Efavirenz, Emtricitabine, kunye neTenofovir

Umxholo

• Phambi kokuthatha i-efavirenz, emtricitabine, kunye ne-tenofovir,
• I-Efavirenz, emtricitabine, kunye ne-tenofovir kunokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Efavirenz, emtricitabine, kunye ne-tenofovir akufuneki isetyenziselwe ukunyanga usulelo lwentsholongwane ye-hepatitis B (HBV; usulelo lwesibindi oluqhubekayo). Xelela ugqirha wakho ukuba unayo okanye ucinga ukuba unayo i-HBV. Ugqirha wakho angakuvavanya ukuze ubone ukuba unayo i-HBV ngaphambi kokuba uqale unyango lwakho nge-efavirenz, emtricitabine, kunye ne-tenofovir. Ukuba unayo i-HBV kwaye uthatha i-efavirenz, emtricitabine, kunye ne-tenofovir, imeko yakho inokuba mandundu mandundu xa uyeka ukuthatha eli yeza. Ugqirha wakho uya kukuvavanya kwaye a-odole uvavanyo lweelebhu rhoqo kwiinyanga ezininzi emva kokuba uyekile ukuthatha eli yeza ukubona ukuba i-HBV yakho iye yanda.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola uvavanyo oluthile ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-efavirenz, emtricitabine, nakwi-tenofovir.

Thetha nogqirha wakho malunga nomngcipheko wokuthatha i-efavirenz, emtricitabine, kunye ne-tenofovir.

Indibaniselwano ye-efavirenz, emtricitabine, kunye ne-tenofovir isetyenziswa yodwa okanye kunye namanye amayeza ukunyanga usulelo lwe-immunodeficiency virus (HIV) kubantu abadala nakubantwana abanobunzima obungapha kwama-40 kg (88 lb). I-Efavirenz ikudidi lwamayeza angenayo i-nucleoside reverse transcriptase inhibitors (NNRTIs). I-Emtricitabine kunye ne-tenofovir bakudidi lwamayeza abizwa ngokuba yi-nucleoside reverse transcriptase inhibitors (NRTIs). Basebenza ngokunciphisa inani le-HIV emzimbeni. Nangona i-efavirenz, i-emtricitabine, kunye ne-tenofovir zingayi kuyinyanga i-HIV, la mayeza angalinciphisa ithuba lakho lokufumana isifo se-immunodeficiency syndrome (i-AIDS) kunye nezifo ezinxulumene ne-HIV ezinje ngezifo ezomeleleyo okanye umhlaza. Ukuthatha la mayeza kunye nokwabelana ngesondo okukhuselekileyo nokwenza olunye utshintsho kwindlela yokuphila kunokunciphisa umngcipheko wokufumana okanye wokuhambisa intsholongwane kaGawulayo kwabanye abantu.

Indibaniselwano ye-efavirenz, emtricitabine, kunye ne-tenofovir iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini ngamanzi esiswini esingenanto (ubuncinci iyure enye ngaphambi okanye iiyure ezi-2 emva kwesidlo). Thatha i-efavirenz, emtricitabine, kunye ne-tenofovir ngexesha elifanayo yonke imihla. Ukuthatha i-efavirenz emtricitabine, kunye ne-tenofovir ngexesha lokulala kunokwenza ukuba iziphumo ebezingalindelekanga ezithile zingakhathazi. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-efavirenz, emtricitabine, kunye ne-tenofovir ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Qhubeka uthatha i-efavirenz, emtricitabine, kunye ne-tenofovir nokuba uziva uphilile. Sukuyeka ukuthatha i-efavirenz, emtricitabine, kunye ne-tenofovir ngaphandle kokuthetha nogqirha wakho. Ukuba uyayeka ukuthatha i-efavirenz, i-emtricitabine, kunye ne-tenofovir nokuba kungexesha elifutshane, okanye ukweqa idosi, intsholongwane isenokunganyangeki kumayeza kwaye kunokuba nzima ukunyanga.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Phambi kokuthatha i-efavirenz, emtricitabine, kunye ne-tenofovir,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-efavirenz, i-emtricitabine, okanye i-tenofovir, nawaphi na amanye amayeza, okanye nasiphi na isithako se-efavirenz, i-emtricitabine kunye neepilisi ze-tenofovir. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha i-voriconazole (Vfend) okanye i-elbasvir kunye ne-grazoprevir (Zepatier). Ugqirha wakho uyakukuxelela ukuba ungathathi i-efavirenz, emtricitabine, kunye ne-tenofovir ukuba uthatha elinye okanye ngaphezulu kula mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, othabathayo okanye oceba ukuthatha Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: acyclovir (Sitavig, Zovirax); i-adefovir (iHepsera); iziyobisi; artemether kunye ne-lumefantrine (Coartem); Atazanavir (Reyataz); atorvastatin (Lipitor, kwiCaduet); atovaquone kunye neproguanil (Malarone); I-boceprevir (iVictrelis); bupropion (Wellbutrin, Zyban, abanye); icarbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); i-clarithromycin (i-Biaxin, kwi-Prevpac); cidofovir; icyclosporine (Gengraf, Neoral, Sandimmune); darunavir (Prezista) kunye ne-ritonavir (Norvir); delavirdine (Umshicileli); i-didanosine (Videx); I-diltiazem (iCardizem, iCartia, iDiltzac, iTaztia, iTiazac); i-ethinyl estradiol kunye ne-norgestimate (Estarylla, Ortho-Tri-Cyclen, Sprintec, nabanye); etonogestrel (Nexplanon, eNuvaring); i-etravirine (ukungakhathali); felodipine; fosamprenavir (iLexiva); ganciclovir (icytovene); gentamicin; glecaprevir kunye nepibrentasvir (Mavyret); indinavir (iCrixivan); itraconazole (Onmel, Sporanox); ketoconazole; lamivudine (Epivir, Epivir HBV, kwiCombivir, Epzicom, Triumeq, Trizivir); ledipasvir kunye nesofosbuvir (Harvoni); lopinavir kunye ne ritonavir (Kaletra); i-maraviroc (i-Selzentry); amayeza oxinzelelo, ukugula ngengqondo, kunye nokuxhuzula; imethadone (iDolophine, iMethadose); nevirapine (Viramune); iNicardipine (Cardene); i-nifedipine (iAdalat, iAfeditab, iProcardia); phenobarbital; phenytoin (iDilantin, iPhenytek); amayeza angasebenziyo (anti-inflammatory) (i-NSAID) anjenge celecoxib (Celebrex), ibuprofen (Advil, Motrin), meloxicam (Mobic), kunye ne naproxen (Aleve, Naprelan, Naprosyn); amanye amayeza e-HIV aqukethe i-efavirenz, emtricitabine, kunye ne-tenofovir (Complera, Descovy, Genvoya, Odefsey, Stribild, Truvada, Sustiva, Emtriva, Viread); i-posaconazole (Noxafil); ipravastatin (Pravachol); i-raltegravir (i-Isentress); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, eRifamate, Rifater); i-ritonavir (eNorvir, eKaletra, eTechnivie, eViekira Pak); i-saquinavir (i-Invirase); ukuthomalalisa; i-sertraline (iZoloft); iipilisi zokulala; isimeprevir (iOlysio); isimvastatin (iZocor, eVytorin); i-sirolimus (iRapamune); isofosbuvir kunye nevelpatasvir (Epclusa); isofosbuvir, velpatasvir, kunye ne-voxilaprevir (Vosevi); itacrolimus (Astagraf, Envarsus, Prograf); izinto zokuthomalalisa; i-valacyclovir (iValtrex); ivalganciclovir (iValcyte); i-verapamil (uCalan, uCovera, uTarka, uVerelan); kunye ne-warfarin (Coumadin, Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-efavirenz, emtricitabine, kunye ne-tenofovir, okanye anganyusa umngcipheko wokuba uya kukhula umonakalo wesibindi ngexesha lonyango lwakho nge-efavirenz, emtricitabine, kunye ne-tenofovir, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owasebenzisayo. , nkqu nezo zingabonakali kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba okwangoku okanye unethuba elide le-QT (ingxaki yentliziyo enqabileyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe), okanye amanqanaba asezantsi e-potassium okanye i-magnesium egazini lakho, osele utywala kakhulu , okanye amayeza amayeza asetyenziswa kakhulu. Xelela ugqirha wakho ukuba ukhe wakha wanayo nayiphi na imiqathango ekhankanywe kwicandelo LESILUMKISO ESIBALULEKILEYO, uxinzelelo okanye ukugula ngengqondo, iingxaki zamathambo kubandakanya i-osteoporosis (imeko apho amathambo esiba buthathaka kwaye abuthathaka kwaye aphuke ngokulula) okanye ukwaphuka kwethambo , ukuxhuzula, okanye isibindi okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, okanye ucwangcise ukukhulelwa.Akufanele ukhulelwe ngexesha lonyango kunye nakwiiveki ezili-12 emva kwedosi yakho yokugqibela. Ukuba unokukhulelwa, kuya kufuneka ukuba ube novavanyo lokukhulelwa olubi ngaphambi kokuba uqale ukuthatha eli yeza kwaye usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho. I-Efavirenz, i-emtricitabine, kunye ne-tenofovir zinokuphazamisa isenzo sezinto zokuthintela ukukhawula (iipilisi zolawulo lokuzalwa, iipatches, iiringi, ukufakelwa, okanye inaliti), ngenxa yoko akufuneki uzisebenzise njengeyona ndlela yakho yolawulo lokuzalwa ngexesha lonyango lwakho. Kuya kufuneka usebenzise indlela yesithintelo yolawulo lokuzalwa (isixhobo esivimba isidoda ukuba singene esibelekweni esifana nekhondom okanye uvalo) kunye nayiphi na enye indlela yolawulo lokuzalwa oyikhethileyo. Buza ugqirha wakho ukuba akuncede ukhethe indlela yolawulo lokuzalwa eya kukusebenzela. Ukuba uyakhulelwa ngelixa uthatha i-efavirenz, emtricitabine, kunye ne-tenofovir, tsalela ugqirha wakho ngokukhawuleza.
• akufuneki uncancise ukuba wosulelwe yi-HIV okanye uthatha i-efavirenz, i-emtricitabine, kunye ne-tenofovir.
• Kuya kufuneka wazi ukuba amanqatha omzimba wakho anganyuka okanye afudukele kwiindawo ezahlukeneyo zomzimba wakho, ezinje ngomqolo wangasentla, intamo (’’ inyathi ’), amabele, kunye nesisu sakho. Ungabona ukulahleka kwamafutha omzimba ebusweni bakho, kwimilenze nakwiingalo.
• Kuya kufuneka uyazi ukuba ngelixa uthatha amayeza ukunyanga usulelo lwe-HIV, amajoni akho omzimba angomelela kwaye aqale ukulwa nezinye izifo ezazisele zisemzimbeni wakho okanye zibangele ezinye iimeko zenzeke. Oku kunokubangela ukuba ukhule iimpawu zolo sulelo okanye iimeko. Ukuba uneempawu ezintsha okanye eziya zisiba mandundu ngexesha lonyango lwakho nge-efavirenz, emtricitabine, kunye ne-tenofovir qiniseka ukuxelela ugqirha wakho.
• Kufuneka uyazi ukuba i-efavirenz, i-emtricitabine, kunye ne-tenofovir zinokukwenza wozele, ube nesiyezi, okanye ungakwazi ukugxila. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.
• Kuya kufuneka uyazi ukuba i-efavirenz, emtricitabine, kunye ne-tenofovir kunokubangela utshintsho kwiingcinga zakho, indlela oziphatha ngayo, okanye impilo yengqondo. Fowunela ugqirha wakho ngoko nangoko xa uvela kwezi mpawu zilandelayo ngelixa uthatha i-efavirenz: ukudakumba, ukucinga ngokuzibulala okanye ukucwangcisa okanye ukuzama ukwenza njalo, ukuba nomsindo okanye ukuba ndlongondlongo, ukubona izinto ezingekhoyo (ukubona izinto okanye ukuva amazwi angekhoyo), iingcinga ezingaqhelekanga, okanye ukulahleka kwebala kunye nenyani. Qiniseka ukuba usapho lwakho luyazazi ukuba zeziphi iimpawu ezinokubanzima ukuze bakwazi ukubiza ugqirha wakho ukuba awukwazi ukuzifunela unyango ngokwakho.
• buza ugqirha wakho malunga nokusetyenziswa okukhuselekileyo kweziselo ezinxilisayo ngelixa uthatha i-efavirenz, emtricitabine, kunye ne-tenofovir. Utywala bungazenza iziphumo ebezingalindelekanga ezivela kwi-efavirenz, emtricitabine, kunye ne-tenofovir.
• Kuya kufuneka uyazi ukuba i-efavirenz inokubangela iingxaki zesistim ezinobunzima, kubandakanya i-encephalopathy (isifo esibi nesinokubulala ingqondo) iinyanga okanye iminyaka emva kokuba uthathe i-efavirenz, emtricitabine, kunye ne-tenofovir. Nangona iingxaki zemithambo-luvo zinokuqala emva kokuba uthathe i-efavirenz, i-emtricitabine, kunye ne-tenofovir kangangexesha elithile, kubalulekile kuwe nakugqirha wakho ukuba niqonde ukuba zingabangelwa yi-efavirenz. Fowunela ugqirha ngoko nangoko xa unengxaki yokulingana nokulungelelana, ukudideka, iingxaki zememori, kunye nobunye ubunzima obubangelwa kukungasebenzi kakuhle kwengqondo, nangaliphi na ixesha kunyango lwakho nge-efavirenz, emtricitabine, kunye ne-tenofovir. Ugqirha wakho angakuxelela ukuba uyeke ukuthatha i-efavirenz, i-emtricitabine kunye ne-tenofovir.

Thetha nogqirha wakho malunga nokutya igrapefruit kunye nokusela ijusi yamagilebhisi ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Efavirenz, emtricitabine, kunye ne-tenofovir kunokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• urhudo
• irhasi
• ukuqunjelwa
• umbala omnyama wolusu, ngakumbi ezintendeni zezandla okanye phantsi kweenyawo
• ulusu oluthuthu
• ubunzima bokulala okanye ukulala
• ukudideka
• ukulibala
• Ukuziva uphazamisekile, ukhathazekile, okanye usoyika
• imeko eyonwabileyo ngokungaqhelekanga
• amaphupha angaqhelekanga
• intlungu edibeneyo okanye yomqolo
• ukurhawuzelela

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukuncipha kokuchama
• uchama izixa ezikhulu
• ukwanda kokoma
• Ukuqhubeka okanye ukuqaqanjelwa kwethambo
• amathambo aqhekekile
• iintlungu ezingalweni, ezandleni, ezinyaweni, okanye emilenzeni
• iintlungu zemisipha okanye ubuthathaka
• irhashalala
• ukuxobuka, ukudubula, okanye ukuchitha ulusu
• ukuba ndindisholo, ukutshisa, okanye ukurhawuzelela izandla, iingalo, iinyawo okanye imilenze
• ukudumba kobuso, umqala, ulwimi, imilebe, amehlo, imilenze, amaqatha okanye iinyawo
• ubunzima bokuginya okanye ukuphefumla
• ukudinwa
• ukuxhuzula
• Iimpawu ezinjengomkhuhlane
• isicaphucaphu
• ukugabha
• ukudinwa kakhulu
• ubumthubi besikhumba okanye amehlo; ukukhanya okukhanyayo; umchamo omnyama omthubi okanye omdaka; ukuphelelwa ngumdla wokutya; iintlungu kwindawo ephezulu yesisu; ukopha okungaqhelekanga okanye ukugruzuka
• ubuthathaka; iintlungu zemisipha; ukuphefumla kancinci okanye ukuphefumla ngokukhawuleza; isisu esibuhlungu isicaphucaphu nokugabha; izandla ezibandayo okanye eziluhlaza kunye neenyawo; uziva unesiyezi okanye unentloko elula; okanye ukubetha kwentliziyo okukhawulezayo okanye okungaqhelekanga

I-Efavirenz, emtricitabine, kunye ne-tenofovir kunokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• iintshukumo zomzimba wakho ongenakuzilawula
• isiyezi
• ubunzima bokugxila
• uvalo
• ukudideka
• ukulibala
• ubunzima bokulala okanye ukulala
• amaphupha angaqhelekanga
• ukozela
• ukubona izinto ezingekhoyo (ukubona izinto okanye ukuva amazwi angabikho)
• imeko eyonwabileyo ngokungaqhelekanga
• iingcinga ezingaqhelekanga

Phambi kokuba wenze uvavanyo lwaselebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha i-efavirenz, emtricitabine, kunye ne-tenofovir.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Gcina unikezelo ngeefavirenz, emtricitabine, kunye ne-tenofovir esandleni. Sukulinda de uphelelwe ngamayeza ukuze uphinde uzalise amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Atripla^® (njengemveliso yokudibanisa equlethe i-Efavirenz, i-Emtricitabine, i-Tenofovir)