Inaliti yeLisocabtagene Maraleucel

Umxholo

• Ngaphambi kokufumana i-lisocabtagene maraleucel,
• I-Lisocabtagene maraleucel inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

Inaliti ye-Lisocabtagene maraleucel inokubangela ukusabela okunobungozi okanye okusongela ubomi okubizwa ngokuba yi-cytokine release syndrome (CRS). Ugqirha okanye umongikazi uya kukujonga ngononophelo ngexesha lokufakwa kwakho kunye ubuncinci iiveki ezi-4 emva koko. Tshela ugqirha wakho ukuba unesifo esivuthayo okanye ukuba unayo okanye ucinga ukuba unalo naluphi na uhlobo losulelo ngoku. Uya kunikwa amayeza imizuzu engama-30 ukuya kwengama-60 ngaphambi kokufakwa kwakho ukunceda ukuthintela ukusabela kwi-lisocabtagene maraleucel. Ukuba ufumana naziphi na kwezi mpawu zilandelayo ngexesha nasemva kokufakwa, xelela ugqirha ngoko nangoko: umkhuhlane, ukugodola, ukukhawuleza kwentliziyo okanye ukubetha kwentliziyo, iintlungu zemisipha, ukungcangcazela, urhudo, ukudinwa, ukuba buthathaka, ukuphefumla nzima, ukuphefumla kancinci, ukukhohlela, ukudideka, isicaphucaphu, ukugabha, isiyezi, okanye iintloko.

Inaliti yeLisocabtagene maraleucel inokubangela ukusabela okubukhali okanye okusongela ubomi. Ezi mpendulo zinokwenzeka emva konyango nge-lisocabtagene maraleucel. Tshela ugqirha wakho ukuba ukhe waxhuzula, wabethwa yistroke, okanye waphulukana nenkumbulo. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngoko nangoko: intloko ebuhlungu, isiyezi, ubunzima bokulala okanye ukulala, ukungazinzi, ukudideka, ixhala, ukungcangcazela okungalawulekiyo komzimba, ukulahleka kwengqondo, ukuphazamiseka, ukuxhuzula, ukulahleka ukulinganisela, okanye ubunzima bokuthetha.

Inaliti ye-Lisocabtagene maraleucel ifumaneka kuphela ngenkqubo ekhethekileyo yokuhanjiswa. Inkqubo yaseBreyanzi REMS (uVavanyo loMngcipheko kunye neQhinga lokuNciphisa) isekiwe ngenxa yomngcipheko weCRS kunye netyhefu ye-neurological. Unokufumana amayeza kugqirha nakwiziko lokhathalelo lwempilo oluthatha inxaxheba kule nkqubo. Buza ugqirha wakho ukuba unemibuzo malunga nale nkqubo.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-lisocabtagene maraleucel kwaye ngalo lonke ixesha uzalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Lisocabtagene maraleucel isetyenziselwa ukunyanga iintlobo ezithile ze-B-cell lymphoma enkulu (uhlobo lomhlaza oluqala kwiiseli ezimhlophe zegazi) kubantu abadala abanomhlaza obuyileyo okanye ongaphenduliyo kwezinye iindlela zonyango ezimbini. I-Lisocabtagene maraleucel ikudidi lwamayeza abizwa ngokuba yi-autologous cellular immunotherapy, uhlobo lonyango olulungiselelwe kusetyenziswa iiseli ezivela kwigazi lesigulana. Isebenza ngokubangela amajoni omzimba (iqela leeseli, izicwili, kunye namalungu akhusela umzimba ekuhlaselweni ziintsholongwane, iintsholongwane, iiseli zomhlaza, kunye nezinye izinto ezibangela izifo) ukuba zilwe neeseli zomhlaza.

I-Lisocabtagene maraleuceliza njengokumiswa (ulwelo) ukuze kutofelwe ngaphakathi (emthanjeni) ngugqirha okanye ngumongikazi kwiofisi kagqirha okanye kwiziko lokumnika. Ihlala inikwa njenge-infusions ezimbini ngaphezulu kwexesha elipheleleyo ukuya kwimizuzu engama-30 njengedosi yexesha elinye. Ngaphambi kokuba ufumane i-lisocabtagene maraleucel dose, ugqirha wakho okanye umongikazi uya kulawula amanye amayeza e-chemotherapy ukulungiselela umzimba wakho kwi-lisocabtagene maraleucel.

Phambi kokuba unikwe inaliti ye-lisocabtagene maraleucel inaliti, isampulu yeeseli zakho ezimhlophe zegazi ziya kuthathwa kwiziko lokuqokelela iiseli kusetyenziswa inkqubo ebizwa ngokuba yileukapheresis (inkqubo esusa iiseli ezimhlophe zegazi emzimbeni). Ngenxa yokuba eli yeza lenziwa kwiiseli zakho, kufuneka unikwe wena kuphela. Kubalulekile ukuba ufike ngexesha kwaye ungaphoswa kukuqokelelwa (okanye) kokuqokelelwa kweeselfowuni okanye ukufumana idosi yonyango. Kuya kufuneka ucwangcise ukuhlala kufutshane nalapho ufumene unyango lwakho lwe-lisocabtagene maraleucel okungenani iiveki ezi-4 emva kwedosi yakho.Umboneleli wakho wezononophelo lwempilo uya kujonga ukuba unyango lwakho luyasebenza na kwaye akubeke esweni naziphi na iziphumo ebezingalindelekanga ezinokubakho. Thetha nogqirha wakho malunga nendlela yokulungiselela i-leukapheresis kunye nento onokuyilindela ngexesha nasemva kwenkqubo.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana i-lisocabtagene maraleucel,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-lisocabtagene maraleucel, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-lisocabtagene maraleucel. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba unayo okanye wakha wanayo intsholongwane ye-hepatitis B okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Uya kudinga kuvavanyo lokukhulelwa ngaphambi kokuba uqalise i-lisocabtagene maraleucel. Ukuba ukhulelwa ngelixa ufumana i-lisocabtagene maraleucel, tsalela ugqirha ngokukhawuleza.
• Kuya kufuneka uyazi ukuba i-lisocabtagene maraleucel inaliti inokukwenza wozele kwaye ubangele ukudideka, ubuthathaka, isiyezi, ukuxhuzula, kunye neengxaki zokulungelelanisa. Musa ukuqhuba imoto okanye usebenzise oomatshini ubuncinci iiveki ezi-8 emva kwedosi yakho ye-lisocabtagene maraleucel.
• musa ukunikela ngegazi, amalungu, izicubu, okanye iiseli zokufakelwa emva kokuba ufumene inaliti ye-lisocabtagene maraleucel.
• jongana nogqirha wakho ukubona ukuba ufuna ukufumana naluphi na ugonyo. Awunalo naluphi na ugonyo ngaphandle kokuthetha nogqirha wakho ubuncinci iiveki ezi-6 ngaphambi kokuqala ichemotherapy, ngexesha lonyango lwe-lisocabtagene maraleucel, de ugqirha akuxelele ukuba amajoni akho omzimba abuyile.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphosa ixesha lokuqokelela iiseli zakho, kuya kufuneka ubize ugqirha wakho kunye neziko lokuqokelela kwangoko. Ukuba uphosa ixesha lokuqeshwa ukuze ufumane idosi yakho ye-lisocabtagene maraleucel, kufuneka ubize ugqirha ngoko nangoko.

I-Lisocabtagene maraleucel inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhina
• isisu esibuhlungu
• Ukuphelelwa ngumdla wokutya
• irhashalala
• ukuba ndindisholo, iintlungu, ukurhawuzelela, okanye ukutshiswa ziinyawo okanye izandla

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ndiziva ndidiniwe
• ukugruzuka okanye ukopha
• umkhuhlane, umqala obuhlungu, ingqele, okanye ezinye iimpawu zosulelo
• ukudideka
• ukukhawuleza kwentliziyo okanye okungaqhelekanga

I-Lisocabtagene maraleucel inokunyusa umngcipheko wokukhula komhlaza othile. Thetha nogqirha wakho malunga neengozi zokufumana eli yeza.

ILisocabtagene maraleucel inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina lonke ixesha lokudibana nogqirha wakho, indawo yokuqokelela iiseli, kunye nelabhoratri. Ugqirha wakho unoku-odola iimvavanyo ezithile zelebhu ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwilisisi ye-lisocabtagene maraleucel.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba ufumana i-lisocabtagene maraleucel.

Buza usokhemesti wakho nayiphi na imibuzo onayo malunga ne-lisocabtagene maraleucel.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• IBreyanzi^®