Ndingasifumana isiqhamo seediliya ngelixa ndithatha iMetformin?

Umxholo

• Yintoni imetformin?
• Ukusebenzisana kweziyobisi nomsebenzi weediliya
• Zeziphi iziyobisi ezinxibelelana nediliya?
• I-grapefruit iyichaphazela njani i-metformin?
• Ezinye izinto onokuthi uziphephe ngelixa ukwimetformin
• I-grapefruit ingabanceda njani abantu abanesifo seswekile
• Yise kude

Ngo-Meyi ka-2020, kucetyiswa ukuba abanye abenzi be-metformin bandise ukukhutshwa kwezinye zeetafile zabo kwintengiso yase-US. Kungenxa yokuba inqanaba elingamkelekanga le-carcinogen enokubakho (iarhente ebangela umhlaza) yafunyanwa kwezinye iipilisi ze-metformin ezandisiweyo. Ukuba ngoku uthatha eli chiza, tsalela umnikezeli wakho wezempilo. Baza kukucebisa malunga nokuba kufuneka uqhubeke na ukuthatha amayeza akho okanye ukuba ufuna iphepha elitsha.

Amayeza amaninzi, anjengee-statins kunye ne-antihistamines, anokuhlangana okungalunganga kunye ne-grapefruit. I-Metformin isetyenziselwa unyango lwe-2 yeswekile.

Ngaba ukufumana iidiliya xa uthatha i-metformin kukhokelela kwiziphumo ebezingalindelekanga? Kukho uphando olulinganiselweyo, kodwa nantsi into ekufuneka uyazi.

Yintoni imetformin?

I-Metformin sisiyobisi esimiselweyo ukunyanga uhlobo lwe-2 yeswekile. Abantu abane-2 yeswekile abanakho ukusebenzisa i-insulin ngokwesiqhelo. Oku kuthetha ukuba abanako ukulawula ubungakanani beswekile egazini labo. I-Metformin inceda abantu abanesifo seswekile sesi-2 ukulawula inqanaba leswekile egazini labo ngeendlela ezininzi, kubandakanya:

• ukunciphisa isixa seswekile esifunxwa ngumzimba wakho ekutyeni
• ukunciphisa inani leswekile eveliswa sisibindi sakho
• ukwandisa impendulo yomzimba wakho kwi-insulin eyenzayo ngokwemvelo

I-Metformin ayinakufane ibangele imeko enobuzaza kakhulu kunye nobungozi bokubizwa ngokuba yi-lactic acidosis. Abantu abanesibindi, izintso, okanye iingxaki zentliziyo kufuneka baphephe ukuthatha i-metformin.

Ukusebenzisana kweziyobisi nomsebenzi weediliya

Kukho okungaphezulu kunoko kwaziwayo ukunxibelelana nesiqhamo seediliya. Kula machiza kunokukhokelela kwiziphumo ezibi. Zonke iintlobo zegrapefruit- kubandakanya ijusi esandula ukufakwa, imithambo efriziwe, kunye nesiqhamo sonke-kunokukhokelela ekusebenzisaneni neziyobisi.

Ezinye zeekhemikhali ezifumaneka kwigrapefruit zinokubopha kwaye zingasebenzi i-enzyme emzimbeni wakho efumaneka emathunjini nakwisibindi sakho. Le enzyme inceda ukwehlisa amayeza owathathayo.

Ngokwesiqhelo xa uthatha iyeza ngomlomo, laphuke kancinci ngee-enzymes ngaphambi kokuba lifike kwigazi lakho. Oku kuthetha ukuba ufumana amachiza amancinci kwigazi lakho kunaleyo ubuyitya ekuqaleni.

Kodwa xa i-enzyme ithintelwe-njengoko kunjalo xa inxibelelana neekhemikhali kwigrapefruit- kukho isixa esikhulu kakhulu sesiyobisi esenza indlela yakho egazini lakho. Oku kukhokelela kumngcipheko ophezulu wokudlula ngaphezulu. Thatha ujongo olunzulu ngakumbi kunxibelelwano lwesiqhamo seediliya.

Zeziphi iziyobisi ezinxibelelana nediliya?

Ngokuka, ezi ndidi zilandelayo zamachiza zinokunxibelelana okungathandekiyo nediliya:

• ii-statins, ezinje nge simvastatin (Zocor) kunye ne atorvastatin (Lipitor)
• iziyobisi zoxinzelelo lwegazi oluphezulu, njenge-nifedipine (Procardia)
• iziyobisi ezikhuselayo, ezinje ngecyclosporine (iSandimmune)
• i-corticosteroids esetyenziselwa ukunyanga isifo sikaCrohn okanye isifo sezilonda, ezifana nebudesonide (Entocort EC)
• iziyobisi eziphatha isingqisho sentliziyo esingaqhelekanga, njenge-amiodarone (Pacerone)
• i-antihistamines, efana ne-fexofenadine (Allegra)
• ezinye iziyobisi ezichasene noxinzelelo, ezinje nge buspirone (BuSpar)

Ijusi yamagilebhisi ayinampembelelo kuwo onke amayeza kwezi ndidi zingasentla. Ukunxibelelana nejusi yeziqhamo zomdiliya kukuchaphazela iziyobisi, hayi kudidi lweziyobisi.

Xa uqala amayeza amatsha, kubaluleke kakhulu ukuba ubuze ugqirha wakho okanye usokhemesti ukuba uyakwazi na ukusebenzisa iidiliya okanye imveliso enxulumene neziqhamo zomdiliya.

I-grapefruit iyichaphazela njani i-metformin?

Kubalulekile ukwazi ukuba i-metformin ayihlulwa yi-enzyme efanayo neziyobisi zidweliswe apha ngasentla. Akuqhubekekiyo ngumzimba wakho kwaye wagxothwa kumchamo wakho.

Kukho ulwazi olulinganiselweyo olufumanekayo malunga nokuba i-grapefruit ngelixa uthatha i-metformin ibachaphazela njani abantu abanesifo seswekile sesi-2.

Kuxoxwe ngeziphumo zediliya kunye ne-metformin kwiigundane ze-nondiabetic. Ezinye iigundane zavezwa kwijusi yeziqhamo ze grapefruit kunye ne-metformin. Abanye bavezwa kwimetformin kuphela. Abaphandi bafumanise ukuba kukho ukwanda kwinani lemveliso yeasidi yeelactic kwiigundane ezaziveliswe kwijusi yeziqhamo zeediliya kunye ne-metformin.

Abaphandi baqikelela ukuba ijusi yamagilebhisi iphucule ukuqokelelwa kwe-metformin esibindini. Oku, kubangele ukwanda kwemveliso yeasidi ye-lactic. Ngenxa yoku, abaphandi bacebisa ukuba ukusela i-juice ye-grapefruit kungakhokelela kumngcipheko we-lactic acidosis kubantu abathatha i-metformin.

Nangona kunjalo, ezi ziphumo ziye zajongwa kwiigundane ze-nondiabetic, hayi ebantwini abanesifo seswekile sesi-2. Ukuza kuthi ga ngoku, khange kubekho sifundo ebantwini esibonisa ukuba ukuthatha i-metformin ngejusi yegrapefruit kukhokelela kwi-lactic acidosis.

Ezinye izinto onokuthi uziphephe ngelixa ukwimetformin

Ukuthatha amayeza athile ngelixa uthatha i-metformin kunokunyusa umngcipheko wokuba ne-lactic acidosis. Kuya kufuneka uxelele ugqirha wakho ukuba uthatha na la mayeza alandelayo:

• womchamo, ezifana acetazolamide
• ii-corticosteroids, ezinje nge-prednisone
• uxinzelelo lwegazi amayeza, anje nge-amlodipine (Norvasc)
• ii-anticonvulsants, ezinje nge-topiramate (Topamax) kunye ne-zonisamide (iZonegran)
• izinto zokucwangcisa ngomlomo
• amayeza antipsychotic, njenge chlorpromazine

Kuphephe ukuselwa izixa ezikhulu zotywala ngelixa ukwimetformin. Ukusela utywala ngelixa uthatha i-metformin kwandisa umngcipheko wokukhula kweswekile esezantsi yegazi okanye i-lactic acidosis.

NgokweYunivesithi yaseMichigan, kufuneka uphephe ukutya ukutya okunefayibha ephezulu emva kokuthatha i-metformin. Kungenxa yokuba ifayibha inokubopha iziyobisi kwaye yehlise uxinzelelo lwayo. Amanqanaba eMetformin ancipha xa ethathwa ngesixa esikhulu sefayibha (ngaphezulu kwama-30 eemiligram ngosuku).

Ezinye izikhokelo zokutya ngokubanzi kubantu abanesifo seswekile zezi zilandelayo:

• Faka icarbohydrate evela kwimifuno, iziqhamo, kunye neenkozo ezipheleleyo. Qinisekisa ukubeka esweni ukutya kwakho kwe-carbohydrate, kuba oku kuya kuchaphazela ngokuthe ngqo iswekile yegazi lakho.
• Kuphephe ukutya okuphezulu kunamafutha athambileyo kunye neetrans. Endaweni yoko, yitya amafutha kwiintlanzi, amandongomane, kunye neoyile yomnquma. Nazi iindlela ezili-10 zokongeza amafutha asempilweni kwisidlo sakho.
• Ukutya i-25 ukuya kwi-30 milligrams yefayibha ngemini kunokunceda ukulawula amanqanaba eglucose egazini. Jonga olu luhlu lwe-22 yokutya okuphezulu kwifayibha ukuze uqalise.
• Gwema isodiyam. Zama ukusebenzisa ngaphantsi kweemiligram ezingama-2,300 ngosuku.

I-grapefruit ingabanceda njani abantu abanesifo seswekile

Ukusela ijusi yamagilebhisi kunokuba luncedo ukuba unesifo seswekile.

Ibonisile ukuba amalungiselelo okusela ecacisiweyo ijusi yeziqhamo zegrape kunciphise ukuzila ukutya kunye nokuzuza ubunzima. Iziphumo eziqwalaselweyo zazifana neziphumo ze-metformin. Kwakungekho siphumo siphuculweyo xa ijusi yeediliya kunye ne-metformin kuvavanywa kunye.

Ngelixa uthembisa, kubalulekile ukuba uqaphele ukuba oku kuqatshelwe kwenziwa kwimodeli yesifo seswekile.

Indima yendima yeziqhamo zomdiliya ekutyeni nasekusebenzisaneni kweziyobisi ikwacebisa ukuba iidiliya ihambelana nokunciphisa umzimba kunye nokuphucula ukunganyangeki kwe-insulin. Ngaphezu, uphononongo lukwachaza ikhompawundi kwijusi yeziqhamo (i-naringin) ifunyenwe ukuphucula i-hyperglycemia kunye ne-cholesterol ephezulu kuhlobo lwesibini lwesifo seswekile. Funda ngakumbi ngokuhlala nesifo seswekile kunye ne-cholesterol ephezulu.

Yise kude

Isiqhamo samagilebhisi sikhokelela kunxibelelwano olubi kunye namanye amayeza. Nangona kunjalo, akukho zifundo zityala apho ukutya ijusi yamagilebhisi ngelixa uthatha i-metformin kukhokelele kwiziphumo ezibi ebantwini.

Kukho ubungqina obuthembisayo bokulinga ukuba kubandakanya iidiliya kwiidayethi yakho kunokunceda ukukhuthaza ukwehla kobunzima kunye nokunciphisa amanqanaba eswekile yokuzila.

Ukuba uthatha i-metformin kwaye ukhathazekile kukunxibelelana kweziyobisi okanye ukusebenzisana neziyobisi, thetha nomboneleli wakho wezempilo.