Uzipho lukaMtyholi

Umxholo

• Inokwenzeka ukuba isebenze ...
• Akukho bungqina baneleyo bokulinganisa ukusebenza ...
• Amanyathelo okhuseleko kunye nezilumkiso:

Uzipho lukaMtyholi yingca. Igama lezityalo, Harpagophytum, lithetha "isityalo sokuloba" ngesiGrike. Esi sityalo sifumana igama laso kwinkangeleko yesiqhamo saso, esigutyungelwe ngamagwegwe ekujongwe ukuba ancanyathiselwe kwizilwanyana ukuze zisasaze imbewu. Iingcambu kunye nezilimo eziyizigaxa zesityalo zisetyenziselwa ukwenza amayeza.

Uzipho lukaMtyholi lusetyenziselwa iintlungu zomqolo, isifo samathambo, isifo samathambo (RA), kunye nezinye iimeko, kodwa abukho ubungqina benzululwazi obuxhasa ezi zinto zisetyenziswayo.

Isifo seCoronavirus 2019 (COVID-19): Ezinye iingcali zilumkisa ukuba uzipho lukaSathana lunokuphazamisa impendulo yomzimba ngokuchasene ne-COVID-19. Akukho datha inamandla yokuxhasa esi silumkiso. Kodwa akukho datha ilungileyo yokuxhasa usebenzisa inzipho kasathana ye-COVID-19.

Amayeza endalo aVimba weDatha Ukusebenza kwexabiso ngokusekwe kubungqina besayensi ngokwala manqanaba alandelayo: Ukusebenza, ukusebenza ngokukuko, okunokwenzeka ukuba kusebenze, okungenzeka kungasebenzi, kunokwenzeka ukungasebenzi, ukungasebenzi, kunye nobungqina obungonelanga bokulinganisa.

Ukulinganiswa kokusebenza kwe IBANGO LIKASathana zezi zilandelayo:

Inokwenzeka ukuba isebenze ...

• Umqolo obuhlungu. Ukuthatha uzipho lukaSathana ngomlomo kubonakala kunciphisa iintlungu ezisezantsi. Uzipho lukaMtyholi lubonakala lusebenza malunga nezinye iziyobisi ezingekho-steroidal ezichasayo (i-NSAIDs).
• Osteoarthritis. Ukuthatha uzipho lwedemon wedwa, nezinye izithako, okanye kunye namachiza alwa nonsteroidal anti-inflammatory (NSAIDs) kubonakala ngathi anokunceda ukunciphisa iintlungu ezinxulumene ne-osteoarthritis. Obunye ubungqina bucebisa ukuba uzipho lwedemon lusebenza malunga ne-diacerhein (iyeza elisebenza kancinci kwi-osteoarthritis elingafumanekiyo e-U.S) ekuphuculeni iintlungu ze-osteoarthritis esinqeni nasemadolweni emva kweeveki ezili-16 zonyango. Abanye abantu abathatha inzipho yomtyholi babonakala bekwazi ukwehlisa idosi yee-NSAID abazidingayo ukuze banciphise iintlungu.

Akukho bungqina baneleyo bokulinganisa ukusebenza ...

• Isifo samathambo (RA). Uphando lwakwangoko lubonisa ukuba ukuthatha uzipho lukasathana ngomlomo akunakuphucula iRA.
• Ukuqina kwemithambo (atherosclerosis).
• Intlungu yesifuba esibukhali xa uphefumla (iintlungu zesifuba).
• Fibromyalgia.
• Igawuthi.
• Cholesterol ephezulu.
• Ukuphelelwa ngumdla wokutya.
• Intlungu yezihlunu.
• Migraine.
• Ukunyanzeliswa (dyspepsia).
• Ifiva.
• Ukuxhuzula kokuya exesheni (idysmenorrhea).
• Amaxesha angaqhelekanga.
• Ubunzima ngexesha lokubeleka.
• Ukudumba (ukudumba) kwethenda (tendinitis).
• Umzimba.
• Isifo sezintso kunye nesinyi.
• Ukuphilisa amanxeba, xa kusetyenziswa kulusu.
• Ezinye iimeko.

Ubungqina obungakumbi buyafuneka ukukala uzipho lukaSathana kwezi zinto zisetyenziswayo.

Uzipho lukaMtyholi luqulethe imichiza enokunciphisa ukudumba kunye nokudumba kunye neentlungu ezibangelwa.

Xa kuthathwa ngomlomo: Uzipho lukaMtyholi UKHUSELEKO OLUNOKWENZEKA uninzi lwabantu abadala xa bethathwe ukuya kuthi ga kunyaka. Iziphumo ebezingalindelekanga zixhaphakileyo kurhudo. Ezinye iziphumo ebezingalindelekanga zinokubandakanya isicaphucaphu, ukugabha, iintlungu zesisu, iintloko, ukukhala ezindlebeni, ukuphelelwa ngumdla wokutya, kunye nelahleko yokungcamla. Uzipho lukaMtyholi lusenokubanga nokwaliwa sisikhumba, iingxaki zokuya exesheni kunye notshintsho kuxinzelelo lwegazi. Ezi ziganeko aziqhelekanga.

Akukho lwazi lwaneleyo lwanokuthenjwa lokwazi ukuba inzipho yomtyholi ikhuselekile xa ithathwa ixesha elingaphezulu konyaka.

Xa isetyenziswa eluswini: Akukho lwazi lwaneleyo lwanokuthenjwa lokwazi ukuba uzipho lukasathana lukhuselekile okanye nokuba zeziphi na iziphumo ebezingalindelekanga.

Amanyathelo okhuseleko kunye nezilumkiso:

Ukukhulelwa: Uzipho lukaMtyholi OKUNGENZEKA UKHUSELEKILE xa isetyenziswe ngexesha lokukhulelwa. Inokonzakalisa umntwana okhulayo. Kuphephe ukusebenzisa.

Ukuncancisa: Akukho lwazi lwaneleyo lunokuthenjwa lokwazi ukuba uzipho lukamtyholi lukhuselekile ukusetyenziswa xa uncancisa. Hlala kwicala elikhuselekileyo kwaye uphephe ukusetyenziswa.

Iingxaki zentliziyo, uxinzelelo lwegazi, uxinzelelo lwegazi: Uzipho lukaMtyholi lunokuchaphazela ukubetha kwentliziyo, ukubetha kwentliziyo, kunye noxinzelelo lwegazi. Inokonzakalisa abantu abanengxaki yentliziyo kunye nenkqubo yokujikeleza kwegazi. Ukuba unayo enye yezi meko, thetha nomboneleli wakho wezempilo ngaphambi kokuba uqale uzipho lukaSathana.

Seswekile: Uzipho lukaMtyholi lunokwehlisa amanqanaba eswekile yegazi.Ukuyisebenzisa kunye namayeza aneswekile esezantsi yegazi kunokubangela ukuba iswekile yegazi yehle kakhulu. Jonga amanqanaba eglucose egazini ngokusondeleyo. Umboneleli wakho wezempilo unokufuna uhlengahlengiso kumthamo wakho wamayeza eswekile.

Amatye egallUzipho lukaMtyholi lunokwandisa imveliso ye-bile. Oku kunokuba yingxaki kubantu abanamatye enyongo. Kuphephe ukusebenzisa uzipho lomtyholi.

Amanqanaba asezantsi esodiyam emzimbeniUzipho lukaMtyholi lunokwehla amanqanaba esodium emzimbeni. Oku kunokuba mandundu ngakumbi iimpawu zabantu esele benamanqanaba asezantsi esodiyam.

Isifo sesilonda Peptic (PUD): Kuba uzipho lukaSathana lunokwandisa imveliso yeeasidi zesisu Oku kunokwenzakalisa abantu abanezilonda esiswini. Kuphephe ukusebenzisa uzipho lomtyholi.

Iphakathi

Lumka ngale nhlanganisela.

Amayeza atshintshwe sisibindi (iiCytochrome P450 2C19 (CYP2C19) substrates)

Amanye amayeza atshintshiwe kwaye aphulwe sisibindi. Uzipho lukaMtyholi lunokunciphisa ukuba isibindi siwaphula ngokukhawuleza njani na amayeza. Ukuthatha uzipho lwedeveli kunye namanye amayeza aphulwe sisibindi kunokunyusa iziphumo kunye neziphumo ebezingalindelekanga zamanye amayeza. Ngaphambi kokuba uthathe intetho yeclaw's claw kumnikezeli wakho wezempilo ukuba uthatha nawaphi na amayeza atshintshwa sisibindi.

Amanye amayeza atshintshwa sisibindi aquka i-omeprazole (Prilosec), i-lansoprazole (Prevacid), kunye ne-pantoprazole (Protonix); diazepam (Valium); icarisoprodol (iSoma); i-nelfinavir (iViracept); nabanye.

Amayeza atshintshwe sisibindi (iiCytochrome P450 2C9 (CYP2C9) substrates)

Amanye amayeza atshintshiwe kwaye aphulwe sisibindi. Uzipho lukaMtyholi lunokunciphisa ukuba isibindi siwaphula ngokukhawuleza njani na amayeza. Ukuthatha uzipho lwedeveli kunye namanye amayeza aphulwe sisibindi kunokunyusa iziphumo kunye neziphumo ebezingalindelekanga zamanye amayeza. Ngaphambi kokuba uthathe intetho yeclaw's claw kumnikezeli wakho wezempilo ukuba uthatha nawaphi na amayeza atshintshwa sisibindi.

Amanye amayeza atshintshwa sisibindi aquka i-diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), kunye ne-piroxicam (Feldene); iselecoxib (iCelebrex); umgca we-amitriptyline (Elavil); iwarfarin (Coumadin); glipizide (Glucotrol); losartan (uCozaar); nabanye.

Amayeza atshintshwe sisibindi (iiCytochrome P450 3A4 (CYP3A4) substrates)

Amanye amayeza atshintshiwe kwaye aphulwe sisibindi. Uzipho lukaMtyholi lunokunciphisa ukuba isibindi siwaphula ngokukhawuleza njani na amayeza. Ukuthatha uzipho lwedeveli kunye namanye amayeza aphulwe sisibindi kunokunyusa iziphumo kunye neziphumo ebezingalindelekanga zamanye amayeza. Ngaphambi kokuba uthathe uzipho lukaSathana, thetha nomboneleli wakho wezempilo ukuba uthatha nawaphi na amayeza atshintshwa sisibindi.

Amanye amayeza atshintshwe sisibindi kubandakanya i-lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), kunye nezinye ezininzi.

IWarfarin (Coumadin)

IWarfarin (Coumadin) isetyenziselwa ukucothisa ukujiya kwegazi. Uzipho lukaMtyholi lunokonyusa ifuthe le-warfarin (Coumadin) kunye nokunyusa amathuba okugruzuka nokopha. Qiniseka ukuba igazi lakho lihlolwe rhoqo. Umthamo we-warfarin yakho (Coumadin) unokufuna ukutshintsha.

Incinci

Jonga olu dibaniso.

Amayeza ashukunyiswa yimpompo kwiiseli (P-glycoprotein Substrates)

Amanye amayeza ahanjiswa ngeempompo kwiiseli. Uzipho lukaMtyholi lunokwenza ukuba ezi mpompo zingasebenzi kwaye zonyuse ukuba mangaphi amayeza afunxwa ngumzimba. Oku kunokunyusa iziphumo ebezingalindelekanga zamayeza athile.

Amanye amayeza ashukunyiswa zezi mpompo aquka i-etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosterosidi (corticosteroid) Allegra), cyclosporine, loperamide (Imodium), quinidine kunye nabanye.

Amayeza anciphisa isisu esiswini (i-H2-blockers)

Uzipho lukaMtyholi lunokunyusa isisu esiswini. Ngokwandisa i-asidi esiswini, uzipho lukaSathana lunokunciphisa ukusebenza kwamanye amayeza anciphisa isisu esiswini, esibizwa ngokuba yi-H2-blockers.

Amanye amayeza anciphisa isisu i-asidi aquka i-cimetidine (Tagamet), i-ranitidine (iZantac), i-nizatidine (i-Axid), kunye ne-famotidine (i-Pepcid).

Amayeza anciphisa isisu esiswini (Proton pump inhibitors)

Uzipho lukaMtyholi lunokunyusa isisu esiswini. Ngokwandisa iasidi yesisu, uzipho lukaSathana lunokunciphisa ukusebenza kwamayeza asetyenziselwa ukunciphisa isisu esiswini, esibizwa ngokuba yiproton pump inhibitors.

Amanye amayeza anciphisa isisu se-asidi aquka i-omeprazole (Prilosec), i-lansoprazole (i-Prevacid), i-rabeprazole (i-Aciphex), i-pantoprazole (i-Protonix) kunye ne-esomeprazole (Nexium).

Akukho kunxibelelana kwaziwayo kunye namayeza kunye nezongezo.

Akukho kunxibelelana kwaziwayo nokutya.

La machiza alandelayo afundwe kuphando lwezesayensi:

NGOMLOMO:

• Kwi-osteoarthritis: I-2-2.6 iigrem zesicwecwe sikaDeveli sithathiwe saya kuthi ga kwiidosi ezintathu ezahlulwe yonke imihla ukuya kwiinyanga ezi-4. Imveliso ethile yokudibanisa ebonelela nge-600 mg ye-devil's claw, i-400 mg ye-turmeric, kunye ne-300 mg ye-bromelain ithathiwe ama-2-3 amaxesha amathathu yonke imihla ukuya kuthi ga kwiinyanga ezi-2. Imveliso ethile yendibaniselwano (iRosaxan, medAgil Gesundheitsgesellschaft mbH) equlathe inzipho kasathana, ukubetheka kwenettle, ukunyuka kwenyonga, kunye nevithamin D ethathwe ngomlomo njenge-40 mL yemihla ngemihla isetyenziswe iiveki ezili-12.
• Kwiintlungu zomqolo: I-0.6-2.4 iigram zesicatshulwa sikaDeveli sithathiwe yonke imihla, ngesiqhelo kwiidosi ezahluliweyo, ukuya kuthi ga kunyaka omnye.

Cilsils Claw, Devil's Claw Root, Garra del Diablo, Grapple Plant, Griffe du Diable, Harpagophyti Radix, Harpagophytum, Harpagophytum procumbens, Harpagophytum zeyheri, Racine de Griffe du Diable, Racine de Windhoek, Teufelskrallenwurzel, Uncaria.

Ukuze ufunde okungakumbi malunga nokubhalwa kweli nqaku, nceda ubone Amayeza endalo aVimba weDatha indlela yokusebenza.

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45. UKundu, J. K., Mossanda, K. S., Na, H.K, kunye noSurh, Y.J.Izithintelo zeziphumo zeSutherlandia frutescens (L.) R. Br. kunye Harpagophytum procumbens DC. kwi-phorbol ester-indased COX-2 expression in the mouse skin: AP-1 and CREB as target upstream. Umhlaza Lett. 1-31-2005; 218: 21-31. Jonga i-abstract.
46. IChrubasik, S. Isihlomelo kwi-ESCOP monograph kwi-Harpagophytum procumbens. Unyango lwezonyango. Ngo-2004; 11 (7-8): 691-695. Jonga i-abstract.
47. UKaszkin, M., Beck, KF, Koch, E., Erdelmeier, C., Kusch, S., Pfeilschifter, J., kunye noLoew, D. Ukwehliswa kwentetho ye-iNOS kwiiseli ze-rat mesangial zizicatshulwa ezikhethekileyo zeHarpagophytum procumbens zivela Ukuxhomekeka kwi-harpagoside kunye nokuzimela. Unyango lwezonyango. Ngo-2004; 11 (7-8): 585-595. Jonga i-abstract.
48. Na, H.K, Mossanda, K. S., Lee, J. Y., kunye no Surh, Y. J. Inhibition ye phorbol ester-indased COX-2 expression zezinye zezityalo ezityiwayo zaseAfrika. Ii-Biofactors 2004; 21 (1-4): 149-153. Jonga i-abstract.
49. UChrubasik, S. [Inzipho kaMtyholi ikhupha njengomzekelo wokusebenza kwe-analgesics ye-herbal]. I-Orthopade 2004; 33: 804-808. Jonga i-abstract.
50. I-Schulze-Tanzil, G., Hansen, C., kunye ne-Shakibaei, M. Iifayile. Ngo-2004; 54: 213-220. Jonga i-abstract.
51. IChrubasik, S., Conradt, C., kunye neRoufogalis, B. D. Ukusebenza ngempumelelo kwezicatshulwa zeHarpagophytum kunye nokusebenza kweeklinikhi. Phytother.Res. Ngo-2004; 18: 187-189. Jonga i-abstract.
52. UBoje, K., Lechtenberg, M., kunye no-Nahrstedt, A. I-iridoid- kunye ne-phenylethanoid glycosides entsha evela kwi-Harpagophytum procumbens kunye ne-in vitro inhibition ye-leukocyte elastase yabantu. IPlanta Med 2003; 69: 820-825. Jonga i-abstract.
53. UClarkson, C., uCampbell, uW., No-Smith, uP. In vitro antiplasmodial activity of abietane kunye totarane diterpenes bodwa kwi-Harpagophytum procumbens (i-devil's claw). IPlanta Med 2003; 69: 720-724. Jonga i-abstract.
54. UBetancor-Fernandez, A., uPerez-Galvez, A., uSies, H., kunye noStahl, W. Amalungiselelo ovavanyo lwamayeza aqukethe izicatshulwa ze-turmeric rhizome, iqabunga le-artichoke, ingcambu yomtyholi kunye negalikhi okanye ioyile yesalmon ye-antioxidant. J Pharm Pharmacol 2003; 55: 981-986. Jonga i-abstract.
55. Munkombwe, N. M. Acetylated phenolic glycosides evela kwiHarpagophytum procumbens. I-Phytochemistry 2003; 62: 1231-1234. Jonga i-abstract.
56. UGobel, H., Heinze, A., Ingwersen, M., Niederberger, U., kunye noGerber, D. intlungu]. Schmerz. 2001; 15: 10-18. Jonga i-abstract.
57. Laudahn, D. kunye noWalper, A. Ukusebenza kunye nokunyamezelana kweHarpagophytum ikhupha i-LI 174 kwizigulana ezinentlungu engapheliyo engapheliyo. Phytother.Res. Ngo-2001; 15: 621-624. Jonga i-abstract.
58. ULoew, D., Mollerfeld, J., Schrodter, A., Puttkammer, S., kunye noKaszkin, M. Uphando kwiipropathi ze-pharmacokinetic zezicatshulwa zeHarpagophytum kunye neziphumo zazo kwi-eicosanoid biosynthesis kwi vitro nakwi-ex vivo. Kwiklinikhi yeParmacol. 2001; 69: 356-364. Jonga i-abstract.
59. I-Leblan, D., Chantre, P., kunye ne-Fournie, B. Harpagophytum proumbens kunyango lwedolo kunye ne-hip osteoarthritis. Iziphumo zeenyanga ezine zetyala elinokubakho, elinemisebenzi emininzi, ityala elingaboni kabini xa kuthelekiswa ne-diacerhein. Umdibaniso weThambo eliDibeneyo 2000; 67: 462-467. Jonga i-abstract.
60. IBaghdikian, B., Guiraud-Dauriac, H., Ollivier, E., N'Guyen, A., Dumenil, G., kunye neBalansard, G. Ukuqulunqwa kweemetabolites eziqulathe i-nitrogen ezivela kwi-iridoids eziphambili zeHarpagophytum procumbens kunye noH. zeyheri ziintsholongwane zomntu emathunjini. UPlanta Med 1999; 65: 164-166. Jonga i-abstract.
61. UChrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., noZappe, H. Ukusebenza kweHarpagophytum kukhupha i-WS 1531 kunyango lokunyusa iintlungu ezisezantsi: i-randomized, i-placebo-elawulwa, iphindwe kabini- ukufunda ungaboni. I-Eur. J iAnaesthesiol. Ngo-1999; 16: 118-129. Jonga i-abstract.
62. UGagnier, J. J., van Tulder, M., Berman, B., kunye neBombardier, C. Amayeza e-Herbal ngenxa yeentlungu ezisezantsi. Idatha yedatha yeCochrane. Ngo-2006; CD004504. Jonga i-abstract.
63. U-Spelman, K., Burns, J., Nichols, D., Winters, N., Ottersberg, S., kunye no-Tenborg, M. Enye indlela. Ngo-2006; 11: 128-150. Jonga i-abstract.
64. U-Ernst, E. kunye noChrubasik, S. Phyto-anti-inflammatories. Uphengululo olucwangcisiweyo lokuvavanywa ngokungalawulekiyo, olulawulwa yi-placebo, iimvavanyo ezingaboni kabini. Rheum.Dis Ikliniki yaseNyakatho Am 2000; 26: 13-27, vii. Jonga i-abstract.
65. URomiti N, uTramonti G, uCorti A, uChieli E. Iziphumo zeClaw kaMtyholi (Harpagophytum procumbens) kwi-multidrug transporter ABCB1 / P-glycoprotein. I-Phytomedicine 2009; 16: 1095-100. Jonga i-abstract.
66. UGagnier JJ, van Tulder MW, Berman B, Bombardier C. Amayeza e-Herbal kwiintlungu ezisezantsi. Uphengululo lweCochrane. Isihlwele 2007; 32: 82-92. Jonga i-abstract.
67. UChrubasik S, Kunzel O, Thanner J, et al. Ulandelo lonyaka-1 emva kophononongo lokuqhuba kunye neDoloteffin yeentlungu ezisezantsi. Unyango lwePhytomedicine 2005; 12: 1-9. Jonga i-abstract.
68. I-Wegener T, iLupke NP. Unyango lwezigulana ezine-arthrosis yenyonga okanye idolo ngesicatshulwa esimanzi senzipho yomtyholi (Harpagophytum procumbens DC). UPhytother Res 2003; 17: 1165-72. Jonga i-abstract.
69. Unger M, uFrank A.Ukuzimisela ngaxeshanye kwamandla okuthintela amayeza ezinto ezenziwayo ekusebenzeni kwee-enzymes ezinkulu ze-cytochrome P450 zisebenzisa i-chromatography engamanzi / i-mass spectrometry kunye ne-automated online extraction. Ukukhawuleza kweMass Communct Spectrom 2004; 18: 2273-81. Jonga i-abstract.
70. UJang MH, uLim S, uHan SM, et al. I-Harpagophytum procumbens icinezela i-lipopolysaccharide-evuselelweyo ye-cyclooxygenase-2 kunye ne-nitric oxide synthase kwi-fibroblast cell line L929. J Pharmacol Sci 2003; 93: 367-71. Jonga i-abstract.
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72. UMoussard C, uAlber D, uToubin MM, et al. Iyeza elisetyenziselwa amayeza emveli, i-harpagophytum procumbens: abukho ubungqina besiphumo esifana ne-NSAID kwimveliso yegazi eicosanoid epheleleyo ebantwini. Iprostaglandins Leukot ibaluleke kakhulu kwiAtyty Acids. Ngo-1992; 46: 283-6 .. Jonga i-abstract.
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74. UFiebich BL, uHeinrich M, uHiller KO, uKammerer N. Uthintelo lwe-TNF-alpha synthesis kwi-LPS-evuselelekileyo i-monocytes yomntu oyintloko yiHarpagophytum ekhupha iSteiHap 69. I-Phytomedicine 2001; 8: 28-30 .. Jonga i-abstract.
75. UBaghdikian B, uLanhers MC, uFleurentin J, et al. Isiseko Isifundo sohlalutyo, isiphumo sokuchasana nokudumba kunye neempembelelo zeHarpagophytum procumbens kunye neHarpagophytum zeyheri. UPlanta Med 1997; 63: 171-6. Jonga i-abstract.
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77. IGrahame R, uRobinson BV. Uzipho lweedemon (Harpagophytum procumbens): izifundo zonyango kunye nezonyango. UAnn Rheum Dis 1981; 40: 632. Jonga i-abstract.
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