Into ekufuneka uyazi ngaphambi kokuba uthathe i-Amitriptyline yokulala

Umxholo

• Yintoni i-amitriptyline?
• Yintoni e-off-label emiselweyo?
• Izilumkiso ze-FDA malunga ne-amitriptyline
• Isebenza njani i-amitriptyline?
• Yiyiphi imilinganiselo eqhelekileyo xa imiselwe ukulala?
• Ngaba kukho iziphumo ebezingalindelekanga ekuthatheni i-amitriptyline yokulala?
• Iziphumo eziqhelekileyo
• Iziphumo ebezingalindelekanga ezimandundu
• Ngaba kukho ukuhlangana namanye amachiza?
• Ngaba zikho izilumkiso malunga nokuthatha i-amitriptyline xa ulele?
• Zeziphi izibonelelo zokuthatha i-amitriptyline yokulala?
• Umgca wezantsi

Ukungabikho kokulala okungaphaya kokukhathaza. Inokuba nefuthe kuyo yonke imimandla yobomi bakho kubandakanya impilo yomzimba neyengqondo. Amaziko oLawulo lweZifo noKhuseleko (CDC) axela ukuba ngaphezulu kwabantu abadala baseMelika abafumani ukulala ngokwaneleyo.

Ukuba awufumani ukulala okudingayo, kukho iindlela ezahlukeneyo zonyango, kubandakanya amayeza anokunceda.

Amayeza okulala asebenza ngeendlela ezahlukeneyo ukukunceda ulale okanye ulale. Ugqirha wakho unokuxoxa ngokumisela i-amitriptyline (Elavil, Vanatrip) ukukunceda ulale.

Ukuba uzama ukuthatha isigqibo sokuba ngaba i-amitriptyline ilungile kuwe, Nazi ezinye zezinto ekufuneka uziqwalasele.

Yintoni i-amitriptyline?

I-Amitriptyline sisiyobisi esisemthethweni esifumaneka njengecwecwe lamandla aliqela. Kuvunyiwe ukuba kusetyenziswe ukunyanga uxinzelelo kodwa kuhlala kumiselwe ezinye iimeko ezininzi ezinjengeentlungu, migraine, kunye nokuqaqanjelwa sisisu.

Nangona ibikho kangangeminyaka emininzi, iseyinto ethandwayo, enexabiso eliphantsi elenziwa lafana nalawo aveliswe ngumenzi.

Yintoni e-off-label emiselweyo?

I-Amitriptyline yamkelwe yi-Food and Drug Administration (i-FDA) ukunyanga uxinzelelo, kodwa oogqirha bakwalinika ichiza ukunceda ukulala. Xa ugqirha emisela iyeza kusetyenziso olungelulo olwamkelweyo yi-FDA, yaziwa ngokuba kukusetyenziswa kwelebheli engekhoyo.

Oogqirha bamisela ngaphandle kwelebheli ngezizathu ezininzi kubandakanya:

• Ubudala. Ugqirha unokuyalela ichiza kumntu omncinci okanye omdala kunokuba kuvunyiwe yileyibhile yeziyobisi ye-FDA.
• Isalathiso okanye ukusetyenziswa. Iyeza linokumiselwa kwimeko engeyiyo eyamkelwe yi-FDA.
• Ithamo. Ugqirha unokuyalela idosi esezantsi okanye ephezulu kunokuba kudwelisiwe kwileyibhile okanye kwi-FDA.

I-FDA ayenzi zindululo koogqirha ngendlela yokuphatha abaguli. Kuye kugqirha wakho ukuba anqume unyango olungcono kuwe ngokusekelwe kubuchule babo kunye nokukhetha kwakho.

Izilumkiso ze-FDA malunga ne-amitriptyline

I-Amitriptyline ine "isilumkiso sebhokisi emnyama" evela kwi-FDA. Oku kuthetha ukuba ichiza lineziphumo ebezingalindelekanga ezibalulekileyo ekufuneka wena nogqirha wakho uziqwalasele ngaphambi kokuba uthathe eli yeza.

• I-Amitriptyline inyuse umngcipheko wokucinga ngokuzibulala kunye nokuziphatha kwabanye abantu, ngakumbi abantwana kunye nabantu abadala abancinci. Kubalulekile ukubeka esweni ukwanda kweempawu zesimo sengqondo, iingcinga, okanye indlela yokuziphatha kwaye ubize u-911 kwangoko ukuba ubona utshintsho.
• Ungatsalela umnxeba iNational Suicide Prevention Lifeline ku-800-273-8255 ukuba wena okanye umntu omaziyo uneengcinga zokuzibulala.
• I-Amitriptyline ayivunyelwanga yi-FDA ukuba isetyenziswe kubantwana abangaphantsi kwe-12.

Isebenza njani i-amitriptyline?

I-Amitriptyline luhlobo lonyango olubizwa ngokuba yi-tricyclic antidepressant (TCA). La mayeza asebenza ngokwandisa imichiza ethile yobuchopho ebizwa ngokuba zii-neurotransmitters ezinje nge-serotonin kunye ne-norepinephrine yokunceda ukuphucula imeko, ukulala, iintlungu kunye noxinzelelo.

Akucaci ncam ukuba i-amitriptyline isebenzela njani ukulala, kodwa enye yeziphumo zayo kukuthintela i-histamine, enokubangela ukozela. Esi sesinye sezizathu sokuba oogqirha bamisele i-amitriptyline njengesixhobo sokulala.

Yiyiphi imilinganiselo eqhelekileyo xa imiselwe ukulala?

I-Amitriptyline yokulala imiselwe ngeedosi ezahlukeneyo. Idosi iya kuxhomekeka kwizinto ezininzi ezinje ngeminyaka yakho, amanye amayeza onokuthi uwathathe, imeko yakho yonyango, kunye neendleko zeziyobisi.

Kubantu abadala, idosi iphakathi kwe-50 kunye ne-100 milligram ngexesha lokulala. Abafikisayo kunye nabantu abadala banokuthatha iidosi ezisezantsi.

Ukuba unolwazi oluthile lokwahluka kwemfuza njengotshintsho kwimfuza, unokufuna uhlengahlengiso lwethamo ukunciphisa amathuba okuba neziphumo ebezingalindelekanga nge-amitriptyline.

Cinga ngokubuza ugqirha wakho okanye usokhemesti malunga novavanyo lofuzo olubizwa ngokuba yi-pharmacogenomics. Oku kuye kwaduma kakhulu ukunceda ukuba ubumbe amayeza akho ukuze asebenze ngcono kuwe.

Ukuqala ngedosi esezantsi kunceda ugqirha ukuba abone ukuba usabela njani kunyango ngaphambi kokwenza utshintsho.

Ngaba kukho iziphumo ebezingalindelekanga ekuthatheni i-amitriptyline yokulala?

I-Amitriptyline inokuba neziphumo ebezingalindelekanga ezibi. Ngaphambi kokuba uthathe iyeza, qiniseka ukuba wazise ugqirha wakho ukuba ngaba wakha waphendula i-amitriptyline okanye amanye amachiza, okanye ukuba wakhe wanazo iingcinga zokuzibulala okanye indlela yokuziphatha.

Yazisa ugqirha wakho ukuba unayo:

• isifo sentliziyo, isibindi, okanye iingxaki zezintso
• i-glaucoma, njengoko i-amitriptyline inokunyusa uxinzelelo kwiso lakho
• Iswekile, njengoko iamitriptyline inokuchaphazela amanqanaba eswekile, kungafuneka ujonge iswekile rhoqo xa uqala ukuthatha i-amitriptyline
• ukuxhuzula, njengoko i-amitriptyline inokunyusa umngcipheko wokubanjwa
• Ukuphazamiseka kwengqondo, i-mania, okanye i-schizophrenia

Thetha nogqirha wakho ukuba ukhulelwe okanye uncelisa. Uphando alukhange lucacise ngokuqinisekileyo ukuba ngaba i-amitriptyline ikhuselekile ukuyisebenzisa ngexesha lokukhulelwa okanye xa uncancisa.

Iziphumo eziqhelekileyo

Xa uqala ukuthatha i-amitriptyline, unokufumana ezinye iziphumo ebezingalindelekanga. Bahlala bemka emva kweentsuku ezimbalwa. Thetha kumachiza okanye kugqirha ukuba bayakhathaza kwaye uqhubeke.

• umlomo owomileyo
• intloko ebuhlungu
• ukutyeba kwakho
• ukuqhina
• ingxaki yokuchama
• ukwehla ngesiquphe koxinzelelo lwegazi ngakumbi xa umile uhleli
• Ukozela okanye ukuba nesiyezi
• ukungaboni kakuhle
• izandla ezingcangcazelisayo (ukungcangcazela)

Iziphumo ebezingalindelekanga ezimandundu

Nangona kunqabile, i-amitriptyline inokubangela iziphumo ezibi kakhulu. Tsalela umnxeba ku-911 ngoko nangoko ukuba ufumana imeko engxamisekileyo yezonyango engxamisekileyo.

Tsalela umnxeba ku-911 ngoko nangoko ukuba ufumana naziphi na kwezi mpawu ngelixa uthatha i-amitriptyline, njengoko zinokubonisa imeko yempilo esongela ubomi:

• ukukhawuleza kwentliziyo okanye okungaqhelekanga
• Intlungu yesifuba kunye nokuphefumla okufutshane, okunokubonakalisa ukuhlaselwa yintliziyo
• ubuthathaka kwelinye icala lomzimba okanye intetho egudileyo, enokuthi ibonakalise ukubetha

Unokufumana ezinye iimpawu ezingadweliswanga apha. Soloko uthetha nogqirha wakho malunga nento onokuhlangabezana nayo ukuze ufunde ukuba amayeza akho anoxanduva.

Ngaba kukho ukuhlangana namanye amachiza?

I-Amitriptyline inokusebenzisana namayeza aliqela. Kubalulekile ukuba ugqirha wakho kunye nosokhemesti bazi onke amayeza amiselweyo, amayeza e-counter-counter, kunye nezongezo zokutya ozithathayo ukuthintela impendulo enokubakho.

Amachiza aqhelekileyo asebenzisana ne-amitriptyline afaka:

• I-monoamine oxidase inhibitors (i-MAOIs) efana ne-selegiline (i-Eldepryl): inokubangela ukuxhuzula okanye ukufa
• I-quinidine: inokubangela iingxaki zentliziyo
• amayeza e-opioid njenge-codeine: anokunyusa ukozela kwaye anyuse umngcipheko we-serotonin syndrome, enokubangela ukonyuka koxinzelelo lwegazi kunye nokuphakama kwentliziyo
• I-epinephrine kunye ne-norepinephrine: inokunyusa uxinzelelo lwegazi, intloko ebuhlungu kunye nentlungu esifubeni
• I-topiramate: inokubangela amanqanaba aphezulu e-amitriptyline emzimbeni wakho, ukwandisa umngcipheko weziphumo ebezingalindelekanga

Olu ayilo luhlu lupheleleyo. Kukho ezinye iziyobisi ezinokuthi zinxibelelane ne-amitriptyline. Khangela ugqirha wakho ukuba unenkxalabo ethile.

Ngaba zikho izilumkiso malunga nokuthatha i-amitriptyline xa ulele?

Kude kube umzimba wakho uqhela amayeza, lumka ngayo nayiphi na imisebenzi efuna ukuba uqaphele njengokuqhuba okanye ukusebenzisa oomatshini.

Akufuneki usele utywala okanye uthathe amanye amayeza anokukwenza wozele nge-amitriptyline kuba inokunyusa ifuthe leziyobisi.

Akufanele uyeke ngesiquphe ukuthatha i-amitriptyline. Thetha nogqirha wakho malunga nendlela efanelekileyo yokumisa ngokuthe ngcembe eli yeza.

Zeziphi izibonelelo zokuthatha i-amitriptyline yokulala?

Izibonelelo ezimbalwa ze-amitriptyline zibandakanya:

• Ixabiso elincinci. I-Amitriptyline liyeza elidala elifumaneka njenge-generic, ngoko ke ayibizi xa kuthelekiswa nezinye izixhobo zokulala ezintsha.
• Akukho mkhwa uyila. I-Amitriptyline ayisiyomlutha okanye isiqhelo sokwakha njengamanye amayeza asetyenziselwa ukulala njenge-diazepam (Valium)

I-Amitriptyline inokuba luncedo ukuba ukuphuthelwa ziziphumo ezivela kwenye imeko onokuba nayo, njengentlungu, uxinzelelo okanye uxinzelelo. Kuya kufuneka uxoxe ngazo zonke iimpawu zakho nogqirha wakho ukuze ufumane olona nyango lulungileyo.

Umgca wezantsi

I-Amitriptyline sele ijikeleze iminyaka emininzi kwaye yinto engabizi kakhulu njengoncedo lokulala. I-Amitriptyline kunye ne-anti-depressants efana nayo ixhaphake kakhulu ngaphandle kwelebheli ukunyanga ukulala, ngakumbi kubantu abaneempawu zokudakumba.

I-Amitriptyline inokubangela iziphumo ebezingalindelekanga ezibalulekileyo kwaye inokusebenzisana namanye amayeza. Ukuba ucinga nge-amitriptyline ukukunceda ufumane ubuthongo obuzolileyo, qiniseka ukuba uthethe nogqirha wakho ngalo naliphi na elinye iyeza kunye nezibonelelo osele uzithatha.