Ukunyanga iMigraines nge-Antidepressants

Umxholo

• Zeziphi iintlobo ezahlukeneyo?
• Ukukhetha i-serotonin reuptake inhibitors (i-SSRIs)
• I-Serotonin-norepinephrine reuptake inhibitors (SNRIs)
• I-Tricyclic yoxinzelelo
• I-Monoamine oxidase inhibitors (i-MAOIs)
• Ukuthintela uxinzelelo kuthintela njani imigraines?
• Zeziphi iziphumo ebezingalindelekanga ze-anti-depressants?
• Ngaba i-anti-depressants ikhuselekile?
• Isifo seSerotonin
• Umgca wezantsi

Zithini i-anti-depressants?

Amayeza okulwa noxinzelelo ngamayeza anceda ukunyanga iimpawu zoxinzelelo. Uninzi lwazo luguqula uhlobo lweekhemikhali olubizwa ngokuba yi-neurotransmitter. Ezi zithwala imiyalezo phakathi kweeseli kwingqondo yakho.

Ngaphandle kwegama labo, i-anti-depressants inokunyanga iimeko ezahlukeneyo ngaphandle koxinzelelo, kubandakanya:

• unxunguphalo kunye nokuphazamiseka
• iingxaki zokutya
• ukuphuthelwa
• iintlungu ezingapheliyo
• kushushu

Ukuxinezeleka kunokuthintela ngokufanelekileyo imigraines. Funda ukuze ufunde ngakumbi.

Zeziphi iintlobo ezahlukeneyo?

Kukho iindidi ezine eziphambili zokuxinezeleka:

Ukukhetha i-serotonin reuptake inhibitors (i-SSRIs)

Ii-SSRI zonyusa inani le-neurotransmitter serotonin kwingqondo yakho. Oogqirha bahlala bemisela ezi zinto zokuqala kuba zibangela iziphumo ebezingalindelekanga ezimbalwa.

I-Serotonin-norepinephrine reuptake inhibitors (SNRIs)

I-SNRI inyusa inani le-serotonin kunye ne-norepinephrine kwingqondo yakho.

I-Tricyclic yoxinzelelo

La mayeza, ekwabizwa ngokuba zii-cyclic antidepressants, anyusa inani le-serotonin kunye ne-norepinephrine.

I-Monoamine oxidase inhibitors (i-MAOIs)

I-Serotonin, i-norepinephrine, kunye ne-dopamine zonke zii-monoamines. Umzimba wakho ngokwendalo wenza i-enzyme ebizwa ngokuba yi-monoamine oxidase ewonakalisayo. I-MAOIs isebenza ngokuthintela le enzyme ekusebenzeni kwii-monoamines kwingqondo yakho.

Ii-MAOIs azifane zimiselwe kuba zibangela iziphumo ebezingalindelekanga ezibi kakhulu.

Ukuthintela uxinzelelo kuthintela njani imigraines?

Iingcali aziqinisekanga ukuba yintoni ebangela imigraines. Ngokwe-Mayo Clinic, ukungalingani kwii-neurotransmitters kunokudlala indima. Amanqanaba eSerotonin nawo ayahla ngexesha le-migraine. Oku kunokucacisa ukuba kutheni i-anti-depressants ibonakala ngathi iyanceda kuthintelo.

I-Tricyclic antidepressants yenye yezona zinto zixhaphakileyo kumayeza kuthintelo lwe-migraine. Nangona kunjalo, isifundo esele sikhona safumanisa ukuba ii-SSRI kunye nee-SNRI zisebenza ngokufanayo. Oku kufumanisa kubalulekile kuba ii-SSRI kunye nee-SNRI zihlala zibangela iziphumo ebezingalindelekanga ezimbalwa kune-tricyclic antidepressants.

Ngelixa izifundo ezichazwe kolu hlaziyo ziyathembisa, ababhali bayaqaphela ukuba uninzi lwezifundo ezikhulu, ezilawulwayo ziyafuneka ukuze baqonde ngokupheleleyo ukuba i-antidepressants ichaphazela njani migraines.

Ukuba ufumana i-migraines rhoqo engaphendulanga kolunye unyango, buza ugqirha wakho malunga nokuzama i-anti-depressants. Gcina ukhumbula ukuba ii-anti-depressants zisetyenziselwa ukuthintela i-migraines, hayi ukunyanga esebenzayo.

Zeziphi iziphumo ebezingalindelekanga ze-anti-depressants?

Ukuxinezeleka kunokubangela uluhlu lweempembelelo. Ii-SSRI ngokubanzi zibangela iziphumo ebezingalindelekanga ezimbalwa, ke ugqirha unokucebisa ukuba uzame olu hlobo kuqala.

Iziphumo eziqhelekileyo ezichaphazelekayo kwiindidi ezahlukeneyo ze-anti-depressants zibandakanya:

• umlomo owomileyo
• isicaphucaphu
• uvalo
• ukungazinzi
• ukuphuthelwa
• iingxaki zesondo, ezinje ngokungasebenzi kakuhle kwe-erectile okanye ukulibaziseka ukunyuka

I-Tricyclic antidepressants, kubandakanya i-amitriptyline, inokubangela iziphumo ebezingalindelekanga, ezinje:

• ukungaboni kakuhle
• ukuqhina
• Yehla kuxinzelelo lwegazi xa umile
• ukugcinwa komchamo
• ukozela

Iziphumo ebezingalindelekanga ziyahluka phakathi kwamayeza, nkqu kuhlobo olunye lwe-anti-depressant. Sebenza nogqirha wakho ukukhetha i-antidepressant ebonelela ngeyona nto inenzuzo ngeziphumo ebezingalindelekanga ezimbalwa. Kuya kufuneka uzame ezimbalwa ngaphambi kokuba ufumane ezisebenzayo.

Ngaba i-anti-depressants ikhuselekile?

Amayeza okulwa noxinzelelo ngokubanzi akhuselekile. Nangona kunjalo, ukuthatha i-antidepressants ukunyanga i-migraines kuthathwa njengokusetyenziswa kwelebheli engekhoyo. Oku kuthetha ukuba abavelisi be-antidepressant khange baqhube izilingo ezifanayo ezifanayo ukuqinisekisa ukhuseleko kunye nokusebenza ngokukuko kunyango lwe-migraine. Uninzi loogqirha abaluniki amayeza okusetyenziswa kwelebhile ngaphandle kokuba ezinye iindlela zonyango ziye zasilela.

Ugqirha wakho unokukunceda ulinganise izibonelelo kunye neengozi zokusebenzisa i-anti-depressants for migraines.

I-anti-depressants iyakwazi ukunxibelelana namanye amayeza, ke xelela ugqirha wakho malunga nayo yonke i-counter-counter (OTC) kunye namayeza amayeza owathathayo. Oku kubandakanya iivithamini kunye nezongezo.

Kuya kufuneka uxelele ugqirha wakho ukuba unayo:

• cholesterol ephezulu
• imbali yesifo sentliziyo
• umngcipheko okhulayo wokuhlaselwa yintliziyo okanye ukubetha
• iglaucoma
• iprotrate eyandisiweyo

Isifo seSerotonin

I-Serotonin syndrome yimeko enqabileyo kodwa enzima eyenzekayo xa amanqanaba akho e-serotonin ephezulu kakhulu. Kuye kwenzeke xa uthatha i-anti-depressants, ngakumbi i-MAOIs, kunye namanye amayeza, izongezo, okanye iziyobisi ezingekho mthethweni ezonyusa amanqanaba akho e-serotonin.

Musa ukuthatha i-anti-depressants ukuba sele uthabathe nawaphi na amayeza e-migraine:

• almotriptan (igwebu)
• naratriptan (Amerge)
• is sumatriptan (Imitrex)

Ezinye izinto ezinokusebenzisana ne-anti-depressants kwaye zibangele i-serotonin syndrome zibandakanya:

• i-dextromethorphan, isithako esiqhelekileyo kumayeza abandayo kunye nokukhohlela e-OTC
• izongezo zemifuno, kubandakanya iginseng kunye neSt
• ezinye iziyobisi
• iziyobisi ezingekho mthethweni, kubandakanya i-ecstasy, icocaine, kunye neamphetamines

Funa unyango lonyango olungxamisekileyo ukuba ufumana enye yeziphumo ebezingalindelekanga ngelixa uthatha i-anti-depressants:

• ukudideka
• ukudumba kwemisipha kunye neenyikima
• ukuqina kwemisipha
• ndingcangcazela
• ukukhawuleza kwentliziyo
• Ingqondo egqithisileyo
• abafundi abaxubileyo
• ukuxhuzula
• ukungaphenduli

Umgca wezantsi

Unyango lwe-Migraine lolunye lwezona zixhobo zisetyenziswayo ngaphandle kwelebheli yeyeza. Ngelixa ubukhulu obukhulu, izifundo ezikumgangatho ophezulu ziyafuneka, uphando esele lukhona lubonisa ukuba i-antidepressants inokusebenza ngokuthintela ukuba umntu akaphenduli kakuhle kolunye unyango. Ukuba uhlala ufumana i-migraines engaphenduliyo kwezinye iindlela zonyango, thetha nogqirha wakho malunga nokuzama ukuthintela uxinzelelo.