Umbhali: William Ramirez
Umhla Wokudalwa: 22 Eyomsintsi 2021
Hlaziya Umhla: 13 Eyenkanga 2024
Anonim
USMLE: Medical Video Lectures Pharmacology about Ganciclovir by UsmleTeam
Ividiyo: USMLE: Medical Video Lectures Pharmacology about Ganciclovir by UsmleTeam

Umxholo

I-Ganciclovir ingalinciphisa inani lazo zonke iintlobo zeeseli egazini lakho, ibangele iingxaki ezinzulu nezisongela ubomi. Tshela ugqirha wakho ukuba unayo okanye wakha wanayo i-anemia (iiseli ezibomvu zegazi azizisi ioksijini eyaneleyo kuwo onke amalungu omzimba); neutropenia (ngaphantsi kwenani eliqhelekileyo leeseli ezimhlophe zegazi); thrombocytopenia (ngaphantsi kwenani eliqhelekileyo leeplatelets); okanye ezinye iingxaki zegazi okanye zokopha. Tshela ugqirha wakho ukuba ukhe wakhula neengxaki zegazi njengeziphumo ebezingalindelekanga zalo naliphi na iyeza. Xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uthatha okanye uthathe nawaphi na amayeza alandelayo: ii-anticoagulants ('blood thinner') ezifana ne-warfarin (Coumadin); amayeza e-chemotherapy chemotherapy; dapsone; iflucytosine (Ancobon); heparin; ii-immunosuppressants ezinje nge-azathioprine (Azasan, Imuran), cyclosporine (Neoral, Sandimmune), methotrexate (Rheumatrex), sirolimus (Rapamune), kunye ne-tacrolimus (Prograf); ii-interferon (Infergen, Intron A, PEGASYS, PEG-Intron, Roferon-A); amayeza okunyanga intsholongwane kaGawulayo (i-HIV) kunye ne-immunodeficiency syndrome (i-AIDS) kubandakanya i-didanosine (Videx), zalcitabine (HIVID), okanye i-zidovudine (Retrovir, AZT); iziyobisi ezichasayo ezinganyangiyo ukunyanga iintlungu kunye nokudumba okufana neasprini, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn) nabanye; ipentamidine (NebuPent, Pentam); ipyrimethamine (iDaraprim, kwiFansidar); i-steroids ezinje nge-dexamethasone (i-Decadron), i-prednisone (Deltasone), okanye ezinye; trimethoprim / sulfamethoxazole (co-trimoxazole, Bactrim, Septra); okanye ukuba ufumene okanye ufumana unyango ngemitha (X-ray) .Ukuba ufumana ezinye zeempawu ezilandelayo, tsalela ugqirha kwangoko: ukudinwa kakhulu; ulusu oluthuthu; intloko ebuhlungu; isiyezi; ukudideka; ukubetha kwentliziyo ngokukhawuleza; ubunzima bokulala okanye ukulala; ubuthathaka; ukuqhawukelwa ngumphefumlo; ukopha okungaqhelekanga okanye ukugruzuka; okanye umqala obuhlungu, umkhuhlane, Ukugodola, ukukhohlela, okanye ezinye iimpawu zosulelo.


Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-ganciclovir.

Izilwanyana zaselebhu ezanikwa i-ganciclovir zakhula neziphene. Ayaziwa ukuba i-ganciclovir ibangela iziphene zokuzalwa ebantwini. Ukuba unokukhulelwa, kuya kufuneka usebenzise ulawulo olusebenzayo lokuzalwa ngelixa uthatha i-ganciclovir. Ukuba uyindoda kwaye iqabane lakho lingakhulelwa, kuya kufuneka usebenzise ikhondom ngelixa uthatha eli yeza, kunye neentsuku ezingama-90 emva konyango lwakho. Thetha nogqirha wakho ukuba unemibuzo malunga nolawulo lokuzalwa. Sukusebenzisa i-ganciclovir ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ukhulelwa ngelixa uthatha i-ganciclovir, biza ugqirha ngokukhawuleza.

Izilwanyana zaselebhu ezazinikwe i-ganciclovir zavelisa inani elisezantsi lobudoda (iiseli zokuzala ezingamadoda) kunye neengxaki zokuzala. Ayaziwa ukuba i-ganciclovir ibangela ukubalwa kwesidoda esisezantsi emadodeni okanye iingxaki zokuchuma kwabasetyhini.

Izilwanyana zaselebhu ezanikwa i-ganciclovir zaba nomhlaza. Ayaziwa ukuba i-ganciclovir inyusa umngcipheko womhlaza ebantwini.


Umenzi ulumkisa ukuba i-ganciclovir kufuneka isetyenziselwe kuphela ukunyanga abaguli abanezifo ezithile kuba iyeza linokubangela iziphumo ebezingalindelekanga ezibi kwaye okwangoku akukho lwazi lwaneleyo lokuxhasa ukhuseleko kunye nokusebenza kwamanye amaqela abaguli. (Jonga icandelo, KUTHENI le amayeza emiselweyo?)

Thetha nogqirha wakho malunga neengozi zokuthatha i-ganciclovir.

Iipilisi zeGanciclovir zisetyenziselwa ukunyanga i-cytomegalovirus (CMV) retinitis (usulelo lwamehlo olunokubangela ubumfama) kubantu abanamajoni omzimba angasebenzi ngendlela eqhelekileyo. Iipilisi zeGanciclovir zisetyenziselwa ukunyanga i-CMV retinitis emva kokuba imeko ilawulwe nge-intravenous (ejojowe emthanjeni) i-ganciclovir. I-Ganciclovir ikwasetyenziselwa ukuthintela isifo se-cytomegalovirus (CMV) kubantu abafumene i-immunodeficiency syndrome (i-AIDS) okanye abo bafumene ukufakelwa komzimba kwaye basemngciphekweni wesifo se-CMV. I-Ganciclovir ikudidi lwamayeza abizwa ngokuba zii-antivirals. Isebenza ngokuthintela ukusasazeka kwesifo se-CMV okanye ukunciphisa ukukhula kwe-CMV.


I-Ganciclovir iza njengephilisi emayithathwe ngomlomo. Ihlala ithathwa ngokutya kathathu ukuya kwesithandathu ngosuku, ukunceda ukhumbule ukuthatha i-ganciclovir, yithathe ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-ganciclovir ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iifomsile; sukuwavula, ungawaqhekezi, ungawahlahli, okanye uwatyumze.

Lumka xa uphatha iifomsile ze-ganciclovir. Sukuvumela ulusu, amehlo, umlomo, okanye impumlo yakho ukuba idibane neepilisi zeganciclovir ezaphukileyo okanye ezaphukileyo. Ukuba unxibelelwano olunjalo luyenzeka, hlamba isikhumba sakho kakuhle ngesepha namanzi okanye uhlambe kakuhle ngamanzi acocekileyo.

Ngokuqhelekileyo uya kufumana i-intravenous (kwi-vein) i-ganciclovir kangangeeveki ezininzi ngaphambi kokuba uqale ukuthatha iifomsile ze-ganciclovir. Ukuba imeko yakho iya isiba mandundu ngexesha lonyango lwakho, unokunikwa ikhosi yesibini ye-ganciclovir efakwa emithanjeni. Ugqirha wakho unokunciphisa umthamo wakho wee-capsules ze-ganciclovir ukuba unemiphumo emibi.

I-Ganciclovir ilawula i-CMV kodwa ayiyinyangi, kungathatha ixesha ngaphambi kokuba uzive uzuze ngokupheleleyo nge-ganciclovir. Qhubeka nokuthatha i-ganciclovir nokuba uziva uphilile. Ungayeki ukuthatha i-ganciclovir ngaphandle kokuthetha nogqirha wakho. Ukuyeka ukuthatha i-ganciclovir kwakamsinya kunokubangela ukuba inani le-CMV egazini lakho lonyuke okanye intsholongwane inganyangeki naliyeza.

Umenzi uthi eli yeza akufuneki ukuba limiselwe ezinye iindlela; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-ganciclovir,

  • xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-ganciclovir, i-acyclovir (iZovirax), i-valganciclovir (iValcyte), okanye nawaphi na amanye amayeza.
  • musa ukuthatha i-ganciclovir ukuba uthatha i-valganciclovir (Valcyte).
  • xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo. Qiniseka ngokukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zinto zilandelayo: tobramycin (Nebcin, Tobi), kunye nabanye; i-amphotericin B (iFungizone); i-captopril (eCapoten, eCapozide); umchamo ('iipilisi zamanzi'); ifosarnarn (Foscavir); iikhompawundi zegolide ezinje nge-auranofin (Ridaura) okanye aurothioglucose (Solganal); imipenem-cilastatin (Primaxin); i-immune globulin (gamma globulin, BayGam, Carimmune, Gammagard, nabanye); imethicillin (iStaphcillin); I-muromonab-CD3 (OKT3); mycophenolate mofetil (CellCept); iitrate ezifana ne-isosorbide dinitrate (Isordil, Sorbitrate) okanye iimveliso ze-nitroglycerin; ipenicillamine (Cuprimine, Depen); eyokuqala; unobangela; irifampin (Rifadin, Rimactane); okanye ezinye ii-analogue ze-nucleoside ezifana ne-acyclovir (Zovirax), famciclovir (Famvir), kunye ne-ribavirin (iCopegus, iRebetol, iVirazole, kwiRebetron). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
  • xelela ugqirha wakho ukuba ukhe wakha wanayo nayiphi na kwezi meko ichazwe kwicandelo LESILUMKISO ESIBALULEKILEYO okanye nakweyiphi na kwezi meko zilandelayo: ukugula ngengqondo; ukuxhuzula; iingxaki zamehlo ngaphandle kwe-CMV retinitis; izintso, okanye isifo sesibindi.
  • xelela ugqirha wakho ukuba uncelisa. Akufanelanga ukuncancisa ngelixa uthatha i-ganciclovir. Thetha nogqirha wakho malunga nokuba ungaqala nini na ukuncancisa emva kokuyeka ukuthatha i-ganciclovir.
  • ukuba uyenziwa utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-ganciclovir.
  • Kuya kufuneka uyazi ukuba i-ganciclovir inokukwenza wozele, ube nesiyezi, ungazinzi, udideke okanye uqaphele kancinci, okanye kunokubangela ukuxhuzula. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.

Qiniseka ukuba usele amanzi amaninzi ngelixa uthatha i-ganciclovir.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Ganciclovir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

  • isicaphucaphu
  • ukugabha
  • urhudo
  • ukuqhina
  • isisu esibuhlungu
  • ukubhinqa
  • Ukuphelelwa ngumdla wokutya
  • utshintsho kubuchule bokungcamla ukutya
  • umlomo owomileyo
  • izilonda zomlomo
  • amaphupha angaqhelekanga
  • uvalo
  • ukudakumba
  • ukubila
  • ukugungxula
  • intlungu edibeneyo okanye yemisipha okanye iicramps

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ezi mpawu zilandelayo aziqhelekanga, kodwa ukuba ufumana enye yazo, okanye ezo zidweliswe kwicandelo LESILumkiso ESIBALULEKILEYO, tsalela ugqirha wakho ngokukhawuleza:

  • ubona amachaphaza amnyama, ukukhanya, okanye umkhusane omnyama kuyo yonke into
  • ukuncipha kokuchama
  • urhwebo
  • irhashalala
  • ukurhawuzelela
  • ukudumba kwezandla, iingalo, iinyawo, amaqatha okanye imilenze esezantsi
  • ukuba ndindisholo, iintlungu, ukutshiswa, okanye ukubetheka ezandleni okanye ezinyaweni
  • ukuxhawula izandla ongenakuzilawula
  • ubunzima bokuphefumla okanye ukugwinya
  • iintlungu zesifuba
  • utshintsho lweemvakalelo
  • ukuxhuzula

I-Ganciclovir inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

  • isicaphucaphu
  • ukugabha
  • urhudo
  • Ukuphelelwa ngumdla wokutya
  • ukopha okungaqhelekanga okanye ukugruzuka
  • ukudinwa kakhulu
  • ubuthathaka
  • ulusu oluthuthu
  • intloko ebuhlungu
  • isiyezi
  • ukudideka
  • ukubetha kwentliziyo ngokukhawuleza
  • ubunzima bokulala
  • ukuqhawukelwa ngumphefumlo
  • umqala obuhlungu, umkhuhlane, Ukugodola, ukukhohlela, okanye ezinye iimpawu zosulelo
  • ukuncipha kokuchama
  • ukudumba kwezandla, iingalo, iinyawo, amaqatha okanye imilenze esezantsi
  • ukuxhuzula
  • mthubi ulusu okanye amehlo
  • Iimpawu ezinjengomkhuhlane
  • iintlungu kwinxalenye ephezulu yesisu

Ugqirha wakho unokuyalela iimviwo zamehlo rhoqo ngelixa uthatha eli yeza. Gcina lonke ixesha lokubonana nodokotela wamehlo (iimviwo zamehlo).

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha i-ganciclovir.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho. Ungavumeli ukunikezelwa kwe-ganciclovir kuphele.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

  • Icytovene® Ngomlomo
  • I-Nordexoyguanosine
  • Isodium yeDHPG
  • Isodium GCV

Le mveliso inophawu akusekho kwimarike. Ezinye iindlela ezinokubakho zinokubakho.

Ukuhlaziywa kokugqibela-05/15/2016

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