I-Teriflunomide

Umxholo

• Ngaphambi kokuba uthathe i-teriflunomide,
• I-Teriflunomide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, yeka ukuthatha iteriflunomide kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Teriflunomide inokubangela ukonakala kwesibindi okanye ukusongela ubomi, okunokufuna ukufakelwa kwesibindi. Umngcipheko wokulimala kwesibindi unokunyuswa kubantu abathatha amanye amayeza aziwayo ukuba abangele ukonakala kwesibindi, nakubantu esele benesifo sesibindi. Tshela ugqirha wakho ukuba unesifo sesibindi. Ugqirha wakho unokukuxelela ukuba ungathathi iteriflunomide. Xelela ugqirha wakho kunye nosokhemesti malunga nawo onke amayeza owathathayo ukuze bakwazi ukujonga ukuba ngaba nawaphi na amayeza akho anokuwonyusa umngcipheko wokuba uya kukhula ukonakala kwesibindi ngexesha lonyango lwakho nge-teriflunomide. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: isicaphucaphu, ukugabha, ukudinwa kakhulu, ukopha okungaqhelekanga okanye ukugruzuka, ukunqongophala kwamandla, ukungabinamdla wokutya, iintlungu kwinxalenye ephezulu yesisu, ukuba tyheli kolusu okanye amehlo , umchamo omnyama-mnyama, okanye iimpawu ezifana nomkhuhlane. Ukuba ukrokrela ukonakala kwesibindi, ugqirha wakho angayeka i-teriflunomide kwaye angakunika unyango oluya kunceda ukususa i-teriflunomide ngokukhawuleza emzimbeni wakho.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi kokuba uqale unyango lwakho kwaye rhoqo ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-teriflunomide.

Musa ukuthatha i-teriflunomide ukuba ukhulelwe okanye ucwangcise ukukhulelwa. I-Teriflunomide inokulimaza umbungu. Akufanele uqale ukuthatha i-teriflunomide de uthathe uvavanyo lokukhulelwa ngeziphumo ezibi kwaye ugqirha wakho ukuxelela ukuba awukhulelwe. Kuya kufuneka usebenzise indlela esebenzayo yolawulo lokuzalwa ngaphambi kokuba uqale ukuthatha i-teriflunomide, ngexesha lonyango lwakho nge-teriflunomide, kwaye ukuya kuthi ga kwi-2 iminyaka emva konyango, de kuvavanyo lwegazi lubonakalise ukuba unamanqanaba asezantsi e-teriflunomide egazini lakho. Ukuba ixesha lakho liphelile, ulahlekelwa lixesha, okanye ucinga ukuba unokukhulelwa ngexesha lonyango lwakho nge-teriflunomide okanye iminyaka emi-2 emva konyango lwakho, tsalela ugqirha ngokukhawuleza. Ukuba uyindoda kwaye iqabane lakho linakho ukukhulelwa, wena neqabane lakho nifanele ukusebenzisa ulawulo lokuzalwa ngexesha elifanelekileyo kunyango lwakho. Ukuba wena okanye iqabane lakho liceba ukukhulelwa okanye unokukhulelwa, thetha nogqirha wakho malunga nonyango oluya kunceda ukususa i-teriflunomide ngokukhawuleza emzimbeni wakho emva kokuyeka ukuthatha iyeza.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-teriflunomide kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-teriflunomide.

I-Teriflunomide isetyenziselwa ukunyanga abantu abadala ngeendlela ezahlukeneyo ze-multiple sclerosis (MS; isifo esingasebenzi kakuhle kwimithambo-luvo kwaye abantu banokufumana ubuthathaka, ukuba ndindisholo, ukuphulukana nokulungelelaniswa kwezihlunu, kunye neengxaki zombono, intetho, kunye nolawulo lwesinyi) kubandakanya :

• I-CIS; Iimpawu zempawu zemithambo-luvo ezihlala ubuncinci iiyure ezingama-24),
• Iifom zokuphinda zibuyele kwakhona (ikhosi yesifo apho iimpawu ziyavela khona amaxesha ngamaxesha), okanye
• iifomati zesekondari eziqhubekayo (ikhosi yesifo apho ukubuyela umva kwenzeka rhoqo).

I-Teriflunomide ikudidi lwamayeza abizwa ngokuba ziiarhente ze-immunomodulatory agents. Kucingelwa ukuba kusebenza ngokunciphisa ukudumba kunye nokunciphisa isenzo samaseli omzimba anokubangela ukonakala kwentliziyo.

I-Teriflunomide iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini kunye okanye ngaphandle kokutya. Thatha i-teriflunomide ngexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-teriflunomide ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

I-Teriflunomide inokunceda ukulawula iimpawu ze-multiple sclerosis, kodwa ayiyinyangi. Qhubeka uthathe i-teriflunomide nokuba uziva uphilile. Ungayeki ukuthatha i-teriflunomide ngaphandle kokuthetha nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-teriflunomide,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-teriflunomide (irhashalala, imihlathi, ukuphefumla kancinci, ukudumba kobuso, amehlo, umlomo, umqala, ulwimi, imilebe, izandla, iinyawo, amaqatha, okanye imilenze esezantsi), leflunomide (Arava) , nawaphi na amanye amayeza, okanye nasiphi na isithako esenziwe kwiipilisi zeteriflunomide. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha i-leflunomide (Arava). Ugqirha wakho uya kukuxelela ukuba ungathathi i-teriflunomide ukuba uthatha eli yeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zilandelayo: alosetron (Lotronex); ii-anticoagulants (’izinciphisi zegazi’) ezifana ne-warfarin (Coumadin, Jantoven); atorvastatin (Lipitor, kwiCaduet); iceflorin; cimetidine (iTagamet); ciprofloxacin (Cipro); duloxetine (ICymbalta); I-eltrombopag (iPractacta); i-furosemide (iLasix); gefitinib (Iressa); ketoprofen; amayeza anokubangela ukonakala kwemithambo-luvo njengamayeza omhlaza, i-HIV, okanye i-AIDS; amanye amayeza acinezela amajoni omzimba njenge-azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), kunye ne-tacrolimus (Astagraf, Envarsus XR, Prograf); imethotrexate (Otrexup, Rasuvo, Trexall); mitoxantrone; icandelo (Starlix); izinto zokucwangcisa ngomlomo (iipilisi zolawulo lokuzalwa); iPaclitaxel (Abraxane, iTaxol); penicillin G; ipioglitazone (Actos, kwiActoplus Met, kwiDuetact); ipravastatin (Pravachol); repaglinide (Prandin, kwi Prandimet); irifampin (Rifadin, Rimactane, eRifamate, eRifater); rosiglitazone (Avandia); irosuvastatin (Crestor); isimvastatin (iZocor, eVytorin); theophylline (Elixophyllin, Theo-24, Uniphyl, nabanye); tizanidine (Zanaflex); kunye ne-zidovudine (Retrovir, kwiCombivir, kwiTrizivir). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-teriflunomide, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba unosulelo ngoku, kubandakanya nosulelo oluqhubekayo olungapheliyo, okanye ukuba uye wakha waphendula kakubi ulusu emva kokuba uthathe elinye iyeza; isifo seswekile; iingxaki zokuphefumla; umhlaza okanye ezinye iimeko ezichaphazela umongo wethambo okanye amajoni omzimba; igazi elonyukayo; i-peripheral neuropathy (ukuba ndindisholo, ukutshisa okanye ukurhawuzelela ezandleni okanye iinyawo eziva zahlukile kwiimpawu zakho ze-MS); okanye isifo sezintso.
• xelela ugqirha wakho ukuba uncelisa. Musa ukuncancisa ngelixa uthatha i-teriflunomide.
• ukuba iqabane lakho liceba ukukhulelwa, kuya kufuneka uthethe nogqirha wakho malunga nokumisa i-teriflunomide kunye nokufumana unyango lokunceda ukususa la mayeza emzimbeni wakho ngokukhawuleza. Ukuba iqabane lakho alicwangcisi ukukhulelwa, wena kunye neqabane lakho kufuneka nisebenzise indlela efanelekileyo yolawulo lokuzalwa ngexesha lonyango lwenu nge-teriflunomide kwaye ukuya kuthi ga kwiminyaka emi-2 emva konyango, kude kube kuvavanyo lwegazi lubonisa ukuba unamanqanaba asezantsi e-teriflunomide igazi.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-teriflunomide.
• usenokuba sele wosulelwe sisifo sephepha (i-TB; isifo esibuhlungu semiphunga) kodwa ungabi nazimpawu zesi sifo. Xelela ugqirha wakho ukuba ukhe wakha okanye wakha wanaso na isifo sephepha, ukuba wakhe wakha okanye watyelela ilizwe apho ixhaphake khona i-TB, okanye ukuba ukhe wakufutshane nomntu owakhe okanye owakhe wanaso. Phambi kokuba uqale unyango lwakho nge-teriflunomide, ugqirha wakho uya kwenza uvavanyo lolusu ukubona ukuba unayo i-TB. Ukuba unayo i-TB, ugqirha wakho uya kulunyanga olu sulelo ngaphambi kokuba uqale ukuthatha i-teriflunomide.
• awunalo ugonyo ngaphandle kokuthetha nogqirha wakho ngelixa uthatha i-teriflunomide kunye neenyanga ezi-6 emva kokuyeka ukuyithatha.
• Kuya kufuneka uyazi ukuba i-teriflunomide inokubangela uxinzelelo lwegazi oluphezulu. Kuya kufuneka ujongiwe uxinzelelo lwegazi ngaphambi kokuqala unyango kwaye rhoqo ngelixa usela la mayeza.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Teriflunomide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukulahleka kweenwele
• urhudo
• ukungaboni kakuhle
• Lizinyo
• induna
• intlungu edibeneyo okanye yemisipha
• ixhala
• ukuhla ukusinda

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, yeka ukuthatha iteriflunomide kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ukukhawuleza, ukungahambi kakuhle, okanye ukubetha kwentliziyo
• intloko ebuhlungu
• isiyezi
• ulusu oluthuthu
• ukudideka
• umkhuhlane, ukukhohlela, umqala obuhlungu, Ukugodola kunye neminye imiqondiso yosulelo
• ukuba ndindisholo, ukutshisa, okanye ukurhawuzelela izandla, iingalo, iinyawo okanye imilenze
• ukulahleka kwethoni yezihlunu
• ubuthathaka okanye ubunzima emilenzeni
• ibanda, isikhumba esingwevu
• obomvu, ukuxobuka, okanye isikhumba esikhanyayo
• irhashalala
• urhwebo
• ukurhawuzelela
• kunzima ukugwinya
• ukudumba kobuso, amehlo, umlomo, umqala, ulwimi, okanye imilebe
• ukuqhawukelwa ngumphefumlo
• ukukhawuleza okungenzeka ngomkhuhlane, ukuvuvukala kwamadlala, okanye ukudumba kobuso
• isisu, icala, okanye iintlungu zomqolo

I-Teriflunomide inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• I-Aubagio^®