Voriconazole

Umxholo

• Ngaphambi kokuba uthathe i-voriconazole,
• IVoriconazole inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe KULUNGILE, biza ugqirha ngoko nangoko:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Voriconazole isetyenziswa kubantu abadala nakubantwana abaneminyaka emi-2 nangaphezulu ukunyanga izifo ezosulelayo ezinje nge-aspergillosis (intsholongwane yokungunda eqala emiphungeni kwaye isasazeka ngokuhamba kwegazi kwamanye amalungu), i-esophageal candidiasis (igwele fungus] usulelo olunokubangela ukuba amachaphaza amhlophe emlonyeni nasemqaleni), kunye ne-candidemia (usulelo lokungunda egazini). Isetyenziselwa ukunyanga ezinye izifo zosulelo xa amanye amayeza engazukusebenza kwizigulana ezithile. IVoriconazole ikwiklasi yamayeza okubulala abizwa ngokuba zii-triazoles. Isebenza ngokunciphisa ukukhula komngundo obangela usulelo.

IVoriconazole iza njengecwecwe kunye nokumiswa (ulwelo) ukuthatha ngomlomo. Ihlala ithathwa rhoqo emva kweeyure ezili-12 kwisisu esingenanto, ubuncinci iyure enye ngaphambi okanye iyure enye emva kwesidlo. Ukukunceda ukhumbule ukuthatha i-voriconazole, yithathe ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-voriconazole ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba uthatha ukunqunyanyiswa kwe-voriconazole, gungqisa ibhotile evaliweyo malunga nemizuzwana eli-10 ngaphambi kokuba uyisebenzise ngokudibanisa amayeza ngokulinganayo. Sukuxuba ukunqunyanyiswa kunye namanye amayeza, amanzi, okanye naluphi na ulwelo. Soloko usebenzisa isixhobo sokulinganisa esiza nonyango lwakho. Awunakufumana isixa esichanekileyo samayeza ukuba usebenzisa icephe lasekhaya ukulinganisa idosi yakho.

Ekuqaleni konyango lwakho, unokufumana i-voriconazole ngenaliti (emthanjeni) ngenaliti. Xa uqala ukuthatha i-voriconazole ngomlomo, ugqirha wakho unokukuqala kwidosi ephantsi kwaye wandise idosi yakho ukuba imeko yakho ayiphucuki. Ugqirha wakho unokunciphisa idosi yakho ukuba uneziphumo ebezingalindelekanga ezivela kwi-voriconazole.

Ubude bonyango lwakho buxhomekeke kwimpilo yakho ngokubanzi, uhlobo losulelo onalo, kunye nendlela osabela ngayo kunyango. Qhubeka nokuthatha i-voriconazole nokuba uziva uphilile. Sukuyeka ukuthatha i-voriconazole ngaphandle kokuthetha nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-voriconazole,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-voriconazole, amanye amayeza okubulala ubushushu afana ne-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), okanye ketoconazole (Nizoral); nawaphi na amanye amayeza, i-lactose, okanye ezinye izithako kunye nokumiswa. Buza usokhemesti wakho uluhlu lwezinto ezikwiipilisi ze-voriconazole kunye nokumiswa.
• musa ukuthatha i-voriconazole ukuba uthatha nawaphi na amayeza alandelayo: carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); i-cisapride (iPropulsid); efavirenz (Sustiva, eAtripla); amayeza ohlobo lwe-ergot anje nge-dihydroergotamine (i-DHE 45, iMigranal), i-ergoloid mesylates (iHydergine), i-ergotamine (i-Ergomar, eCafergot, eMigergot), kunye ne-methylergonovine (Methergine); ivabradine (Corlanor); naloxegol (iMonvatik); phenobarbital; ipimozide (Orap); quinidine (kwiNuedexta); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, eRifamate, eRifater); i-ritonavir (iNorvir, eKaletra); i-sirolimus (iRapamune); I-wort yaseSt. tolvaptan (Jynarque, Samsca); kunye ne-venetoclax (Venclexta).
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini kunye nezongezelelo zesondlo ozithathayo. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-anticoagulants ('i-blood thinner') efana ne-warfarin (Coumadin, Jantoven); i-benzodiazepines ezifana ne-alprazolam (Niravam, Xanax), midazolam, kunye ne-triazolam (Halcion); iicalcium block blockers ezinje ngeamlodipine (Norvasc, eAmturnide, eTekamlo), felodipine (Plendil), isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab, Procardia), nimodipine (Nymalize), kunye ne-nisoldipine (Sular); iyeza elinciphisa i-cholesterol (ii-statins) ezinje nge-atorvastatin (Lipitor, eCaduet, eLiptruzet), fluvastatin (Lescol), lovastatin (Altoprev, kwi-Advicor), pravastatin (Pravachol), kunye ne-simvastatin (iZocor, eSimcor, eVytorin); icyclosporine (Gengraf, Neoral, Sandimmune); i-everolimus (i-Afinitor, iZortress); fentanyl (Abstral, Actiq, Fentora, Lazanda, Subsys); amayeza eswekile efana ne-glipizide (Glucotrol), glyburide (Diabeta, Glynase,, in Glucovance), kunye ne-tolbutamide; amayeza e-HIV afana ne-delavirdine (Rescriptor), nelfinavir (Viracept), nevirapine (Viramune), kunye ne-saquinavir (Invirase); imethadone (iDolophine, iMethadose); nonsteroidal iziyobisi anti-ukudumba (diclofenac, ibuprofen), zokucwangcisa ngomlomo; iOxycodone (iOxecta, iOxycontin, kwiOxycet, ePercocet, ePercodan, eRoxicet, kwiXartemis); phenytoin (iDilantin, iPhenytek); iiproton-pump inhibitors ezinje nge-esomeprazole (Nexium, eVimovo), lansoprazole (Prevacid), omeprazole (Prilosec, Prevpac), pantoprazole (Protonix), kunye ne-rabeprazole (AcipHex); itacrolimus (Astagraf, Prograf); vinblastine; kunye no-vincristine. Uninzi lwamanye amayeza anokusebenzisana ne-voriconazole, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe wanyangwa ngamayeza e-chemotherapy kumhlaza, kwaye ukuba ukhe wanethuba elide le-QT (ingxaki yentliziyo enqabileyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe), okanye ukhe ubenentliziyo ebetha kancinci okanye engaqhelekanga, amanqanaba egazi asezantsi e-potassium, i-magnesium, okanye i-calcium, i-cardiomyopathy (eyandisiweyo okanye ejiyileyo yentliziyo emisa intliziyo ekupompeni igazi ngokwesiqhelo), umhlaza weeseli zegazi, ukunganyamezelani kwe-galactose okanye i-glucose-galactose malabsorption ( iimeko ezizuze njengelifa apho umzimba ungakwazi ukunyamezela i-lactose); nayiphi na imeko eyenza kubenzima kuwe ukwetyisa i-sucrose (iswekile yetafile) okanye i-lactose (efumaneka kubisi nakwiimveliso zobisi), okanye isifo sesibindi okanye sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Akufanele ukhulelwe ngelixa uthatha i-voriconazole. Kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ukuthintela ukukhulelwa ngexesha lonyango lwakho nge-voriconazole. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba ukhulelwa ngelixa uthatha i-voriconazole, biza ugqirha ngokukhawuleza. IVoriconazole inokwenzakalisa umntwana ongekazalwa.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-voriconazole.
• Kuya kufuneka uyazi ukuba i-voriconazole inokubangela ukungaboni kakuhle okanye ezinye iingxaki ngamehlo akho kwaye zingenza amehlo akho abe nokukhanya kukukhanya okuqaqambileyo. Musa ukuqhuba imoto ebusuku ngelixa uthatha i-voriconazole. Musa ukuqhuba imoto emini okanye usebenzise oomatshini ukuba unayo nayiphi na ingxaki ngombono wakho ngelixa uthatha eli yeza.
• cwangcisa ukuthintela ukukhanya elangeni ngokungeyomfuneko okanye ixesha elide kunye nokunxiba impahla ekhuselayo, iiglasi zelanga kunye nescreen selanga. IVoriconazole inokwenza ulusu lwakho lubuthathaka kwilanga.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IVoriconazole inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• umbono ongaqhelekanga
• kunzima ukubona imibala
• urhudo
• isicaphucaphu
• ukugabha
• intloko ebuhlungu
• isiyezi
• umlomo owomileyo
• ukugungxula

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe KULUNGILE, biza ugqirha ngoko nangoko:

• ifiva
• Ukugodola okanye ukugungqa
• ukubetha kwentliziyo ngokukhawuleza
• ukuphefumla ngokukhawuleza
• ukudideka
• isisu esimoshakele
• ukudinwa kakhulu
• ukugruzuka okanye ukopha okungaqhelekanga
• Ukuphelelwa ngumdla wokutya
• ukurhawuzelela, umchamo omnyama, ukungabinamdla wokutya, ukudinwa, ubumthubi besikhumba okanye amehlo, iintlungu kwinxalenye ephezulu yesisu, isicaphucaphu, ukugabha, okanye iimpawu ezinje ngomkhuhlane.
• ukudinwa; ukungabikho kwamandla; ubuthathaka; isicaphucaphu; ukugabha; isiyezi; ukunciphisa umzimba, okanye iintlungu esiswini
• ukutyeba kwakho; ukutyeba okunamafutha phakathi kwamagxa; ubuso obujikeleziweyo (ubuso benyanga); ubumnyama besikhumba esiswini, emathangeni, emabeleni, nasezingalweni; ulusu olucekethekileyo; ukugruzuka; ukukhula okugqithisileyo kweenwele; okanye ukubila
• ukubona izinto ezingekhoyo (ukubona izinto okanye ukuva amazwi angabikho)
• iintlungu esifubeni okanye ukuqina
• irhashalala
• ukubila
• urhudo okanye isikhumba esixobukayo
• ubunzima bokuphefumla okanye ukugwinya
• ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi

IVoriconazole inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Gcina iitafile kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Gcina ukunqunyanyiswa ngomlomo okungaxutywanga kwisikhenkcisi, kodwa xa sele uxubekile yigcine kubushushu begumbi kwaye musa ukuyifaka efrijini okanye uyiqande. Lahla nakuphi na ukumiswa okungasetyenziswanga emva kweentsuku ezili-14.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• uvakalelo ekukhanyeni
• banzi abafundi (izangqa ezimnyama embindini wamehlo)
• amehlo avaliweyo
• ukuvuza amathe
• ukulahleka kwemali eseleyo xa ushukuma
• ukudakumba
• ukuqhawukelwa ngumphefumlo
• ukuxhuzula
• isisu esidumbileyo
• ukudinwa kakhulu

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ukujonga impendulo yomzimba wakho kwi-voriconazole.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho. Ukuba usenempawu zosulelo emva kokuba ugqibe i-voriconazole, tsalela ugqirha wakho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Vfend^®