I-Abemaciclib

Umxholo

• Ngaphambi kokuba uthathe i-abemaciclib,
• I-Abemaciclib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye naliphi na icandelo kwicandelo lokuLumkisa, tsalela umnxeba kwangoko:

[Ngeposi 09/13/2019]

Abaphulaphuli: Isigulana, iNgcali yezeMpilo, iOncology

KHUPHA: I-FDA isilumkiso sokuba i-palbociclib (Ibrance^®), I-ribociclib (Kisqali^®), kunye ne-abemaciclib (Verzenio^®) esetyenziselwa ukunyanga ezinye izigulana ezinomhlaza wamabele osele unokubangela kunqabile kodwa ukudumba okukhulu kwemiphunga. I-FDA ivume izilumkiso ezitsha malunga nalo mngcipheko kulwazi olumiselweyo kunye nePakeji yePatent Patient Insert yeklasi yonke yala machiza axhomekeke kwi-cyclin 4/6 (CDK 4/6). Isibonelelo esipheleleyo se-CDK 4/6 inhibitors sisengaphezulu komngcipheko xa sisetyenziswe njengoko kumiselwe.

Imvelaphi: I-CDK 4/6 inhibitors ludidi lwamayeza kagqirha asetyenziswa ngokudibana nonyango lwehomoni ukunyanga abantu abadala abanehormone receptor (HR) -positive, ukukhula kwesifo somntu esikhulayo 2 (HER2) -uhlaselo oluphambili okanye umhlaza wamabele osasazekileyo amanye amalungu omzimba. I-CDK 4/6 inhibitors ibhloka iimolekyuli ezithile ezibandakanyekayo ekukhuthazeni ukukhula kweeseli zomhlaza. I-FDA ivume i-palbociclib ngo-2015, kwaye zombini i-ribociclib kunye ne-abemaciclib ngo-2017. I-CDK 4/6 inhibitors ibonakalisiwe ukuphucula ixesha emva kokuqala konyango umhlaza awukhuli kakhulu kwaye isigulana siyaphila, esibizwa ngokuba kukuqhubeka kokungabikho (Jonga uluhlu lwe-CDK 4/6 Inhibitors engezantsi).

UKUQONDA:Izigulana Kuya kufuneka wazise ukhathalelo lwempilo yakho kwangoko ukuba unayo nayiphi na impawu ezintsha okanye ezibaxekileyo ezibandakanya imiphunga yakho, njengoko zinokubonisa imeko enqabileyo kodwa esongela ubomi enokuthi ikhokelele ekufeni. Iimpawu zokubukela zibandakanya:

• Ubunzima okanye ukungathandeki ngokuphefumla
• Ukuphefumla kancinci ngexesha lokuphumla okanye ngomsebenzi ophantsi

Sukuyeka ukuthatha amayeza akho ungakhange uthethe nonyango. Onke amayeza aneziphumo ebezingalindelekanga nokuba asetyenziswe ngokuchanekileyo njengoko kumiselwe, kodwa ngokubanzi izibonelelo zokuthatha la mayeza zingaphezulu kobu bungozi.Kubalulekile ukuba wazi ukuba abantu baphendula ngokwahlukileyo kuwo onke amayeza kuxhomekeke kwimpilo yabo, izifo abanazo, izinto zofuzo, amanye amayeza abawathathayo, kunye nezinye izinto. Imeko ezithile zomngcipheko wokumisela ukuba kunokwenzeka njani ukuba umntu othile abe namava okuqhaqha komphunga xa ethatha i-palbociclib, i-ribociclib, okanye i-abemaciclib ayichongwanga.

Abaqeqeshi bezempilo Kufuneka ukuba zibeke iliso kwizigulana rhoqo kwiimpawu ze-pulmonary ezibonisa isifo se-lung (interstitial lung disease) Iimpawu kunye neempawu zingabandakanya:

• hypoxia
• ukukhohlela
• Dyspnea
• ukungena ngaphakathi kwiimviwo ze-radiologic kwizigulana ekungafakwanga kusuleleka kuzo, isifo se-neoplastic, kunye nezinye izizathu.

Ukuphazamisa unyango lwe-CDK 4/6 unyango kwizigulana ezineempawu ezintsha zokuphefumla okanye ezenza mandundu, kwaye uyeke ngokusisigxina unyango kwizigulana ezine-ILD kunye / okanye inyumoniya.

Ngolwazi oluthe kratya ndwendwela iwebhusayithi ye-FDA apha: http://www.fda.gov/Safety/MedWatch/SafetyInformation kunye ne-http: //www.fda.gov/Drugs/DrugSafety.

I-Abemaciclib isetyenziswa kunye ne-fulvestrant (Faslodex) ukunyanga uhlobo oluthile lwe-hormone receptor-positive, umhlaza webele ophambili (umhlaza webele oxhomekeke kwiihomoni ezinje nge-estrogen ukukhula) okanye umhlaza webele osasazeke kwamanye amalungu omzimba emva konyango amayeza antiestrogen ezifana tamoxifen (Nolvadex). I-Abemaciclib ikwasetyenziswa kunye ne-anastrozole (Arimidex), i-exemestane (i-Aromasin), okanye i-letrozole (i-Femara) njengonyango lokuqala lwe-hormone receptor-positive, umhlaza webele ophambili okanye umhlaza webele osasazeke kwamanye amalungu omzimba. I-Abemaciclib ikwasetyenziswa yodwa ukunyanga uhlobo oluthile lwe-hormone receptor eyamkelekileyo, umhlaza webele osele uqhubekile okanye umhlaza webele osele wanda kwamanye amalungu omzimba wabantu abasele bephethwe ngamayeza e-antiestrogen kunye ne-chemotherapy. I-Abemaciclib ikudidi lwamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

I-Abemaciclib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kabini yonke imihla kunye okanye ngaphandle kokutya. Thatha i-abemaciclib kumaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-abemaciclib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze. Musa ukuthatha iipilisi ezaphukileyo, eziqhekekileyo, okanye ezonakeleyo nangayiphi na indlela.

Ukuba uyagabha emva kokuthatha i-abemaciclib, ungathathi elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho anganciphisa umthamo wakho okanye ayeke unyango lwakho okwethutyana okanye ngokusisigxina ukuba uneziphumo ebezingalindelekanga ezithile. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-abemaciclib.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-abemaciclib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-abemaciclib, nawaphi na amanye amayeza, okanye nasiphi na isithako kwiipilisi ze-abemaciclib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: clarithromycin (Biaxin, in Prevpac), diltiazem (Cardizem, Tiazac, others), itraconazole (Sporanox), ketoconazole (Nizoral), rifampin (Rifadin, Rimactane, eRifater), kunye ne-verapamil (Calan , Verelan, abanye). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-abemaciclib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba unefiva, ubandayo, okanye naziphi na ezinye iimpawu zosulelo okanye ukuba unesifo sesibindi okanye sezintso.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Uya kudinga ukuthatha uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kwaye ubuncinci iiveki ezi-3 emva kwedosi yakho yokugqibela. Ukuba ukhulelwa ngelixa uthatha i-abemaciclib, tsalela ugqirha ngokukhawuleza. I-Abemaciclib inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufanele uncelise ngelixa uthatha i-abemaciclib kwaye ubuncinci iiveki ezi-3 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuzala emadodeni. Thetha nogqirha wakho malunga nomngcipheko wokuthatha i-abemaciclib.
• Kuya kufuneka uyazi ukuba i-abemaciclib ihlala ibangela urhudo, olunokuba lukhulu. Ugqirha wakho usenokukuxelela ukuba usele ulwelo oluninzi kwaye uthathe amayeza okuthintela urhudo ukunqanda ukomisa (ukulahleka kwamanzi amaninzi emzimbeni wakho) xa uqala ukuba nesifo sorhudo okanye izitulo ezikhululekileyo. Tsalela umnxeba kwangoko ukuba unazo naziphi na kwezi mpawu zilandelayo zokoma: ukoma kakhulu, umlomo owomileyo okanye ulusu, ukuncipha komchamo, okanye ukubetha kwentliziyo okukhawulezayo.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Abemaciclib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• isisu esibuhlungu
• ukuqhina
• izilonda emilebeni, emlonyeni, nasemqaleni
• ukunciphisa ukutya
• ukuhla ukusinda
• ukulahleka kweenwele
• ukurhawuzelela
• irhashalala
• intloko ebuhlungu
• utshintsho kwincasa
• isiyezi
• intlungu edibeneyo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye naliphi na icandelo kwicandelo lokuLumkisa, tsalela umnxeba kwangoko:

• ukudinwa
• iintlungu kwinxalenye ephezulu yesisu
• mthubi ulusu okanye amehlo
• Ukuphelelwa ngumdla wokutya
• ukopha okanye ukugruzuka ngokulula
• iintlungu ezingalweni okanye emilenzeni
• ukudumba kwezandla, iinyawo, imilenze okanye amaqatha
• ukuqhawukelwa ngumphefumlo
• iintlungu zesifuba
• ukuphefumla ngokukhawuleza
• ngokukhawuleza, ngokungaqhelekanga, okanye ukubetha kwentliziyo
• ifiva, ingqele, ukukhohlela okanye ezinye iimpawu zosulelo
• ulusu oluthuthu

I-Abemaciclib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho angayalela iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-abemaciclib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• IVerzenio^®