Lenvatinib

Umxholo

• Ngaphambi kokuthatha i-lenvatinib,
• I-Lenvatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Lenvatinib isetyenziselwa ukunyanga uhlobo oluthile lomhlaza we-thyroid obuyileyo okanye osasazeke kwamanye amalungu omzimba kwaye awunakunyangwa nge-iodine ene-radioactive. I-Lenvatinib ikwasetyenziswa kunye ne-everolimus (Afinitor, Zortress) ukunyanga i-renal cell carcinoma (RCC, uhlobo lomhlaza oqala kwizintso) kubantu ababekhe bafumana unyango ngamanye amayeza e-chemotherapy. I-Lenvatinib ikwasetyenziselwa ukunyanga i-hepatocellular carcinoma (HCC; uhlobo lomhlaza wesibindi) ongenakunyangwa ngoqhaqho. I-Lenvatinib ikwasetyenziswa kunye ne-pembrolizumab (Keytruda) ukunyanga uhlobo oluthile lomhlaza we-endometrium (ulwelwesi lwesibeleko) ethe yasasazeka kwamanye amalungu omzimba okanye yaba mandundu ngexesha okanye emva konyango ngamayeza e-chemotherapy okanye angenakuphathwa utyando okanye unyango ngemitha. U-Lenvatinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukunqanda ukusasazeka kweeseli zomhlaza.

U-Lenvatinib uza njengepilisi yokuthatha ngomlomo. Ihlala ithathwa kanye yonke imihla kunye okanye ngaphandle kokutya. Thatha i-lenvatinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-lenvatinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iifomsile; sukuwavula, uwahlafune, okanye uwaqhekeze.

Ukuba awukwazi ukuginya njengezingxobo, zifake kwiglasi encinci kwaye udibanise icephe elinye lamanzi okanye ijusi yeapile. Musa ukuphula okanye ukuchoboza iifomsile. Shiya iifomsile kulwelo ubuncinci imizuzu eyi-10 uze uvuselele imixholo okungenani imizuzu emi-3. Sela lo mxube. Emva kokusela umxube, yongeza enye icephe 1 lamanzi okanye ijusi yeapile kwiglasi. Jikelezisa iziqulatho izihlandlo ezimbalwa kwaye uginye umxube.

Ugqirha wakho unokunciphisa idosi ye-lenvatinib okanye akuxelele ukuba uyeke ukuthatha amayeza okwexeshana okanye ngokusisigxina ukuba uneziphumo ebezingalindelekanga ezibi. Qiniseka ukuba uthetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho ngelenvatinib.

Ubude bonyango lwakho buxhomekeke kwindlela ophendula ngayo kunyango kunye neziphumo ozifumanayo. Qhubeka nokuthatha i-lenvatinib nokuba uziva uphilile. Sukuyeka ukuthatha i-lenvatinib ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuthatha i-lenvatinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-lenvatinib, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwii-capsule ze-lenvatinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha.Qiniseka ukuba ukhankanya nayiphi na kwezi zilandelayo: amayeza athile okubetha kwentliziyo okungaqhelekanga kubandakanya i-amiodarone (Nexterone, Pacerone), disopyramide (Norpace), procainamide, quinidine (eNuedexta), kunye ne-sotalol (iBetapace, iBetapace AF, iSorine, iSotylize). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe waxhuzula, uxinzelelo lwegazi oluphezulu, ukubetha, isifo sentliziyo, intloko ebuhlungu, ukutshintsha kombono, ngakumbi ezo zibangelwa ligazi, i-fistula (unxibelelwano olungaqhelekanga phakathi kwamalungu amabini ngaphakathi komzimba wakho okanye phakathi ilungu nangaphandle komzimba wakho), inyembezi eludongeni lwesisu sakho okanye emathunjini, ukwanda kwexesha lekota le-QT (isingqi esingaqhelekanga sentliziyo esinokukhokelela ekuphelelweni lithemba, ukulahleka kwengqondo, ukuxhuzula, okanye ukufa ngesiquphe), ukusilela kwentliziyo, amanqanaba asezantsi calcium, potassium, okanye wemagniziyam egazini lakho, iingxaki ukopha, okanye intliziyo, izintso, okanye isifo sesibindi. Xelela ugqirha wakho ukuba ukhe wanyangwa ngonyango lwemitha.
• Kuya kufuneka uyazi ukuba i-lenvatinib inokunciphisa ukuchuma emadodeni nakwabasetyhini. Nangona kunjalo, awufanelanga ukucinga ukuba wena okanye iqabane lakho aninakukhulelwa. Tshela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Uya kudinga kuvavanyo lokukhulelwa ngaphambi kokuba uqale unyango ngelenvatinib. Ukuba unokukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa ngexesha lonyango lwakho ngelenvatinib kwaye ubuncinci iiveki ezi-4 emva kwedosi yakho yokugqibela. Ukuba ukhulelwa ngelixa uthatha i-lenvatinib, tsalela umnxeba kwangoko. U-Lenvatinib unokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufuneki uncancise ngelixa uthatha i-lenvatinib
• xelela ugqirha wakho ukuba uceba ukwenza olunye utyando, kubandakanya nonyango lwamazinyo. Ugqirha wakho uya kukuxelela ukuba uyeke unyango lwakho nge-lenvatinib ubuncinci kwiintsuku ezingama-6 ngaphambi kotyando lwakho olucwangcisiweyo kuba lunokuchaphazela ukuphola kwenxeba. Ugqirha wakho uza kukuxelela ukuba uqale nini ukuthatha i-lenvatinib kwakhona emva kotyando lwakho.
• Kuya kufuneka uyazi ukuba uxinzelelo lwegazi lwakho lunokunyuka ngexesha lonyango lwakho ngelenvatinib. Ugqirha wakho uya kuthi abeke esweni uxinzelelo lwegazi ngexesha lonyango lwakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba idosi yakho elandelayo ifanelekile kwiiyure ezili-12 okanye nangaphezulu, thabatha idosi ephosiweyo kwakamsinya nje ukuba uyikhumbule. Nangona kunjalo, ukuba idosi elandelayo iya kuthathwa ngaphantsi kweeyure ezili-12, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Lenvatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukudinwa okanye ukudinwa
• irhashalala, ukuba bomvu, ukurhawuzelela, okanye ukuxobuka kolusu ezintendeni kunye nasezinyaweni
• isicaphucaphu
• ukuqhina
• isilungulela
• ukunciphisa ukutya
• ukuhla ukusinda
• utshintsho kwisakhono sokungcamla ukutya
• ukukhohlela
• ukudinwa
• izilonda zomlomo
• umlomo owomileyo
• intloko ebuhlungu
• iintlungu ezidibeneyo kunye nezihlunu
• ubunzima bokulala okanye ukulala
• ukulahleka kweenwele
• ifiva
• ukutshisa ngexesha lokuchama
• irhashalala

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ukuqhawukelwa ngumphefumlo
• ukudumba kwemilenze namaqatha
• iintlungu zesifuba
• Ukuba ndindisholo okanye ukuba buthathaka kobuso, ingalo, okanye umlenze kwelinye icala lomzimba wakho
• iintlungu ezingalweni, emqolo, entanyeni, okanye emhlathini
• ngequbuliso, intloko ebuhlungu
• intetho ecothayo okanye enzima
• utshintsho olukhawulezileyo kumbono
• urhudo oluqatha
• mthubi ulusu okanye amehlo
• isisu esibuhlungu
• umchamo omnyama (onetayi)
• izitulo ezikhanyayo
• ukuxhuzula
• ubuthathaka
• ukudideka
• ukuphuma kwempumlo kakhulu nangokuzingisileyo
• ukugabha okunegazi
• emnyama, ilindile, okanye ilindle eligazi
• ukukhohlela igazi okanye amahlwili egazi
• ukuphuma kwegazi okunzima
• ukugabha, urhudo, okanye iimpawu zokuphelelwa ngamanzi emzimbeni
• amanxeba angapholiyo

I-Lenvatinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwilenvatinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Lenvima^®