Ribociclib

Umxholo

• Ngaphambi kokuba uthathe i-ribociclib,
• I-Ribociclib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

I-Ribociclib isetyenziswa ngokudibanisa nelinye iyeza ukunyanga uhlobo oluthile lwe-hormone receptor-positive (kuxhomekeke kwiihomoni ezinje nge-estrogen ukukhula) umhlaza webele osele uhambile okanye osasazeke kwamanye amalungu omzimba kwabasetyhini abangakhange babe namaxesha okuyeka ukuya exesheni. kobomi; ukuphela kwexesha lokuya exesheni ngenyanga) nakwabo basondeleyo okanye esele benamava okuyeka ukuya exesheni. I-Ribociclib ikwasetyenziswa ngokudibeneyo ne-fulvestrant (Faslodex) ukunyanga uhlobo oluthile lomhlaza webele we-receptor receptor-positive okanye osasazeke kwamanye amalungu omzimba njengonyango lokuqala okanye kubantu abangakhange banyangwe ngempumelelo ngezinye iindlela zonyango kwabasetyhini abasele benamava okuyeka ukuya exesheni. I-Ribociclib ikudidi lwamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

I-Ribociclib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye yonke imihla kusasa kwiintsuku ezingama-21 zokuqala komjikelo weentsuku ezingama-28. Thatha i-ribociclib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-ribociclib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze. Musa ukuthatha iipilisi ezaphukileyo okanye ezaphukileyo.

Ukuba uhlanza emva kokuthatha i-ribociclib, ungathathi elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho unokunciphisa idosi yakho ye-ribociclib okanye ngokusisigxina okanye okwexeshana uyeke unyango lwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Qiniseka ukuba uxelela ugqirha wakho indlela oziva ngayo ngexesha lonyango lwakho kunye ne-ribociclib.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-ribociclib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-ribociclib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze ribociclib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qinisekisa ukukhankanya nayiphi na kwezi zilandelayo: amiodarone (Nexterone, Pacerone); ii-antibiotics ezithile ezifana ne-clarithromycin (i-Biaxin, kwi-Prevpac), i-erythromycin (i-EES, i-Ery-tab, i-Eryped), kunye ne-moxifloxacin (Avelox); amayeza athile okubola anje nge-itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), kunye ne-voriconazole (Vfend); i-bepridil (ayisekho e-US); i-boceprevir (iVictrelis, ayisafumaneki e-U.S.); chloroquine (Aralen); ikhonkco icyclosporine (Gengraf, Neoral, Sandimmune); dihydroergotamine (DHE 45, Migranal); iDisopyramide (iNorpace); ergotamine (Ergomar, eCafergot, eMigergot); i-everolimus (i-Afinitor, iZortress); fentanyl (Abstral, Actiq, Fentora, Onsolis); I-halofantrine (Halfan; ayisafumaneki e-US); haloperidol (iHaldol); amayeza athile kwintsholongwane (HIV) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), lopinavir (e-Kaletra), nelfinavir (Viracept), ritonavir (Norvir, e-Kaletra), kunye ne-saquinavir (Invirase); amayeza athile okubanjwa afana ne-carbamazepine (Carbatrol, Equetro, Teril, others) kunye ne-phenytoin (Dilantin, Phenytek); imethadone (iDolophine, iMethadose); nefazodone; ondansetron (efakwa ngaphakathi); ipimozide (Orap); ukuvelisa; quinidine (kwiNuedexta); irifampin (Rimactane, Rifadin, eRifamate, eRifater); i-sirolimus (iRapamune); i-sotalol (iBetapace, iSotylize); itacrolimus (Envarsus XR, Prograf), kunye netamoxifen (Soltamox). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.Uninzi lwamanye amayeza anokusebenzisana ne-ribociclib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza ozithathayo, ngakumbi iSort John's Wort.
• xelela ugqirha wakho ukuba ukhe wahlaselwa sisifo sentliziyo kutshanje; okanye ubenokubetha kwentliziyo kancinci; ixesha elide leQT (ingxaki yentliziyo enqabileyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe); amanqanaba angaqhelekanga potassium, calcium, phosphorus, okanye wemagniziyam egazini lakho; ukumelwa yintliziyo; okanye isibindi, izintso, okanye isifo sentliziyo.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Uya kudinga ukuthatha uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango. Sebenzisa indlela ethembekileyo yolawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango kunye nakwiiveki ezi-3 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba ukhulelwa ngelixa uthatha i-ribociclib, biza ugqirha ngokukhawuleza. I-Ribociclib inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufanele uncelise ngelixa uthatha i-ribociclib kwaye ubuncinci iiveki ezi-3 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuzala emadodeni. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-ribociclib.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-ribociclib.

Sukutya igrapefruit okanye usele iziqhamo zomdiliya ngelixa uthatha eli yeza.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Ribociclib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• ukuqhina
• isisu esibuhlungu
• intloko ebuhlungu
• ukulahleka kweenwele
• umqolo obuhlungu
• ukurhawuzelela
• izilonda zomlomo
• ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi
• ubunzima bokulala okanye ukulala

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• umkhuhlane, umqala obuhlungu, ingqele, okanye ezinye iimpawu zosulelo
• irhashalala
• ukudumba okanye ukuxobuka kolusu
• ukutshisa okanye ukudumba kwemilebe, amehlo, okanye umlomo
• ukukhawuleza kwentliziyo, ukungahambi kakuhle, okanye ukubetha kwentliziyo
• ubunzima bokuphefumla okanye ukuphefumla okufutshane; ukukhohlela kunye okanye ngaphandle kwencindi; okanye iintlungu esifubeni
• isiyezi
• isiqaqa
• mthubi ulusu okanye amehlo
• umchamo omnyama okanye omdaka (umbala weti)
• ukudinwa
• Ukuphelelwa ngumdla wokutya
• iintlungu kwicala lasekunene lesisu
• isicaphucaphu
• ukugabha
• ukopha okanye ukugruzuka ngokulula kunesiqhelo

I-Ribociclib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ngaphambi kwaye ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-ribociclib. Ugqirha wakho unokuyalela i-electrocardiogram (i-ECG; uvavanyo olulinganisa umsebenzi wombane entliziyweni) ngaphambi nangexesha lonyango lwakho.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Kisqali^®

• Kisqali^® Femera^® (njengemveliso yokudibanisa equlethe iLetrazole kunye neRibociclib)