazi oluthe vetshe, qhagamshelana neSage Therapeutics kwi-617-299-8380. Ungajonga ulwazi oluhlaziyiweyo kwiwebhusayithi yenkampani.

Iziphumo ebezingalindelekanga zeZulresso

I-Zulresso inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha iZulresso. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ezinokubakho zeZulresso, thetha nogqirha wakho okanye usokhemesti. Banokukunika iingcebiso malunga nendlela yokujongana nayo nayiphi na imiphumela emibi enokuthi ikhathaze.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo eziqhelekileyo zeZulresso zingabandakanya:

• ukulala (ukulala, ingxaki yokucinga ngokucacileyo, ukungakwazi ukuqhuba okanye ukusebenzisa oomatshini abanzima)
• isiyezi okanye i-vertigo (uziva ngathi uyahamba xa ungekho)
• ndiziva ngathi uza kufa isiqaqa
• umlomo owomileyo
• ukugungxula ulusu (ububomvu kunye nemvakalelo yokufudumala kulusu lwakho)

Uninzi lweziphumo ebezingalindelekanga zinokuhamba zingaphelanga iintsuku okanye iiveki ezimbalwa. Ukuba zinzima kakhulu okanye azihambi, thetha nogqirha wakho okanye usokhemesti.

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ebezingalindelekanga ezimandundu ezivela eZulresso zinokwenzeka. Tsalela umnxeba kwangoko ukuba uneziphumo ebezingalindelekanga ezimandla emva kokuba ushiye indawo yokhathalelo lwempilo apho ufumene idosi yakho. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Iziphumo ebezingalindelekanga ezimandundu kunye neempawu zazo zinokubandakanya oku kulandelayo:

• Ukuphulukana nokuqonda. Iimpawu zingabandakanya:
• Iingcinga zokuzibulala kunye nokuziphatha kubantu abadala abancinci (abangaphantsi kweminyaka engama-25 ubudala). * Iimpawu zinokubandakanya:

Ezi ziphumo zinokwenzeka nakubantwana. Eli chiza alivunyelwanga ukuba lisetyenziswe ebantwaneni.

Iinkcukacha zesiphumo

Unokuzibuza ukuba zenzeka kangaphi ezinye iziphumo ebezingalindelekanga ngeli chiza. Nazi ezinye iinkcukacha kwiziphumo ebezingalindelekanga ezinokubangelwa leli chiza.

Ukuphendula ngokuchaseneyo

Njengokuba kuninzi lweziyobisi, abanye abantu banokuphendula emva kokuthatha iZulresso. Iimpawu zokuphendula kancinci kunokubandakanya:

• irhashalala
• ukucheba
• ukucoca (ukufudumala nokubomvu kwesikhumba sakho)

Impendulo eyingozi kakhulu inqabile kodwa inokwenzeka. Iimpawu zokungaziphathi kakuhle kunokubandakanya:

• i-angioedema (ukudumba phantsi kolusu lwakho, ubukhulu becala kwiinkophe zakho, imilebe, izandla, okanye iinyawo)
• ukudumba kolwimi lwakho, umlomo, okanye umqala
• ingxaki yokuphefumla

Fowunela ugqirha wakho ngoko nangoko ukuba uneempendulo ezomeleleyo ku-Zulresso emva kokuba ushiye indawo yokhathalelo lwempilo. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Ukuhlala kunye nokulahleka kwengqondo

Ukuhlala sisiphumo secala esiqhelekileyo kunye neZulresso. Iimpawu zibandakanya ukulala kunye nengxaki yokucinga ngokucacileyo. Kwezinye iimeko, i-sedation ingaba nzima, ekhokelela ekulaleni okugqithisileyo kunye nokulahleka kwengqondo.

Kwizifundo zeklinikhi, iipesenti ezintlanu zabantu babene-sedation enzima efuna ukumiswa okwexeshana okanye utshintsho kunyango. Kubantu abathatha i-placebo (unyango olungenalo iyeza elisebenzayo), akukho namnye ubenempembelelo efanayo.

Ukuphulukana nokuqonda kuthetha ukuphelelwa ngamandla okanye ukubonakala ngathi ulele. Ngeli xesha, awukwazi ukuphendula kwisandi okanye ukubamba. Kwizifundo zeklinikhi, iipesenti ezi-4 zabantu abathathe iZulresso baphulukana nomqondo. Akukho namnye kubantu abathathe indawo ye-placebo onale mpembelelo.

Umntu ngamnye olahlekileyo ezingqondweni kwizifundo, unyango lwamiswa. Ngamnye waba bantu wabuyela ezingqondweni malunga nemizuzu eli-15 ukuya kwengama-60 emva kokuyeka unyango.

Xa ufumana iZulresso, ugqirha wakho uya kukujonga ukuba ulahlekelwe sisazela. Bayakwenza oku rhoqo kwiiyure ezimbini ngexesha lokungalali. (Uya kulandela ishedyuli yokulala eqhelekileyo ngexesha lonyango lwakho.)

Zombini i-sedation eqatha kunye nokulahleka kwengqondo kungakhokelela kumanqanaba asezantsi eoksijini (hypoxia). Ukuba uhleli phantsi okanye ulahlekelwe yingqondo, ukuphefumla kwakho kunokuhamba kancinci. Xa oku kusenzeka, umzimba wakho uthatha ioksijini encinci. Ioksijini encinci kwiiseli kunye nakwizicubu zakho inokubangela umonakalo kwingqondo yakho, kwisibindi nakwamanye amalungu.

Ngesi sizathu, ugqirha wakho uya kujonga amanqanaba eoksijini egazini lakho kunyango lwakho lonke.Ukuba ulahlekelwa sisazela okanye uneqondo eliphantsi leoksijini egazini lakho, ugqirha wakho uza kuyeka unyango lweZulresso okwethutyana. Ukuba banquma ukuqala kwakhona unyango lweZulresso, banokusebenzisa idosi esezantsi.

Ngenxa yomngcipheko wokulahleka kwengqondo, iZulresso inikwa kuphela ngabaqeqeshi bezempilo abaqinisekisiweyo ukuba banike olu nyango.

[Imveliso: Nceda ufake i-Widget yoThintelo lokuBulala ngokuBulala)

I-Zulresso yoxinzelelo lwasemva kokubeleka

Ulawulo lokutya kunye neziyobisi (i-FDA) livuma amayeza amiselweyo anjengeZulresso ukunyanga iimeko ezithile.

I-Zulresso yamkelwe yi-FDA ukunyanga abantu abadala abanexinzelelo lwasemva kokubeleka (PPD). Le meko luhlobo olubi lokudakumba okukhulu okwenzeka kwisithuba seeveki ukuya kwiinyanga zokubeleka. Inzima ngakumbi kune "baby blues" uninzi lwabasetyhini lunemva nje kokubeleka. Ukunganyangwa kwe-PPD kunokwenza ukuba umama angabinako ukukhathalela usana lwakhe.

I-PPD inokubangelwa zizinto ezininzi, kubandakanya:

• utshintsho kumanqanaba akho ehomoni
• ukudinwa (ukunqongophala kwamandla)
• ukutya okungafanelekanga okanye okungaqhelekanga
• utshintsho kubomi bakho bezentlalo okanye bobungcali (njengokuhlala ekhaya ngaphezulu kunangaphambili)
• ishedyuli yokulala engalunganga okanye engaqhelekanga
• ndiziva ndililolo

Iimpawu zoxinzelelo lwasemva kokubeleka zinokubandakanya:

• ukudinwa
• ixhala
• Ukutshintsha kwemozulu kakhulu
• Ndiziva ngathi "ungomama ombi"
• unengxaki yokulala okanye yokutya
• uloyiko malunga nokuzenzakalisa wena okanye abanye
• Iingcinga zokuzibulala okanye indlela yokuziphatha

Kwizifundo zeklinikhi, iZulresso ikhuphe iimpawu ze-PPD ngaphezulu kwe-placebo (unyango ngaphandle kwesiyobisi esisebenzayo). Izifundo zisebenzise isikali sokulinganisa ukulinganisa ukuba lukhulu kangakanani uxinzelelo lomntu ngamnye ngaphambi nasemva kokunikwa iZulresso. Isikali sokulinganisa sinamanqaku aphezulu angama-52, ngamanqaku aphezulu abonisa ukudakumba okunzulu. Ngokwezifundo, i-PPD ephakathi ifunyaniswa inamanqaku angama-20 ukuya kuma-25. I-PPD ebukhali ifunyaniswa inamanqaku angama-26 okanye ngaphezulu.

Olunye uphononongo lubandakanya abasetyhini abane-PPD enzima. Emva kokufakwa kwe-Zulresso iiyure ezingama-60, amanqaku oxinzelelo kula mabhinqa aphuculwe ngama-3.7 ukuya kuma-5.5 amanqaku ngakumbi kunamanqaku abasetyhini abathatha indawo ye-placebo. Kwisifundo esasibandakanya abasetyhini abane-PPD elungeleleneyo, iZulresso iphucule amanqaku oxinzelelo ngamanqaku angama-2.5 ngaphezulu kwe-placebo emva kokufakwa kweyure ezingama-60.

Umthamo weZulresso

Umthamo weZulresso ogqirha ugqirha wakho uya kuxhomekeka kwindlela umzimba wakho uphendula ngayo kwiZulresso.

Ugqirha wakho uyakuqala kwidosi ephantsi kwaye ayonyuse ngaphezulu kweeyure ezininzi. Baza kuyilungisa ngokuhamba kwexesha ukufikelela kwisixa esinyamezelwa ngumzimba wakho ngaphandle kwemiphumo emibi. Kwiiyure ezimbalwa zokugqibela zonyango, baya kuthoba idosi kwakhona.

Olu lwazi lulandelayo luchaza iidosi ezisetyenziswa okanye ezicetyiswayo. Ugqirha wakho uya kugqiba eyona milinganiselo ilungele iimfuno zakho.

Iifom zamachiza kunye namandla

I-Zulresso iza njengesisombululo esinikwa njenge-intravenous (IV) infusion, eya emthanjeni wakho. Uya kufumana ukumiliselwa kwisithuba seeyure ezingama-60 (iintsuku ezi-2.5). Uya kuhlala kwiziko lokhathalelo lwempilo kulo lonke ukumiliselwa.

Isisombululo soxinzelelo lwasemva kokubeleka (PPD)

Ugqirha wakho uya kumisela idosi yakho ngokusekwe kubunzima bakho. Ikhilogremu (kg) ilingana ne-2.2 yeepawundi.

Idosi ecetyiswayo yeZulresso yePPD yile:

• Ukuqala kokufakwa ngaphakathi ngeyure yesi-3: 30 mcg / kg ngeyure
• Iiyure 4–23: 60 mcg / kg ngeyure
• Iiyure ezingama-24–51: 90 mcg / kg ngeyure
• Iiyure 52-55: 60 mcg / kg ngeyure
• Iiyure 56-60: 30 mcg / kg ngeyure

Ukuba uneziphumo ebezingalindelekanga ezimandla ngexesha lokufakwa, ugqirha wakho unokuphazamisa unyango okanye anciphise idosi yeZulresso. Baza kuqalisa kwakhona unyango okanye bagcine idosi ukuba bathathe isigqibo sokuba kukhuselekile ukuba uqhubeke nokufumana iZulresso.

Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?

I-Zulresso ayenzelwanga ukuba isetyenziswe njengonyango lwexesha elide. Emva kokufumana iZulresso, wena kunye nogqirha wakho ninokuthetha ngonyango olukhuselekileyo nolusebenzayo lokuthintela uxinzelelo onokuthi uluthathe ixesha elide xa kufuneka.

I-Zulresso kunye notywala

Akufuneki usele utywala kwangoko ngaphambi okanye ngexesha lonyango lweZulresso. Utywala bunokunyusa umngcipheko wokuhlala ubuthathaka obunzima (ukulala, ingxaki yokucinga ngokucacileyo) ukuba ityiwe yiZulresso. Inokonyusa umngcipheko wokulahleka kwengqondo (ukungabinakho ukuphendula kwisandi okanye ukubamba).

Ukuba unenkxalabo malunga nokukwazi ukunqanda utywala kufutshane nexesha lonyango lwakho, thetha nogqirha wakho. Unokuthetha kwakhona malunga nokuba ukusela utywala kukhuselekile kuwe emva konyango lwakho.

Unxibelelwano lweZulresso

I-Zulresso inokusebenzisana namanye amayeza.

Unxibelelwano olwahlukileyo kunokubangela iziphumo ezahlukeneyo. Umzekelo, unxibelelwano oluthile lunokuphazamisa ukusebenza kakuhle kwesiyobisi. Olunye unxibelelwano lunokunyusa iziphumo ebezingalindelekanga okanye lubenze bube nzima ngakumbi.

I-Zulresso kunye namanye amayeza

Apha ngezantsi kukho uluhlu lwamayeza anokusebenzisana neZulresso. Olu luhlu alunazo zonke iziyobisi ezinokusebenzisana neZulresso.

Ngaphambi kokuba uthathe iZulresso, thetha nogqirha wakho kunye nosokhemesti. Baxelele ngawo onke amayeza kagqirha, ekhawuntareni, kunye nezinye iziyobisi ozithathayo. Baxelele malunga nazo naziphi na iivithamini, amayeza esintu kunye nezixhasi ozisebenzisayo. Ukwabelana ngolu lwazi kunokukunceda uphephe unxibelelwano olunokubakho.

Ukuba unemibuzo malunga nokunxibelelana kweziyobisi okunokuchaphazela, buza ugqirha wakho okanye usokhemesti.

I-Zulresso kunye neopioids

Ukuthatha amayeza entlungu afana neopioid ngaphambi okanye ngexesha lonyango lweZulresso kunokunyusa umngcipheko weziphumo ebezingalindelekanga. Ukuthatha i-Zulresso nge-opioids kunokunyusa umngcipheko we-sedation enzima (ukulala, ingxaki yokucinga ngokucacileyo, kunye nokungakwazi ukuqhuba okanye ukusebenzisa oomatshini abanzima). Inokonyusa umngcipheko wokulahleka kwengqondo (ukungabinakho ukuphendula kwisandi okanye ukubamba).

Imizekelo yeeopioid ezinokunyusa umngcipheko wokuhlala kunye nokulahleka kwengqondo xa kuthathwe iZulresso zibandakanya:

• i-hydrocodone (iHysingla, iZohydro)
• Oxycodone (Oxycontin, Roxicodone, Xtampza ER)
• ikhowudi
• morphine (eKadian, kwi-MS Contin)
• fentanyl (Abstral, Actiq, Duragesic, abanye)
• imethadone (iDolophine, iMethadose)

Amayeza amaninzi entlungu aqukethe indibaniselwano yeeopioid kunye nezinye iziyobisi. Qiniseka ukuba uxelela ugqirha wakho ngawo onke amayeza owathathayo. Ukuba uthatha iyeza leentlungu, banokucebisa ukuba ungayithathi kwangoko ngaphambi nangexesha lonyango lweZulresso. Oku kuya kunceda ukunciphisa umngcipheko wokudinwa okunzima kunye nokulahleka kwengqondo.

I-Zulresso kunye neyeza ezithile zokuxhalabisa

Ukuthatha iZulresso nge-benzodiazepines (amayeza asetyenziselwa ukunyanga uxinzelelo) kunokunyusa umngcipheko weziphumo ebezingalindelekanga. Ukuthatha i-Zulresso nge-benzodiazepine kunokunyusa umngcipheko we-sedation enzima (ukulala, ingxaki yokucinga ngokucacileyo, ukungakwazi ukuqhuba okanye ukusebenzisa oomatshini abanzima). Inokonyusa umngcipheko wokulahleka kwengqondo (ukungabinakho ukuphendula kwisandi okanye ukubamba).

Imizekelo ye-benzodiazepines enokunyusa umngcipheko wokuhlala kunye nokulahleka kwengqondo xa kuthathwe iZulresso kubandakanya:

• alprazolam (Xanax, Xanax XR)
• diazepam (Valium)
• ILorazepam (Ativan)
• temazepam (Ukubuyisela kwakhona)
• I-triazolam (iHalcion)

I-Zulresso kunye namayeza athile okulala

Ukuthatha i-Zulresso ngamayeza athile okulala (ukungalali kakuhle) kunokunyusa umngcipheko wokudakumba okuqatha. Iimpawu zokudakumba zinokubandakanya ukulala, ingxaki yokucinga ngokucacileyo, kunye nokungakwazi ukuqhuba okanye ukusebenzisa oomatshini abanzima. Banokubandakanya ukulahleka kwengqondo (ukungabinakho ukuphendula kwisandi okanye ukubamba).

Imizekelo yamayeza okulala angonyusa umngcipheko wokuhlala kunye nokulahleka kwengqondo ukuba uthathwe kunye neZulresso zibandakanya:

• eszopiclone (iLunesta)
• zaleplon (Sonata)
• zolpidem (Ambien, Ambien CR, Edluar, Intermezzo, Zolpimist)

I-Zulresso kunye ne-anti-depressants

Ukuthatha iZulresso kunye namanye amayeza athomalalisa uxinzelelo kunokwandisa umngcipheko weziphumo ebezingalindelekanga ezimandundu, ezinje ngokulala kakhulu, ukulala, ingxaki yokucinga ngokucacileyo, ukungakwazi ukuqhuba okanye ukusebenzisa oomatshini abanzima. isandi okanye ubambe).

Imizekelo yokuxinezeleka enokunyusa umngcipheko wokuhlala kunye nokulahleka kwengqondo kubandakanya:

• I-fluoxetine (Prozac, Sarafem, Selfemra)
• i-sertraline (iZoloft)
• Ikitalopram (Celexa)
• I-escitalopram (iLexapro)
• iparoxetine (iBrisdelle, Paxil, Pexeva)
• venlafaxine (i-Effexor XR)
• duloxetine (ICymbalta)

Eminye indlela eya kwiZulresso

Amanye amachiza asetyenziselwa uxinzelelo anokunceda ekunyangeni uxinzelelo lwasemva kokubeleka (PPD). Elinye lala machiza lisetyenziswa ngaphandle kwelebheli ukunyanga i-PPD. Ukusetyenziswa ngaphandle kwelebula kuxa ichiza elivunyiweyo kusetyenziso olunye limiselwe olunye usetyenziso.

Amanye ala machiza anokulungela wena kunabanye. Ukuba unomdla wokufumana enye indlela eya kwiZulresso, thetha nogqirha wakho. Banokukuxelela ngamanye amayeza anokukusebenzela.

Imizekelo yezinye iziyobisi ezinokuthi zisetyenziswe ngaphandle kwelebheli ukunyanga i-PPD zibandakanya:

• I-fluoxetine (Prozac, Sarafem, Selfemra)
• iparoxetine (iBrisdelle, Paxil, Pexeva)
• i-sertraline (iZoloft)
• Umda we-nortriptyline (Pamelor)
• mzantsiweb
• Ibupropion (Wellbutrin SR, Wellbutrin XL, Zyban)
• esketamine (Spravato)

I-Zulresso vs. iZoloft

Unokuzibuza ukuba iZulresso ithelekiswa njani namanye amayeza amiselwe ukusetyenziswa okufanayo. Apha sijonga indlela iZulresso kunye neZoloft ezifanayo kunye ezahlukeneyo.

Sebenzisa

I-Zulresso kunye ne-Zoloft zivunyiwe yi-Food and Drug Administration (FDA) ukunyanga iimeko ezahlukeneyo.

I-Zulresso ivunyiwe yi-FDA ukunyanga uxinzelelo lwasemva kokubeleka (PPD) kubantu abadala.

I-Zoloft ivunyiwe yi-FDA ukuphatha abantu abadala ngezi meko zilandelayo:

• Ukudakumba okukhulu
• ukuphazamiseka kovalo
• Uxinzelelo lwasemva koxinzelelo
• ukuphazamiseka kwangaphambi kokuya exesheni
• ingxaki yokuxhalaba ekuhlaleni

IZoloft ikwavunyiwe ukuba inyange abantu abaneminyaka emi-6 nangaphezulu ngokugula okunganyanzelekanga. I-Zoloft isetyenzisiwe ngaphandle kwelebheli ukunyanga i-PPD.

I-Zulresso iqulethe i-brexanolone. I-Zoloft iqulethe i-sertraline yeziyobisi.

Iifom zeziyobisi kunye nolawulo

I-Zulresso iza njengesisombululo esinikwa njenge-intravenous (IV) infusion, eya emthanjeni wakho. Uyakufumana ukumiliselwa kwiziko lokhathalelo lwempilo ngaphezulu kweeyure ezingama-60 (iintsuku eziyi-2.5).

UZoloft uza njengethebhulethi okanye isisombululo esithathwa ngomlomo. Ithathwa kanye ngemini.

Iziphumo kunye neengozi

IZulresso kunye neZoloft ziqulathe iziyobisi ezahlukeneyo. Ke ngoko, amayeza anokubangela iziphumo ebezingalindelekanga ezahlukileyo. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga eziqhelekileyo ezinokuthi zenzeke ngeZulresso kunye neZoloft.

• Inokwenzeka ngeZulresso:
  • ukulala (ukulala, ingxaki yokucinga ngokucacileyo, ukungakwazi ukuqhuba okanye ukusebenzisa oomatshini abanzima)
  • isiyezi okanye i-vertigo (uziva ngathi uyahamba xa ungekho)
  • ndiziva ngathi uza kufa isiqaqa
  • umlomo owomileyo
  • ukugungxula ulusu (ubomvu kunye nemvakalelo efudumeleyo kulusu)
• Inokwenzeka ngeZoloft:
  • isicaphucaphu
  • urhudo okanye ilindle elixegayo
  • isisu esimoshakele
  • Ukuphelelwa ngumdla wokutya
  • ukubila okugqithisileyo
  • ukungcangcazela (ukuhamba okungalawulekiyo kwamalungu omzimba wakho)
  • ukungakwazi ukukhupha i-ejaculate
  • yehle i-libido (encinci okanye akukho ngesondo)

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho kunye neZulresso, kunye neZoloft, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Inokwenzeka ngeZulresso:
  • ukuthomalalisa kakhulu
  • ukulahleka kwengqondo (ukungakwazi ukuphendula kwisandi okanye ukuchukumisa)
• Inokwenzeka ngeZoloft:
  • i-serotonin syndrome (i-serotonin eninzi kakhulu emzimbeni)
  • ukwanda kwengozi yokopha
  • i-hyponatremia (amanqanaba asezantsi e-sodium)
  • isingqisho sentliziyo esingaqhelekanga
  • ukurhoxa
  • ngenxa yokumisa i-glaucoma yokuvalwa kweZoloftangle (uxinzelelo olwandileyo kwiso lakho)
• Inokwenzeka kunye neZulresso kunye neZoloft:
  • Iingcinga zokuzibulala kunye nokuziphatha kubantu abadala abancinci (abangaphantsi kweminyaka engama-25 ubudala)

Ukusebenza ngempumelelo

I-Zulresso kunye neZoloft zinokusetyenziswa okuvunyiweyo kwe-FDA, kodwa zombini zisetyenziselwa ukunyanga iPPD. Oku kukusetyenziswa kwelebheli engekho kwiZoloft. Sukusebenzisa iZoloft ukunyanga iPPD ngaphandle kokuthetha nogqirha wakho kuqala.

La machiza awathelekiswa ngokuthe ngqo kwizifundo zeklinikhi, kodwa izifundo zifumanise ukuba iZulresso iyasebenza ekunyangeni i-PPD.

Ukuphononongwa kwezifundo ezininzi zeklinikhi kufumanise ukuba iZoloft yayisebenza ngokunyanga iPPD kwezinye izifundo kodwa hayi kwezinye.

Iindleko

I-Zulresso kunye neZoloft zombini zinegama leziyobisi. Okwangoku azikho iifom ze-generic zeZulresso, kodwa kukho uhlobo oluthile lweZoloft olubizwa ngokuba yi-sertraline. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Uluhlu lwamaxabiso eZulresso lilonke lixabisa malunga ne-34, 000 yeedola yokufakwa ngaphambi kwezaphulelo, ngokwengxelo yekota yomenzi. Ngokusekwe kwelo xabiso kunye nexabiso eliqikelelweyo leZoloft ukusuka kwiGoodRx, iZulresso ibiza kakhulu. Elona xabiso uzakuhlawula ngalo naliphi na ichiza lixhomekeke kwisicwangciso sakho seinshurensi.

I-Zulresso vs. iLexapro

I-Zulresso kunye neLexapro zichazwe ngokusetyenziswa okufanayo. Apha ngezantsi kukho iinkcukacha zendlela la mayeza afanayo kwaye ahlukile ngayo.

Sebenzisa

I-Zulresso kunye neLexapro zamkelwe yi-Food and Drug Administration (FDA) ukunyanga iimeko ezahlukeneyo.

I-Zulresso yamkelwe ukunyanga uxinzelelo lwasemva kokubeleka (PPD) kubantu abadala.

ILexapro ivunyiwe ukuba inyange uxinzelelo olukhulu lokudakumba kubantu abaneminyaka eli-12 nangaphezulu. Kukwavunyiwe ukunyanga uxinzelelo oluqhelekileyo kubantu abadala. ILexapro isetyenzisiwe ngaphandle kwelebheli ukunyanga iPPD.

I-Zulresso iqulethe i-brexanolone. ILexapro iqulethe i-escitalopram yeziyobisi.

Iifom zeziyobisi kunye nolawulo

I-Zulresso iza njengesisombululo esinikwa njenge-intravenous (IV) infusion, eya emthanjeni wakho. Uyakufumana ukumiliselwa kwiziko lokhathalelo lwempilo ngaphezulu kweeyure ezingama-60 (iintsuku eziyi-2.5).

ILexapro iza njengecwecwe kunye nesisombululo. Yonke ifom ithathwa ngomlomo kanye yonke imihla.

Iziphumo kunye neengozi

I-Zulresso kunye neLexapro ziqulethe iziyobisi ezahlukeneyo. Ke ngoko, zinokubangela iziphumo ebezingalindelekanga ezahlukileyo kakhulu. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeZulresso, iLexapro, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Inokwenzeka ngeZulresso:
  • isiyezi okanye i-vertigo (uziva ngathi uyahamba xa ungekho)
  • ndiziva ngathi uza kufa isiqaqa
  • umlomo owomileyo
  • ukugungxula ulusu (ububomvu kunye nemvakalelo efudumeleyo kulusu lwakho)
• Ngaba kunokwenzeka ngeLexapro:
  • ukulala (kunzima ukulala)
  • isicaphucaphu
  • ukubila
  • ukudinwa (ukunqongophala kwamandla)
  • yehle i-libido (encinci okanye akukho ngesondo)
  • ukungabinakho ukuba ne-orgasm
  • ukulibaziseka okude
• Inokwenzeka kunye neZulresso kunye neLexapro:
  • ukulala (ukulala, ingxaki yokucinga ngokucacileyo, ukungakwazi ukuqhuba okanye ukusebenzisa oomatshini abanzima)

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho kunye neZulresso, kunye neLexapro, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Inokwenzeka ngeZulresso:
  • ukuthomalalisa kakhulu
  • ukulahleka kwengqondo
• Ngaba kunokwenzeka ngeLexapro:
  • i-serotonin syndrome (i-serotonin eninzi kakhulu emzimbeni)
  • i-hyponatremia (amanqanaba asezantsi e-sodium)
  • ukwanda kwengozi yokopha
  • Ukurhoxa ngenxa yokumisa iLexapro
  • Ukuvalwa kwe-glaucoma (ukunyuka koxinzelelo kwiso)
• Inokwenzeka kunye neZulresso kunye neLexapro:
  • Iingcinga zokuzibulala kunye nokuziphatha kubantu abadala abancinci (abangaphantsi kweminyaka engama-25 ubudala)

Ukusebenza ngempumelelo

I-Zulresso kunye neLexapro banezinto ezahlukileyo ezamkelweyo ze-FDA, kodwa zombini zisetyenziselwa ukunyanga iPPD. Oku kukusetyenziswa kwelebheli engekho kwiLexapro. Sukusebenzisa iLexapro ukunyanga iPPD ngaphandle kokuthetha nogqirha wakho kuqala.

La machiza khange athelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Nangona kunjalo, izifundo zifumanise ukuba iZulresso iyasebenza kunyango lwe-PPD. Kwaye uphononongo lwezifundo luchaze isifundo esifumene ukuba iLexapro inokusebenza kunyango lwe-PPD.

Iindleko

I-Zulresso kunye neLexapro zombini iziyobisi ezinamagama. Okwangoku azikho iintlobo ze-generic zeZulresso, kodwa kukho uhlobo oluthile lweLexapro ekuthiwa yi-escitalopram. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Uluhlu lwamaxabiso eZulresso lilonke lixabisa malunga ne-34, 000 yeedola yokufakwa ngaphambi kwezaphulelo, ngokwengxelo yekota yomenzi. Ngokusekwe kuloo xabiso kunye nexabiso eliqikelelweyo leLexapro ukusuka kwiGoodRx, iZulresso ibiza kakhulu. Elona xabiso uzakuhlawula ngalo naliphi na ichiza lixhomekeke kwisicwangciso sakho seinshurensi

Inikwa njani iZulresso

Uya kunikwa iZulresso ngugqirha wakho kwiziko lokhathalelo lwempilo. Uya kuyifumana njengokufakwa ngaphakathi kwe-intravenous (IV), okuya kungena emithanjeni yakho. Ukufakwa ngenaliti ngenaliti ehlala ixesha elide. Ukufakwa kwe-Zulresso kuya kuhlala malunga neeyure ezingama-60 (iintsuku ezi-2.5).

Ngeli xesha, uya kuhlala kwiziko lokhathalelo lwempilo. Oku kuyakuvumela ugqirha wakho ukuba ahlengahlengise idosi ecwangcisiweyo. Iya kubavumela ukuba bakubeke iliso kwiziphumo ebezingalindelekanga ezimandundu, ezinje ngokuthomalalisa kunye nokulahleka kwengqondo.

Ukuba uneziphumo ebezingalindelekanga ezimandundu, njengokulahleka kwengqondo, ugqirha wakho uya kuphazamisa ukumiliselwa. Bazokunyanga iziphumo ebezingalindelekanga ngaphambi kokuqalisa kwakhona ukumnika. Kwimeko enqabileyo ugqirha wakho ethatha isigqibo sokuba akukhuselekanga ukuba uqhubeke nokufumana iZulresso, baya kuyeka unyango.

Xa iZulresso inikwa

I-Zulresso inikwa njenge-infusion kwisithuba seeyure ezingama-60 (iintsuku ezi-2.5). Ngeli xesha, uya kuhlala kwiziko lokhathalelo lwempilo. Uya kulandela ishedyuli eqhelekileyo yokutya nokulala ngexesha lonyango lwakho. Unokuchitha ixesha kunye neendwendwe, kubandakanya umntwana wakho (okanye abantwana).

Ugqirha wakho uya kuqala unyango kusasa. Oku kubavumela ukuba babeke esweni iziphumo ebezingalindelekanga emini, xa kunokwenzeka ukuba uvuke.

Ukuthatha iZulresso ngokutya

Ukufakwa kwe-Zulresso kuhlala iiyure ezingama-60 (iintsuku ezi-2.5), ke uya kutya ukutya ngelo xesha. Indawo yokhathalelo lwempilo iya kubonelela ngokutya ngexesha lokuhlala kwakho.

Isebenza njani iZulresso

Ayaziwa ngokuthe ngqo ukuba iZulresso inceda njani ukunyanga uxinzelelo lwasemva kokubeleka (PPD).

Malunga nePPD

I-PPD ibangelwa ngokuyinxenye kukungalingani kwemisebenzi yee-neurosteroids kunye noxinzelelo lwehomoni, kunye nenkqubo yakho ye-neva iyonke. I-Neurosteroids zii-steroids ezifumaneka ngokwendalo emzimbeni. Ezi zinto zidlala indima ekulawuleni umsebenzi wenkqubo yakho yemithambo-luvo.

Inokunceda njani iZulresso

I-Zulresso yinguqulelo eyenziwe ngumntu ye-allopregnanolone, i-neurosteroid. Kucingelwa ukubuyisela ibhalansi kwinkqubo yakho yemithambo-luvo kunye noxinzelelo lwehomoni. Ikwenza oku ngokwandisa umsebenzi wee-neurotransmitters ezithile (iikhemikhali ezithumela imiyalezo phakathi kweeseli zemithambo-luvo).

Ngokukodwa, iZulresso inyusa umsebenzi we-gamma aminobutyric acid (GABA), i-neurotransmitter enceda ukuvelisa isiphumo sokuthomalalisa. Umsebenzi owandisiweyo we-GABA unokunceda ekunciphiseni iimpawu ze-PPD.

Kuthatha ixesha elingakanani ukusebenza?

Uyakuthi uqaphele ukuncitshiswa kweempawu zakho ze-PPD kwiiyure ezimbalwa ukuqala kokufakwa kwakho.

Kwizifundo zeklinikhi, iZulresso ikhulule iimpawu zabantu kwiiyure ezimbini zokuqala amayeza.

I-Zulresso kunye nokukhulelwa

I-Zulresso ayenzelwe ukuba isetyenziswe ngexesha lokukhulelwa. Kuvunyelwe yi-Food and Drug Administration (FDA) ukuba isetyenziswe ngexesha "emva kokubeleka", okwenzeka emva kokubeleka.

Akukho zifundo zisetyenziswayo zeZulresso ebantwini ngexesha lokukhulelwa. Kwizifundo zezilwanyana, iZulresso yabangela ingozi kwimveku engekazalwa xa umama wafumana ichiza. Nangona kunjalo, izifundo zezilwanyana azihlali ziqikelela ukuba kuya kwenzeka ntoni ebantwini.

Ngaphambi kokuba uthathe iZulresso, xelela ugqirha wakho ukuba kukho ithuba lokukhulelwa. Baza kuxoxa nawe ngomngcipheko kunye nezibonelelo zokusetyenziswa kweZulresso ngexesha lokukhulelwa.

Ukuba ufumana iZulresso ngelixa ukhulelwe, cinga ukubhalisa kwirejista yokukhulelwa. Iirejista zokukhulelwa ziqokelela ulwazi malunga nokusetyenziswa kweziyobisi ngexesha lokukhulelwa ukunceda oogqirha bafunde ngakumbi ngokhuseleko lweziyobisi. Ungabhalisa kwiRejista yeSizwe yokuKhulelwa kweeNtsholongwane okanye ngokutsalela umnxeba ku-844-405-6185.

I-Zulresso kunye nokuncelisa

Ukuncancisa ngexesha lonyango lweZulresso kunokwenzeka ukuba kukhuselekile. Isifundo esincinci ebantwini sifumanise ukuba iZulresso iyagqitha kubisi lwebele. Nangona kunjalo, ifunyenwe kumanqanaba asezantsi kakhulu kubisi lwebele.

Ukongeza, ukuba umntwana uginya ubisi lwebele oluqukethe iZulresso, iyeza alinakuba nampembelelo kubo. Kungenxa yokuba iZulresso yophukile kwaye ayisebenzi esiswini somntwana. Ke ngoko, abantwana abancancisayo baya kufumana kuphela ixabiso elincinci leZulresso esebenzayo.

Thetha nogqirha wakho malunga nokuba ukuncancisa ngexesha lonyango lweZulresso lukhetho olufanelekileyo kuwe.

Imibuzo eqhelekileyo malunga neZulresso

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga neZulresso.

Ngaba iZulresso inokunyanga ezinye iintlobo zoxinzelelo ngaphandle koxinzelelo lwasemva kokubeleka?

Ngeli xesha, akwaziwa ukuba iZulresso inokunyanga ezinye iindlela zoxinzelelo. I-Zulresso ihlolwe kuphela ukukhuseleka kunye nokusebenza kwabasetyhini abanexinzelelo lwasemva kokubeleka (PPD).

Ukuba unemibuzo malunga nokuba iZulresso ikulungele na, thetha nogqirha wakho.

Kutheni iZulresso ifumaneka kuphela kwiziko eliqinisekisiweyo leREMS?

I-Zulresso ifumaneka kuphela kwiziko eliqinisekisiweyo le-REMS ngenxa yokuba zinokuba mbi kangakanani iziphumo ebezingalindelekanga. I-REMS (uVavanyo loMngcipheko kunye neZicwangciso-qhinga zokuNciphisa) yinkqubo eyenziweyo yi-Food and Drug Administration (FDA). Kuyanceda ukuqinisekisa ukuba iziyobisi zisetyenziswa ngokukhuselekileyo kwaye zibonelelwa ngoochwephesha abaqeqeshiweyo bezempilo.

I-Zulresso inokubangela iziphumo ebezingalindelekanga ezimandundu, ezinje ngokudinwa okunzima. Iimpawu zinokubandakanya ukulala kakhulu, ingxaki yokucinga ngokucacileyo, kunye nokungakwazi ukuqhuba okanye ukusebenzisa oomatshini abanzima. I-Zulresso nayo inokubangela ukulahleka kwengqondo ngokukhawuleza (ukungakwazi ukuphendula kwisandi okanye ukuchukumisa).

Ngenxa yokuba zinokuba mbi kangakanani iziphumo ebezingalindelekanga, iZulresso inikwa kuphela kumaziko athile ezempilo. Ezi zibonelelo zinoogqirha abaqeqeshelwe ngokukodwa ukujonga nokunyanga iziphumo ezinokubakho zeZulresso. Oku kunceda ukuqinisekisa ukuba ufumana iZulresso ngokukhuselekileyo.

Ndiza kusafuna ukuthatha iipilisi zokunyanga umlomo emva konyango lweZulresso?

Unga. Kanye njengokuba i-anti-depressants ayinyangi ezinye iintlobo zoxinzelelo (zinceda kuphela ukukhulula iimpawu), iZulresso ayinyangi i-PPD. Ke ngoko, unokufuna unyango oluqhubekekayo kuxinzelelo lwakho emva konyango lwakho neZulresso.

Emva kokufumana unyango lweZulresso, wena nogqirha wakho niza kuqhubeka nokusebenza kunye ukufumana ezona ndlela zingcono zonyango zokukunceda uzive ungcono. Ungayeki ukuthatha i-anti-depressants yakho yomlomo ngaphandle kokuba ugqirha ukuxelele ukuba wenze njalo.

Ngaba amadoda anokufumana uxinzelelo lwasemva kokubeleka? Ukuba kunjalo, bangayisebenzisa iZulresso?

Kucingelwa ukuba amadoda nawo angabandezeleka yi-PPD. Uhlalutyo oluhlangeneyo kwiziphumo ezivela kumazwe angama-22 ahlukeneyo aquka amadoda angaphezu kwama-40,000. Olu hlalutyo lufumanise ukuba malunga ne-8% yamadoda kolu phando ayenoxinzelelo emva kokuba umntwana ezelwe. Amadoda amaninzi axele ukuba adandathekile kwiinyanga ezintathu ukuya kwezintandathu emva kokuba umntwana ezelwe, xa kuthelekiswa namanye amaxesha exesha.

Nangona kunjalo, akwaziwa ukuba iZulresso iyasebenza ekunyangeni i-PPD emadodeni. Izifundo zonyango lweZulresso zibandakanye kuphela abantu basetyhini abanePDD.

Ngaba iZulresso inganyanga isifo sengqondo emva kokubeleka?

Hayi ngeli xesha. I-Zulresso ayivunyelwanga yi-FDA ukunyanga isifo sengqondo sasemva kokubeleka. Uvavanyo lwezonyango lweZulresso alubandakanyi abasetyhini abanesifo sengqondo emva kokubeleka. Ke ngoko, akwaziwa ukuba iZulresso ikhuselekile kwaye iyasebenza ekunyangeni le meko.

I-postpartum psychosis ibangela ukuba umfazi abe neempawu ezinokubandakanya:

• amazwi okuva
• ukubona izinto ezingekhoyo ngenene
• ukuba neemvakalelo ezigqithisileyo zosizi kunye noxinzelelo

Ezi mpawu zinobuzaza. Ukuba ufumana amava, tsalela umnxeba ku-911.

Ngaba iZulresso ingalunyanga uxinzelelo lwasemva kokubeleka kulutsha?

I-Zulresso ivunyiwe yi-FDA ukunyanga iPPD kwabasetyhini abaneminyaka eli-18 nangaphezulu. Izifundo zeklinikhi azibandakanyi abantu ababhinqileyo abangaphantsi kweminyaka eyi-18. Ayaziwa ukuba iZulresso ikhuselekile okanye iyasebenza na ukunyanga ulutsha oluncinci nge-PPD.

Izilumkiso zeZulresso

Eli chiza liza nezilumkiso ezininzi.

Isilumkiso se-FDA: Ukudakumba okugqithisileyo kunye nokulahleka ngesiquphe kwengqondo

Eli chiza linesilumkiso esibhokisiweyo. Isilumkiso esibhokisi sisilumkiso esinzulu esivela kuLawulo lokutya kunye noLawulo lweziyobisi (FDA). Yazisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.

I-Zulresso inokubangela ukuthomalalisa okunzima. Iimpawu zinokubandakanya ukulala, ingxaki yokucinga ngokucacileyo, kunye nokungakwazi ukuqhuba okanye ukusebenzisa oomatshini abanzima. I-Zulresso nayo inokubangela ukulahleka kwengqondo ngokukhawuleza (ukungakwazi ukuphendula kwisandi okanye ukuchukumisa).

I-Zulresso ifumaneka kuphela ngezixhobo eziqinisekisiweyo. Ugqirha wakho uya kukujonga ngokusondeleyo kunyango lwakho lweZulresso. Bazakubakho ukuba ukunye nomntwana wakho (okanye abantwana) xa kunokwenzeka ukuba ulahlekelwe sisazela.

Ezinye izilumkiso

Ngaphambi kokuba uthathe iZulresso, thetha nogqirha wakho malunga nembali yakho yezempilo. I-Zulresso isenokungakulungeli ukuba uneemeko ezithile zonyango. Oku kubandakanya:

• Isifo sesifo sokuphela. Ayaziwa ukuba iZulresso ikhuselekile kubantu abanesifo sokugqibela (sezintso). Ukuba unesifo sesifo sokuphela kwaye ufuna iZulresso, thetha nogqirha wakho malunga nomngcipheko kunye nezibonelelo. Banokukunika ichiza elahlukileyo.

Phawula: Ngolwazi oluthe kratya malunga neziphumo ezibi ezinokubakho zeZulresso, jonga icandelo le "Zulresso icala ebezingalindelekanga" icandelo elingentla.

Ulwazi lobungcali lweZulresso

Olu lwazi lulandelayo lubonelelwe ngoochwephesha kunye nabanye abaqeqeshi bezempilo.

Iimpawu

I-Zulresso (i-brexanolone) yamkelwe yi-Food and Drug Administration (i-FDA) ukunyanga uxinzelelo lwasemva kokubeleka (PPD) kubantu abadala. Sisisiyobisi sokuqala nesikuphela kwaso i-FDA evume ukuba inyange ngokuthe ngqo i-PPD.

Indlela yokusebenza

I-Zulresso yinto yokwenziwa kwe-allopregnanolone. Eyona ndlela yokusebenza kweZulresso ayaziwa, kodwa iziphumo zayo kwi-PPD kucingelwa ukuba zinxulumene ne-gamma aminobutyric acid (GABA) yokuphucula imisebenzi ngokwenza imodyuli ye-allosteric elungileyo. Ukumodareyitha kwe-Allosteric kwenzeka xa iZulresso ibopha indawo ngaphandle kwe-GABA receptor kwaye yonyusa isiphumo se-GABA esibophelelayo kwi-receptor yayo. Kucingelwa ukuba ukuphuculwa komsebenzi we-GABA kulawula uxinzelelo ku-axothalamic-pituitary-adrenal axis (HPA). Umsebenzi ongasebenziyo we-HPA udlala indima kwi-PPD.

I-Pharmacokinetics kunye ne-metabolism

I-Zulresso ibonisa i-pharmacokinetics elingana nedosi. Kukho ukuhanjiswa okubanzi kwizicubu kunye nangaphezulu kwe-99% yeeproteni ezibophayo.

I-Zulresso i-metabolized ngeendlela ezingezizo ze-CYP kwii-metabolites ezingasebenziyo. Ukupheliswa kwesiqingatha sobomi kwisithuba esimalunga neeyure ezilithoba. Kwindle, i-47% yeZulresso iyakhutshwa, ngelixa kumchamo i-42% ikhutshiwe.

Iziphumo zesifo se-renal sokugqibela kwi-Zulresso pharmacokinetics ayaziwa; Ukusetyenziswa kweZulresso kufuneka kuthintelwe kwaba bantu.

Ukungqinelana

Akukho zingqinisiso ekusebenziseni iZulresso.

Ukuphathwa gadalala kunye nokuxhomekeka

I-Zulresso yinto elawulwayo, kwaye ihlelwa njenge-schedule 4 (IV) iziyobisi.

Ukugcina

I-Zulresso kufuneka igcinwe kwifriji kwi-36⁰F-46⁰F (2⁰C-7⁰C). Khusela iibhotile ekukhanyeni kwaye ungabandi.

Emva kokuxutywa, iZulresso inokugcinwa kwisingxobo sokufakwa ngaphakathi ukuya kuthi ga kwiiyure ezili-12 kubushushu begumbi. Ukuba ayisetyenziswanga kwangoko emva kokuxutywa, inokugcinwa ukuya kuthi ga kwiiyure ezingama-96 kwifriji.

Iphepha elichazayo ukuba awusenanto oyifunayo: I-Healthline yenze yonke imizamo yokuqinisekisa ukuba lonke ulwazi luchanekile, lubanzi kwaye luhlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.