Uvavanyo lweTensilon

Uvavanyo lweTensilon yindlela yokunceda ukufumanisa isifo se-myasthenia gravis.

Iyeza elibizwa ngokuba yiTensilon (ekwabizwa ngokuba yi-edrophonium) okanye iyeza ledummy (i-placebo engasebenziyo) linikwa ngexesha lovavanyo. Umboneleli wezempilo unika amayeza ngemithambo yakho (ngaphakathi, nge-IV). Unokunikwa iyeza elibizwa ngokuba yiatropine ngaphambi kokufumana iTensilon ukuze ungazi ukuba ufumana amayeza.

Uya kucelwa ukuba wenze ezinye iintshukumo zemisipha ngokuphindaphindiweyo, njengokuwela kunye nokunganqamli imilenze yakho okanye ukuvuka kwindawo yokuhlala esihlalweni. Umboneleli uya kujonga ukuba i-Tensilon iphucula amandla akho emisipha. Ukuba unobuthathaka kwiliso okanye kwimisipha yobuso, umphumo weTensilon koku uya kujongwa.

Uvavanyo lunokuphindwa kwaye unokuba nolunye uvavanyo lweTensilon ukunceda uchaze umahluko phakathi kwe-myasthenia gravis kunye nezinye iimeko.

Akukho lungiselelo lukhethekileyo ludla ngokufuneka. Landela imiyalelo yomboneleli wakho malunga nendlela yokulungiselela.

Uyakuva ukuhlaba okubukhali njengoko inaliti ye-IV ifakiwe. Iyeza linokubangela ukuziva kwesisu okanye imvakalelo encinci yokunyuka kwentliziyo, ngakumbi ukuba i-atropine ayinikiwanga kuqala.

Uvavanyo luyanceda:

• Ukuchonga i-myasthenia gravis
• Xelela umahluko phakathi kwe-myasthenia gravis kunye nezinye iimeko ezifanayo zobuchopho kunye neenkqubo zovalo
• Ukubeka iliso kunyango ngamachiza e-anticholinesterase yomlomo

Uvavanyo luyakwenziwa kwakhona kwiimeko ezinje ngeLambert-Eaton syndrome. Esi sisifo apho unxibelelwano oluphosakeleyo phakathi kwemithambo-luvo kunye nezihlunu lukhokelela kubuthathaka bemisipha.

Kubantu abaninzi abane-myasthenia gravis, ubuthathaka bemisipha buya kuphucula kanye emva kokufumana iTensilon. Ukuphuculwa kuhlala kuphela imizuzu embalwa. Kwezinye iintlobo ze-myasthenia, iTensilon ingenza ubuthathaka bube nzima.

Xa esi sifo siba mandundu ngokwaneleyo ukuba sidinga unyango (ingxaki ye-myasthenic), kukho ukuphucuka okufutshane kumandla emisipha.

Xa kukho i-anticholinesterase (ingxaki ye-cholinergic), i-Tensilon iya kwenza ukuba umntu abe buthathaka ngakumbi.

Iyeza elisetyenzisiweyo ngexesha lovavanyo linokubangela iziphumo ebezingalindelekanga, kubandakanya ukuphelelwa ngamandla okanye ukusilela ukuphefumla. Kungenxa yoko le nto uvavanyo lwenziwa ngumboneleli kwindawo yezonyango.

Uvavanyo lwe-Myasthenia gravis-tensilon

• Ukudinwa kwezihlunu

IChernecky CC, iBerger BJ. Uvavanyo lweTensilon-isifo. Ku: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 1057-1058.

ISanders DB, iGuptill JT. Ukuphazamiseka kokuhanjiswa kwe-neuromuscular. Ku: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, ii-eds. I-Neurology kaBradley kwiKlinikhi yokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier; Ngo-2016: isahluko 109.