Ichoriocarcinoma

I-Choriocarcinoma ngumhlaza okhula ngokukhawuleza owenzeka kwisibeleko sowasetyhini (isibeleko). Iiseli ezingaqhelekanga ziqala kwiithishu ezihlala njengeplacenta. Eli lilungu elivela ngexesha lokukhulelwa ukondla umntwana ongekazalwa.

I-Choriocarcinoma luhlobo lwesifo se-trophoblastic.

I-Choriocarcinoma ngumhlaza onqabileyo owenzeka njengokukhulelwa okungaqhelekanga. Usana lunakho okanye alunakukhula kolu hlobo lokukhulelwa.

Umhlaza ukwenzeka kwakhona emva kokukhulelwa okuqhelekileyo. Kodwa oko kwenzeka rhoqo ngemolekyuli epheleleyo yehydatidiform. Oku kukukhula okuvela ngaphakathi esibelekweni ekuqaleni kokukhulelwa. Izicubu ezingaqhelekanga ezivela kwimolekyuli zinokuqhubeka nokukhula nasemva kokuzama ukususwa, kwaye zinokuba ngumhlaza. Phantse isiqingatha sabo bonke abafazi abane-choriocarcinoma babenemole ye-hydatidiform, okanye ukukhulelwa kwe-molar.

I-Choriocarcinomas nayo inokwenzeka emva kokukhulelwa kwangoko okungaqhubekiyo (ukuphuma kwesisu). Ziyakwenzeka kwakhona emva kokukhulelwa kwe-ectopic okanye i-tumor yesini.

Iimpawu ezinokubakho kukuphaphaza gwenxa okanye ngokungaqhelekanga kwilungu lobufazi kumfazi osandula ukuba ne-hydatidiform mole okanye ukukhulelwa.

Ezinye iimpawu zingabandakanya:

• Ukopha ngokungaqhelekanga kwilungu lobufazi
• Ubuhlungu, obunokudibaniswa nokuphuma kwegazi, okanye ngenxa yokwandiswa kwama-ovari okuhlala kwenzeka nge-choriocarcinoma

Uvavanyo lokukhulelwa luya kuba ntle, nokuba awukhulelwe. Inqanaba lokukhulelwa lehomoni (HCG) liya kuba phezulu.

Uvavanyo lwe-pelvic lunokufumana isibeleko esandisiweyo kunye nee-ovari.

Uvavanyo lwegazi olunokwenziwa lunokubandakanya:

• Ubungakanani beserum HCG
• Gcwalisa ubalo lwegazi
• Uvavanyo lwezintso
• Uvavanyo lomsebenzi wesibindi

Ukulinganisa iimvavanyo ezinokwenziwa kubandakanya:

• Ukuskena i-CT
• IMRI
• Iipelvic ultrasound
• I-x-ray yesifuba

Kufuneka ujongwe ngononophelo emva kwemolekyuli ye-hydatidiform okanye emva kokukhulelwa. Ukuchongwa kwangoko kwe-choriocarcinoma kunokuphucula iziphumo.

Emva kokuba ufunyanisiwe, kuya kwenziwa imbali ngononophelo kunye novavanyo ukuqinisekisa ukuba umhlaza awunwenwanga kwamanye amalungu. I-Chemotherapy lolona hlobo lonyango luphambili.

I-Hysterectomy ukususa isibeleko kunye nonyango lwemitha akufuneki.

Ungaluphelisa uxinzelelo lokugula ngokujoyina iqela lokuxhasa umhlaza. Ukwabelana nabanye abanamava afanayo kunye neengxaki kunokukunceda ungaziva ulilolo.

Uninzi lwabasetyhini abanomdlavuza ongazange usasazeke bayanyangeka kwaye baya kuba nakho ukuba nabantwana. I-choriocarcinoma inokubuya emva kweenyanga ezimbalwa ukuya kwiminyaka emi-3 emva konyango.

Imeko kunzima ukunyanga ukuba umhlaza usasazekile kwaye kwenzeka enye okanye ezingaphezulu kwezi zilandelayo:

• Izifo zisasazeka kwisibindi okanye kwingqondo
• Inqanaba lokukhulelwa (HCG) liphezulu kune-40,000 mIU / mL xa unyango luqala
• Umhlaza ubuya emva kokufumana ichemotherapy
• Iimpawu okanye ukukhulelwa kwenzeka ngaphezulu kweenyanga ezi-4 ngaphambi kokuba unyango luqale
• I-Choriocarcinoma yenzeka emva kokukhulelwa okwakhokelela ekuzalweni komntwana

Abasetyhini abaninzi (malunga ne-70%) abanembono engalunganga ekuqaleni baya kuxolelo (imeko engenasifo).

Biza ukuqeshwa kunye nomboneleli wakho wezempilo ukuba uhlakulela iimpawu kwisithuba sonyaka omnye emva kwe-hydatidiform mole okanye ukukhulelwa.

Chorioblastoma; Ithumba elibi; Chorioepithelioma; Isifo esibuhlungu sokukhula kwesisu; Umhlaza - choriocarcinoma

Kwiwebhusayithi yeZiko loMhlaza weSizwe. Unyango lwesifo se-Gestational trophoblastic (PDQ) -uhlobo lobungcali kwezempilo. www.cancer.gov/cancertopics/pdq/treatment/gestationaltrophoblastic/HealthProfessional. Ukuhlaziywa ngoDisemba 17, 2019. Ifikeleleke ngoJuni 25, 2020.

USalani R, uBixel K, uCopeland LJ. Izifo ezinobungozi kunye nokukhulelwa. Ku: Landon MB, Galan HL, Jauniaux ERM, et al, ii-eds. Ii-Obstetrics zikaGabbe: Ukukhulelwa okuqhelekileyo kunye neengxaki. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2021: isahluko 55.