I-Duvelisib

Umxholo

• Ngaphambi kokuba uthathe i-duvelisib,
• I-Duvelisib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

I-Duvelisib inokubangela usulelo olubi okanye olusongela ubomi. Tshela ugqirha wakho ukuba unentsholongwane, okanye ukuba unayo okanye unayo i-cytomegalovirus (i-CMV; intsholongwane yentsholongwane engabangela iimpawu kwizigulane ezinamajoni omzimba obuthathaka). Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: umkhuhlane, umqala obuhlungu, ukugodola, ukuphefumla kancinci, okanye ezinye iimpawu zosulelo.

I-Duvelisib inokubangela isifo sohudo okanye i-colitis (ukuvuvukala kwamathumbu amakhulu). Tshela ugqirha wakho ukuba unesifo sohudo okanye ukuba uke waba ne-colitis okanye ezinye iimeko ezichaphazela isisu okanye isisu sakho. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: ukonyuka kwenani lokuhamba kwamathumbu ngosuku, igazi kwisitulo sakho, okanye nasiphi na isisu okanye iintlungu.

I-Duvelisib inokubangela ulusu olunobuzaza okanye olusongela ubomi. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha wakho kwangoko: irhashalala entsha okanye eyandayo, irhashaza elinomkhuhlane, irhashalala ngokurhawuzelela, iblisters okanye isikhumba esixobukayo, okanye izilonda ezibuhlungu okanye izilonda kulusu lwakho, emilebeni nasemlonyeni.

I-Duvelisib inokubangela ukuba i-pneumonitis (okanye ukudumba kwemiphunga). Tshela ugqirha wakho ukuba unesifo semiphunga okanye unengxaki yokuphefumla. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: ukukhwehlela okutsha okanye okuya kusiba mandundu, ukuphefumla nzima, ukuphefumla, okanye ukuphefumla kancinci.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-duvelisib.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-duvelisib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Duvelisib isetyenziselwa ukunyanga i-lymphocytic leukemia (CLL; uhlobo lomhlaza oqala kwiiseli ezimhlophe zegazi) okanye i-lymphocytic lymphoma (SLL; uhlobo lomhlaza oqala ikakhulu kwii-lymph node) ezibuyileyo okanye ezingaphenduliyo ezinye iindlela zonyango ezimbini. Isetyenziselwa ukunyanga iintlobo ezithile ze-follicular lymphoma (FL; uhlobo lomhlaza oqala kwiiseli ezimhlophe zegazi) kubantu abadala abanomhlaza obuyileyo okanye ongaphenduliyo kwezinye iindlela zonyango ezimbini. UDuvelisib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela imiqondiso ebangela ukuba iiseli zomhlaza zande. Oku kunceda ukunqanda ukusasazeka kweeseli zomhlaza.

UDuvelisib uza njengepilisi yokuthatha ngomlomo. Ihlala ithathwa kabini yonke imihla kunye okanye ngaphandle kokutya. Thatha i-duvelisib malunga namaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-duvelisib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya ipilisi yonke; musa ukuzivula, uzihlafune, okanye uzaphule.

Ugqirha wakho unokunciphisa umthamo wakho we-duvelisib okanye akuxelele ukuba uyeke ukuthatha iyeza ixesha okanye ngokusisigxina ukuba unemiphumo emibi ngexesha lonyango lwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka nokuthatha i-duvelisib nokuba uziva uphilile. Ungayeki ukuthatha i-duvelisib ngaphandle kokuthetha nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-duvelisib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-duvelisib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifomsile ze duvelisib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, othabathayo okanye oceba ukuthatha Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: carbamazepine (Epitol, Tegretol, Teril, others); i-clarithromycin (i-Biaxin); amayeza asetyenziselwa ukunyanga intsholongwane kaGawulayo (i-HIV) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), kunye ne-ritonavir (Norvir, kwezinye); itraconazole (Onmel, Sporanox); ketoconazole, midazolam; nefazodone; phenobarbital; phenytoin (iDilantin, iPhenytek); ipioglitazone (Actos); irifabutin (Mycobutin); kunye nerifampin (Rifadin, Rimactane, eRifamate). Uninzi lwamanye amayeza anokusebenzisana ne-duvelisib, ke qiniseka ukuxelela ugqirha wakho malunga nawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe unesifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Kufuneka ube novavanyo lokukhulelwa ngaphambi kokuba uqale ukuthatha i-duvelisib. Akufanele ukhulelwe ngexesha lonyango lwakho nge-duvelisib. Ukuba ungowasetyhini, kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye ne-duvelisib kwaye ubuncinci inyanga e-1 emva kwedosi yakho yokugqibela. Ukuba uyindoda kwaye iqabane lakho linokukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye nenyanga e-1 emva kwedosi yakho yokugqibela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-duvelisib, biza ugqirha wakho ngokukhawuleza. UDuvelisib unokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngelixa uthatha i-duvelisib kwaye ubuncinci inyanga e-1 emva kwedosi yakho yokugqibela.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphoswa ithamo le-duvelisib ngaphantsi kweeyure ezingama-6, thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule kwaye emva koko uthathe idosi elandelayo ngexesha elimiselweyo. Nangona kunjalo, ukuba uphosa idosi ngaphezulu kweeyure ezingama-6, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Duvelisib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• ukuqhina
• ukudinwa
• intloko ebuhlungu
• umsipha okanye ujoyine iintlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• Amehlo atyheli okanye ulusu; intlungu zesisu; ukugruzuka okungachazwanga okanye ukopha; ukuphelelwa ngumdla wokutya; umchamo omthubi okanye omdaka ngombala; ilindle eluthuthu; okanye iintlungu kwinxalenye ephezulu yesisu

I-Duvelisib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• ICopiktra^®