Ukusweleka kwe-fibrinogen

Ukusilela kwe-fibrinogen ye-Congenital yinto enqabileyo kakhulu, enesifo sokuphazamiseka kwegazi apho igazi lingagugi ngokwesiqhelo. Ichaphazela iprotein ebizwa ngokuba yi-fibrinogen. Le protein iyafuneka ukuze igazi lijiye.

Esi sifo sibangelwa yimfuza engaqhelekanga. I-Fibrinogen iyachaphazeleka kuxhomekeke kwindlela eziza ngayo izakhi zofuzo:

• Xa ufuzo olungaqhelekanga ludluliselwa kubazali bobabini, umntu uya kuba nokusilela ngokupheleleyo kwe-fibrinogen (afibrinogenemia).
• Xa uhlobo olungaqhelekanga ludlula lusuka kumzali omnye, umntu uya kuba nenqanaba elincitshisiweyo le-fibrinogen (hypofibrinogenemia) okanye ingxaki yomsebenzi we-fibrinogen (i-dysfibrinogenemia). Ngamanye amaxesha, ezi ngxaki zimbini ze-fibrinogen zinokwenzeka kumntu ofanayo.

Abantu abanokungabikho ngokupheleleyo kwe-fibrinogen banokuba nazo naziphi na iimpawu zokuphuma kwegazi:

• Ukukrala ngokulula
• Ukopha kwimvaba emva kokuba uzelwe
• Ukopha kwiimbumba ezinamaqhekeza
• Ukopha kwingqondo (kunqabile kakhulu)
• Ukopha kumalungu
• Ukopha kakhulu emva kokonzakala okanye uqhaqho
• Ukuphuma kweempumlo okungayeki ngokulula

Abantu abaneqondo elincitshisiweyo le-fibrinogen bopha kancinci kwaye ukopha akukho kubi kangako. Abo banengxaki nomsebenzi we-fibrinogen bahlala bengenazo iimpawu.

Ukuba umboneleli wakho wezempilo ukrokrela le ngxaki, uya kuba novavanyo lwelebhu ukuqinisekisa uhlobo kunye nobukhulu besifo.

Uvavanyo lubandakanya:

• Ixesha lokopha
• Uvavanyo lwe-Fibrinogen kunye nexesha lokubuyisela kwakhona ukujonga inqanaba le-fibrin kunye nomgangatho
• Ixesha lecandelo le-thromboplastin (PTT)
• Ixesha leprothrombin (PT)
• Ixesha leThrombin

Olu nyango lulandelayo lunokusetyenziselwa ukopha iziqendu okanye ukulungiselela utyando:

• I-Cryoprecipitate (imveliso yegazi equkethe i-fibrinogen egxile kunye nezinye izinto ezijiyileyo)
• Ifibrinogen (iRiaSTAP)
• Iplasma (ulwelo olunezixa zegazi olunezinto ezijiyisayo)

Abantu abakule meko kufuneka bafumane isitofu sokugonya i-hepatitis B. Ukuba notofelo-gazi oluninzi kuphakamisa umngcipheko wakho wokufumana i-hepatitis.

Ukopha kakhulu kuqhelekile ngale meko. Ezi ziqendu zinokuba nzima, okanye zibulale. Ukopha ebuchotsheni ngoyena nobangela wokufa kwabantu abakule ngxaki.

Iingxaki zinokubandakanya:

• Amahlwili egazi ngonyango
• Ukuphuhliswa kwee-antibodies (inhibitors) kwi-fibrinogen ngonyango
• Ukopha emathunjini
• Ukuphuma kwesisu
• Ukuqhekeka kwepeni
• Ukunyanga okucothayo kwamanxeba

Fowunela umboneleli wakho okanye ufumane ukhathalelo olungxamisekileyo ukuba wopha kakhulu.

Xelela ugqirha wakho wotyando ngaphambi kokuba wenze utyando ukuba uyazi okanye ukrokrela ukuba unengxaki yokopha.

Le yimeko yelifa. Akukho sithintelo saziwayo.

Afibrinogenemia; Hypofibrinogenemia; Idysfibrinogenemia; Ukusilela kwento

UGailani D, Wheeler AP, Neff AT. Ukunqongophala kwezinto ezinqabileyo. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ii-eds. I-Hematology: Imigaqo esisiseko kunye nokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier; I-2018: isahluko 137.

Ragni MV. Ukuphazamiseka kwento eyophayo: ukungabikho kwento ekunqandeni. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Umhla wama-25. IPhiladelphia, PA: Elsevier Saunders; Ngo-2016: isahluko 174.