Uvavanyo lwegazi lwePyruvate kinase

Uvavanyo lwe-pyruvate kinase lilinganisa inqanaba le-enzyme pyruvate kinase egazini.

IPyruvate kinase yi-enzyme efumaneka kwiiseli ezibomvu zegazi. Inceda ukutshintsha iswekile egazini (iswekile) iye kumandla xa amanqanaba eoksijini ephantsi.

Isampulu yegazi iyafuneka. Kwilabhoratri, iiseli ezimhlophe zegazi ziyasuswa kwisampulu yegazi kuba zinokutshintsha iziphumo zovavanyo. Inqanaba lepyruvate kinase emva koko lilinganisiwe.

Akukho lungiselelo lukhethekileyo luyimfuneko.

Ukuba umntwana wakho unolu vavanyo, kunokunceda ekuchazeni ukuba uvavanyo luza kuziva njani kwaye lubonise nodoli. Chaza isizathu sovavanyo. Ukwazi ukuba "kanjani kwaye kutheni" kunokunciphisa uxinzelelo lomntwana wakho.

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye baziva behlaba okanye behlaba kuphela. Emva koko, kunokubakho ukubetha okanye ukukrala kancinci. Oku kuya kuhamba kungekudala.

Olu vavanyo lwenziwa ukufumana inqanaba elisezantsi ngokungaqhelekanga le-pyruvate kinase. Ngaphandle kwale enzyme, iiseli ezibomvu zegazi zihla ngokukhawuleza kunesiqhelo. Oku kubizwa ngokuba yi-hemolytic anemia.

Olu vavanyo lunceda ukufumanisa ukusilela kwe-pyruvate kinase (PKD).

Iziphumo ziyahluka ngokuxhomekeka kwindlela yovavanyo esetyenzisiweyo. Ngokubanzi, ixabiso eliqhelekileyo liiyunithi ezili-179 ± 16 nge-100 ml yeeseli ezibomvu zegazi.

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye ukuvavanya iisampulu ezahlukeneyo. Thetha nomboneleli wakho wezempilo malunga nentsingiselo yeziphumo zakho zovavanyo.

Inqanaba eliphantsi le-pyruvate kinase iqinisekisa i-PKD.

Akukho mngcipheko ubandakanyekileyo ekuthatheni igazi lakho. Imithambo kunye nemithambo iyahluka ngobukhulu ukusuka komnye umntu ukuya komnye nakwelinye icala lomzimba liye kwelinye. Ukuthatha igazi kwabanye abantu kunokuba nzima ngakumbi kunabanye.

Eminye imingcipheko enxulumene nokutsalwa kwegazi incinci, kodwa inokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• Ukugqobhoza okuninzi ukufumana imithambo
• I-Hematoma (igazi elakhiweyo phantsi kolusu)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

I-Elghetany MT, i-Schexneider KI, i-Banki K.Ukuphazamiseka kwe-Erythrocytic. Ku: McPherson RA, Pincus MR, ii-eds. Ukuchongwa kweKlinikhi kaHenry kunye noLawulo ngeendlela zeLebhu. Umhla we-23. ISt Louis, MO: Elsevier; Ngo-2017: isahluko 32.

IGallagher PG. I-hemolytic anemias: inwebu ebomvu yeseli kunye neziphene ze-metabolic. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahl. 152.

UPapachristodoulou D. Amandla emetabolism. Ku: Naish J, Inkundla yaseSyndercombe D, ii-eds. IiSayensi zezoNyango. Ngomhla wesi-3. IPhiladelphia, PA: Elsevier; I-2019: isahluko 3.

van Solinge WW, van Wijk R. I-Enzymes yeseli ebomvu yegazi. Ku: Rifai N, ed. I-Tietz yeNcwadi yeKlinikhi yeKhemistry kunye neDiagnostics yeMolekyuli. Umhla wesi-6. IPhiladelphia, PA: Elsevier; 2018: isahluko 30.