Inaliti ye-Ipilimumab

Umxholo

• Ngaphambi kokufumana inaliti ye-ipilimumab,
• I-Ipilimumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na iimpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo.

Inaliti ye-Ipilimumab isetyenziswa:

• ukunyanga i-melanoma (uhlobo lomhlaza wolusu) kubantu abadala nakubantwana abaneminyaka eli-12 ubudala nangaphezulu enganyangekiyo ngotyando okanye ethe yanwenwela kwamanye amalungu omzimba.
• ukunceda ukuthintela i-melanoma ekubuyeni emva kotyando ukuyisusa kunye nazo naziphi na ii-lymph node ezichaphazelekayo.
• ngokudibeneyo ne-nivolumab (Opdivo) ukunyanga i-renal cell carcinoma (RCC; uhlobo lomhlaza oqala kwiiseli zezintso).
• ngokudibeneyo ne-nivolumab ukunyanga iintlobo ezithile zomhlaza obomvu (umhlaza oqala emathunjini amakhulu) kubantu abadala nakubantwana abaneminyaka eli-12 ubudala nangaphezulu osasazeke kwamanye amalungu omzimba kwaye uye wanda emva konyango namanye amayeza e-chemotherapy.
• ngokudibeneyo ne-nivolumab ukunyanga i-hepatocellular carcinoma (HCC; uhlobo lomhlaza wesibindi) kubantu ababekade bephathwa nge-sorafenib (Nexafar).
• ngokudibeneyo ne-nivolumab kuhlobo oluthile lomhlaza wemiphunga (umhlaza womhlaza wamaphaphu ongekho mncinci; NSCLC) kubantu abadala abasasazeke kwamanye amalungu omzimba.
• ngokudibeneyo ne-nivolumab kunye neplatinum chemotherapy ukunyanga uhlobo oluthile lwe-NSCLC kubantu abadala ababuyileyo okanye abasasazeke kwamanye amalungu omzimba.
• ngokudibeneyo ne-nivolumab ukunyanga i-mesothelioma enobungozi (uhlobo lomhlaza oluchaphazela ulusu lwangaphakathi lwemiphunga kunye nesifuba) kubantu abadala abangenakususwa ngotyando.

Inaliti ye-Ipilimumab ikudidi lwamayeza abizwa ngokuba zii-antibodies ze-monoclonal. Isebenza ngokunceda umzimba ukuba ucothe okanye umise ukukhula kweeseli zomhlaza.

Inaliti ye-Ipilimumab iza njengesisombululo (ulwelo) sokutofelwa ngaphakathi (emthanjeni) ngugqirha okanye ngumongikazi esibhedlele okanye kwiziko lonyango. Xa ipilimumab inikwa ukunyanga i-melanoma, ihlala inikwa ngaphezulu kwemizuzu engama-90 kanye kwiiveki ezi-3 ukuba ugqirha ucebisa ukuba ufumane unyango. Xa ipilimumab inikwa i-nivolumab ukunyanga i-renal cell carcinoma, i-hepatocellular carcinoma, okanye umhlaza we-colorectal cancer, ihlala inikwa ngaphezulu kwemizuzu engama-30 kanye kwiiveki ezintathu ukuya kuthi ga kwiidosi ezi-4. Xa ipilimumab inikwa nge-nivolumab okanye nge-nivolumab kunye neplatinum chemotherapy ukunyanga i-NSCLC, ihlala inikwa ngaphezulu kwemizuzu engama-30 kube kanye kwiiveki ezi-6 ukuba ugqirha ucebisa ukuba ufumane unyango. Xa ipilimumab inikwa nge-nivolumab ukunyanga i-mesothelioma enobungozi, ihlala inikwa ngaphezulu kwemizuzu engama-30 kanye kwiiveki ezi-6 ukuba ugqirha ucebisa ukuba ufumane unyango.

Inaliti ye-Ipilimumab inokubangela ukusabela okunobuzaza okanye okusongela ubomi ngexesha lokufakwa. Ugqirha okanye umongikazi uya kukujonga ngokusondeleyo ngelixa ufumana ukumiliselwa kwaye kungekudala emva kokufakwa ukuze uqiniseke ukuba awunampendulo imbi kunyango. Xelela ugqirha wakho okanye umongikazi kwangoko ukuba unazo naziphi na kwezi mpawu zilandelayo ezinokuthi zenzeke ngexesha lokufakwa ngaphakathi: ukugodola okanye ukungcangcazela, ukurhawuzelela, irhashalala, ukugungxula, ukuphefumla nzima, isiyezi, umkhuhlane, okanye ukuziva udiniwe.

Ugqirha wakho unokunciphisa ukunyuswa kwakho, ukulibaziseka, okanye ukuyeka unyango lwakho ngenaliti ye-ipilimumab, okanye ukunyanga ngamayeza ongezelelweyo kuxhomekeke kwimpendulo yakho kunyango kunye naziphi na iziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-ipilimumab kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-ipilimumab,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana nenaliti ye-ipilimumab, nawaphi na amanye amayeza, okanye naziphi na izithako ezikuyo ngenaliti ye-ipilimumab. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe wafakelwa ilungu elithile, isifo sesibindi, okanye ukuba isibindi sakho sonakaliswe lunyango okanye sisifo. Kwakhona xelela ugqirha wakho ukuba ukhe unesifo sokuzimela komzimba (imeko apho amajoni omzimba ahlasela indawo esempilweni yomzimba) njengesifo sikaCrohn (imeko apho amajoni omzimba ahlasela khona umgca wokugaya obangela iintlungu. , urhudo, ukwehla kobunzima bomzimba, kunye nefiva), ulcerative colitis (imeko ebangela ukudumba kunye nezilonda kumngxunya wekholoni [amathumbu amakhulu] kunye ne-rectum), i-lupus (imeko apho amajoni omzimba ahlasela izicwili kunye namalungu amaninzi kubandakanya ulusu, amalungu, igazi kunye nezintso), okanye i-sarcoidosis (imeko apho iiseli ezingaqhelekanga zikhula kwiindawo ezahlukeneyo zomzimba kubandakanya imiphunga, ulusu namehlo).
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Uya kudinga ukuthatha uvavanyo lokukhulelwa ngaphambi kokuba ufumane ipilimumab. Kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ukuthintela ukukhulelwa ngexesha lonyango lwakho ngenaliti ye-ipilimumab kunye neenyanga ezi-3 emva kwedosi yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba ukhulelwa ngelixa ufumana inaliti ye-ipilimumab, tsalela ugqirha ngokukhawuleza. Inaliti ye-Ipilimumab inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufanelanga ukuncancisa ngelixa ufumana inaliti ye-ipilimumab kunye neenyanga ezi-3 emva kwedosi yakho yokugqibela.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

I-Ipilimumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ubunzima bokulala okanye ukulala
• intlungu edibeneyo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na iimpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo.

• ukuncipha kokuchama, igazi kumchamo, ukudumba kweenyawo, amaqatha, okanye imilenze esezantsi, okanye ukulahleka kwesidlo
• urhudo, igazi okanye mnyama, hlala, izitulo ezinamathelayo, isisu esibuhlungu okanye ukuthamba, okanye umkhuhlane
• ukukhwehlela, iintlungu esifubeni, okanye ukuphefumla kancinci
• ukudinwa, ukudideka, iingxaki zememori, ukubona izinto ezingekhoyo, ukuxhuzula, okanye intamo elukhuni
• ukuziva udiniwe, ukwanda kwesidlo, ukwanda kokoma, ukwanda kokuchama, okanye ukunciphisa umzimba
• ukubetha kwentliziyo okukhawulezayo, ukungcangcazela okungalawulekiyo kwilungu lomzimba, ukwanda kwesidlo, okanye ukubila
• ukudinwa okanye ukonqena, ukonyusa ubuntununtunu kubanda, ukuqhina, ukuqaqamba kwemisipha kunye nobuthathaka, ukutyeba, ubunzima ngaphezu kwexesha eliqhelekileyo okanye elingaqhelekanga lokuya exesheni, ukucheba iinwele, intloko ebuhlungu, isiyezi, ukuba nochuku, ukulibala, ukuncipha kwesondo, okanye uxinzelelo
• ubumthubi besikhumba okanye amehlo, umchamo omnyama (onetayi), iintlungu kwinxalenye ephezulu yesisu, isicaphucaphu, ukugabha, okanye ukugruzuka okulula okanye ukopha
• ubuthathaka obungaqhelekanga bemilenze, iingalo, okanye ubuso; okanye ukuba ndindisholo okanye ukurhawuzelelwa zizandla okanye iinyawo
• ukukhawuleza kunye okanye ngaphandle kokubamba, ukukhupha okanye ukukhupha ulusu, okanye izilonda zomlomo
• umbono ophazamisayo, umbono ophindwe kabini, iintlungu zamehlo okanye ubomvu, okanye ezinye iingxaki zombono

Inaliti ye-Ipilimumab inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nenaliti ye-ipilimumab.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi nangexesha lonyango lwakho ukuze abone ukuba kukhuselekile na kuwe ukufumana inaliti ye-ipilimumab kwaye ujonge impendulo yomzimba wakho kwisitofu se-ipilimumab.

Kwezinye iimeko, ugqirha wakho uya kuyalela uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba umhlaza wakho unganyangwa nge-ipilimumab.

Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nenaliti ye-ipilimumab.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Yervoy^®