Umbhali: Virginia Floyd
Umhla Wokudalwa: 10 Eyethupha 2021
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PALLAS Trial Demotes Dronedarone for Atrial Fibrillation
Ividiyo: PALLAS Trial Demotes Dronedarone for Atrial Fibrillation

Umxholo

Akufanele uthathe i-dronedarone ukuba unesifo sentliziyo esibi. I-Dronedarone inokunyusa umngcipheko wokufa kwabantu abanesifo sentliziyo esomeleleyo. Tshela ugqirha wakho ukuba unokusilela kwentliziyo okunzima ngokwaneleyo ukuba kunokubangela ukuphefumla okufutshane xa uphumle, emva komthamo omncinci wokuzilolonga, okanye emva kwawo nawuphi na umsebenzi womzimba. Xelela ugqirha wakho ukuba uye walaliswa esibhedlele ngenxa yokusilela kwentliziyo kwinyanga ephelileyo nokuba uziva ungcono. Ugqirha wakho akanakukumisela i-dronedarone.

Akufanele uthathe i-dronedarone ukuba une-fibrillation ye-atrial (isifo senhliziyo esinokubangela ukuba ukubetha kwentliziyo kukhawuleze kwaye kungahambelani) okungayi kuthi okanye kungenakuguqulwa kubuyelwe kwisingqi sentliziyo esiqhelekileyo. I-Dronedarone inokunyusa umngcipheko wokufa, ukubetha, kunye nesidingo sokulaliswa esibhedlele kubantu abane-fibrillation engapheliyo. Ugqirha wakho uyakujonga isigqi sentliziyo sakho ubuncinci qho kwiinyanga ezi-3 ngelixa uthatha idronearone. Biza ugqirha wakho kwangoko ukuba ukubetha kwentliziyo yakho kukhawuleza okanye kungahambelani ngelixa uthatha i-dronearone.


Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-dronedarone kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Dronedarone isetyenziselwa ukunyanga abantu okwangoku abanesingqisho sentliziyo esiqhelekileyo, kodwa babe ne-atrial fibrillation ngaphambili. I-Dronedarone inciphisa umngcipheko wokuba abantu abanale meko baya kulaliswa esibhedlele ukuze banyange i-fibrillation ye-atrial. I-Dronedarone ikudidi lwamayeza abizwa ngokuba yi-antiarrhythmics. Isebenza ngokunceda intliziyo ukuba ibethe ngokwesiqhelo.

I-Dronedarone iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kabini ngemini, kunye nesidlo sakusasa kunye nesidlo sangokuhlwa. Thatha i-dronedarone ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-dronedarone kanye njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.


Ugqirha wakho unokuyalela amayeza athile ukunciphisa umngcipheko wokubetha ngelixa uthatha idronearone. Thatha la mayeza ngokuchanekileyo njengoko uxelelwe ngexesha lonyango lwakho.

I-Dronedarone iyakunceda ukulawula ukubetha kwentliziyo yakho kuphela ukuba uqhubeka uyithatha. Qhubeka nokuthatha idronearone nokuba uziva uphilile kwaye uzive kamnandi ixesha elide.Sukuyeka ukuthatha idronearone ngaphandle kokuthetha nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-dronedarone,

  • xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana nedronarone, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi zeedronone. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
  • xelela ugqirha wakho ukuba ngaba uthatha nawaphi na amayeza alandelayo: amayeza athile njenge-amitriptyline (eLimbitrol), amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor ), Protriptyline (Vivactil), kunye netrimipramine (iSurmontil); ii-antifungals ezithile ezinje nge-itraconazole (Sporanox), ketoconazole (Nizoral), okanye voriconazole (Vfend); i-clarithromycin (i-Biaxin); icyclosporine (Gengraf, Neoral, Sandimmune); i-erythromycin (i-EES, i-E-Mycin, i-Erythrocin); amayeza okubetha kwentliziyo okungaqhelekanga afana ne-amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), flecainide (Tambocor), propafenone (Rythmol), quinidine, kunye ne-sotalol (Betapace); nefazodone; phenothiazine amayeza ukugula ngengqondo okanye isicaphucaphu; i-ritonavir (iNorvir); okanye telithromycin (Ketek). Ugqirha wakho unokukuxelela ukuba ungathathi idronearone ukuba uthatha elinye okanye nangaphezulu la mayeza.
  • xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-beta blockers ezinje nge-atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), kunye nepropranolol (Inderal); iicalcium block blockers ezinjenge diltiazem (Cardizem, Dilacor, Tiazac), nifedipine (Adalat, Procardia), kunye neverapamil (Calan, Covera, Isoptin, Verelan); carbamazepine (Epitol, Equetro, Tegretol); cholesterol-ukunciphisa amayeza (ii-statins) ezinjenge-atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), kunye ne-simvastatin (Zocor); i-digoxin (iLanoxicaps, iLanoxin); womchamo (iipilisi zamanzi); phenobarbital; phenytoin (Dilantin); irifampin (Rifadin, Rimactane); i-serotonin reuptake inhibitors (i-SSRIs) ekhethiweyo njengecitalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), kunye sertraline (Zoloft); i-sirolimus (iRapamune); kunye netacrolimus (Prograf). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
  • xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
  • xelela ugqirha wakho ukuba unazo naziphi na ezinye iingxaki zentliziyo ezinje ngokubetha kwentliziyo okukhawulezayo okanye okucothayo, ixesha elide le-QT (ingxaki yentliziyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe), isifo sesibindi, okanye ukuba unesibindi okanye imiphunga iingxaki eziye zaphuhliswa emva kokuthatha i-amiodarone (Pacerone). Ugqirha wakho unokukuxelela ukuba ungathathi idronearone.
  • xelela ugqirha wakho ukuba ubukhe wanazo naziphi na iimeko zonyango.
  • xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho ngedronarone. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba ukhulelwe ngelixa uthatha i-dronedarone, tsalela ugqirha ngokukhawuleza. I-Dronedarone inokulimaza umbungu.
  • Akufanele uncancise ibele ngexesha lonyango lwakho nge-dronedarone.
  • thetha nogqirha wakho malunga nemingcipheko kunye nezibonelelo zokuthatha i-dronedarone ukuba uneminyaka eyi-65 ubudala okanye ngaphezulu. Abanye abantu abadala abadala akufuneki bathathe i-dronearone kuba ayikhuselekanga okanye ayisebenzi njengamanye amayeza anokusetyenziswa ukunyanga imeko efanayo.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.


Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Ungazami ukwenza idosi ephosiweyo okanye uthathe idosi ephindwe kabini ukwenza enye ephosiweyo.

I-Dronedarone inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

  • urhudo
  • isilungulela
  • ubuthathaka
  • irhashalala
  • bomvu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu, okanye ezo zidweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO, yeka ukuthatha i-dronedarone kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

  • ukuqhawukelwa ngumphefumlo
  • ubunzima bokuginya okanye ukuphefumla
  • ukuvutha
  • ukuqina kwesifuba
  • ukukhohlela owomileyo
  • ukukhohlela amafinyila angqindilili
  • ubunzima bokulala ngenxa yeengxaki zokuphefumla
  • Kufuneka uzixhase ngemiqamelo eyongezelelweyo ukuze uphefumle ebusuku
  • ukutyeba (kweeponti ezi-5 nangaphezulu) ngexesha elifutshane
  • ukudumba kwamehlo, ubuso, imilebe, umqala, izandla, iinyawo okanye imilenze
  • ukubetha kwentliziyo
  • isiqaqa
  • ifiva
  • Iimpawu ezinjengomkhuhlane
  • mthubi ulusu okanye amehlo
  • ukurhawuzelela
  • ukugruzuka okanye ukopha okungaqhelekanga
  • isicaphucaphu
  • ukugabha
  • Ukuphelelwa ngumdla wokutya
  • iintlungu kwinxalenye ephezulu yesisu
  • ukudinwa okanye ukungabikho kwamandla
  • ubumnyama ngokungaqhelekanga komchamo
  • izitulo ezikhanyayo
  • intloko ebuhlungu ngesiquphe
  • ukulahleka ngokukhawuleza kombono
  • ubuthathaka okanye ukuba ndindisholo kwengalo okanye umlenze
  • kunzima ukucinga ngokucacileyo, ukukhumbula, okanye ukufunda izinto ezintsha

I-Dronedarone inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho unokuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-dronedarone.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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Ukuhlaziywa kokugqibela-08/15/2018

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