Umbhali: Gregory Harris
Umhla Wokudalwa: 10 Utshazimpuzi 2021
Hlaziya Umhla: 18 Eyenkanga 2024
Anonim
Fibromyalgia, Serotonin & Stress | 5-HTP, Decreased Serotonin and Worsening Fibromyalgia Symptoms
Ividiyo: Fibromyalgia, Serotonin & Stress | 5-HTP, Decreased Serotonin and Worsening Fibromyalgia Symptoms

Umxholo

I-5-HTP (5-hydroxytryptophan) yikhemikhali eyenziwe ngemveliso yeprotein block block L-tryptophan. Ikwaveliswa ngentengiso ukusuka kwimbewu yesityalo saseAfrika esaziwa njenge Griffonia simplicifolia.

I-5-HTP isetyenziselwa ukuphazamiseka kokulala njengokungalali, uxinzelelo, unxunguphalo, kunye nezinye iimeko ezininzi, kodwa abukho ubungqina benzululwazi obuxhasa uninzi lwezi zinto zisetyenziswayo.

Amayeza endalo aVimba weDatha Ukusebenza kwexabiso ngokusekwe kubungqina besayensi ngokwala manqanaba alandelayo: Ukusebenza, ukusebenza ngokukuko, okunokwenzeka ukuba kusebenze, okungenzeka kungasebenzi, kunokwenzeka ukungasebenzi, ukungasebenzi, kunye nobungqina obungonelanga bokulinganisa.

Ukulinganiswa kokusebenza kwe I-5-HTP zezi zilandelayo:

Inokwenzeka ukuba isebenze ...

  • Uxinzelelo. Ukuthatha i-5-HTP ngomlomo kubonakala ngathi kuphucula iimpawu zoxinzelelo kwabanye abantu. Olunye uphando lweklinikhi lubonisa ukuba ukuthatha i-5-HTP ngomlomo kunokuba luncedo njengokuyalelwa ngamachiza athile okunyanga uxinzelelo ekuphuculeni iimpawu zoxinzelelo. Kwizifundo ezininzi, i-150-800 mg mihla le ye-5-HTP yathathwa. Kwezinye iimeko, amanani aphezulu asetyenzisiwe.

Kusenokwenzeka ukuba ayisebenzi ...

  • Isifo esiphantsi. Olunye uphando lubonisa ukuba ukunika i-5-HTP kwiintsana ezine-Down syndrome kunokuphucula imisipha kunye nomsebenzi. Olunye uphando lubonisa ukuba ayiphuculisi imisipha okanye ukukhula xa ithathwa kwasebusaneni kude kube yiminyaka eyi-3-4. Uphando lukwabonisa ukuba ukuthatha i-5-HTP kunye namayeza aqhelekileyo kuphucula ukukhula, izakhono zentlalo, okanye izakhono zolwimi.

Akukho bungqina baneleyo bokulinganisa ukusebenza ...

  • Uhlobo loxinzelelo oluphawulwe ziingcinga eziphindaphindayo kunye nokuziphatha okuphindaphindayo (ukuphazamiseka okungafunekiyo okanye i-OCD). Uphando lwakwangoko lubonisa ukuba ukuthatha i-5-HTP nge-anti-depressant drug fluoxetine (Prozac) kwiiveki ezili-12 kunokuphucula iimpawu ze-OCD.
  • Ukusetyenziswa kotywala kotywala. Uphando lwakwangoko lubonisa ukuba ukuthatha i-5-HTP kunye ne-D-phenylalanine kunye ne-L-glutamine kangangeentsuku ezingama-40 kunokunciphisa iimpawu zokurhoxa kotywala. Nangona kunjalo, ukuthatha i-5-HTP kunye ne-carbidopa yonke imihla unyaka omnye akubonakali kunceda abantu bayeke ukusela. Iziphumo ze-5-HTP kuphela yotywala ayicacanga.
  • Isifo se-Alzheimer. Uphando lwakwangoko lubonisa ukuba ukuthatha i-5-HTP ngomlomo akuncedi zimpawu zesifo se-Alzheimer.
  • Ixhala. Ubungqina kwiziphumo ze-5-HTP yoxinzelelo abucaci. Uphando lwakwangoko lubonisa ukuba ukuthatha i-25-150 mg ye-5-HTP ngomlomo yonke imihla kunye ne-carbidopa kubonakala kunciphisa iimpawu zoxinzelelo kubantu abaneengxaki zokukhathazeka. Nangona kunjalo, olunye uphando lwakwangoko lubonisa ukuba ukuthatha iidosi eziphezulu ze-5-HTP, 225 mg yonke imihla okanye nangaphezulu, kubonakala ngathi kwenza uxinzelelo lube lubi. Kwakhona, ukuthatha i-60 mg ye-5-HTP mihla le ngokusebenzisa umthambo akukunciphisi ukuxhalaba kubantu abanengxaki yokuphazamiseka.
  • Ukulimala kwengqondo okuchaphazela ukuhamba kwemisipha (i-cerebellar ataxia). Ubungqina ekusetyenzisweni kwe-5-HTP ye-cerebellar ataxia akucaci. Ubungqina bokuqala bubonisa ukuba ukuthatha i-5 mg / kg ye-5-HTP mihla le kwiinyanga ezi-4 kunokunciphisa ukungasebenzi kakuhle kwenkqubo yemithambo-luvo. Nangona kunjalo, olunye uphando lubonisa ukuba ukuthatha i-5-HTP mihla le ukuya kuthi ga kunyaka ongaziphuculiyo iimpawu ze-cerebellar ataxia.
  • Fibromyalgia. Uphando lwakwangoko lubonisa ukuba ukuthatha i-100 mg ye-5-HTP ngomlomo kathathu ngemini kangangeentsuku ezingama-30 ukuya kuma-90 kunokuphucula iintlungu, ukuthamba, ukulala, unxunguphalo, ukudinwa, kunye nokuqina kwentsasa kubantu abane-fibromyalgia.
  • Iimpawu zokuyeka ukuya exesheni. Uphando lwakwangoko lubonisa ukuba ukuthatha i-150 mg ye-5-HTP mihla le kwiiveki ezi-4 akukunciphisi ukukhanya kwabasetyhini emva kokuyeka ukuya exesheni.
  • Migraine. Ubungqina kwiziphumo ze-5-HTP yothintelo okanye unyango lwe-migraines kubantu abadala abucaci. Olunye uphononongo lubonisa ukuba ukuthatha i-5-HTP mihla le akuyinciphisi imigraines, ngelixa ezinye izifundo zibonisa ukuba kunokuba luncedo njengamachiza amiselweyo. I-5-HTP ibonakala ngathi ayinciphisi migraines ebantwaneni.
  • Ukutyeba kakhulu. Uphando lwakwangoko lubonisa ukuba ukuthatha i-5-HTP kunokunceda ukunciphisa ukutya, ukutya ikhalori, kunye nobunzima kubantu abatyebe kakhulu. Olunye uphando lubonisa ukuba ukusebenzisa isitshizi somlomo esine-5-HTP kunye nezinye izicatshulwa (i-5-HTP-Nat Exts, iMedestea Biotech Sp, iTorino, e-Itali) iiveki ezi-4 zonyusa ukwehla kobunzima malunga neepesenti ezingama-41 kwabasetyhini abatyebe kakhulu emva kokuyeka ukuya exesheni.
  • Ukurhoxa kwi-heroin, morphine, kunye nezinye iziyobisi ze-opioid. Uphando lwakwangoko lubonisa ukuba ukuthatha i-200 mg ye-5-HTP mihla le kwiintsuku ezingama-6 kunye ne-tyrosine, phosphatidylcholine, kunye ne-L-glutamine, kunokunciphisa ukulala nokungabikho kweempawu zokubuyisa iziyobisi ze-heroin.
  • Isifo seParkinson. Uphando lwakwangoko lubonisa ukuba ukuthatha i-100-150 mg ye-5-HTP ngomlomo yonke imihla ngamachiza aqhelekileyo kubonakala kunciphisa ukushukuma, kodwa ezi zibonelelo ziyaqhubeka ukuya kuthi ga kwiinyanga ezi-5. Olunye uphando lwakwangoko lubonisa ukuba ukuthatha i-50 mg ye-5-HTP mihla le kunokunciphisa iimpawu zokuphazamiseka kokuhamba kwelevodopa, kunye neempawu zokudakumba, kubantu abanesifo sikaParkinson. Kodwa ukuthatha iidosi ezinkulu ze-5-HTP, 275-1500 mg yonke imihla, kunye ne-carbidopa kunokuba mandundu ngakumbi kwiimpawu ezithile.
  • Intloko yentloko. Uphando lwakwangoko lubonisa ukuba ukuthatha i-100 mg ye-5-HTP kathathu mihla le kwiiveki ze-8 ayinciphisi iintlungu okanye ubude beentloko zentloko.
  • Ukuqwalaselwa kwentsilelo-yokuchaphazeleka kwengqondo (ADHD).
  • Ukuphuthelwa.
  • Ukuphazamiseka kwangaphambi kokuya exesheni (PMDD).
  • Isifo se-Premenstrual syndrome (PMS).
  • Isifo sikaRamsey-Hunt.
  • Ezinye iimeko.
Ubungqina obungakumbi buyafuneka ukukala ukusebenza kwe-5-HTP kwezi zinto zisetyenziswayo.

I-5-HTP isebenza kwingqondo nakwinkqubo ye-nervous system ngokunyusa imveliso ye-serotonin yemichiza. I-Serotonin inokuchaphazela ukulala, ukutya, ubushushu, indlela yokuziphatha ngokwesondo, kunye nentlungu. Kuba i-5-HTP inyusa ukwenziwa kwe-serotonin, isetyenziselwa izifo ezininzi apho i-serotonin kukholelwa ukuba idlala indima ebalulekileyo kubandakanya ukudakumba, ukulala, ukutyeba, kunye nezinye iimeko ezininzi.

Xa kuthathwa ngomlomo: 5-HTP yiyo UKHUSELEKO OLUNOKWENZEKA xa uthatha ngomlomo ngokufanelekileyo. Isetyenziswe ngokukhuselekileyo kwiidosi ukuya kuthi ga kwi-400 mg yonke imihla ukuya kunyaka omnye. Kodwa abanye abantu abathathe i-5-HTP baye bavelisa imeko ebizwa ngokuba yi-eosinophilia-myalgia syndrome (EMS). I-EMS yimeko enzulu ebandakanya ukutyeba kakhulu kwemisipha (myalgia) kunye nokungaqhelekanga kwegazi (i-eosinophilia). Abanye abantu bacinga ukuba i-EMS inokubangelwa sisithako esenzekileyo okanye ukungcoliseka kwezinye iimveliso ze-5-HTP. Kodwa abukho ubungqina obaneleyo benzululwazi bokwazi ukuba ngaba i-EMS ibangelwa yi-5-HTP, ukungcola, okanye enye into. Kude kube kwaziwa ngakumbi, i-5-HTP kufuneka isetyenziswe ngononophelo.

Ezinye iziphumo ebezingalindelekanga ezinokubakho ze-5-HTP zibandakanya ukutsha kwentliziyo, iintlungu zesisu, isicaphucaphu, ukugabha, urhudo, ukozela, iingxaki zesini kunye neengxaki zemisipha.

5-HTP yiyo OKUNGENZEKA UKHUSELEKILE xa ithathwa ngomlomo ngeedosi ezinkulu. Iidosi ezivela kwi-6-10 gram yemihla ngemihla zinxulunyaniswe neengxaki ezinzima zesisu kunye nokuqaqamba kwemisipha.

Amanyathelo okhuseleko kunye nezilumkiso:

Ukukhulelwa kunye nokuncancisa: Akukho lwazi lwaneleyo oluthembekileyo lokwazi ukuba ngaba i-5-HTP ikhuselekile ukusetyenziswa xa ukhulelwe okanye uncancisa. Hlala kwicala elikhuselekileyo kwaye uphephe ukusetyenziswa.

Abantwana: 5-HTP yiyo UKHUSELEKO OLUNOKWENZEKA xa kuthathwe ngomlomo ngokufanelekileyo. Iidosi ukuya kuthi ga kwi-5 mg / kg yonke imihla zisetyenziswe ngokukhuselekileyo ukuya kuthi ga kwi-3 iminyaka kwiintsana nakubantwana ukuya kwi-12-iminyaka ubudala. Njengabantu abadala, kukho inkxalabo malunga ne-eosinophilia-myalgia syndrome (i-EMS) ebantwaneni, imeko enzima ebandakanya ukutyeba kakhulu kwemisipha (myalgia) kunye nokungaqhelekanga kwegazi (eosinophilia).

Ugqirha: 5-HTP inokuchaphazela imichiza yengqondo ebizwa ngokuba yi-serotonin. Ezinye iziyobisi ezenziwa ngexesha lotyando zinokuchaphazela i-serotonin. Ukuthatha i-5-HTP ngaphambi kotyando kunokubangela i-serotonin eninzi kwingqondo kwaye kunokubangela iziphumo ebezingalindelekanga ezinzulu kubandakanya iingxaki zentliziyo, ukungcangcazela kunye noxinzelelo. Xelela izigulana ukuba ziyeke ukuthatha i-5-HTP ubuncinci iiveki ezimbini ngaphambi kotyando.

Mkhulu
Sukuyithatha le indibaniselwano.
Amayeza oxinzelelo (MAOIs)
I-5-HTP inyusa ikhemikhali kwingqondo ebizwa ngokuba yi-serotonin. Amanye amayeza asetyenziselwa uxinzelelo anyusa i-serotonin. Ukuthatha i-5-HTP ngala mayeza asetyenziselwa ukudakumba kunokunyusa i-serotonin kakhulu. Oku kunokubangela iziphumo ebezingalindelekanga ezibi kubandakanya intloko ebuhlungu, iingxaki zentliziyo, ukungcangcazela, ukudideka kunye noxinzelelo.

Olunye lala mayeza asetyenziselwa uxinzelelo lubandakanya i-phenelzine (Nardil), tranylcypromine (Parnate), kunye nezinye.
Iphakathi
Lumka ngale nhlanganisela.
ICarbidopa (iLodosyn)
I-5-HTP inokuchaphazela ingqondo. ICarbidopa (iLodosyn) inokuchaphazela nengqondo. Ukuthatha i-5-HTP kunye ne-carbidopa kunokunyusa umngcipheko weziphumo ebezingalindelekanga ezinzulu kubandakanya intetho ekhawulezileyo, uxinzelelo, ubundlongondlongo kunye nabanye.
Amayeza okudambisa (i-CNS depressants)
I-5-HTP inokubangela ukozela nokozela. Amayeza abangela ubuthongo abizwa ngokuba kukuthomalalisa. Ukuthatha i-5-HTP kunye namayeza okuthambisa kunokubangela ukulala kakhulu.

Amanye amayeza okuthambisa afaka i-clonazepam (iKlonopin), i-lorazepam (Ativan), i-phenobarbital (i-Donnatal), i-zolpidem (i-Ambien) kunye nezinye.
Iziyobisi zeSerotonergic
I-5-HTP inokunyusa imichiza kwingqondo ebizwa ngokuba yi-serotonin. Amanye amayeza anyusa ne-serotonin. Ukuthatha i-5-HTP kunye nala mayeza kunokunyusa i-serotonin kakhulu. Oku kunokubangela iziphumo ebezingalindelekanga ezibi kubandakanya intloko ebukhali, iingxaki zentliziyo, ukungcangcazela, ukudideka kunye noxinzelelo.

Amanye ala mayeza aquka i-fluoxetine (Prozac), i-paroxetine (i-Paxil), i-sertraline (i-Zoloft), i-amitriptyline (i-Elavil), i-clomipramine (i-Anafranil), i-imipramine (i-Tofranil), i-sumatriptan (Imitrex), i-zolmitriptan (i-Zomig), i-rizatriptan methadone (Dolophine), tramadol (Ultram), kunye nezinye ezininzi.
Iherbs kunye nezongezelelo ezineempawu zokuthomalalisa
I-5-HTP inokubangela ukozela okanye ukozela. Ukuyisebenzisa kunye namanye amayeza kunye nezongezo ezinefuthe elifanayo kunokubangela ukulala kakhulu. Ezinye zale mifuno kunye nezongezelelo zibandakanya i-calamus, i-poppy yaseCalifornia, i-catnip, i-hops, i-dogwood yase-Jamaican, i-kava, i-wort yase-St.
Iherbs kunye nezongezo ezineepropathi ze-serotonergic
I-5-HTP yonyusa umchiza wobuchopho obizwa ngokuba yi-serotonin. Ukuthatha i-5-HTP kunye namanye amayeza kunye nezongezo ezonyusa i-serotonin kunokukhokelela kwi-serotonin eninzi kwaye kubangele iziphumo ebezingalindelekanga kubandakanya iingxaki zentliziyo, ukungcangcazela kunye noxinzelelo. Amanye amayeza kunye nezongezo ezonyusa amanqanaba e-serotonin zibandakanya i-Hawaiian baby woodrose, L-tryptophan, S-adenosylmethionine (SAMe), kunye neSt.
Akukho kunxibelelana kwaziwayo nokutya.
La machiza alandelayo afundwe kuphando lwezesayensi: ABADALA

NGOMLOMO:
  • Ukudakumba: Ngokuqhelekileyo, i-150-800 mg imihla ngemihla ithathwa kwiiveki ezi-2-6. Ngamanye amaxesha la maqondo ahlukaniswa kwaye alawulwa njenge-50 mg ukuya kwi-100 mg kathathu ngemini. Ngamanye amaxesha idosi iqala iphantsi kwaye inyuke ngokuthe ngcembe kwiiveki ezi-1-2 kude kufike idosi ekujolise kuyo. Ngaphantsi kwesiqhelo, kusetyenziswa iidosi eziphezulu. Kwisifundo esinye, idosi inyuswe ngokuthe chu ukuya kwi-3 gram ngosuku.
2-Amino-3- (5-Hydroxy-1H-Indol-3-yl) Propanoic Acid, 5 Hydroxy-Tryptophan, 5 Hydroxy-Tryptophane, 5-Hydroxytryptophan, 5-Hydroxytryptophane, 5-Hydroxy L-Tryptophan, 5-Hydroxy L-Tryptophane, 5-Hydroxy Tryptophan, 5-L-Hydroxytryptophan, L-5 HTP, L-5-Hydroxytryptophan, L-5-Hydroxytryptophane, iOxitriptan.

Ukuze ufunde okungakumbi malunga nokubhalwa kweli nqaku, nceda ubone Amayeza endalo aVimba weDatha indlela yokusebenza.


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  53. van Praag HM, Korf J, Dols LC, Schut T.Uvavanyo lokuqhuba lwexabiso lokuqikelela kovavanyo lweprobenecid ekusebenziseni i-5-hydroxytryptophan njenge-antidepressant. I-Psychopharmacologia 1972; 25: 14-21. Jonga i-abstract.
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  55. UChadwick, D., Hallett, M., Harris, R., Jenner, P., Reynolds, EH, kunye no-Marsden, i-CD Clinical, i-biochemical, kunye neempawu zomzimba ezahlula i-myoclonus ephendula kwi-5-hydroxytryptophan, tryptophan ene-monoamine oxidase inhibitor, kunye neclonazepam. Ubungqina 1977; 100: 455-487. Jonga i-abstract.
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