Uvavanyo lweprotein ye-Bence-Jones

Olu vavanyo lilinganisa inqanaba leeproteni ezingaqhelekanga ezibizwa ngokuba zii-Bence-Jones protein kumchamo.

Isampulu yomchamo ococekileyo iyafuneka. Indlela yokubambisa ecocekileyo isetyenziselwa ukunqanda iintsholongwane ezivela kwilungu lobudoda okanye kwilungu lobufazi ekungeneni kwisampulu yomchamo. Ukuqokelela umchamo wakho, umboneleli wezempilo unokukunika ikiti yokubambisa ecocekileyo ekhethekileyo enesisombululo sokucoca kunye nokusula okungenazintsholongwane. Landela imiyalelo ngokuchanekileyo ukuze iziphumo zichaneke.

Isampulu ithunyelwa elebhu. Apho, enye yeendlela ezininzi isetyenziselwa ukufumanisa iiproteni zeBence-Jones. Enye indlela, ebizwa ngokuba yi-immunoelectrophoresis, yeyona ichanekileyo.

Uvavanyo lubandakanya kuphela ukuchama okuqhelekileyo, kwaye akukho kungonwabi.

Iiproteni zeBence-Jones ziyinxalenye ye-antibodies eziqhelekileyo ezibizwa ngokuba ngamakhonkco amancinci. Ezi proteni aziqhelekanga kumchamo. Ngamanye amaxesha, xa umzimba wakho usenza ii-antibodies ezininzi kakhulu, inqanaba lamakhonkco okukhanya nawo ayenyuka. Iiproteni zeBence-Jones zincinci ngokwaneleyo ukuba zingacocwa zizintso. Iiproteni emva koko zichithele kumchamo.

Umboneleli wakho unoku-odola olu vavanyo:

• Ukuchonga iimeko ezikhokelela kwiprotheyini kumchamo
• Ukuba uneeproteni ezininzi kumchamo wakho
• Ukuba unempawu zomhlaza wegazi obizwa ngokuba yi-myeloma emininzi

Iziphumo eziqhelekileyo zithetha ukuba azikho iiprotein zeBence-Jones ezifumaneka kumchamo wakho.

Iiproteni zeBence-Jones azifane zifumaneke kumchamo. Ukuba kunjalo, ihlala inxulunyaniswa ne-myeloma eninzi.

Iziphumo ezingaqhelekanga zinokubangelwa:

• Ukwakhiwa okungaqhelekanga kweeproteni kwizicubu kunye namalungu (amyloidosis)
• Umhlaza wegazi obizwa ngokuba yi-lymphocytic leukemia
• Inkqubo yesifo somhlaza (lymphoma)
• I-buildup egazini leprotein ebizwa ngokuba yi-M-protein (monoclonal gammopathy yokubaluleka okungaziwayo; MGUS)
• Ukusilela okungapheliyo kwezintso

Akukho bungozi kolu vavanyo.

Imixokelelwane yokukhanya ye-Immunoglobulin - umchamo; Umchamo Bence-Jones protein

• Inkqubo yomchamo wamadoda

IChernecky CC, iBerger BJ. Iiproteni electrophoresis - umchamo. Ku: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 920-922.

URiley RS, uMcPherson RA. Uvavanyo olusisiseko lomchamo. Ku: McPherson RA, Pincus MR, ii-eds. Ukuchongwa kweKlinikhi kaHenry kunye noLawulo ngeendlela zeLebhu. Umhla we-23. ISt Louis, MO: Elsevier; Ngo-2017: isahluko 28.

URajkumar SV, iDispenzieri A. Multiple myeloma kunye nokuphazamiseka okunxulumene noko. Ku: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, ii-eds. I-Oncology yeklinikhi yase-Abeloff. Umhla wesi-6. IPhiladelphia, PA: Elsevier; 2020: isahl. 101.