Deutetrabenazine

Umxholo

• Ngaphambi kokuba uthathe i-deutetrabenazine,
• I-Deutetrabenazine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO, yeka ukuthatha i-deutetrabenazine kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Deutetrabenazine inokunyusa umngcipheko woxinzelelo okanye iingcinga zokuzibulala (ukucinga ngokuzenzakalisa okanye ukuzibulala okanye ukucwangcisa okanye ukuzama ukwenza njalo) kubantu abanesifo sikaHuntington (isifo esizuzwe njengelifa esibangela ukonakala okuqhubekayo kweeseli zemithambo-luvo kwingqondo). Xelela ugqirha wakho ukuba ukhe wanalo uxinzelelo olwenziweyo okanye wakha wanombono wokuzenzakalisa okanye ukuzibulala. Ukuba unesifo sikaHuntington kwaye uxinezelekile okanye uneengcinga zokuzibulala, ugqirha wakho uya kuthi mhlawumbi ungathathi i-deutetrabenazine. Wena, usapho lwakho, okanye umnonopheli kufuneka ubize ugqirha wakho ngoko nangoko ukuba unazo naziphi na kwezi mpawu zilandelayo: uxinzelelo olutsha okanye olubi, iingcinga ngokuzenzakalisa okanye ukuzibulala okanye ukucwangcisa okanye ukuzama ukwenza njalo, ukukhathazeka kakhulu, ukuphazamiseka, ubunzima bokulala okanye ukuhlala ulele, ukuba ndlongondlongo okanye ukungaziphathi kakuhle, ukuba nochuku, ukusebenza ungacingi, ukungazinzi, ixhala, utshintsho kubunzima bomzimba, ukuphulukana nomdla kunxibelelwano lwasentlalweni, ubunzima bokubeka ingqalelo, okanye naluphi na olunye utshintsho olungaqhelekanga kwindlela yokuziphatha. Qiniseka ukuba usapho lwakho okanye umntu okhathalelayo uyakujonga rhoqo kwaye uyazi ukuba zeziphi iimpawu ezinokuba nobuzaza ukuze babize ugqirha ukuba awukwazi ukuzifumanela unyango wedwa.

Gcina lonke ixesha lokudibana nogqirha wakho. Ugqirha wakho uya kufuna ukuthetha nawe malunga nempilo yakho yengqondo ngelixa uthatha eli yeza.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-deutetrabenazine kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Deutetrabenazine isetyenziselwa ukunyanga i-chorea (intshukumo ngequbuliso ongakwaziyo ukuyilawula) ebangelwa sisifo sika-Huntington (isifo esizuzwe njengelifa esibangela ukonakala okuqhubekayo kweeseli zemithambo-luvo kwingqondo). Isetyenziselwa ukunyanga i-tardive dyskinesia (intshukumo engalawulekiyo yobuso, ulwimi, okanye amanye amalungu omzimba). I-Deutetrabenazine ikwiklasi yamayeza abizwa ngokuba yi-vesicular monoamine transporter 2 (VMAT2) inhibitors. Isebenza ngokutshintsha umsebenzi wezinto ezithile zendalo kwingqondo ezichaphazela imithambo kunye nezihlunu.

I-Deutetrabenazine iza njengecwecwe lokuthatha ngomlomo. Kwizigulana ezinesifo sikaHuntington, zihlala zithathwa ngokutya kube kanye ngemini kuqala kwaye zonyuswe ziye kabini ngemini. Kwizigulana ezine-tardive dyskinesia, zihlala zithathwa ngokutya kabini imihla ngemihla. Thatha i-deutetrabenazine malunga nexesha elifanayo (ii) yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-deutetrabenazine kanye njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ugqirha wakho uya kukuqala ngedosi esezantsi ye-deutetrabenazine kwaye ngokuthe ngcembe uyonyuse umthamo wakho, hayi ngaphezulu kwesinye kanye ngeveki.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-deutetrabenazine,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-deutetrabenazine, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi ze-deutetrabenazine. Isebenza ngokutshintsha umsebenzi wezinto ezithile zendalo kwingqondo. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha i-reserpine, i-tetrabenazine (i-Xenazine), i-valbenazine (Ingrezza), okanye i-monoamine oxidase (MAO) inhibitor efana ne-isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldeprylline) , Emsam, Zelapar), kunye ne-tranylcypromine (iParnate), okanye ukuba uyekile ukuthatha i-monoamine oxidase inhibitor kwiiveki ezi-2 ezidlulileyo okanye uyekile ukuthatha i-reserpine kwiintsuku ezingama-20 ezidlulileyo. Ugqirha wakho uya kukuxelela ukuba akufuneki uthathe i-deutetrabenazine.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amayeza oxinzelelo; iziyobisi ezifana ne-bupropion (Aplenzin, Wellbutrin, Zyban), fluoxetine (Prozac, Sarafem, Selfemra), kunye neparoxetine (Brisdelle, Paxil, Pexeva); I-antipsychotic efana ne-chlorpromazine, i-haloperidol (i-Haldol), i-olanzapine (i-Zyprexa), i-quetiapine (i-Seroquel), i-risperidone (i-Risperdal), i-thioridazine kunye ne-ziprasidone (i-Geodon); amayeza athile okubetha kwentliziyo ngokungaqhelekanga njenge-amiodarone (Nexterone, Pacerone), procainamide, quinidine (eNuedexta), kunye ne-sotalol (iBetapace, iSorine, iSotylize); moxifloxacin (Avelox); amayeza okuxhuzula; ukuthomalalisa, iipilisi zokulala, okanye izinto zokuthomalalisa. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba unesifo sesibindi. Ugqirha wakho uya kukuxelela ukuba ungathathi i-deutetrabenazine.
• xelela ugqirha wakho ukuba ukhe okanye wakha wanayo i-QT syndrome (imeko eyonyusa umngcipheko wokuba nesifo sentliziyo esingaqhelekanga esinokubangela ukuba utyhafe okanye usweleke ngesiquphe) okanye olunye uhlobo lokubetha kwentliziyo okungaqhelekanga okanye ingxaki yesingqisho sentliziyo. Xelela ugqirha wakho ukuba unamanqanaba asezantsi egazi le-magnesium okanye i-potassium egazini lakho okanye kumhlaza webele.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa uthatha i-deutetrabenazine, tsalela umnxeba ugqirha wakho.
• Kuya kufuneka uyazi ukuba i-deutetrabenazine inokukwenza wozele okanye ubangele ukudinwa. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.
• Kuya kufuneka uyazi ukuba utywala bunokongeza ukozela okubangelwa leli yeza.Musa ukusela utywala ngelixa uthatha i-deutetrabenazine.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Ukuba uyaphoswa ukuthatha i-deutetrabenazine ngaphezulu kweveki, thetha nogqirha wakho ngaphambi kokuba uqale ukuyithatha kwakhona. Kuya kufuneka uphinde uqalise ukuyithatha ngedosi esezantsi.

I-Deutetrabenazine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• ukuqhina
• umlomo owomileyo
• ukudinwa
• intlungu okanye ukutshisa xa uchama
• ukugruzuka
• usulelo oluphezulu lokuphefumula

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO, yeka ukuthatha i-deutetrabenazine kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• umkhuhlane, ukubila, ukudideka, ukubetha kwentliziyo okukhawulezayo okanye okungaqhelekanga, kunye nokuqina kwemisipha
• ukugubha, ukuqina, okanye ubunzima bokuhamba okanye ukugcina ibhalansi
• ukuwa
• ukubetha kwentliziyo okungaqhelekanga okanye okukhawulezayo
• isiqaqa

I-Deutetrabenazine inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nokukhanya, ubushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• iintshukumo ezijijekileyo okanye ezixhuzulayo
• ukunyakaza kwamehlo ngokukhawuleza
• isicaphucaphu
• ukugabha
• ukubila
• ukuthomalalisa
• ukudideka
• urhudo
• ukubona izinto ezingekhoyo (ukubona into okanye ukuva amazwi angabikho)
• ukuba bomvu kwesikhumba
• ukungcangcazela okungalawulekiyo

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• UAustedo^®