IVandetanib

Umxholo

• Ngaphambi kokuba uthathe i-vandetanib,
• IVandetanib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

I-Vandetanib inokubangela ukongezwa kwe-QT (isingqisho sentliziyo esingaqhelekanga esinokukhokelela ekuphelelweni lithemba, ukuphulukana nokuqonda, ukuxhuzula, okanye ukufa ngesiquphe). Tshela ugqirha wakho ukuba wena okanye nabani na kusapho lwakho ukhe waba ne-QT syndrome (imeko ezuzwe njengelifa apho umntu kunokwenzeka ukuba abe nokwandiswa kwe-QT) okanye ukhe waba namanqanaba asezantsi e-calcium, i-potassium okanye i-magnesium igazi lakho, ukubetha kwentliziyo okungaqhelekanga, ukusilela kwentliziyo, okanye isifo sentliziyo. Xelela ugqirha wakho kunye nosokhemesti ukuba uthatha i-chloroquine (Aralen); i-clarithromycin (i-Biaxin, kwi-Prevpac); haloperidol (iHaldol); amayeza okubetha kwentliziyo okungaqhelekanga afana ne-amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), procainamide, kunye ne-sotalol (Betapace); amayeza athile isicaphucaphu ezifana dolasetron (Anzemet) kunye granisetron (Sancuso); imethadone (iDolophine, iMethadose); moxifloxacin (Avelox); kunye nepimozide (Orap). Ukuba ufumana naziphi na kwezi mpawu zilandelayo, yeka ukuthatha i-vandetanib kwaye ufowunele ugqirha wakho kwangoko okanye ufumane unyango olukhawulezileyo: ukukhawuleza, ukubetha, okanye ukubetha kwentliziyo okungaqhelekanga; isiqaqa; intloko emhlophe; okanye ukulahleka kwengqondo. IVandetanib inokuhlala emzimbeni wakho kangangeenyanga ezininzi emva kokuba uyekile ukuthatha amayeza, ukuze uqhubeke nokuba semngciphekweni weziphumo ebezingalindelekanga ngelo xesha.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile, ezinje ngovavanyo lwegazi kunye nee-electrocardiograms (EKGs, iimvavanyo ezirekhoda umsebenzi wombane wentliziyo) ngaphambili kwaye rhoqo ngexesha lonyango lwakho ukuze uqiniseke ukuba kukhuselekile kuwe ukuthatha i-vandetanib. Ugqirha wakho uya kuyalela ezi mvavanyo nanini na ukuba idosi yakho ye-vandetanib itshintshiwe okanye ukuba uqala ukuthatha amayeza amatsha.

Inkqubo ebizwa ngokuba yiCaprelsa Risk Evaluation and Mitigation Strategy (REMS) sele isetelwe ukulawula ubungozi beliyeza. Uyakwazi kuphela ukufumana i-vandetanib ukuba ugqirha omisela amayeza akho abhalisiwe kule nkqubo. Unokufumana kuphela amayeza kwikhemesti ethatha inxaxheba kule nkqubo. Buza ugqirha wakho ukuba unemibuzo malunga nokuthatha inxaxheba kule nkqubo okanye indlela yokufumana amayeza akho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-vandetanib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-vandetanib.

IVandetanib isetyenziselwa ukunyanga uhlobo oluthile lomhlaza we-thyroid ongenakunyangwa ngoqhaqho okanye osasazeke kwamanye amalungu omzimba. IVandetanib ikudidi lwamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

IVandetanib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye ngemini. Thatha i-vandetanib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-vandetanib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo ngeglasi yamanzi. Musa ukwahlula, ukuhlafuna, okanye ukuchoboza. Ukuba ithebhulethi ichithwe ngengozi, thintela unxibelelwano nolusu lwakho. Ukuba kukho naluphi na unxibelelwano olwenzekayo, hlamba indawo echaphazelekayo kakuhle ngamanzi.

Ukuba awukwazi ukuginya iipilisi zizonke, unokuzinyibilikisa emanzini. Beka ithebhulethi kwiglasi equlathe ii-ounces ezi-2 zamanzi okusela acocekileyo, angenacarbon. Sukusebenzisa naluphi na ulwelo ukunyibilikisa ithebhulethi. Hlanganisa umxube malunga nemizuzu eyi-10 de ithebhulethi ibe ngamaqhekeza amancinci kakhulu; ithebhulethi ayizukunyibilika ngokupheleleyo. Sela lo mxube ngoko nangoko. Hlanganisa iglasi ngenye i-ounces ezi-4 zamanzi angenayo ikharbon kwaye usele amanzi okuhlamba ukuze uqiniseke ukuba uyawaginya onke amayeza.

Ugqirha wakho unokunciphisa idosi yakho ye-vandetanib okanye akuxelele ukuba uyeke ukuthatha i-vandetanib kangangexesha elithile kunyango lwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka nokuthatha i-vandetanib nokuba uziva uphilile. Sukuyeka ukuthatha i-vandetanib ungakhange uthethe nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-vandetanib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-vandetanib, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi ze-vandetanib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ngokukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zilandelayo: carbamazepine (Tegretol, Carbatrol, Equetro), dexamethasone, phenobarbital, phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), rifampin (Rifadin, , rifapentin (Priftin), kunye neehomoni ze-thyroid ezifana ne-levothyroxine (Synthroid). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-vandetanib, ke qiniseka ukuba uxelele ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt Johns Wort.
• xelela ugqirha wakho ukuba usandula ukukhohlela igazi okanye unayo nayiphi na enye ingxaki yokuphuma kwegazi kwaye ukuba unayo okanye wakhe wanengxaki yoxinzelelo lwegazi, naluphi na uhlobo lwesifo solusu, ukuxhuzula, okanye imiphunga, isifo sezintso okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Akufanele ukhulelwe ngelixa uthatha i-vandetanib kwaye ubuncinci iinyanga ezi-4 emva konyango lwakho. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba ukhulelwa ngelixa uthatha i-vandetanib, biza ugqirha wakho ngokukhawuleza. IVandetanib inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-vandetanib.
• Kuya kufuneka uyazi ukuba i-vandetanib inokukwenza uzive usozela, ubuthathaka, okanye ubangele umbono ophuthileyo. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.
• cwangcisa ukuthintela ukukhanya elangeni ngokungeyomfuneko okanye ixesha elide kunye nokunxiba impahla ekhuselayo, iiglasi zelanga kunye nescreen selanga. I-Vandetanib inokwenza ulusu lwakho lubonakale kukukhanya kwelanga ngexesha lonyango lwakho kwaye ubuncinci iinyanga ezi-4 emva kokuyeka unyango lwakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba idosi yakho elandelayo ifanelekile kwiiyure ezili-12 okanye nangaphezulu, thabatha idosi ephosiweyo kwakamsinya nje ukuba uyikhumbule. Nangona kunjalo, ukuba idosi elandelayo iya kuthathwa ngaphantsi kweeyure ezili-12, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IVandetanib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• isilungulela
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda
• isisu esibuhlungu
• impumlo enemifinya
• ukudinwa kakhulu
• ubuthathaka
• ubunzima bokulala okanye ukulala
• ukudakumba

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• urhudo
• irhashalala okanye amabala
• yomile, iyaxobuka, okanye isikhumba silume
• Amadyungudyungu okanye izilonda kulusu okanye emlonyeni
• ukuba bomvu kobuso, izandla, okanye iinyawo
• izihlunu okanye amalungu ngokudibeneyo
• ifiva
• iintlungu zesifuba (ezinokuthi zibe mandundu ngokuphefumla okunzulu okanye ukukhwehlela)
• hiccups okanye ukuphefumla ngokukhawuleza
• ukuphefumla ngokukhawuleza
• ukukhohlela okungapheliyo
• ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi
• ukukhawuleza ukutyeba
• Ukuba ndindisholo okanye ukuba buthathaka kobuso, ingalo, okanye umlenze, ngakumbi kwelinye icala lomzimba
• ukudideka ngequbuliso
• kunzima ukuthetha okanye ukuqonda
• inkathazo yequbuliso ukubona kwiliso elinye okanye omabini
• ukuhamba ngesiquphe okanye ukungalingani
• intloko ebuhlungu ngesiquphe
• ukuxhuzula
• ukugruzuka okanye ukopha okungaqhelekanga

IVandetanib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ukujonga impendulo yomzimba wakho kwi-vandetanib. Ugqirha wakho uya kujonga uxinzelelo lwegazi rhoqo ngexesha lonyango lwakho kunye ne-vandetanib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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