Inaliti yePembrolizumab

Umxholo

• Inaliti yePembrolizumab iyasetyenziswa: Inaliti yePembrolizumab ikwiklasi yamayeza abizwa ngokuba ngamachiza omzimba. Isebenza ngokunceda amajoni akho omzimba ukuba acothise okanye ayeke ukukhula kweeseli zomhlaza.
• Ngaphambi kokufumana inaliti ye-pembrolizumab,
• Inaliti yePembrolizumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

Inaliti yePembrolizumab iyasetyenziswa: Inaliti yePembrolizumab ikwiklasi yamayeza abizwa ngokuba ngamachiza omzimba. Isebenza ngokunceda amajoni akho omzimba ukuba acothise okanye ayeke ukukhula kweeseli zomhlaza.

• ukunyanga i-melanoma (uhlobo lomhlaza wolusu) ongenakunyangwa ngoqhaqho okanye osasazeke kwamanye amalungu omzimba, okanye ngokudibeneyo namanye amayeza e-chemotherapy ukunyanga nokukhusela ukubuya kwe-melanoma emva kotyando ukuyisusa kunye nayiphi na i-lymph echaphazelekayo. iindawo;
• ukunyanga iintlobo ezithile zomhlaza wamaphaphu ongekho mncinci (i-NSCLC) ongenakunyangwa ngoqhaqho, amanye amayeza e-chemotherapy, okanye unyango ngemitha okanye osasazeke kwamanye amalungu omzimba okanye wanda ngexesha okanye emva kokuba uphathwe ngeplatinamu amayeza e-chemotherapy (cisplatin, carboplatin), okanye ngokudibanisa namanye amayeza e-chemotherapy (paclitaxel, pemetrexed) ukunyanga iintlobo ezithile ze-NSCLC ethe yasasazeka kwamanye amalungu omzimba;
• ukunyanga uhlobo oluthile lomhlaza wentloko nentamo oqhubeka ubuya okanye usasazekile kwamanye amalungu omzimba kwaye awunakususwa ngotyando. Ingasetyenziswa ngokudibeneyo ne-fluorouracil kunye neplatinamu enamayeza e-chemotherapy (cisplatin, carboplatin) ukunyanga uhlobo oluthile lomhlaza wentloko nentamo oqhubeka ubuya okanye usasazeke kwamanye amalungu omzimba kwaye awunakunyangwa ngoqhaqho. I-Pembrolizumab ikwasetyenziselwa ukunyanga uhlobo oluthile lomhlaza wentloko kunye nentamo ethe yanda okanye yasasazeka kwamanye amalungu omzimba ngexesha okanye emva konyango ngamayeza e-chemotherapy;
• ukunyanga uhlobo oluthile lwe-Hodgkin's lymphoma (isifo sikaHodgkin) ebantwaneni nakubantu abadala esingakhange sibengcono ngezinye iindlela zonyango lwe-chemotherapy okanye sabangcono kodwa sabuya emva konyango ngamanye amayeza e-chemotherapy nakubantwana emva kokunyangwa izihlandlo ezibini nangaphezulu ngamanye amayeza e-chemotherapy. ;
• ukunyanga uhlobo oluthile lwe-B-cell lymphoma (PMBCL; non-Hodgkin lymphoma) ebantwaneni nakubantu abadala abangakhange babengcono ngezinye iindlela zonyango lwe-chemotherapy okanye babuyile emva kokuphathwa kabini okanye nangaphezulu ngamanye amayeza e-chemotherapy;
• ukunyanga uhlobo oluthile lomhlaza we-urothelial (umhlaza welinen yesinyi kunye nezinye iinxalenye zendlela yokuchama) ethe yanwenwa kwizicubu ezikufutshane okanye kwamanye amalungu omzimba wabantu abangakwaziyo ukufumana iplatinamu enamayeza e-chemotherapy (cisplatin, carboplatin) , okanye ukuba umhlaza wakhe waba mandundu ngexesha okanye emva kokuba uphathwe ngamayeza e-chemotherapy;
• ukunyanga uhlobo oluthile lomhlaza wesinyi kubantu abangakhange baphile nelinye iyeza (Bacillus Calmette-Guerin; unyango lwe-BCG) kwaye abangakwaziyo okanye abagqibe ekubeni banganyangwa ngoqhaqho ukuze kususwe isinyi;
• ukunyanga iintlobo ezithile zomhlaza ongalunganga (umhlaza oqala emathunjini amakhulu) kunye neentlobo ezithile zamathumba aqinileyo njengonyango lokuqala ebantwaneni nakubantu abadala olungenakunyangwa ngoqhaqho okanye olunwenweleyo kwamanye amalungu omzimba okanye kwezo iba mandundu emva kokuba iphathwe ngamanye amayeza e-chemotherapy;
• ukunyanga iintlobo ezithile zomhlaza wesisu (umhlaza wesisu) okanye umhlaza obekwe kwindawo apho isisu sihlangana khona nomqala (ityhubhu phakathi komqala nesisu) ebuyileyo okanye ethe yanwenwela kwamanye amalungu omzimba ngexesha okanye emva 2 okanye ngaphezulu unyango lwe-chemotherapy;
• ukunyanga uhlobo oluthile lomhlaza wokuqhinwa obuyileyo nosasazeke kwizicwili ezikufuphi okanye amanye amalungu omzimba emva konyango ngenye okanye nangaphezulu amayeza e-chemotherapy kwaye awunakunyangwa ngoqhaqho okanye ngonyango lwemitha;
• ukunyanga iintlobo ezithile zomhlaza womlomo wesibeleko (umhlaza oqala ekuvulekeni kwesibeleko [isibeleko] esibuyileyo okanye esisasazeke kwamanye amalungu omzimba ngexesha okanye emva konyango ngelinye iyeza le-chemotherapy;
• ukunyanga iintlobo ezithile ze-hepatocellular carcinoma (HCC; uhlobo lomhlaza wesibindi) kubantu ababephathwe ngaphambili nge-sorafenib (Nexafar) ngaphambili;
• ukunyanga iMerkel cell carcinoma (MCC; uhlobo lomhlaza wolusu) ebantwaneni nakubantu abadala abathe babuyela basasazeka kwizicwili ezikufutshane okanye kwamanye amalungu omzimba;
• ngokudibeneyo ne-axitinib (Inlyta) ukunyanga i-renal cell carcinoma (RCC; uhlobo lomhlaza oqala kwizintso);
• ngokudibeneyo nelenvatinib (Lenvima) ukunyanga uhlobo oluthile lomhlaza we-endometrium (ulwelwesi lwesibeleko) oluthe lwasasazeka kwamanye amalungu omzimba okanye luba mandundu ngexesha okanye emva konyango ngamayeza e-chemotherapy okanye angenakunyangwa ngoqhaqho okanye ngemitha unyango;
• ukunyanga iintlobo ezithile zamathumba aqinileyo asasazeke kwamanye amalungu omzimba okanye angenakunyangwa ngoqhaqho kubantu abadala nasebantwaneni ababephathwe ngaphambili ngelinye ixesha ngokungaphumeleli ngamanye amayeza e-chemotherapy kwaye abanalo olunye unyango olwanelisayo;
• ukunyanga iintlobo ezithile ze-squamous cell carcinoma (CSCC; umhlaza wolusu) obuyileyo okanye osasazeke kwamanye amalungu omzimba kwaye awunakunyangwa ngoqhaqho okanye ngonyango lwemitha;
• kwaye ngokudibeneyo ne-chemotherapy ukunyanga uhlobo oluthile lomhlaza wamabele obuyele kwizicubu ezikufutshane okanye osasazeke kwamanye amalungu omzimba kwaye awunakunyangwa ngoqhaqho.

Inaliti yePembrolizumab iza njengomgubo oxutywe nolwelo kwaye itofwe ngaphakathi (emthanjeni) ngaphezulu kwemizuzu engama-30 ngugqirha okanye umongikazi esibhedlele okanye kwiziko lonyango. Ihlala itofwe kanye kwiiveki ezi-3 okanye ezi-6 okoko ugqirha ekucebisa ukuba ufumane unyango.

Inaliti yePembrolizumab inokubangela iimpendulo ezinzulu ngexesha, okanye kungekudala emva kokufakwa kweyeza. Ukuba unazo naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngoko nangoko: ukugungxula, umkhuhlane, ukugodola, ukungcangcazela, isiyezi, ukuziva udiniwe, ukuphefumla kancinci, ukuphefumla nzima, ukurhawuzelela, irhashalala, okanye umngxunya.

Ugqirha wakho unokulibazisa okanye ayeke unyango lwakho ngenaliti ye-pembrolizumab, okanye akunyange ngamayeza ongezelelweyo, kuxhomekeke kwimpendulo yakho kunyango kunye naziphi na iziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngenaliti ye-pembrolizumab kwaye ngalo lonke ixesha ufumana idosi. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-pembrolizumab,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-pembrolizumab, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-pembrolizumab injection. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba wakha wanamalungu omzimba okanye uboya kwaye wakha wanaso okanye wakha wanyanga imitha kwindawo yesifuba sakho; isifo se-autoimmune (imeko apho amajoni omzimba ahlasela indawo esempilweni yomzimba) njengesifo sikaCrohn (imeko apho amajoni omzimba ahlasela umgca wokugaya obangela iintlungu, urhudo, ukwehla komzimba kunye nomkhuhlane), ulcerative colitis (imeko ebangela ukudumba kunye nezilonda kumngxunya wekholoni [amathumbu amakhulu] kunye ne-rectum), okanye i-lupus (imeko apho amajoni omzimba ahlasela izihlunu namalungu amaninzi kubandakanya ulusu, amalunga, igazi kunye nezintso); isifo seswekile; iingxaki ze-thyroid; naluphi na uhlobo lwesifo semiphunga okanye iingxaki zokuphefumla; okanye isifo sezintso okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuqala unyango. Akufanele ukhulelwe ngelixa ufumana inaliti ye-pembrolizumab kunye neenyanga ezi-4 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba ukhulelwa ngelixa ufumana inaliti ye-pembrolizumab, tsalela ugqirha ngokukhawuleza. Inaliti yePembrolizumab inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Ugqirha wakho unokukuxelela ukuba ungancancisi ngelixa ufumana inaliti ye-pembrolizumab, kunye neenyanga ezi-4 emva kwedosi yakho yokugqibela.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Inaliti yePembrolizumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intlungu edibeneyo okanye yomqolo
• ukudumba komzimba okanye ubuso
• utshintsho kumbala wolusu
• ukudinwa kakhulu okanye ukungabikho kwamandla
• ifiva
• isicaphucaphu
• ukugabha

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• iblisters okanye isikhumba esixobukayo; ubomvu besikhumba; irhashalala; okanye ukurhawuzelela
• izilonda ezibuhlungu okanye izilonda emlonyeni, empumlweni, emqaleni, okanye kwindawo yesini
• ukuqhawukelwa ngumphefumlo
• iintlungu zesifuba
• ukukhwehlela okutsha okanye okuya kusiba mandundu
• urhudo
• ilindle elimnyama, elilindileyo, elincangathi, okanye eliqulathe igazi okanye intshinyela
• iintlungu ezinzima zesisu
• isicaphucaphu kakhulu nokugabha
• ukwanda okanye ukunciphisa ukutya
• ukwanda kokoma
• iintlungu kwindawo ephezulu yesisu
• mthubi ulusu okanye amehlo
• ukopha ngokulula okanye ukugruzuka
• ukubetha kwentliziyo ngokukhawuleza
• utshintsho kubunzima (ukuzuza okanye ukulahleka)
• ukulahleka kweenwele
• ukwanda kokubila
• ndiziva ndibanda
• Ukujula kwelizwi okanye ukungxola
• ukudumba phambi kwentamo (goiter)
• ukubetha kunye nobuthathaka kwiinyawo, imilenze, izandla kunye neengalo
• intloko ebuhlungu okanye engapheliyo, iintlungu zemisipha
• ubuthathaka obunzima bemisipha
• utywala okanye intloko
• isiqaqa
• utshintsho kwisixa okanye umbala womchamo
• iintlungu okanye imvakalelo evuthayo ngelixa uchama
• igazi kumchamo
• utshintsho kumbono
• ndiziva ndididekile

Inaliti yePembrolizumab inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwisitofu se-pembrolizumab. Kwezinye iimeko, ugqirha wakho uya kuyalela uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba umhlaza wakho unganyangwa nge pembrolizumab.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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