ILorlatinib

Umxholo

• Ngaphambi kokuba uthathe i-lorlatinib,
• ILorlatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Lorlatinib isetyenziselwa ukunyanga uhlobo oluthile lomhlaza wesifo somhlaza ongasencinci (i-NSCLC) ethe yasasazeka kwamanye amalungu omzimba kwaye iye yambi emva konyango ngamanye amayeza e-chemotherapy. ULorlatinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukumisa okanye ukucothisa ukusasazeka kweeseli zomhlaza.

ILorlatinib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye yonke imihla. Thatha i-lorlatinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-lorlatinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba uyagabha emva kokuthatha iyeza, musa ukuthatha elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze. Musa ukuthatha iipilisi esele ziphukile okanye ziqhekekile.

Ugqirha wakho anganciphisa umthamo wakho okanye ayeke okwethutyana okanye ayeke isigxina unyango lwakho ngokuxhomekeke ekubeni unazo naziphi na iziphumo ebezingalindelekanga. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho kunye ne-lorlatinib.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-lorlatinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-lorlatinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-lorlatinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha i-carbamazepine (Epitol, Equetro, Carbatrol, Tegretol, Teril), efavirenz (Sustiva, eAtripla), nevirapine (Viramune), phenobarbital, phenytoin (Dilantin, Phenytek), pioglitazone (Actos, in Actop, in Actop ), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, eRifamate, Rifater), okanye iSt John's wort. Ugqirha wakho uya kukuxelela ukuba ungathathi i-lorlatinib ukuba uthatha elinye okanye nangaphezulu la mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: alprazolam (Xanax); iicalcium block blockers ezinje ngeamlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), felodipine (Plendil), nifedipine (Adalat, Procardia), nisoldipine (Sular), kunye neverapamil (Calan, Covera); amayeza athile ukunyanga i-cholesterol ephezulu njenge-atorvastatin (Lipitor) kunye ne-lovastatin (Mevacor); i-clarithromycin (i-Biaxin, kwi-Prevpac); icyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); i-erythromycin (i-E.S.S, i-Erytab, iEryped); amayeza athile anyanga i-HIV kubandakanya i-atazanavir (Reyataz, e-Evotaz), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra, e Technivie), okanye saquinavir (Invirase); itraconazole (Onmel, Sporanox); ketoconazole; midazolam; nefazodone; izinto zokucwangcisa ngomlomo (iipilisi zolawulo lokuzalwa); quinidine (kwiNuedexta); sildenafil (Revatio, Viagra); i-sirolimus (iRapamune); itacrolimus (Prograf); tadalafil (Adcirca, Cialis); ithenda i-triazolam (iHalcion); okanye vardenafil (Levitra, Staxyn). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-lorlatinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ukhe wabethwa yintliziyo ngendlela engaqhelekanga, ukudakumba, ukuxhuzula, amanqanaba aphezulu e-cholesterol kunye nezinye izinto ezinamafutha egazini, okanye isifo semiphunga.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ucwangcise ukuba ngutata womntwana. ILorlatinib inokuphazamisa isenzo sezinto zokucwangcisa zehomoni (iipilisi zolawulo lokuzalwa, iipatches, iiringi, ukufakelwa, okanye inaliti), ke akufuneki ukuba uzisebenzise njengokuphela kwendlela yolawulo lokuzalwa ngexesha lonyango lwakho. Kuya kufuneka usebenzise indlela yokuzalwa engeyiyo ihomoni enje ngendlela yothintelo (isixhobo esivimba isidoda ukuba singene esibelekweni esifana nekhondom okanye uvalo). Buza ugqirha wakho ukuba akuncede ukhethe indlela yolawulo lokuzalwa eya kukusebenzela. Ukuba ungowasetyhini, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye kufuneka usebenzise ulawulo lokuzalwa olungenalo ihomoni ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye neenyanga ezi-6 emva kwethamo lakho lokugqibela. Ukuba uyindoda, wena neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kunye nakwiinyanga ezi-3 emva kwedosi yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-lorlatinib, tsalela ugqirha ngokukhawuleza. ILorlatinib inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Akufanelanga ukuncancisa ngelixa uthatha i-lorlatinib kunye neentsuku ezisi-7 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linokunciphisa ukuchuma okwethutyana emadodeni. Thetha nogqirha wakho malunga nomngcipheko wokuthatha i-lorlatinib.

Thetha nogqirha wakho malunga nokutya igrapefruit kunye nokusela ijusi yamagilebhisi ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba ngaphakathi kweeyure ezingama-4 zedosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo rhoqo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

ILorlatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukutyeba kwakho
• umsipha, ukudibana, okanye iintlungu zomqolo
• urhudo
• ukuqhina
• isicaphucaphu
• ukugabha
• ukudinwa
• intloko ebuhlungu
• utshintsho lombono
• irhashalala okanye ukurhawuzelela

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ukudumba ezingalweni, emilenzeni, ezandleni nasezinyaweni
• ubunzima bokuphefumla
• ukuphefumla kancinci, ukukhohlela, okanye umkhuhlane
• ukuba ndindisholo kunye nokugungqa kwimvakalelo yakho kumalungu akho okanye kwiingalo nasemilenzeni
• ubunzima bokucinga okanye ukudideka
• ukuxhuzula
• ukubona izinto okanye ukuva amazwi angekhoyo
• utshintsho kwiimvakalelo, uziva ulusizi okanye uxhalabile
• iingxaki ngentetho
• ubunzima bokulala okanye ukulala
• amaphupha angaqhelekanga okanye amaphupha amabi
• isiyezi, uziva utyhafile, okanye ukubetha kwentliziyo ngendlela engaqhelekanga

ILorlatinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola uvavanyo oluthile lweelebhu kunye ne-electrocardiogram (ECG; uvavanyo olulinganisa umsebenzi wombane entliziyweni) ngaphambi kwaye ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwilorlatinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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