Inaliti yeBrentuximab Vedotin

Umxholo

• Inaliti yeBrentuximab vedotin iyasetyenziswa
• Ngaphambi kokufumana inaliti ye-brentuximab vedotin,
• Inaliti yeBrentuximab vedotin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

Ukufumana inaliti ye-brentuximab vedotin kunokunyusa umngcipheko wokuba uphuhlise i-leukoencephalopathy (PML; isifo esinqabileyo sobuchopho esinganyangekiyo, esinokuthintelwa, okanye esinganyangekiyo esihlala sibangela ukufa okanye ukukhubazeka kakhulu). Xelela ugqirha wakho ukuba ukhe wakha wanesimo esichaphazela amajoni akho omzimba. Xelela ugqirha wakho kunye nosokhemesti ukuba uthatha nawaphi na amayeza acinezela amajoni omzimba. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, yeka ukufumana inaliti ye-brentuximab vedotin kwaye ubize ugqirha ngoko nangoko: ukunciphisa amandla okanye ubuthathaka kwelinye icala lomzimba; ukuhamba nzima; ukulahleka koququzelelo; intloko ebuhlungu; ukudideka; ubunzima bokucinga ngokucacileyo; ukulahleka kwememori; utshintsho kwimood okanye indlela yokuziphatha eqhelekileyo kunzima ukuthetha; okanye utshintsho lombono.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho unokuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwisitofu se-brentuximab vedotin.

Thetha nogqirha wakho malunga neengozi zokufumana inaliti ye-brentuximab vedotin.

Inaliti yeBrentuximab vedotin iyasetyenziswa

• ngokudibeneyo namanye amayeza e-chemotherapy ukunyanga i-Hodgkin's lymphoma (isifo sikaHodgkin) kwabo bangazange bafumane unyango ngaphambili,
• ukunyanga i-Hodgkin's lymphoma kwabo basemngciphekweni wokuba izifo zabo zibe mandundu okanye babuye emva kokufakwa kwe-stem cell (inkqubo etshintsha umongo wethambo onesifo somongo wethambo),
• ukunyanga i-Hodgkin's lymphoma kwabo bangaphendulanga ekufakweni kwe-stem cell (inkqubo etshintsha umongo wethambo onesifo somongo wethambo) okanye amaxesha amabini onyango lwe-chemotherapy,
• ngokudibeneyo namanye amayeza e-chemotherapy ukunyanga i-lymphoma enkulu (i-sALCL; uhlobo lwe-non-Hodgkin lymphoma) kunye nezinye iintlobo zeepheripheral T-cell lymphomas (PTCL; uhlobo lwe-non-Hodgkin lymphoma) kwabo bangazange ngaphambili unyango,
• Ukunyanga inkqubo ye-SALCL kwabo bangakhange baphendule kwelinye ixesha lonyango lwe-chemotherapy,
• ukunyanga uhlobo oluthile lwe-primary cutaneous anaplastic large cell lymphoma (pcALCL; uhlobo lwe-non-Hodgkin's lymphoma) kubantu abakhe bafumana olunye unyango.

Inaliti ye-Brentuximab vedotin ikudidi lwamayeza abizwa ngokuba zii-anti-drug conjugates. Isebenza ngokubulala iiseli zomhlaza.

Inaliti ye-Brentuximab vedotin iza njengomgubo wokudityaniswa nolwelo kwaye itofwe ngaphezulu kwemizuzu engama-30 efakwa ngaphakathi (emthanjeni) ngugqirha okanye ngumongikazi kwiofisi yezonyango okanye esibhedlele. Xa i-brentuximab vedotin inikwa unyango lweHodgkin's lymphoma, i-sALCL, okanye i-PTCL, ihlala itofwa kanye kwiiveki ezi-3 okoko ugqirha ekucebisa ukuba ufumane unyango. Xa i-brentuximab vedotin isetyenziswa ngokudibanisa ne-chemotherapy ukunyanga i-Hodgkin lymphoma njengonyango lokuqala, ihlala itofwa kanye kwiiveki ezi-2 ukuba ugqirha ucebisa ukuba ufumane unyango.

Inaliti ye-Brentuximab vedotin inokubangela ukusabela okungafunekiyo komzimba, okuhlala kwenzeka ngexesha lokufakwa kweyeza okanye kwiiyure ezingama-24 zokufumana idosi. Unokufumana amayeza athile ngaphambi kokufakwa kwakho ukuthintela ukungahambelani komzimba ukuba ubunempendulo kunyango lwangaphambili. Ugqirha wakho uya kukujonga ngononophelo ngelixa ufumana i-brentuximab vedotin. Ukuba unazo naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngoko nangoko: umkhuhlane, Ukugodola, irhashalala, irhashalala, ukurhawuzelela, okanye ukuphefumla nzima.

Ugqirha wakho unokufuna ukulibazisa unyango lwakho, uhlengahlengise idosi yakho, okanye uyeke unyango lwakho ukuba uneziphumo ebezingalindelekanga. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho ngenaliti ye-brentuximab vedotin.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-brentuximab vedotin,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-brentuximab vedotin, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-brentuximab vedotin injection. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho ukuba ufumana i-bleomycin. Ugqirha wakho uya kuthi ungasebenzisi inaliti ye-brentuximab vedotin ukuba ufumana eli yeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zilandelayo: clarithromycin (Biaxin, kwi-PrevPac), indinavir (Crixivan), itraconazole (Sporanox), ketoconazole, nefazodone, nelfinavir (Viracept), rifampin (Rifadin, Rimactane, eRifamate, naseRifater ritonavir (ENorvir, eKaletra). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe unesifo sesibindi okanye sezintso.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ungumfazi okwaziyo ukukhulelwa, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye neenyanga ezi-6 emva kwethamo lakho lokugqibela. Ukuba uyindoda kunye neqabane lowasetyhini okhulelweyo okanye onokukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye neenyanga ezi-6 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa ufumana i-brentuximab vedotin injection, biza ugqirha wakho ngokukhawuleza. Inaliti yeBrentuximab vedotin inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Akufanelanga ukuncancisa ngelixa ufumana inaliti ye-brentuximab vedotin.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuzala emadodeni. Thetha nogqirha wakho malunga neengozi zokufumana inaliti ye-brentuximab vedotin.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Inaliti yeBrentuximab vedotin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhina
• izilonda zomlomo
• ukunciphisa ukutya
• ukuhla ukusinda
• ukudinwa
• isiyezi
• ubuthathaka
• ubunzima bokulala okanye ukulala
• ixhala
• isikhumba esomileyo
• ukulahleka kweenwele
• ukubila ebusuku
• ngokudibeneyo, ithambo, umsipha, umqolo, ingalo, okanye iintlungu zomlenze
• ukudumba kwezihlunu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukopha okungaqhelekanga okanye ukugruzuka
• ukuba ndindisholo, ukutshisa, okanye ukurhawuzelela izandla, iingalo, iinyawo okanye imilenze
• ubuthathaka bemisipha
• Ukuxobuka okanye ukudumba kolusu
• urhwebo
• irhashalala
• ukurhawuzelela
• isicaphucaphu
• ukugabha
• urhudo
• ukukhohlela okanye ukuphefumla kancinci
• ukuncipha kokuchama
• ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi
• kunzima, kubuhlungu, okanye ukuchama rhoqo
• umkhuhlane, ukugodola, ukukhohlela, okanye ezinye iimpawu zosulelo
• iintlungu eziqhubekayo eziqala kwindawo yesisu kodwa zinokusasazeka ngasemva
• ulusu oluthuthu
• mthubi ulusu okanye amehlo
• iintlungu okanye ukungaphatheki kakuhle kwindawo ephezulu yesisu
• umchamo omnyama
• intshukumo yombala wodongwe
• isisu esibuhlungu
• ukopha okungaqhelekanga okanye ukugruzuka
• izitulo ezimnyama kunye nokulinda
• Igazi elibomvu ilindle

Inaliti yeBrentuximab vedotin inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• umkhuhlane, ukugodola, ukukhohlela, okanye ezinye iimpawu zosulelo

Buza usokhemesti wakho nayiphi na imibuzo onayo malunga ne-brentuximab vedotin injection.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Adcetris^®