I-Dolutegravir kunye neLamivudine

Umxholo

• Ngaphambi kokuba uthathe i-dolutegravir kunye ne-lamivudine,
• I-Dolutegravir kunye ne-lamivudine zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, okanye ezo zidweliswe kwicandelo LOKUKHUSELWA OKUQHELEKILEYO, tsalela ugqirha wakho kwangoko:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, yeka ukuthatha i-dolutegravir kunye ne-lamivudine kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

Tshela ugqirha wakho ukuba unayo okanye ucinga ukuba unokuba nosulelo lwe-virus ye-hepatitis B (HBV; isifo esiqhubekayo sesibindi). Ugqirha wakho angakuvavanya ukuze ubone ukuba unayo i-HBV ngaphambi kokuba uqale unyango lwakho nge-dolutegravir kunye ne-lamivudine. Ukuba unayo i-HBV kwaye uthatha i-dolutegravir kunye ne-lamivudine, imeko yakho inokuba mandundu mandundu xa uyeka ukuthatha i-dolutegravir kunye ne-lamivudine. Ugqirha wakho uyakukuvavanya kwaye aodole uvavanyo lwelebhu rhoqo kwiinyanga ezininzi emva kokuba uyekile ukuthatha i-dolutegravir kunye ne-lamivudine ukubona ukuba i-HBV yakho iye yaba mbi na.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-dolutegravir kunye ne-lamivudine.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-dolutegravir kunye ne-lamivudine.

Indibaniselwano ye-dolutegravir kunye ne-lamivudine isetyenziswa yodwa ukunyanga usulelo lwe-immunodeficiency virus (HIV) kubantu abathile abangazange banyangwe nangamayeza e-HIV ngaphambili. I-Lamivudine ikwiklasi yamayeza abizwa ngokuba yi-nucleoside analogue reverse transcriptase inhibitors (NRTIs) kunye ne-dolutegravir ikudidi lwamayeza abizwa ngokuba yi-integrase strand transfer inhibitors (INSTIs). Zisebenza ngokunciphisa inani le-HIV egazini lakho kwaye zonyusa inani leeseli zomzimba ezinceda ukulwa usulelo emzimbeni wakho. Nangona i-dolutegravir kunye ne-lamivudine zingayi kuyinyanga i-HIV, la mayeza angalinciphisa ithuba lakho lokufumana isifo se-immunodeficiency syndrome (i-AIDS) kunye nezifo ezinxulumene ne-HIV ezinje ngezifo ezinzulu okanye umhlaza. Ukuthatha la mayeza kunye nokwabelana ngesondo okukhuselekileyo nokwenza olunye utshintsho kwindlela yokuphila kunokunciphisa umngcipheko wokufumana okanye wokuhambisa intsholongwane kaGawulayo kwabanye abantu.

Indibaniselwano ye-dolutegravir kunye ne-lamivudine iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye ngemini. Thatha i-dolutegravir kunye ne-lamivudine ngexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-dolutegravir kunye ne-lamivudine kanye njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi, okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

I-Dolutegravir kunye ne-lamivudine banceda ukulawula usulelo lwe-HIV kodwa abalunyangi. Qhubeka uthathe i-dolutegravir kunye ne-lamivudine nokuba uziva uphilile. Sukuyeka ukuthatha i-dolutegravir, kunye ne-lamivudine ngaphandle kokuthetha nogqirha wakho. Ukuba uyeka ukuthatha i-dolutegravir kunye ne-lamivudine okanye uphose iidosi, imeko yakho kunokuba nzima ukunyanga. Xa unikezelo lwakho lwe-dolutegravir kunye ne-lamivudine ziqala ukwehla, fumana okungakumbi kugqirha wakho okanye kwikhemesti.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-dolutegravir kunye ne-lamivudine,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana nedolutegravir, lamivudine, nawaphi na amanye amayeza, okanye nasiphi na isithako esikwipilisi zedolutegravir kunye ne-lamivudine. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha i-dofetilide (Tikosyn). Ugqirha wakho uza kukuxelela ukuba ungathathi i-dolutegravir kunye ne-lamivudine ukuba uthatha eli yeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nononyango, iivithamini, izongezo zesondlo ozithathayo okanye oceba ukuzithatha. Qinisekisa ukukhankanya nayiphi na kwezi zilandelayo: carbamazepine (Carbatrol, Equetro, Tegretol, abanye), dalfampridine (Ampyra), metformin (Glumetza, Glucophage, Riomet, e-Invokamet, eJanumet, abanye), oxcarbazepine (Oxtellar XR, Trileptal), phenobarbital, phenytoin (Dilantin, Phenytek), rifampin (Rifadin, Rimactane, eRifamate, eRifater), kunye ne-sorbitol okanye amayeza ane-sorbitol. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• ukuba uthatha ii-antacids okanye i-laxatives eziqukethe i-aluminium okanye i-magnesium; I-sucralfate (iKarafate); okanye amayeza angqiniweyo anjenge-aspirin ebanjiweyo, thatha ubuncinci iiyure ezi-2 emva okanye iiyure ezi-6 phambi kokuba uthathe i-dolutegravir kunye ne-lamivudine.
• Ukuba uthatha izongezo zentsimbi okanye zekhalsiyam, okanye ii-multivitamini ezine-iron okanye i-calcium, zithathe ngaxeshanye uthathe i-dolutegravir kunye ne-lamivudine kunye nokutya, okanye uzithathe ubuncinci iiyure ezi-2 emva okanye kwiiyure ezi-6 ngaphambi kokuba uthathe i-dolutegravir kunye ne-lamivudine .
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe wosuleleka sisifo se-hepatitis C (i-HCV; isifo esiqhubekayo sesibindi) okanye esinye isifo sesibindi, okanye isifo sesintso.
• xelela ugqirha wakho ukuba ukhulelwe, okanye ucwangcise ukukhulelwa. Uya kudinga ukuthatha uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango. Akufanele ukhulelwe ngelixa uthatha i-dolutegravir kunye ne-lamivudine. Thetha nogqirha wakho malunga neendlela ezifanelekileyo zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba ukhulelwa ngelixa uthatha i-dolutegravir kunye ne-lamivudine, tsalela umnxeba kwangoko.
• xelela ugqirha wakho ukuba uncelisa.Akufuneki uncancise xa wosulelwe yi-HIV okanye ukuba uthatha i-dolutegravir kunye ne-lamivudine.
• Kuya kufuneka uyazi ukuba ngelixa uthatha amayeza ukunyanga usulelo lwe-HIV, amajoni akho omzimba angomelela kwaye aqale ukulwa nezinye izifo ezazisele zisemzimbeni wakho okanye zibangele ezinye iimeko zenzeke. Oku kunokubangela ukuba ukhule iimpawu zolo sulelo okanye iimeko. Ukuba uneempawu ezintsha okanye eziba mandundu ngexesha lonyango lwakho nge-dolutegravir kunye ne-lamivudine, qiniseka ukuxelela ugqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Dolutegravir kunye ne-lamivudine zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• isicaphucaphu
• urhudo
• irhasi
• ubunzima bokulala okanye ukulala
• ukudinwa
• ubuthathaka bemisipha

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, okanye ezo zidweliswe kwicandelo LOKUKHUSELWA OKUQHELEKILEYO, tsalela ugqirha wakho kwangoko:

• mthubi wamehlo okanye ulusu, iintlungu zesisu, ilindle elinombala okhanyayo, umchamo onombala omnyama, isicaphucaphu, ukugabha, ukuphelelwa ngumdla wokutya
• ukudinwa kakhulu okanye ubuthathaka, iintlungu zemisipha, ukuphefumla nzima, iintlungu esiswini, isicaphucaphu, ukugabha, ukuziva ubanda ingakumbi ezingalweni nasemilenzeni, isiyezi, ukukhawuleza okanye ukubetha kwentliziyo ngendlela engaqhelekanga
• irhashalala (ngaphandle kwazo naziphi na ezinye iimpawu)

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, yeka ukuthatha i-dolutegravir kunye ne-lamivudine kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• imihlathi, ukudumba kobuso, umqala, ulwimi, okanye imilebe, amehlo abomvu okanye adumbileyo, kunzima ukugwinya okanye ukuphefumla
• Ukukhawuleza kunye naziphi na iimpawu ezilandelayo; ifiva; iimpawu ezifana nomkhuhlane; ukudinwa kakhulu; izihlunu okanye amalungu ngokudibeneyo; ukuxobuka okanye ukudumba kolusu; izilonda okanye izilonda emlonyeni; okanye bomvu, urhawuzelele, amehlo amanzi,

I-Dolutegravir kunye ne-lamivudine zinokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Phambi kokuba wenze uvavanyo lwaselebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha i-dolutegravir kunye ne-lamivudine.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Gcina unikezelo lwe dolutegravir kunye ne lamivudine ngesandla. Sukulinda de uphelelwe ngamayeza ukuze uphinde uzalise amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• UDovato^® (njengemveliso yokudibanisa equlethe iDolutegravir, iLamivudine)

• dolutegravir kunye ne3TC