Cladribine

Umxholo

• Ngaphambi kokuthatha i-cladribine,
• I-Cladribine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Cladribine inokunyusa umngcipheko wokuba ube nomhlaza. Tshela ugqirha wakho ukuba ukhe waba nomhlaza. Ugqirha wakho unokukuxelela ukuba ungathathi i-cladribine.Thetha nogqirha wakho malunga nento ekufuneka uyenzile ukukhangela iimpawu zomhlaza njengokuzihlola kunye novavanyo lokuhlola.

Thetha nogqirha wakho malunga neengozi zokuthatha i-cladribine.

Musa ukuthatha i-cladribine ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ukhulelwa ngelixa uthatha i-cladribine, yeka ukuthatha i-cladribine kwaye ubize ugqirha ngokukhawuleza. Kukho umngcipheko wokuba i-cladribine inokubangela ukulahleka kokukhulelwa okanye iya kubangela ukuba umntwana azalwe enesiphene sokuzalwa (iingxaki zomzimba ezikhoyo ngexesha lokuzalwa).

Ugqirha wakho uya kujonga ukuba ukhulelwe ngaphambi kokuba uqale ikhosi nganye yonyango. Kuya kufuneka usebenzise ulawulo lokuzalwa ukukhusela ukukhulelwa ngexesha ngalinye lonyango kunye ne-cladribine kwaye ubuncinci iinyanga ezintandathu ubuncinci emva kwethamo lakho lokugqibela lonyango ngalunye. Ukuba usebenzisa i-hormonal (estrogen) izinto zokucwangcisa (iipilisi zolawulo lokuzalwa, iipatches, iiringi, ukufakelwa, okanye inaliti) kuya kufuneka usebenzise enye indlela yolawulo lokuzalwa ngexesha ngalinye lonyango kunye ne-cladribine kwaye ubuncinci iiveki ezi-4 emva kwedosi yakho yokugqibela ikhosi nganye yonyango. Ukuba uyindoda eneqabane lomfazi onokukhulelwa, qiniseka ukuba usebenzisa ulawulo lokuzalwa ngexesha ngalinye lonyango kunye ne-cladribine kwaye ubuncinci iinyanga ezintandathu ubuncinci emva kwethamo lakho lokugqibela lonyango ngalunye. Thetha nogqirha wakho malunga neendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha nasemva konyango lwakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-cladribine kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Cladribine isetyenziselwa ukunyanga abantu abadala abaneendlela eziphinda zibuyele kwakhona ze-multiple sclerosis (MS; isifo apho imithambo-luvo ingasebenzi kakuhle kwaye abantu banokufumana ubuthathaka, ukuba ndindisholo, ukuphulukana nokulungelelaniswa kwemisipha, kunye neengxaki ngombono, intetho, kunye nolawulo lwesinyi), kubandakanya ukubuyela ekuphindiseni (iifom zesifo apho iimpawu zivela khona amaxesha ngamaxesha) kunye neefom zesekondari ezisebenzayo (ikhosi yesifo elandela ikhondo lokubuyela umva apho iimpawu ziye zisiba mandundu ngokuhamba kwexesha). I-Cladribine isetyenziswa ngokubanzi kwizigulana esele zizame olunye unyango lwe-MS. Cladribine kwiklasi yamayeza abizwa ngokuba yi-purine antimetabolites. Isebenza ngokumisa iiseli ezithile zamajoni omzimba ekubangeleni umonakalo we-luvo.

I-Cladribine iza njengecwecwe lokuthatha ngomlomo ngamanzi. Ihlala ithathwa kunye okanye ngaphandle kokutya, kanye ngemini kangangeentsuku ezi-4 okanye ezi-5 zilandelelana kumjikelo omnye wonyango. Umjikelo wesibini wonyango kufuneka uphindwe emva kweentsuku ezingama-23 ukuya kwezi-27 ukugqiba ikhosi enye yonyango. Ikhosi yesibini (2 imijikelo yonyango) ihlala inikwa ubuncinci iiveki ezingama-43 emva kwedosi yokugqibela yomjikelo wesibini. Thatha i-cladribine ngexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-cladribine ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Susa ithebhulethi kwipakethi yeblister ngezandla ezomileyo emva koko uginye ithebhulethi ngoko nangoko. Nciphisa ixesha apho ithebhulethi inxibelelana nolusu lwakho. Kuphephe ukubamba impumlo, amehlo, namanye amalungu omzimba. Emva kokuba uthathe amayeza, hlamba izandla zakho kakuhle ngamanzi. Ukuba ithebhulethi inxibelelana nayo nayiphi na indawo okanye amanye amalungu omzimba wakho, zihlambe kakuhle ngamanzi ngoko nangoko.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuthatha i-cladribine,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba u-aleji kwi-cladribine, nawaphi na amanye amayeza, okanye nasiphi na isithako kwiipilisi ze-cladribine. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: dipyridamole (Persantine, kwiAgrenrenox); i-elrombopag (iPractacta); i-furosemide (iLasix); gabapentin (Gralise, Horizant, Neurontin); ibuprofen (Advil, Midol, Motrin, nabanye); I-beta ye-interferon (Avonex, Betaseron, Extavia, Rebif); lamivudine (Epivir, kwi-Epzicom); amayeza athintela amajoni omzimba anje nge-azathioprine (Azasan), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), sirolimus (Rapamune), kunye netacrolimus (Astagraf, Envarsus, Prograf); i-nifedipine (iAdalat, iProcardia); nimodipine (Nymalize); gqithisela; ribavirin (Rebetol, Ribasphere, Virazole); irifampin (Rifadin, Rimactane, eRifamate, eRifater); i-ritonavir (i-Norvir, e-Kaletra, e-Technivie, e-Viekira); istavudine (iZerit); ii-steroids ezinje nge-dexamethasone (i-Decadron, i-Dexpak), i-methylprednisolone (Medrol), kunye ne-prednisone (i-Rayos); sulindac; kunye ne-zidovudine (Retrovir, kwiCombivir, kwiTrizivir). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-cladribine, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• ukuba uthatha naliphi na iyeza ngomlomo, thatha iiyure ezi-3 ngaphambi okanye iiyure ezi-3 emva kwe-cladribine.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi i-curcumin kunye neSt.
• xelela ugqirha wakho ukuba unayo intsholongwane kaGawulayo (i-HIV), i-hepatitis (intsholongwane eyosulela isibindi kwaye inokubangela ukonakala kwesibindi), isifo sephepha (i-TB; isifo esosulelayo esihlasela imiphunga kwaye ngamanye amaxesha namanye amalungu omzimba), okanye ezinye izifo eziqhubekayo. Ugqirha wakho uya kukuxelela ukuba ungathathi i-cladribine.
• xelela ugqirha wakho ukuba ukhe unesibindi, izintso, okanye isifo sentliziyo.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncancise ibele ngexesha lomjikelo wonyango, kunye neentsuku ezili-10 emva kwethamo lokugqibela lomjikelo wonyango.
• ukuba uyenziwa utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-cladribine.
• awunalo ugonyo ngaphakathi kweeveki ezi-4 ukuya kwezi-6 ngaphambi, ngexesha, okanye emva konyango lwakho nge-cladribine ngaphandle kokuthetha nogqirha wakho. Thetha nogqirha wakho malunga nokuba kufuneka ufumane naluphi na ugonyo ngaphambi kokuba uqale unyango lwakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule kwangolo suku lunye. Nangona kunjalo, ukuba ayithathiwanga ngomhla ocwangcisiweyo, thabatha idosi ephosiweyo ngosuku olulandelayo kwaye wongeze olunye usuku kulo mjikelo wonyango. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Cladribine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• isicaphucaphu
• umqolo obuhlungu
• intlungu edibeneyo kunye nokuqina
• ubunzima bokulala okanye ukulala
• ukudakumba
• ukulahleka kweenwele
• ukurhawuzelela, ukurhawuzelela, okanye ukutshisa izilonda kwiintsini, kwimilebe, okanye emlonyeni

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• umkhuhlane, umqala obuhlungu, ukugodola, ukuqaqamba okanye izihlunu ezibuhlungu, ukukhohlela, okanye ezinye iimpawu zosulelo
• ukukhohlela, iintlungu esifubeni, ukukhohlela igazi okanye amafinyila, ubuthathaka okanye ukudinwa, ukunciphisa umzimba, ukungabi namdla wokutya, ukugodola, umkhuhlane, ukubila ebusuku
• irhashalala elibuhlungu namadyungudyungu
• ukutshisa, ukubetha, ukuba ndindisholo, okanye ukurhawuzelela ulusu
• irhashalala, ukuphefumla nzima okanye ukugwinya, ukudumba okanye ukurhawuzelela ubuso, imilebe, ulwimi, okanye umqala
• Ukugodola, umkhuhlane, isicaphucaphu, ukugabha, iintlungu emqolo, ecaleni, okanye ekuncwineni, ukuchama rhoqo nokubuhlungu
• ukopha okungaqhelekanga okanye ukugruzuka
• ubuthathaka kwelinye icala lomzimba wakho, ukulahleka kokulungelelaniswa kwiingalo zakho okanye emilenzeni, ukunciphisa amandla, iingxaki ngokulinganisela, ukudideka, utshintsho kumbono wakho, ukucinga, imemori okanye ubuntu
• ukuphefumla kancinci, ukubetha kwentliziyo okukhawulezayo, intloko ebuhlungu, isiyezi, ulusu olukhanyayo, ukudideka, ukudinwa
• isicaphucaphu, ukugabha, ukudinwa kakhulu, ukuphelelwa ngumdla wokutya, iintlungu kwinxalenye ephezulu yesisu, ukuba tyheli kolusu okanye amehlo, umchamo omnyama
• ukuphefumla okufutshane, ukukhawuleza okanye ukubetha kwentliziyo okungagungqiyo, ukudumba kwilungu lomzimba wakho

I-Cladribine inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokuya kugqirha kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi, ngexesha, nasemva konyango lwakho ukuze uqiniseke ukuba kukhuselekile ukuba ungathatha i-cladribine kwaye ujonge impendulo yomzimba wakho kwi-cladribine.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Mavenclad^®