Iadrenocortical carcinoma

I-Adrenocortical carcinoma (ACC) ngumhlaza wedlala yamadlala. Amadlala ngamadlala amabini amile okonxantathu. Idlala elinye libekwe ngaphezulu kwentso nganye.

I-ACC ixhaphake kakhulu kubantwana abangaphantsi kweminyaka emi-5 ubudala kunye nabantu abadala abakwiminyaka yama-40 nama-50.

Imeko inokunxulunyaniswa nesifo somhlaza esidluliswa kwiintsapho (ezizuzwe njengelifa). Amadoda nabasetyhini banokuliphucula eli thumba.

I-ACC inokuvelisa iihormoni cortisol, aldosterone, estrogen, okanye testosterone, kunye nezinye iihormone. Kwabasetyhini ithumba lihlala likhupha ezi hormone, ezinokukhokelela kwiimpawu zesilisa.

I-ACC inqabile. Unobangela awaziwa.

Iimpawu zokunyuka kwe-cortisol okanye ezinye i-adrenal gland hormone zinokubandakanya:

• Amanqatha, i-hump ejikelezileyo ephezulu ngasemva nje entanyeni (i-buffalo hump)
• Ubuso obujikeleziweyo, obujikelezileyo obunezihlathi (ubuso benyanga)
• Ukutyeba kakhulu
• Ukukhula okumileyo (ubude obufutshane)
• I-Virilization -ukubonakala kweempawu zamadoda, kubandakanya ukwanda kweenwele zomzimba (ngakumbi ebusweni), iinwele ze-pubic, i-acne, ukunyanzeliswa kwelizwi, kunye ne-clitoris eyandisiweyo (abantu ababhinqileyo)

Iimpawu zokunyuka kwe-aldosterone ziyafana neempawu ze-potassium ephantsi, kwaye zibandakanya:

• Iintlanzi zemisipha
• Ubuthathaka
• Intlungu esiswini

Umboneleli wezempilo uya kwenza uvavanyo lomzimba kwaye abuze malunga neempawu zakho.

Uvavanyo lwegazi luya kwenziwa ukujonga amanqanaba ehomoni:

• Inqanaba le-ACTH liya kuba sezantsi.
• Inqanaba le-Aldosterone liya kuba phezulu.
• Inqanaba leCortisol liya kuba phezulu.
• Inqanaba lePotassium liya kuba sezantsi.
• Amadoda okanye amabhinqa amahomoni anokuphakama ngokungaqhelekanga.

Ukujonga iimvavanyo zesisu kunokubandakanya:

• I-Ultrasound
• Ukuskena i-CT
• IMRI
• Ukuskena iPET

Unyango olusisiseko lutyando lokususa ithumba. I-ACC ayinakuphucula nge-chemotherapy. Amayeza anokunikwa ukunciphisa imveliso ye-cortisol, ebangela uninzi lweempawu.

Isiphumo sixhomekeke ekubeni uxilongo lwenziwe kwangoko kangakanani kwaye nokuba isisu sisasazekile (sisasazekile). Izidumbu ezisasazekileyo zihlala zikhokelela ekufeni kwisithuba seminyaka emi-1 ukuya kwemithathu.

I-tumor ingasasazeka kwisibindi, ithambo, imiphunga, okanye ezinye iindawo.

Tsalela umnikezeli wakho ukuba wena okanye umntwana wakho uneempawu ze-ACC, i-Cushing syndrome, okanye ukusilela ukukhula.

Ithumba - adrenal; I-ACC-adrenal

• Amadlala endocrine
• I-Adrenal metastases-CT ukuskena
• Ukudumba kweAdrenal - CT

I-Allolio B, iFassnacht M.I-carrenoma ye-Adrenocortical. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, ii-eds. Endocrinology: Abantu abadala kunye nabantwana. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; Ngo-2016: isahluko 107.

Kwiwebhusayithi yeZiko loMhlaza weSizwe. Unyango lwe-adrenocortical carcinoma (yabantu abadala) (PDQ) -uhlobo lobungcali kwezempilo. www.cancer.gov/types/adrenocortical/hp/adrenocortical- unyango-pdq. Ukuhlaziywa ngoNovemba 13, 2019. Ifikeleleke ngo-Okthobha 14, 2020.