Zanubrutinib

Umxholo

• Ngaphambi kokuba uthathe i-zanubrutinib,
• I-Zanubrutinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Zanubrutinib isetyenziselwa ukunyanga i-mantle cell lymphoma (i-MCL; umhlaza okhula ngokukhawuleza oqala kwiiseli zamajoni omzimba) kubantu abadala abasele bephethwe ngamanye amayeza e-chemotherapy. UZanubrutinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukunqanda ukusasazeka kweeseli zomhlaza.

UZanubrutinib uza njengephilisi emayithathwe ngomlomo. Ihlala ithathwa kanye okanye kabini yonke imihla kunye okanye ngaphandle kokutya. Thatha i-zanubrutinib malunga nexesha elifanayo (ii) yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-zanubrutinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Gwinya zonke njengezingxobo ngeglasi yamanzi; ungahluleli, ungahlaleli, okanye uzityumze.

Ugqirha wakho unokunciphisa idosi yakho, okanye uphazamise okanye uyeke unyango lwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka uthathe i-zanubrutinib nokuba uziva uphilile. Sukuyeka ukuthatha i-zanubrutinib ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-zanubrutinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-zanubrutinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifomsile zanubrutinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amayeza e-anticoagulant ('igazi elincinci') njengewarfarin (Coumadin, Jantoven); izinto zokubulala ezinje nge-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), okanye ketoconazole; Aprepitant (Cinvanti, Emend); i-clarithromycin (i-Biaxin, kwi-Prevpac); idigoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, nabanye); erythromycin (EES, Erythrocin, abanye); amayeza athile okunyanga intsholongwane kaGawulayo (i-HIV) okanye i-immunodeficiency syndrome (i-AIDS) efana ne-efavirenz (Sustiva, e-Atripla), nelfinavir (Viracept), ritonavir (Norvir, e-Kaletra), kunye ne-saquinavir (Invirase); nefazodone; omeprazole (Prilosec); phenobarbital; phenytoin (iDilantin, iPhenytek); ipioglitazone (Actos); rifampin (Rifadin, Rifamate, Rimactane, nabanye); midazolam; kunye nee-steroids zomlomo ezinje nge-dexamethasone, methylprednisolone (Medrol), kunye ne-prednisone (iRayos). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza ozithathayo, ngakumbi iSort John's Wort.
• xelela ugqirha wakho ukuba unentsholongwane okanye usandula kwenziwa utyando. Xelela ugqirha wakho ukuba ukhe wabetha ngentliziyo ngendlela engaqhelekanga, uxinzelelo oluphezulu lwegazi, iingxaki zokopha, okanye isifo sentliziyo okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba ngutata womntwana. Akufanele ukhulelwe ngelixa uthatha i-zanubrutinib. Ukuba ungumfazi, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye kufuneka usebenzise ulawulo lokuzalwa ukukhusela ukukhulelwa ngexesha lonyango lwakho kunye neveki e-1 emva kwedosi yakho yokugqibela. Ukuba uyindoda, wena kunye neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kunye ne-zanubrutinib kwaye niqhubeke iveki e-1 emva kwedosi yokugqibela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-zanubrutinib, biza ugqirha wakho ngokukhawuleza. I-Zanubrutinib inokubangela ingozi kumntwana.
• xelela ugqirha wakho ukuba uncelisa. Musa ukuncancisa ngelixa uthatha i-zanubrutinib kunye neeveki ezi-2 emva kwedosi yakho yokugqibela.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-zanubrutinib. Ugqirha wakho angakuxelela ukuba uyeke ukuthatha i-zanubrutinib kangangexesha eliphambi nasemva kotyando okanye inkqubo.
• cwangcisa ukuthintela ukukhanya elangeni ngokungeyomfuneko okanye ixesha elide kunye nokunxiba impahla ekhuselayo, iiglasi zelanga kunye nescreen selanga. I-Zanubrutinib inokwenza ulusu lwakho lubuthathaka kwimiphumela yelanga, kwaye inokunyusa umngcipheko wokuba nomhlaza wolusu.

Thetha nogqirha wakho malunga nokutya igrapefruit kunye nokusela ijusi yamagilebhisi ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo kwakamsinya nje emva kokuba uyikhumbule ngalo mhla kwaye uqhubeke neshedyuli yakho yethosi rhoqo ngosuku olulandelayo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Zanubrutinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• ukuqhina
• ukukhohlela
• umsipha, ukudibana, okanye iintlungu zomqolo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• umkhuhlane, umqala obuhlungu, ingqele, okanye ezinye iimpawu zosulelo
• ukuchama okubuhlungu, rhoqo, okanye okungxamisekileyo
• ukukhohlela, ukuphefumla kancinci, iintlungu esifubeni xa uphefumla okanye ukhohlela, okanye umkhuhlane
• ukugruzuka okanye ukopha okungaqhelekanga
• igazi kwizitulo zakho okanye emnyama, ilindle; umchamo opinki okanye omdaka; ukugabha igazi okanye umhlaba wekhofi; ukhohlela igazi
• Ukuziva unesiyezi, ubuthathaka, okanye udidekile; utshintsho kwintetho; Intloko ehlala ixesha elide
• irhashalala
• ukukhawuleza kwentliziyo okanye okungaqhelekanga, ukubetha, ukuziva unentloko okanye udizzy, ukuphelelwa amandla, ukuphefumula okufutshane, iintlungu zesifuba

I-Zanubrutinib inokunyusa umngcipheko wokuphuhlisa iintlobo ezithile zomhlaza kubandakanya umhlaza wolusu. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-zanubrutinib.

I-Zanubrutinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho angayalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-zanubrutinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Brukinsa^®