Ngokuzimela hepatitis

I-autoimmune hepatitis kukudumba kwesibindi. Kwenzeka xa iiseli zokhuselo lomzimba zenze impazamo kwiiseli eziqhelekileyo zesibindi zabahlaseli eziyingozi kwaye zibahlasele.

Olu hlobo lwe-hepatitis sisifo sokuzimela. Amajoni omzimba awunako ukwahlula phakathi kwethishu yomzimba esempilweni kunye nezinto ezinobungozi, izinto zangaphandle.Isiphumo kukukhusela komzimba okutshabalalisa izicubu zomzimba eziqhelekileyo.

Ukuvuvukala kwesibindi, okanye i-hepatitis, kunokwenzeka kunye nezinye izifo ezizimele. Oku kubandakanya:

• Isifo samangcwaba
• Ukudumba kwesifo
• Irheumatoid Arthritis
• Iscleroderma
• Isifo seSjögren
• Inkqubo ye lupus erythematosus
• Idlala lengqula
• Uhlobo lwe-1 yeswekile
• Ukudumba okwenziwa sisilonda sikabhobhosi

I-autoimmune hepatitis ingenzeka kumalungu osapho abantu abanezifo ezizimele. Kunokubakho unobangela wemfuza.

Esi sifo sixhaphake kakhulu kumantombazana nakwabasetyhini abancinci.

Iimpawu zingabandakanya:

• Ukudinwa
• Ukungakhululeki ngokubanzi, ukungonwabi, okanye ukuziva ungonwabanga (malaise)
• Ukurhawuzelela
• Ukuphelelwa ngumdla wokutya
• Isihlunu okanye ukugabha
• Intlungu edibeneyo
• Ipeyinti okanye izitulo ezinombala wodongwe
• Umchamo omnyama
• Ukuqaqanjelwa sisisu

Ukungabikho exesheni (amenorrhea) kunokuba luphawu.

Uvavanyo lwe-hepatitis yokuzimela komzimba lubandakanya ezi mvavanyo zegazi zilandelayo:

• Uvavanyo lomsebenzi wesibindi
• I-anti-isibindi sezintso ze-microsome type 1 antibody (anti LKM-1)
• Unyango lwenyukliya (i-ANA)
• Ulwahlulo lwe-muscle anti-smooth (SMA)
• Isirum IgG
• I-biopsy yesibindi ukukhangela i-hepatitis yexesha elide

Unokufuna i-prednisone okanye amanye amayeza e-corticosteroid ukunceda ukunciphisa ukudumba. I-Azathioprine kunye ne-6-mercaptopurine ziziyobisi ezisetyenziselwa ukunyanga ezinye iingxaki zomzimba. Baye baboniswa benceda abantu abane-autoimmune hepatitis, ngokunjalo.

Abanye abantu banokufuna ukufakelwa kwesibindi.

Iziphumo ziyahluka. Amayeza e-Corticosteroid anokucothisa inkqubela phambili yesi sifo. Nangona kunjalo, i-autoimmune hepatitis inokuqhubela phambili kwi-cirrhosis. Oku kuya kufuna ukufakelwa kwesibindi.

Iingxaki zinokubandakanya:

• Isibindi
• Iziphumo ebezingalindelekanga ezivela kwii-steroids kunye namanye amayeza
• I-hepatocellular carcinoma
• Ukungaphumeleli kwesibindi

Tsalela umnxeba ukhathalelo lwempilo ukuba ubona iimpawu zesifo sokuqina kwesifo somzimba.

I-autoimmune hepatitis ayinakuthintelwa kwiimeko ezininzi. Ukwazi iimeko ezinobungozi kunokukunceda ukuba usibone kwaye usinyange esi sifo kwangoko.

Lupoid hepatitis

• Inkqubo yokwetyisa
• Inkqubo yokugaya ukutya

ICzaja AJ. Ngokuzimela hepatitis. Ku: UFeldman M, uFriedman LS, uBrandt LJ, ii-eds. Sleisenger kunye neFordtran's Gastrointestinal and Liver Disease. Ngomhla we-10. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 90.

IPawlotsky JM. I-hepatitis yentsholongwane engapheliyo. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Umhla wama-25. IPhiladelphia, PA: Elsevier Saunders; I-2016: isahluko 149.