Unyango lweHormone lomhlaza webele

Unyango lweHormone lomhlaza wedlala lobuchopho lisebenzisa utyando okanye iziyobisi ukuthoba amanqanaba ehomoni yesini emzimbeni womntu. Oku kunceda ukucothisa ukukhula komhlaza wedlala lobudoda.

I-Androgens ziihomoni zesini zesini. I-testosterone lolunye uhlobo oluphambili lwe-androgen. Uninzi lwe testosterone lwenziwa ngamasende. Amadlala adrenal nawo avelisa isixa esincinci.

I-Androgens ibangela ukuba iiseli zomhlaza wedlala lendlala zikhule. Unyango lweHormone lomhlaza wedlala lobuchwephesha luyehlisa izinga le-androgens emzimbeni. Inokwenza oku ngo:

• Ukumisa amasende ekwenzeni i-androgens usebenzisa utyando okanye amayeza
• Ukuthintela isenzo se-androgens emzimbeni
• Ukuyekisa umzimba ekwenzeni i-androgens

Unyango lweHormone phantse aluzange lusetyenziselwe abantu abaneSigaba se-I okanye seCandelo II somhlaza webele.

Isetyenziselwa ikakhulu:

• Umhlaza ophucukileyo osasazeke ngaphaya kweprotrate gland
• Umhlaza ongaphumelelanga ukuphendula kutyando okanye kwimitha
• Umhlaza obuye wabuya

Inokusetyenziswa kwakhona:

• Phambi kwemitha okanye utyando ukunceda ukuncipha amathumba
• Kunye nonyango lwemitha kumhlaza ekunokwenzeka ukuba uphinde

Olona nyango luxhaphakileyo kukuthatha iziyobisi ezinciphisa inani le-androgens eyenziwe ngamatyhalarha. Babizwa ngokuba yi-luteinizing hormone-releasing hormone (LH-RH) analogs (inaliti) kunye ne-anti-androgens (iipilisi zomlomo). La machiza asezantsi amanqanaba e-androgen kunye nokuhlinzwa. Olu hlobo lonyango ngamanye amaxesha lubizwa ngokuba yi "chemical castration."

Amadoda afumana unyango lwe-androgen lokuncitshiswa kufuneka abe noviwo lokulandela kunye nogqirha omisela amayeza:

• Kwiinyanga ezi-3 ukuya kwezi-6 emva kokuqala unyango
• Ubuncinane kanye ngonyaka, ukujonga uxinzelelo lwegazi kunye nokwenza iswekile yegazi (iswekile) kunye neemvavanyo ze-cholesterol
• Ukufumana uvavanyo lwegazi lwePSA lokujonga ukuba unyango lusebenza njani

Iimpawu ze-LH-RH zinikezelwa ngokudutyulwa okanye njengokufakwa kancinci phantsi kolusu. Banikwa naphi na ukusuka kanye ngenyanga ukuya kube kanye ngonyaka. La machiza abandakanya:

• Leuprolide (iLupron, Eligard)
• IGoserelin (iZoladex)
• I-Triptorelin (iTrelstar)
• Imbali (Vantas)

Elinye iyeza, i-degarelix (Firmagon), ngumchasi we-LH-RH. Iyanciphisa amanqanaba e-androgen ngokukhawuleza kwaye ineempembelelo ezimbalwa. Isetyenziswe kumadoda anomhlaza ophakamileyo.

Abanye oogqirha bancomela ukuyeka kunye nokuqala kwakhona unyango (unyango lwangaphakathi). Le ndlela ibonakala inceda ukunciphisa iziphumo ebezingalindelekanga zonyango lwehomoni. Nangona kunjalo, akucaci ukuba unyango lwangaphakathi luyasebenza kunye nonyango oluqhubekayo. Olunye uphononongo lubonisa ukuba unyango oluqhubekayo lusebenza ngakumbi okanye ukuba unyango lwangaphakathi kufuneka lusetyenziselwe kuphela iintlobo ezikhethiweyo zomhlaza wesibeletho.

Utyando lokususa amasende (ukuthena) luyekisa imveliso ye-androgens eninzi emzimbeni. Oku kuyehla okanye kumise umhlaza webala le-Prostate ekukhuleni. Ngelixa isebenza, uninzi lwamadoda alukhethi olu khetho.

Amanye amachiza asebenza ngokuthintela ifuthe le-androgen kwiiseli zomhlaza wedlala lobudoda. Babizwa ngokuba yi-anti-androgens. La machiza athathwa njengeepilisi. Zihlala zisetyenziswa xa amayeza okunciphisa amanqanaba e-androgen engasasebenzi ngokunjalo.

I-anti-androgens ibandakanya:

• IFlutamide (i-Eulexin)
• Enzalutamide (Xtandi)
• Iabiraterone (iZytiga)
• Bicalutamide (Casodex)
• I-Nilutamide (i-Nilandron)

I-Androgens inokuveliswa kwezinye iindawo zomzimba, ezinje ngamadlala eadrenal. Ezinye iiseli zomhlaza wedlala lobuchwephesha zinokwenza i-androgens. Amachiza amathathu anceda ukumisa umzimba ekwenzeni i-androgens kwizicubu ngaphandle kwamatyhalarha.

Amayeza amabini, i-ketoconazole (Nizoral) kunye ne-aminoglutethimide (Cytradren), anyanga ezinye izifo kodwa ngamanye amaxesha asetyenziselwa ukunyanga umhlaza wedlala lobudoda. Okwesithathu, i-abiraterone (Zytiga) inyanga umhlaza weprostate osasazeke wasiwa kwezinye iindawo emzimbeni.

Ixesha elingaphezulu, umhlaza wedlala lobudoda uyaxhathisa kunyango lwehomoni. Oku kuthetha ukuba umhlaza ufuna kuphela amanqanaba asezantsi e-androgen ukuze akhule. Xa oku kusenzeka, amachiza ongezelelweyo okanye olunye unyango lunokongezwa.

I-Androgens ineziphumo kuwo wonke umzimba. Ke, unyango olwehlisa la mahomoni kunokubangela iziphumo ebezingalindelekanga ezininzi ezahlukeneyo. Okukhona uwathatha la mayeza, kokukhona kunokwenzeka ukuba ube neziphumo ebezingalindelekanga.

Ziquka:

• Ingxaki yokufumana ulungiso kunye nokungabi namdla kwisini
• Ukuncipha kwamasende kunye nepipi
• Kushushu
• Amathambo abuthathaka okanye aphukileyo
• Incinci, izihlunu ezibuthathaka
• Utshintsho kumanqatha egazi, njenge-cholesterol
• Utshintsho kwiswekile yegazi
• Ukutyeba kwakho
• Ukuhamba kweemvakalelo
• Ukudinwa
• Ukukhula kwethishu yamabele, ukuthamba kwebele

Unyango lokuthintela i-Androgen lunokunyusa umngcipheko wesifo seswekile kunye nesifo sentliziyo.

Ukuthatha isigqibo kunyango lwehomoni kumhlaza wedlala lesibeleko kunokuba sisigqibo esintsonkothileyo kwaye nokuba kunzima. Uhlobo lonyango lunokuxhomekeka:

• Umngcipheko womhlaza ubuya
• Uhambele phambili kangakanani umhlaza wakho
• Nokuba ezinye iindlela zonyango ziyekile ukusebenza
• Nokuba umhlaza usasazekile

Ukuthetha nomboneleli wakho malunga nokhetho lwakho kunye nezibonelelo kunye nomngcipheko kunyango ngalunye kunokukunceda wenze esona sigqibo silungileyo kuwe.

Unyango lwe-Androgen yokuthintela; ADT; Unyango lokucinezelwa kweAndrogen; Ukudibanisa i-androgen blockade; Orchiectomy - umhlaza webele; Ukuhanjiswa - umhlaza wedlala lobudoda

• I-anatomy yokuzala eyindoda

Umbutho waseMelika woMhlaza. Unyango lweHormone lomhlaza webele. www.cancer.org/cancer/prostate-cancer/treating/hormone-therapy.html. Ukuhlaziywa ngoDisemba 18, 2019. Kufumaneka ngo-Matshi 24, 2020.

Kwiwebhusayithi yeZiko loMhlaza weSizwe. Unyango lweHormone lomhlaza webele. www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet. Ukuhlaziywa ngoFebruwari 28, 2019. Kufikeleleke ngoDisemba 17, 2019.

Kwiwebhusayithi yeZiko loMhlaza weSizwe. Unyango lwe-Prostate cancer (PDQ) -uhlobo lobungcali kwezempilo. www.cancer.gov/types/prostate/hp/prostate-kunyanga-pdq. Ukuhlaziywa ngoJanuwari 29, 2020. Ifikeleleke ngo-Matshi 24, 2020.

Iwebhusayithi yeNethiwekhi yeCancer epheleleyo yoMhlaza. Izikhokelo ze-NCCN zokuziqhelanisa neklinikhi kwi-oncology (izikhokelo ze-NCCN): umhlaza webele Inguqulelo 1.2020. www.nccn.org/professionals/physician_gls/pdf/prostate.pdf. Ukuhlaziywa ngo-Matshi 16, 2020. Ifikeleleke ngo-Matshi 24, 2020.

Unyango lwe-Eggener S. Hormonal yomhlaza wedlala lobudoda. Ku: UPartin AW, uDmochowski RR, uKavoussi LR, uPeter CA, ii-eds. UCampbell-Walsh Urology. Umhla we-12. IPhiladelphia, PA: Elsevier; 2021: isahluko 161.

• Umhlaza wedlala lobudoda