Umbhali: Judy Howell
Umhla Wokudalwa: 4 Eyekhala 2021
Hlaziya Umhla: 15 Eyenkanga 2024
Anonim
Efavirenz, Emtricitabine and Tenofovir Treat HIV and AIDs in Adults - Overview
Ividiyo: Efavirenz, Emtricitabine and Tenofovir Treat HIV and AIDs in Adults - Overview

Umxholo

Yintoni iAtripla?

I-Atripla liyeza-igama lonyango elisetyenziselwa ukunyanga i-HIV kubantu abadala nasebantwaneni. Imiselwe abantu abanobunzima ubuncinci iiponti ezingama-88 (iikhilogram ezingama-40).

I-Atripla inokusetyenziswa yodwa njengerejimeni yonyango epheleleyo (isicwangciso). Ingasetyenziselwa ukudibanisa namanye amachiza. Iza njengepilisi enye equlathe amachiza amathathu:

  • I-efavirenz (600 mg), eyi-non-nucleoside reverse transcriptase inhibitor (NNRTI)
  • i-tenofovir disoproxil fumarate (300 mg), eyi-nucleoside analog reverse transcriptase inhibitor (NRTI)
  • i-emtricitabine (200 mg), ekwayiyo i-nucleoside analog reverse transcriptase inhibitor (NRTI)

Izikhokelo ezikhoyo azikhuthazi i-Atripla njengonyango lokuqala kubantu abaninzi abane-HIV. Kungenxa yokuba kukho unyango olutsha olunokuthi lukhuseleke okanye lusebenze ngakumbi kubantu abaninzi. Nangona kunjalo, iAtripla inokuba ilungele abanye abantu. Ugqirha wakho uya kuthatha isigqibo sonyango olufanelekileyo kuwe.

Kubalulekile ukuba uqaphele ukuba i-Atripla ayivunyelwanga ukuthintela i-HIV.


Atripla generic

I-Atripla ifumaneka kuphela njengegama lonyango. Okwangoku ayifumaneki ngendlela eqhelekileyo.

I-Atripla inezithako ezintathu ezisebenzayo zeziyobisi: i-efavirenz, emtricitabine, kunye ne-tenofovir disoproxil fumarate. Elinye lala machiza lifumaneka ngokukodwa kwiifom zohlobo oluqhelekileyo. Kukho ukubakho kwezinye indibaniselwano zala machiza akhoyo njengamayeza enziwe afana nalawo aveliswe ngumenzi.

Iziphumo ebezingalindelekanga ze-Atripla

I-Atripla inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha iAtripla. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga ezinokubakho zeAtripla, okanye iingcebiso ngendlela yokujongana nefuthe elibi, thetha nogqirha okanye usokhemesti

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo ezichaphazelekayo ze-Atripla zingabandakanya:

  • urhudo
  • isicaphucaphu
  • intloko ebuhlungu
  • amandla aphantsi
  • amaphupha angaqhelekanga
  • ingxaki yokujonga
  • isiyezi
  • ingxaki yokulala
  • ukudakumba
  • irhashalala okanye ukurhawuzelela ulusu
  • ukwanda kwecholesterol

Uninzi lweziphumo ebezingalindelekanga kolu luhlu ziziphumo ezinobulali kwindalo. Ukuba zinzima kakhulu okanye zenza kube nzima ukuqhubeka uthatha amayeza akho, thetha nogqirha wakho okanye usokhemesti.


Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ezibi kakhulu ezivela eAtripla aziqhelekanga, kodwa zinokwenzeka. Shayela ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Iziphumo ebezingalindelekanga ezimandundu kunye neempawu zazo zinokubandakanya oku kulandelayo:

  • Ukwanda ngamandla kwe-hepatitis B (HBV). Iimpawu zingabandakanya:
    • ukudinwa
    • umchamo omnyama-mnyama
    • iintlungu zomzimba kunye nobuthathaka
    • ubumthubi besikhumba sakho kunye namhlophe wamehlo akho
  • Irhashalala. Esi siphumo sisecaleni sihlala sivela kwiiveki ezi-2 zokuqala i-Atripla kwaye iyazimela ngokwayo kwinyanga enye. Iimpawu zingabandakanya:
    • obomvu, ulusu olurhawuzayo
    • amaqhuma kulusu
  • Umonakalo wesibindi. Iimpawu zingabandakanya:
    • ubumthubi besikhumba sakho kunye namhlophe wamehlo akho
    • intlungu kwindawo ephezulu yesisu sakho (isisu)
    • isicaphucaphu nokugabha
  • Imood iyatshintsha. Iimpawu zingabandakanya:
    • ukudakumba
    • Iingcinga zokuzibulala
    • Ukuziphatha gwenxa
    • iimpendulo eziphazamisayo
  • Iingxaki zenkqubo. Iimpawu zingabandakanya:
    • nemibono
  • Ukonakala kwezintso. Iimpawu zingabandakanya:
    • iintlungu zethambo
    • iintlungu ezingalweni okanye emilenzeni
    • amathambo aqhekekile
    • iintlungu zemisipha okanye ubuthathaka
  • Ukuphulukana nethambo. Iimpawu zingabandakanya:
    • iintlungu zethambo
    • iintlungu ezingalweni okanye emilenzeni
    • amathambo aqhekekile
  • Ukuxhuzula. Iimpawu zingabandakanya:
    • ukulahleka kwengqondo
    • ukudumba kwezihlunu
    • amazinyo atshixeneyo
  • Ukwakhiwa kwe-lactic acid kunye nomonakalo wesibindi. Iimpawu zingabandakanya:
    • ukudinwa
    • iintlungu zemisipha kunye nobuthathaka
    • intlungu okanye ukungonwabi kwisisu sakho (isisu)
  • I-immune system reconstitution syndrome (xa amajoni omzimba ephucula ngokukhawuleza kwaye eqala "ukusebenza ngaphezulu"). Iimpawu zingabandakanya:
    • ifiva
    • ukudinwa
    • usulelo
    • ukudumba kwamalungu enkovu
    • irhashalala okanye inxeba lolusu
    • ingxaki yokuphefumla
    • ukudumba ujikeleze amehlo akho
  • Utshintsho ekubekweni kwamafutha nakwimo yomzimba. Iimpawu zingabandakanya:
    • ukwanda kwamafutha ajikeleze embindini wakho (torso)
    • ukukhula kwesigaxa esinamafutha ngasemva kwamagxa akho
    • amabele awandisiweyo (kokubini amadoda nabasetyhini)
    • ukwehla kobunzima ebusweni bakho, kwiingalo, nasemilenzeni

Ukutyeba kwakho

Ukutyeba kobunzima yayingeyompembelelo ecaleni eyenzekileyo kwizifundo zeklinikhi zeAtripla. Nangona kunjalo, unyango lwe-HIV ngokubanzi kunokubangela ukutyeba. Kungenxa yokuba i-HIV inokubangela ukwehla kobunzima, ke ukunyanga imeko kunokubangela ukubuya kobunzima obulahlekileyo.


Abantu abathatha i-Atripla banokuqaphela ukuba amanqatha omzimba wabo atshintshele kwiindawo ezahlukeneyo zomzimba wabo. Oku kubizwa ngokuba yi-lipodystrophy. Amafutha omzimba anokuqokelelana embindini womzimba wakho, njengasesinqeni sakho, emabeleni nasentanyeni. Isenokutshintsha kude neengalo kunye nemilenze yakho.

Ayaziwa ukuba ezi ziphumo ziyahamba ngokuhamba kwexesha, okanye ukuba ziyanyamalala emva kokuba uyekile ukusebenzisa iAtripla. Ukuba ufumana ezi ziphumo, xelela ugqirha wakho. Banokukutshintshela kwelinye iyeza.

Ipancreatitis

Kunqabile, kodwa i-pancreatitis (i-pancreas edumbileyo) ibonakele kubantu abathatha iziyobisi ezine-efavirenz. I-Efavirenz lelinye lala machiza mathathu aqulathwe eAtripla.

Ukunyuka kwamanqanaba ee-enzyme zepancreatic kubonwe kwabanye abantu abathatha i-efavirenz, kodwa akwaziwa ukuba oku bekudibene ne-pancreatitis.

Tshela ugqirha wakho ukuba unempawu ezinokubakho zepancreatitis. Oku kubandakanya iintlungu kwisisu sakho, isicaphucaphu okanye ukugabha, ukubetha kwentliziyo okukhawulezayo, kunye nesisu esincinci okanye esidumbileyo. Ugqirha wakho unokukutshintshela kwelinye iyeza.

Phawula: I-Pancreatitis iye yaqatshelwa rhoqo ngokusetyenziswa kwezinye iziyobisi ze-HIV ezinjenge-didanosine.

Iziphumo ebezingalindelekanga ebantwaneni

Kwizifundo zeklinikhi zeAtripla, uninzi lweziphumo ebezingalindelekanga ebantwaneni ziyafana nezo zabantu abadala. URash yenye yeziphumo ebezingalindelekanga ezenzeka rhoqo kubantwana.

Ukuqhaqha kwenzeka kwiipesenti ezingama-32 zabantwana, ngelixa iipesenti ezingama-26 zabantu abadala bafumana ukukhawuleza. Irhashalala ebantwaneni idla ngokubonakala malunga neentsuku ezingama-28 emva kokuqalisa unyango ngeAtripla. Ukukhusela ukukhawuleza kumntwana wakho, ugqirha wabo unokucebisa ukuba asebenzise amayeza okunyanga njengama-antihistamines ngaphambi kokuqala unyango lwe-Atripla.

Ezinye iziphumo ebezingalindelekanga eziqhelekileyo ezibonwayo ebantwaneni kodwa hayi kubantu abadala zibandakanya utshintsho kumbala wolusu, njengamabala amnyama okanye ulusu olumnyama. Oku kwenzeka kakhulu ezintendeni zezandla okanye kwiinyawo. Iziphumo ebezingalindelekanga zibandakanya i-anemia, eneempawu ezinje ngamanqanaba asezantsi amandla, ukubetha kwentliziyo okukhawulezayo, kunye nezandla kunye neenyawo ezibandayo.

Irhashalala

I-Rash sisiphumo esichaphazeleka kakhulu kunyango lwe-Atripla.

Kwizilingo zeklinikhi, irhashalala yenzeke kwi-26% yabantu abadala abafumene i-efavirenz, elinye lamachiza e-Atripla. Kukho iingxelo zerhashalala elibi kakhulu ngokusetyenziswa kwe-efavirenz, kodwa zenzeke kuphela kwi-0.1% yabantu abafundileyo. Ukuqhaqhaqhaqha okubangelwa ngamadyungudyungu okanye amanxeba avulekileyo kwenzeke malunga ne-0.9% yabantu.

Uninzi lwerhashalala olubonwe nge-efavirenz lwaluthambile ukuya kumodareyitha, lwaluneendawo ezibomvu nezirhabaxa kunye namaqhuma athile kulusu. Olu hlobo lokukhawuleza lubizwa ngokuba yi-maculopapular rash. La marhashalala avele ngaphakathi kwiiveki ezi-2 zokuqalisa konyango lwe-efavirenz kwaye aphela kungaphelanga nenyanga yokubonakala kwawo.

Tshela ugqirha wakho ukuba ukhula ngokukhawuleza ngelixa uthatha iAtripla. Ukuba uhlakulela i-blisters okanye umkhuhlane, yeka ukuthatha i-Atripla kwaye ubize ugqirha wakho kwangoko. Ugqirha wakho unokukunika iziyobisi ukunyanga impendulo. Ukuba irhashalala inzima, banokutshintsha baye kwelinye iyeza.

Phawula: Xa umntu eqala ukufumana i-HIV, ukukhawuleza kunokuba luphawu lokuqala. Oku kugqobhoza kuhlala iiveki ezi-2 ukuya kwezi-4. Kodwa ukuba unayo i-HIV okwethutyana kwaye uqale unyango nge-Atripla, irhashalala entsha inokubakho ngenxa ye-Atripla.

Uxinzelelo

Uxinzelelo yayiyimpembelelo yecala eliqhelekileyo kwizilingo zekliniki zeAtripla. Kwenzeka kwi-9% yabantu abathatha ichiza.

Tshela ugqirha wakho ngoko nangoko ukuba unempawu zokudakumba. Oku kunokubandakanya iimvakalelo zosizi, ukungabi nathemba, kunye nokuphelelwa ngumdla kwimisebenzi yemihla ngemihla. Ugqirha wakho angakutshintshela kwelinye iyeza le-HIV. Banokucebisa ngonyango lweempawu zakho zokudakumba.

Uthintelo lokuzibulala

  • Ukuba uyazi umntu osemngciphekweni wokuzenzakalisa, ukuzibulala, okanye ukwenzakalisa omnye umntu:
  • Tsalela u-911 okanye inombolo yongxamiseko yendawo.
  • Hlala naloo mntu de kufike uncedo lobungcali.
  • Susa naziphi na izixhobo, amayeza, okanye ezinye izinto ezinokuba yingozi.
  • Mamela umntu ngaphandle komgwebo.
  • Ukuba wena okanye umntu omaziyo uneengcinga zokuzibulala, umnxeba wokuthintela unokunceda. I-National Suicide Prevention Lifeline ifumaneka kwiiyure ezingama-24 ngemini ngo-800-273-8255.

Iindleko ze-Atripla

Njengawo onke amayeza, indleko zeAtripla ziyahluka.

Ixabiso lakho liya kuxhomekeka kwi-inshurensi yakho.

Uncedo lwezezimali kunye neinshurensi

Ukuba ufuna inkxaso yemali ukuhlawula i-Atripla, okanye ukuba ufuna uncedo ekuqondeni i-inshurensi yakho, uncedo luyafumaneka.

Isayensi yaseGiliyadi, Inc., umenzi weAtripla, ubonelela ngenkqubo ebizwa ngokuba yiAdvanced Access. Ngolwazi oluthe kratya kunye nokufumanisa ukuba uyakufanelekela na ukuxhaswa, tsalela umnxeba ku-800-226-2056 okanye undwendwele iwebhusayithi yenkqubo.

I-Atripla isebenzisa

Ulawulo lokutya kunye neziyobisi (i-FDA) livuma amayeza amiselweyo anjengeAtripla ukunyanga iimeko ezithile. I-Atripla yamkelwe kuphela ukunyanga i-HIV.

I-Atripla ye-HIV

I-Atripla ivunyiwe ukuba inyange i-HIV kubantu abadala kunye nabantwana abanobunzima obungama-88 eekhilogram (40 kilograms). I-Atripla isetyenziswa nokuba iyodwa okanye xa idityaniswe namanye amachiza e-HIV.

Uninzi lwamachiza amatsha e-HIV avunyelwe kubantu abangazange bathathe amachiza e-HIV okanye abazinzileyo kolunye unyango lwe-HIV. I-Atripla ayinalo usetyenziso oluthile oluvunyiweyo.

Ukusetyenziswa okungavunyelwanga

I-Atripla ayivunyelwanga nayiphi na enye into. Kufuneka isetyenziswe kuphela ukunyanga i-HIV.

I-Atripla ye-hepatitis B

I-Atripla ayivunyelwanga i-hepatitis B kwaye ayifanele isetyenziselwe ukuyinyanga. Nangona kunjalo, elinye lamachiza e-Atripla (tenofovir disoproxil fumarate) lisetyenziselwa ukunyanga i-hepatitis B.

I-Atripla yePEP

I-Atripla ayivunyelwanga kwaye ayifanele isetyenziselwe i-post-exposure prophylaxis (PEP). I-PEP ibhekisa ekusetyenzisweni kwamayeza e-HIV emva kokubhencwa kwi-HIV ukuthintela usulelo.

Ukongeza, i-Atripla ayivunyelwanga kwaye ayifanele isetyenziselwe i-pre-exposure prophylaxis (PrEP). I-PrEP ibhekisa ekusetyenzisweni kwamayeza e-HIV phambi kokubhencwa kwi-HIV ukuthintela usulelo.

Elona chiza livunyiweyo le-FDA le-PrEP yiTruvada, equlathe i-emtricitabine kunye ne-tenofovir disoproxil fumarate. Ngelixa i-Atripla iqulethe omabini la machiza, khange ifundwe njengonyango lokuthintela i-HIV.

Atripla abantwana

I-Atripla ingasetyenziselwa ukunyanga i-HIV kubantu bayo nayiphi na iminyaka ubudala ukuba nje inobunzima obungama-88 eekhilogram (40 kilograms). Oku kubandakanya abantwana.

Atripla balawule

Olu lwazi lulandelayo luchaza iidosi eziqhelekileyo ezisetyenziswayo okanye ezicetyiswayo. Nangona kunjalo, qiniseka ukuthatha idosi ekumisela ugqirha wakho.

Iifom zamachiza kunye namandla

I-Atripla iza njengecwecwe lomlomo. Ithebhulethi nganye ineziyobisi ezintathu:

  • I-600 mg ye-efavirenz
  • I-300 mg ye-tenofovir disoproxil fumarate
  • I-200 mg ye-emtricitabine

Idosi ye-HIV

Ithebhulethi enye yeAtripla kufuneka ithathwe kanye yonke imihla kwisisu esingenanto (ngaphandle kokutya). Kwiimeko ezininzi, kufuneka kuthathwe ngexesha lokulala.

Idosi yabantwana

Umthamo we-Atripla wabantwana uyafana nedosi yabantu abadala. Umthamo awuguquki ngokusekwe kubudala.

Kuthekani ukuba ndiphose idosi?

Ukuba uthatha iAtripla kwaye uphoswe ithamo, thatha idosi elandelayo ngokukhawuleza ukuba uyakhumbula. Ukuba phantse lixesha ledosi yakho elandelayo, thatha nje idosi elandelayo. Akufanele uyiphindaphinde idosi yakho ukuze wenze idosi ephosiweyo.

Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?

Ukuba wena kunye nogqirha wakho uthatha isigqibo sokuba i-Atripla yonyango olufanelekileyo kuwe, kuya kufuneka uthathe ixesha elide.

Nje ukuba uqalise unyango, ungayeki ukuthatha i-Atripla ngaphandle kokuthetha nogqirha wakho kuqala.

Ukuncamathela kwisicwangciso sonyango sakho seAtripla

Ukuthatha iipilisi zeAtripla ngokuchanekileyo njengoko ugqirha wakho ekuxelela ukuba kubaluleke kakhulu. Ukuthatha i-Atripla rhoqo kuya kwandisa amathuba okuphumelela kunyango.

Iidosi ezingekhoyo zinokuchaphazela indlela esebenza ngayo iAtripla ukunyanga i-HIV. Ukuba uphosa idosi, unokuhlakulela ukumelana neAtripla. Oku kuthetha ukuba ichiza alinakuphinda lisebenze ukunyanga i-HIV yakho.

Ukuba une-hepatitis B kunye ne-HIV, unobungozi obongezelelekileyo. Iidosi ezingekhoyo ze-Atripla zinokubangela ukuba i-hepatitis B yakho ibe mandundu.

Qiniseka ukuba ulandela imiyalelo kagqirha wakho kwaye uthathe iAtripla kanye ngemini, yonke imihla, ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela. Sebenzisa isixhobo sokukhumbuza kunokuba luncedo ekuqinisekiseni ukuba uthatha iAtripla yonke imihla.

Ukuba unemibuzo okanye uxhalaba malunga nonyango lwakho lwe-Atripla, thetha nogqirha wakho. Banokukunceda ukusombulula nayiphi na imiba onokuba nayo kwaye uncede uqiniseke ukuba i-Atripla isebenza kakuhle kuwe.

Eminye iAtripla

Ukongeza kwiAtripla, zininzi ezinye iziyobisi ezikhoyo ezinokunyanga i-HIV. Abanye banokukulungela ngcono kunabanye. Ukuba unomdla ekufumaneni enye i-Atripla, thetha nogqirha wakho ukuze ufunde ngakumbi ngamanye amayeza anokukusebenzela.

Olunye udibaniso lwamayeza

Bonke abantu abane-HIV ngokubanzi kufuneka bathathe ngaphezulu kwesiyobisi esinye. Ngesi sizathu, zininzi iindlela zokudibanisa amayeza e-HIV akhoyo. La mayeza aneziyobisi ezingaphezulu kwesinye. I-Atripla lunyango oludibeneyo oluqulethe amachiza amathathu: i-emtricitabine, i-tenofovir disoproxil fumarate, ne-efavirenz.

Imizekelo yezinye indibaniselwano zamachiza ezikhoyo zokunyanga i-HIV zibandakanya:

  • IBiktarvy (bictegravir, emtricitabine, kunye ne-tenofovir alafenamide)
  • IComplera (emtricitabine, rilpivirine, kunye ne-tenofovir disoproxil fumarate)
  • Descovy (emtricitabine kunye ne-tenofovir alafenamide)
  • IGenvoya (elvitegravir, cobicistat, emtricitabine, kunye ne-tenofovir alafenamide)
  • UJuluca (dolutegravir kunye ne-rilpivirine)
  • I-Odefsey (emtricitabine, rilpivirine, kunye ne-tenofovir alafenamide)
  • Stribild (elvitegravir, cobicistat, emtricitabine, kunye ne-tenofovir disoproxil fumarate)
  • ISymtuza (darunavir, cobicistat, emtricitabine, kunye ne-tenofovir alafenamide)
  • I-Triumeq (abacavir, dolutegravir, kunye ne-lamivudine)
  • Truvada (emtricitabine kunye ne-tenofovir disoproxil fumarate)

Amayeza ngabanye

Umntu ngamnye one-HIV, ugqirha wabo uyakuyila isicwangciso sonyango ngokukodwa kubo. Oku kunokuba sisiyobisi esidibeneyo, okanye inokuba ngamachiza awahlukeneyo.

Uninzi lwamachiza afumaneka ngokudibeneyo amachiza e-HIV ayafumaneka ngokwawo. Ugqirha wakho angakuxelela ngakumbi ngamachiza anokusebenza ngcono kuwe.

Atripla vs.Genvoya

Unokuzibuza ukuba iAtripla ithelekiswa njani namanye amayeza amiselwe ukusetyenziswa okufanayo. Apha, sijonga indlela iAtripla kunye neGenvoya ezifanayo kunye ezahlukeneyo.

Sebenzisa

Zombini iAtripla kunye neGenvoya zamkelwe ukunyanga i-HIV. IGenvoya ivunyiwe ukuba isetyenziswe ebantwini nakweyiphi na iminyaka okoko nje benobunzima obungama-55 eekhilogram (25 kilograms). Kwelinye icala, i-Atripla ivunyiwe ukuba isetyenziswe ebantwini nakweyiphi na iminyaka, ukuba nje benobunzima obungama-88 eekhilogram.

Iifom zeziyobisi kunye nolawulo

Zombini iAtripla kunye neGenvoya ziza njengeepilisi zomlomo ezithathwa kanye yonke imihla. UGenvoya kufuneka athathwe kunye nokutya, ngelixa i-Atripla kufuneka ithathwe ngaphandle kwesisu. Kwaye ngelixa uGenvoya angathathwa nanini na emini, kuyacetyiswa ukuba uthathe iAtripla ngexesha lokulala ukunceda ukuthintela iziphumo ezithile ebezingalindelekanga.

Ithebhulethi nganye yeAtripla iqulethe iziyobisi emtricitabine, efavirenz, kunye ne-tenofovir disoproxil fumarate. Ithebhulethi nganye yeGenvoya iqulethe iziyobisi emtricitabine, elvitegravir, cobicistat, kunye ne-tenofovir alafenamide.

Iziphumo kunye neengozi

I-Atripla kunye neGenvoya baneziphumo ezifanayo emzimbeni kwaye ke zibangela iziphumo ebezingalindelekanga ezifanayo. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeAtripla, kunye noGenvoya, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo)

  • Inokwenzeka ngeAtripla:
    • ukudakumba
    • usulelo oluphezulu lokuphefumla
    • ixhala
    • umqala obuhkungu
    • ukugabha
    • isiyezi
    • irhashalala
    • ingxaki yokulala
  • Inokwenzeka ngoGenvoya:
    • ukwanda kwamanqanaba e-cholesterol yeLDL
  • Inokwenzeka kunye neAtripla kunye neGenvoya:
    • urhudo
    • isicaphucaphu
    • intloko ebuhlungu
    • ukudinwa
    • ukwanda kwenqanaba lecholesterol

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho nge-Atripla, kunye noGenvoya, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Inokwenzeka ngeAtripla:
    • utshintsho lwempilo yengqondo, ezinje ngoxinzelelo olukhulu okanye isimilo esiqatha
    • ukuxhuzula
    • Utshintsho kwindawo enamafutha emzimbeni wonke
  • Inokwenzeka ngoGenvoya:
    • zimbalwa iziphumo ebezingalindelekanga ezimandundu
  • Inokwenzeka kunye neAtripla kunye neGenvoya:
    • ukonakala kwamathambo
    • ukwanda kakhulu kwe-hepatitis B * (ukuba sele unayo intsholongwane)
    • immune reconstitution syndrome (xa amajoni omzimba ephucula msinya kwaye eqala "ukusebenza ngaphezulu")
    • ukulimala kwezintso * *
    • I-lactic acidosis (ingozi eyakhiweyo yeasidi emzimbeni)
    • isifo sesibindi esibi (isibindi esandisiweyo kunye ne-steatosis)

U-Atripla noGenvoya bobabini banesilumkiso esibhokisiweyo esivela kwi-FDA malunga nokwanda kwe-hepatitis B. Isilumkiso esinebhokisi sisilumkiso esomeleleyo esifunwa yi-FDA. Yazisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.

I-Tenofovir, elinye lamachiza eGenvoya naseAtripla, linxulunyaniswe nomonakalo wezintso. Nangona kunjalo, uhlobo lwe-tenofovir e-Genvoya (tenofovir alafenamide) lunomngcipheko omncinci wokonzakala kwezintso kunohlobo oluku-Atripla (tenofovir disoproxil fumarate).

Ukusebenza ngempumelelo

La machiza awathelekiswanga ngokuthe ngqo kwizifundo zeklinikhi, kodwa izifundo zifumanise ukuba zombini iAtripla kunye neGenvoya ziyasebenza ekunyangeni i-HIV.

Nangona kunjalo, akukho siyobisi sicetyiswayo njengokhetho lokuqala kunyango kubantu abaninzi abane-HIV. Kungenxa yokuba iAtripla kunye neGenvoya ngamachiza amadala e-HIV, kwaye kukho amachiza amatsha afumanekayo ahlala ekhetha ngcono. Amachiza amatsha e-HIV ahlala esebenza ngakumbi kwaye aneziphumo ebezingalindelekanga ezimbalwa kunalawo mdala.

I-Atripla kunye neGenvoya inokuba ilungele abanye abantu, kodwa ngokubanzi, ayilulo ukhetho lokuqala olunokunconywa ngoogqirha kubantu abaninzi.

Iindleko

I-Atripla kunye neGenvoya zombini amayeza anegama lophawu. Azifumaneki kwiifom zegeneric, ezihlala zitshiphu kuneziyobisi ezinamagama.

Ngokwengqikelelo yeGoodRx.com, iAtripla isenokuxabisa kancinane kuneGenvoya. Elona xabiso ubuya kulihlawula ngalo naliphi na ichiza lixhomekeke kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

I-Atripla vs. ezinye iziyobisi

Ukongeza kuGenvoya (ngasentla), amanye amayeza amiselwe ukunyanga i-HIV. Apha ngezantsi kuthelekiswa phakathi kweAtripla kunye namanye amayeza e-HIV.

Atripla vs Truvada

I-Atripla lunyango oludibeneyo oluqulethe iziyobisi emtricitabine, tenofovir disoproxil fumarate, kunye ne-efavirenz. I-Truvada ikwayindibaniselwano yamayeza, kwaye iqulethe amachiza amabini afanayo ase-Atripla: emtricitabine kunye ne-tenofovir disoproxil fumarate.

Sebenzisa

Zombini iAtripla kunye neTruvada zamkelwe kunyango lwe-HIV. I-Atripla ivunyiwe ukuba isetyenziswe yodwa, kodwa iTruvada ivunyiwe kuphela ukuba isetyenziswe ne-dolutegravir (Tivicay) okanye ezinye iziyobisi ze-HIV.

I-Atripla ivunyiwe ukuba isetyenziswe kubantu nabuphi na ubudala okoko nje benobunzima obungama-88 eekhilogram (40 kilograms). I-Truvada ivunyiwe ukuba inyange i-HIV kubantu bayo nayiphi na iminyaka yobudala ukuba nje banobunzima ubuncinci iipesenti ezingama-37 (iikhilogram ezili-17).

ITruvada ikwavunyiwe kuthintelo lwe-HIV. I-Atripla yamkelwe kuphela ukunyanga i-HIV.

Iifom zeziyobisi kunye nolawulo

Zombini iAtripla kunye neTruvada ziza njengeepilisi zomlomo ezithathwa kanye yonke imihla. I-Truvada ingathathwa kunye okanye ngaphandle kokutya, ngelixa i-Atripla kufuneka ithathwe ngaphandle kwesisu. Kwaye ngelixa iTruvada ingathathwa nangaliphi na ixesha emini, kuyacetyiswa ukuba uthathe iAtripla ngexesha lokulala ukunceda ukuthintela iziphumo ebezingalindelekanga ezithile.

Iziphumo kunye neengozi

I-Atripla iqulethe iziyobisi ezifanayo neTruvada, kunye ne-efavirenz. Ke ngoko, baneziphumo ebezingalindelekanga ezifanayo.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho kunye neAtripla kunye neTruvada (xa zithathwa ngokwahlukeneyo). Phawula: Iziphumo ebezingalindelekanga zeTruvada ezidweliswe apha zivela kuvavanyo lweklinikhi apho iTruvada yathathwa khona nge-efavirenz.

  • Inokwenzeka kunye neAtripla kunye neTruvada:
    • urhudo
    • isicaphucaphu nokugabha
    • isiyezi
    • intloko ebuhlungu
    • ukudinwa
    • ingxaki yokulala
    • umqala obuhkungu
    • izifo zokuphefumla
    • amaphupha angaqhelekanga
    • irhashalala
    • ukwanda kwenqanaba lecholesterol

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho nge-Atripla okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo). Phawula: Iziphumo ebezingalindelekanga zeTruvada ezidweliswe apha zivela kuvavanyo lweklinikhi apho iTruvada yathathwa khona nge-efavirenz.

  • Inokwenzeka ngeAtripla:
    • ukuxhuzula
    • utshintsho kwindawo enamafutha emzimbeni wonke
  • Inokwenzeka kunye neAtripla kunye neTruvada:
    • utshintsho lwempilo yengqondo, ezinje ngoxinzelelo olukhulu okanye isimilo esiqatha
    • ukwanda kakhulu kwe-hepatitis B * (ukuba sele unayo intsholongwane)
    • immune reconstitution syndrome (xa amajoni omzimba ephucula msinya kwaye eqala "ukusebenza ngaphezulu")
    • ukonakala kwamathambo
    • ukulimala kwezintso * *
    • I-lactic acidosis (ingozi eyakhiweyo yeasidi emzimbeni)
    • isifo sesibindi esibi (isibindi esandisiweyo kunye ne-steatosis)

I-Atripla kunye ne-Truvada bobabini banesilumkiso esibhokisi esivela kwi-FDA malunga nokwanda kwe-hepatitis B. Isilumkiso sebhokisi sisilumkiso esomeleleyo esifunwa yi-FDA. Yazisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.

I-Tenofovir, elinye lamachiza eTruvada naseAtripla, linxulunyaniswe nomonakalo wezintso.

Ukusebenza ngempumelelo

La machiza awathelekiswanga ngokuthe ngqo kwizifundo zeklinikhi, kodwa izifundo zifumanise ukuba zombini iAtripla kunye neTruvada ziyasebenza ekunyangeni i-HIV.

Nangona i-Atripla inokusebenza ngokunyanga i-HIV, ayikhuthazwa njengonyango lokuqala lwe-HIV. Kungenxa yokuba amachiza amatsha anokunyanga i-HIV kodwa anganeziphumo ebezingalindelekanga ezimbalwa kune-Atripla.

I-Truvada isetyenziswe ngokudibeneyo ne-dolutegravir (Tivicay), nangona kunjalo, kuyacetyiswa njengonyango lokuqala lokukhetha kubantu abaninzi abane-HIV.

Iindleko

I-Atripla kunye neTruvada zombini amayeza anegama lophawu. Azifumaneki kwiifom ze-generic, ezihlala zibiza kakhulu kuneziyobisi ezinamagama.

Ngokwengqikelelo yeGoodRx.com, iAtripla inokubiza ngaphezulu kweTruvada. Elona xabiso ubuya kulihlawula ngalo naliphi na ichiza lixhomekeke kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Atripla vs.Complera

I-Atripla lunyango oludibeneyo oluqulethe iziyobisi emtricitabine, tenofovir disoproxil fumarate, kunye ne-efavirenz. IComplera ikwayindibaniselwano yamayeza, kwaye iqulethe amachiza amabini afanayo aseAtripla: emtricitabine kunye ne-tenofovir disoproxil fumarate. Isithako sayo sesithathu seziyobisi yi-rilpivirine.

Sebenzisa

Zombini iAtripla kunye neComplera zivunyiwe kunyango lwe-HIV.

I-Atripla ivunyiwe ukuba isetyenziswe kubantu nabuphi na ubudala okoko nje benobunzima obungama-88 eekhilogram (40 kilograms). IComplera, kwelinye icala, yamkelwe ukuba isetyenziswe ebantwini nakweyiphi na iminyaka ukuba nje benobunzima obungama-77 eekhilogram).

I-Complera isetyenziswa kuphela kubantu abanomthamo wentsholongwane ophantsi ngaphambi kokuqala unyango. I-Atripla ayinaso esi sithintelo.

Iifom zeziyobisi kunye nolawulo

Zombini iAtripla kunye neComplera ziza njengeepilisi zomlomo ezithathwa kanye yonke imihla. I-Complera kufuneka ithathwe kunye nokutya, ngelixa i-Atripla kufuneka ithathwe ngaphandle kwesisu. Kwaye ngelixa iComplera inokuthathwa nanini na emini, kuyacetyiswa ukuba uthathe iAtripla ngexesha lokulala ukunceda ukuthintela iziphumo ezithile ebezingalindelekanga.

Iziphumo kunye neengozi

I-Atripla kunye neComplera zineziyobisi ezifanayo. Ke ngoko, baneziphumo ebezingalindelekanga ezifanayo.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo eziqhelekileyo ezinokuthi zenzeke nge-Atripla, kunye neComplera, okanye zombini iziyobisi (xa zithathwa ngokukodwa).

  • Inokwenzeka ngeAtripla:
    • zimbalwa iziphumo ebezingalindelekanga eziqhelekileyo
  • Ngaba kunokwenzeka neComplera:
    • zimbalwa iziphumo ebezingalindelekanga eziqhelekileyo
  • Inokwenzeka kunye neAtripla kunye neComplera:
    • urhudo
    • isicaphucaphu nokugabha
    • isiyezi
    • intloko ebuhlungu
    • ukudinwa
    • ingxaki yokulala
    • umqala obuhkungu
    • usulelo oluphezulu lokuphefumla
    • amaphupha angaqhelekanga
    • irhashalala
    • ukudakumba
    • ixhala
    • ukwanda kwenqanaba lecholesterol

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho nge-Atripla, kunye neComplera, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Inokwenzeka ngeAtripla:
    • ukuxhuzula
    • Utshintsho kwindawo enamafutha emzimbeni wonke
  • Ngaba kunokwenzeka neComplera:
    • ukudumba kwinyongo yakho
    • ngamatye enyongo
  • Inokwenzeka kunye neAtripla kunye neComplera:
    • utshintsho lwempilo yengqondo, ezinje ngoxinzelelo olukhulu okanye isimilo esiqatha
    • ukwanda kakhulu kwe-hepatitis B * (ukuba sele unayo intsholongwane)
    • immune reconstitution syndrome (xa amajoni omzimba ephucula msinya kwaye eqala "ukusebenza ngaphezulu")
    • ukonakala kwamathambo
    • ukulimala kwezintso * *
    • I-lactic acidosis (ingozi eyakhiweyo yeasidi emzimbeni)
    • isifo sesibindi esibi (isibindi esandisiweyo kunye ne-steatosis)

I-Atripla kunye ne-Complera bobabini banesilumkiso esibhokisiweyo esivela kwi-FDA malunga nokwanda kwe-hepatitis B. Isilumkiso esibhokisi sisilumkiso esomeleleyo esifunwa yi-FDA. Yazisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.

I-Tenofovir, elinye lamachiza kuzo zombini iComplera kunye neAtripla, linxulunyaniswe nomonakalo wezintso.

Ukusebenza ngempumelelo

Ukusetyenziswa kweziyobisi ezifumaneka e-Atripla (efavirenz, emtricitabine, kunye ne-tenofovir disoproxil fumarate) kuthelekiswa ngqo nokusetyenziswa kweComplera kufundo lweklinikhi. Ezi zonyango zimbini zifunyenwe zisebenza ngokulinganayo kunyango lwe-HIV.

Kubantu abangazange banyangelwe i-HIV ngaphambili, zombini i-Complera kunye ne-Atripla indibaniselwano yamachiza babe nempumelelo kunyango lwe-77% ngeveki ye-96. Unyango lwaluthathwa njengempumelelo ukuba umthamo wentsholongwane yomntu wawungaphantsi kwama-50 ekupheleni kophononongo.

Nangona kunjalo, i-8% yabantu abathathe indibaniselwano yeziyobisi i-Atripla khange bafumane sibonelelo, ngelixa i-14% yabantu abathathe iComplera abanazibonelelo. Oku kuphakamisa ukuba iComplera inokuba nonyango olungaphezulu kokudityaniswa kweziyobisi e-Atripla.

Akukho Atripla okanye iComplera eyacetyiswayo njengonyango lokuqala kubantu abaninzi abane-HIV. La machiza anokulungela abanye abantu, kodwa ngokubanzi, amachiza amatsha anconyelwa rhoqo. Kungenxa yokuba amachiza amatsha, anjengeBiktarvy okanye iTriumeq, anokusebenza ngcono kwaye abe neziphumo ebezingalindelekanga ezimbalwa.

Iindleko

I-Atripla kunye neComplera zizo zombini iziyobisi. Okwangoku azikho iifom zohlobo oluthile ezifumaneka nakweliphi na ichiza. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokutsho koqikelelo oluvela kwi-GoodRx.com, iAtripla kunye neComplera ngokubanzi zibiza malunga nokufanayo. Elona xabiso ubuya kulihlawula ngalo naliphi na ichiza lixhomekeke kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Indlela yokuthatha iAtripla

Kufuneka uthathe i-Atripla ngokwemiyalelo kagqirha wakho okanye yezempilo.

Ixesha

Kufuneka uthathe i-Atripla ngexesha elifanayo yonke imihla, ngakumbi ngexesha lokulala. Ukuyithatha ngexesha lokulala kunokunceda ukunciphisa ezinye zeziphumo ebezingalindelekanga, ezinje ngengxaki yokugxila kunye nesiyezi.

Ukuthatha i-Atripla kwisisu esingenanto

Kufuneka uthathe i-Atripla kwisisu esingenanto (ngaphandle kokutya). Ukuthatha i-Atripla ngokutya kunokunyusa iziphumo zonyango. Ukuba namayeza amaninzi kwinkqubo yakho kunokukhokelela kwiziphumo ebezingalindelekanga ezibi.

Ngaba iAtripla inokuchotshozwa?

Ngokubanzi, akukhuthazwa ukwahlula, ukutyumza, okanye ukuhlafuna iipilisi zeAtripla. Kufuneka ziginywe ziphelele.

Ukuba unengxaki yokuginya iipilisi zizonke, thetha nogqirha wakho ngamanye amayeza anokusebenza ngcono kuwe.

Atripla kunye notywala

Kungcono ukunqanda ukusela utywala ngelixa uthatha iAtripla. Kungenxa yokuba ukudibanisa utywala kunye neAtripla kunokukhokelela kwiziphumo ebezingalindelekanga ezingakumbi. Oku kunokubandakanya:

  • isiyezi
  • iingxaki zokulala
  • ukudideka
  • nemibono
  • ingxaki yokujonga

Ukuba unengxaki yokuphepha utywala, yazisa ugqirha wakho ngaphambi kokuba uqale unyango kunye no-Atripla. Basenokucebisa ngolunye unyango.

Unxibelelwano lweAtripla

I-Atripla inokusebenzisana namayeza amaninzi ahlukeneyo kunye nezibonelelo ezithile kunye nokutya.

Unxibelelwano olwahlukileyo kunokubangela iziphumo ezahlukeneyo. Umzekelo, ezinye zinokuphazamisa ukusebenza kakuhle kwesiyobisi, ngelixa ezinye zinokubangela ukwanda kweempembelelo.

Atripla kunye namanye amayeza

Apha ngezantsi luluhlu lwamayeza anokusebenzisana neAtripla. Olu luhlu alunazo zonke iziyobisi ezinokusebenzisana neAtripla. Zininzi ezinye iziyobisi ezinokusebenzisana neAtripla.

Ngaphambi kokuba uthathe i-Atripla, qiniseka ukuxelela ugqirha wakho kunye nosokhemisti malunga nayo yonke imigqaliselo, kwi-counter-counter, kunye nezinye iziyobisi ozithathayo. Baxelele malunga nazo naziphi na iivithamini, amayeza esintu kunye nezinto ozincedayo. Ukwabelana ngolu lwazi kunokukunceda uphephe unxibelelwano olunokubakho.

Ukuba unemibuzo malunga nokunxibelelana kweziyobisi okunokuchaphazela, buza ugqirha wakho okanye usokhemesti.

Ezinye iziyobisi ze-HIV

I-Atripla inxibelelana namanye amachiza amaninzi e-HIV. Sukuqala ukuthatha amachiza amaninzi kwi-HIV ngaphandle kokuba uyalelwe njalo ngugqirha wakho. Ukuthatha i-Atripla kunye nezinye iziyobisi ze-HIV kunokunciphisa iziphumo zala machiza okanye kwandise umngcipheko weziphumo ebezingalindelekanga.

Imizekelo yala machiza e-HIV aquka:

  • protease inhibitors, ezinje:
    • mzing
    • fosamprenavir calcium
    • eyifuman
    • idarunavir / ritonavir
    • lopinavir / ritonavir
    • ritonavir
    • iqequa
  • i-non-nucleoside reverse transcriptase inhibitors (i-NNRTIs), enje nge:
    • wboydine
    • etravirine
    • doravirine
  • i-maraviroc, eyi-CCR5 echasene nayo
  • I-didanosine, eyi-nucleoside reverse transcriptase inhibitor (NRTI)
  • i-raltegravir, eyi-integrase inhibitor

Amachiza athile e-hepatitis C

Ukuthatha i-Atripla ngamachiza athile e-hepatitis C angenza ukuba ezo ziyobisi zingasebenzi kakuhle. Inokwenza umzimba wakho ukuba uxhathise iziyobisi ze-hepatitis C. Ngokuxhathisa, amachiza anokungasebenzi konke konke kuwe. Kwezinye iziyobisi ze-hepatitis C, ukuthatha i-Atripla kunye nazo kunokunyusa iziphumo ebezingalindelekanga ze-Atripla.

Imizekelo yamayeza e-hepatitis C angafanele kuthathwa kunye ne-Atripla ibandakanya:

  • I-Epclusa (sofosbuvir / velpatasvir)
  • IHarvoni (ledipasvir / sofosbuvir)
  • Imavyret (glecaprevir / pibrentasvir)
  • I-Olysio (simeprevir)
  • IVictrelis (boceprevir)
  • I-Vosevi (sofosbuvir / velpatasvir / voxilaprevir)
  • I-Zepatier (elbasvir / grazoprevir)

Iziyobisi ezichasayo

Ukuthatha i-Atripla ngamayeza athile okubulala intsholongwane kunokwenza ukuba la machiza angasebenzi kakuhle. Inokonyusa iziphumo ebezingalindelekanga ezithile. Imizekelo yala mayeza okubola abandakanya:

  • itraconazole
  • ketoconazole
  • posaconazole
  • voriconazole

Iziyobisi ezinokuchaphazela ukusebenza kwezintso

Ukuthatha i-Atripla ngamachiza athile achaphazela indlela ezisebenza ngayo izintso zakho kunokunyusa iziphumo ze-Atripla. Oku kunokukhokelela kwiziphumo ebezingalindelekanga ezandisiweyo. Imizekelo yala machiza ibandakanya:

  • amachiza athile antiviral, anje ngala:
    • acyclovir
    • I-adefovir dipivoxil
    • cidofovir
    • ganciclovir
    • xabisoocvalir
    • valganciclovir
  • ii-aminoglycosides, ezinjenge-gentamicin
  • iziyobisi ezichasayo (ii-NSAID), ezinje nge-ibuprofen, piroxicam, okanye ketorolac, xa zisetyenziswa kunye okanye ngeedosi eziphezulu

Iziyobisi ezineempembelelo ezinokuncitshiswa

Zininzi iziyobisi ezinokuncitshiswa xa kuthathwe iAtripla. Imizekelo yala machiza ibandakanya:

  • ii-anticonvulsants ezithile, ezinje:
    • icarbazazepine
    • Yenyani
    • ifumanobarbital
  • ezinye izidambisi zengqondo, ezinje:
    • bupropion
    • Unyango
  • iicalcium block blockers, ezinje:
    • mzantsi
    • felodipine
    • nicardipine
    • nifedipine
    • mzantsi
  • imimiselo ethile (amayeza e-cholesterol), njenge:
    • imvulatin
    • Ipravastatin
    • simvastatin
  • amachiza athile anciphisa ukusebenza kwamajoni akho, njenge:
    • cyclosporine
    • itrolrolimus
    • mnqambi
  • iipilisi ezithile zolawulo lokuzalwa, ezinje nge-ethinyl estradiol / norgestimate
  • amachiza athile asetyenziswa kwizixhobo zolawulo lokuzalwa ezinjenge-etonogestrel
  • ukucacisa
  • mzantsiweb
  • amayeza athile anyanga isifo seengcongconi, njenge:
    • artemether / lumefantrine
    • atovaquone / proguanil
    • imethadone

IWarfarin

Ukuthatha i-Atripla nge-warfarin (Coumadin, Jantoven) kunokwenza ukuba i-warfarin isebenze ngakumbi okanye ingasebenzi. Ukuba uthatha i-warfarin, thetha nogqirha wakho malunga neziphumo zokuthatha la machiza kunye.

Rifampin

Ukuthatha i-Atripla nge-rifampin kunokwenza i-Atripla ingasebenzi kakuhle. Kungenxa yokuba inokunciphisa isixa se-efavirenz emzimbeni wakho. I-Efavirenz lelinye lamachiza afumaneka e-Atripla.

Ukuba ugqirha wakho uthatha isigqibo sokuba kufuneka uthathe i-Atripla nge-rifampin, banokucebisa ngokuthatha i-200 mg eyongezelelweyo ngosuku lwe-efavirenz.

Atripla kunye neViagra

I-Atripla inokunyusa ukuba i-sildenafil (Viagra) ekhawulezayo idlula njani emzimbeni wakho. Oku kunokwenza iViagra isebenze kancinci.

Ukuba ungathanda ukuthatha iViagra ngexesha lonyango lwakho no-Atripla, thetha nogqirha wakho kuqala. Banokukucebisa malunga nokuba iViagra yeyona ndlela ilungileyo kuwe, okanye ukuba likho elinye ichiza elinokusebenza ngcono.

Atripla kunye nemifuno kunye nezongezelelo

Ukuthatha iwort yaseSt. John's kunye neAtripla kunokwenza ukuba iAtripla ingasebenzi kakuhle. Ukuba ungathanda ukuthatha ezi mveliso kunye, thetha nogqirha wakho kuqala malunga nokuba kukhuselekile na.

Kwaye qiniseka ukuba ugqirha wakho kunye nosokhemisti bazi ngayo nayiphi na imveliso yendalo oyithathayo, nokuba ucinga ukuba yeyendalo kwaye ikhuselekile. Oku kubandakanya iti, enje ngeti eluhlaza, kunye namayeza emveli, anje nge-ma-huang.

Atripla kunye nokutya

Ukutya i-grapefruit ngelixa uthatha i-Atripla kunokunyusa amanqanaba eziyobisi emzimbeni wakho. Oku kunokunyusa iziphumo zakho ebezingalindelekanga ezivela kwi-Atripla, ezinje ngokuba isicaphucaphu kunye nokugabha. Kuphephe ukutya igrapefruit okanye ijusi yeediliya ngexesha lonyango lwakho kunye neAtripla.

Isebenza njani iAtripla

INTSHOLONGWANE KAGAWULAYO ​​yintsholongwane eyonakalisa amajoni omzimba, oko kukuthi ukuzikhusela komzimba kwizifo. Xa i-HIV inganyangwa, ithatha iiseli zokhuselo lomzimba ezibizwa ngokuba ziiseli ze-CD4. Intsholongwane kaGawulayo isebenzisa ezi seli ukuphindaphinda (zenze iikopi zazo) kwaye isasazeke emzimbeni wonke.

Ngaphandle konyango, i-HIV inokukhula ibe nguGawulayo. NgoGawulayo, amajoni omzimba abuthathaka kangangokuba umntu angahlakulela ezinye iimeko, ezinje nge-pneumonia okanye i-lymphoma. Ekugqibeleni, uGawulayo angalinciphisa ixesha lokuphila lomntu.

I-Atripla sisiyobisi esidibeneyo esiqulethe amayeza amathathu ee-antiretroviral. La mayeza a:

  • i-efavirenz, eyi-non-nucleoside reverse transcriptase inhibitor (NNRTI)
  • i-emtricitabine, eyi-nucleoside analog reverse transcriptase inhibitors (NRTI)
  • i-tenofovir disoproxil fumarate, ekwayiyo i-NRTI

Omathathu la machiza asebenza ngokunqanda i-HIV ekuziphindaphindeni. Oku kunciphisa kancinci umthamo wentsholongwane yomntu, eli lixabiso le-HIV emzimbeni. Xa eli nqanaba liphantsi kangangokuba i-HIV ayisabonakali kwiziphumo zovavanyo lwe-HIV, ibizwa ngokuba ayifumaneki. Ubungakanani bentsholongwane obungenakubonwa yinjongo yonyango lwe-HIV.

Kuthatha ixesha elingakanani ukusebenza?

Ngalo naluphi na unyango lwe-HIV, kubandakanya i-Atripla, kuthatha iiveki ezisibhozo ukuya kwezingama-24 ukufikelela kumthamo wentsholongwane kaGawulayo ongabonakaliyo. Oku kuthetha ukuba umntu usenayo i-HIV, kodwa ikumanqanaba asezantsi kangangokuba ayifumaneki kuvavanyo.

Ngaba kuya kufuneka ndilithathe eli chiza ixesha elide?

Okwangoku alukho unyango lwe-HIV. Ke ngoko, ukugcina umthamo wentsholongwane kaGawulayo uphantsi kolawulo, uninzi lwabantu luya kusoloko ludinga ukuthatha uhlobo oluthile lonyango lwe-HIV.

Ukuba wena nogqirha wakho uthatha isigqibo sokuba u-Atripla usebenza kakuhle kuwe, kuya kufuneka uthathe ixesha elide.

Atripla kunye nokukhulelwa

Ukukhulelwa kufuneka kuthintelwe ngexesha lonyango kunye ne-Atripla, kwaye ubuncinci iiveki ezili-12 emva kokuba unyango luphelile. Kungenxa yokuba iAtripla inokulimaza ukukhulelwa kwakho.

Ukuba ukhulelwe okanye uceba ukukhulelwa, thetha nogqirha wakho. Basenokucebisa ngonyango olwahlukileyo lwe-HIV yakho. Kwaye ukuba uyakhulelwa ngelixa uthatha uAatripla, biza ugqirha wakho kwangoko.

Ukuba uthatha i-Atripla ngelixa ukhulelwe, unokucinga ngokujoyina irejista yokukhulelwa ye-Antiretroviral. Le registry ilandelela impilo kunye nokukhulelwa kwabantu abathatha amayeza ee-antiretroviral ngelixa bekhulelwe. Ugqirha wakho unokukuxelela ngakumbi.

Atripla kunye nokuncancisa

Amachiza e-Atripla adlula kubisi lwebele. Abantu abathatha i-Atripla akufuneki bancancise, kuba umntwana wabo uya kulithatha iyeza ngobisi lwebele. Ukuba oku kuyenzeka, umntwana unokuba neziphumo ebezingalindelekanga ezivela kwichiza, ezinjengorhudo.

Olunye uqwalaselo kukuba i-HIV inokudlula emntwaneni ngobisi lwebele. E-United States, iZiko loLawulo lweZifo kunye noThintelo (CDC) licebisa ukuba abantu abane-HIV bakuphephe ukuncancisa.

Nangona kunjalo, uMbutho wezeMpilo weHlabathi (i-WHO) usakhuthaza ukuncancisa abantu abane-HIV kwamanye amazwe amaninzi.

Imibuzo eqhelekileyo malunga neAtripla

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga neAtripla.

Ngaba iAtripla ingabangela uxinzelelo?

Ewe, iAtripla inokubangela uxinzelelo. Kwizifundo zeklinikhi, i-9% yabantu abathatha ichiza baphuhlise uxinzelelo.

Ukuba uqaphela naluphi na utshintsho kwiimvakalelo zakho ngelixa uthatha iAtripla, thetha nogqirha wakho kwangoko. Banokutshintsha unyango lwakho lwe-HIV, kwaye banokubonelela ngezinye iingcebiso zonyango ezinokukunceda ekunciphiseni ukudakumba kwakho.

Ngaba i-Atripla iyayinyanga i-HIV?

Hayi, okwangoku alukho unyango lwe-HIV. Kodwa unyango olusebenzayo kufuneka lwenze ukuba intsholongwane ingabonakali. Oku kuthetha ukuba umntu usenayo i-HIV, kodwa ikumanqanaba asezantsi kangangokuba ayifumaneki kuvavanyo. I-FDA okwangoku ithathela ingqalelo inqanaba elingafumanekiyo njengempumelelo yonyango.

Ngaba i-Atripla inokuthintela i-HIV?

Hayi, i-Atripla ayivunyelwanga ukuthintela i-HIV. Olona nyango kuphela luvunyiweyo ukuthintela i-HIV yiTruvada, nesetyenziselwa ipre-exposure prophylaxis (PrEP). Nge-PrEP, amayeza ayathathwa ngaphambi kokubhencwa kwi-HIV ukunceda ukuthintela ukusasazeka kwintsholongwane.

I-Atripla khange ifundelwe olu setyenziso, nangona iqulethe zombini iziyobisi ezifumaneka eTruvada (emtricitabine kunye ne-tenofovir disoproxil fumarate). Ngako oko, i-Atripla ayifanele isetyenziselwe le njongo.

Umntu ongenayo i-HIV kodwa unethuba lokuyifumana kufuneka athethe nogqirha wakhe. Banokucebisa ngeendlela zokuthintela ezinje nge-PrEP okanye i-post-exposure prophylaxis (PEP). Banokucebisa ngamanye amanyathelo othintelo, njengokuhlala usebenzisa ikhondom ngexesha lokwabelana ngesondo kwilungu lobufazi okanye ezimpundu.

Kwenzeka ntoni ukuba ndiphose idosi ezininzi zeAtripla?

Ukuba uphosa idosi ezininzi zeAtripla, ungathathi idosi ezininzi ukwenza ezo ziphosiweyo. Endaweni yokuthetha nogqirha wakho ngokukhawuleza. Baza kukwazisa ukuba ngawaphi amanyathelo alandelayo ekufuneka uwathathile.

Kubalulekile ukuthatha iAtripla yonke imihla. Kungenxa yokuba ukuba uphoswa ngamayeza, umzimba wakho unokukwazi ukumelana neAtripla. Ngokuxhathisa iziyobisi, ichiza alisasebenzi ukunyanga imeko ethile.

Kodwa ukuba uphoswa yidosi enye, ngokubanzi, kuya kufuneka uyithathe ngokukhawuleza emva kokuba ukhumbule.

Izilumkiso zeAtripla

Eli chiza liza nezilumkiso ezininzi.

Isilumkiso se-FDA: Ukunyuka kwe-hepatitis B (HBV)

Eli chiza linesilumkiso esibhokisiweyo. Esi sisilumkiso esibi kakhulu esivela kuLawulo lokutya kunye noLawulo lweziyobisi (FDA). Isilumkiso esinebhokisi silumkisa oogqirha kunye nezigulana malunga neziyobisi ezinokuba yingozi.

  • Kubantu abathatha i-Atripla kwaye bane-HIV kunye ne-HBV, ukumisa i-Atripla kungakhokelela ekubeni i-HBV ibe mandundu. Oku kunokukhokelela kwiingxaki ezifana nomonakalo wesibindi.
  • Zonke izigulana kufuneka zivavanyelwe i-HBV ngaphambi kokuqala unyango nge-Atripla. Kwakhona, akufuneki uyeke ukuthatha iAtripla ngaphandle kokuba ugqirha akuxelele.
  • Ukuba unayo i-HIV kunye ne-HBV kwaye uyeke ukuthatha i-Atripla, ugqirha wakho kufuneka abeke iliso ekusebenzeni kwesibindi ngokusondeleyo kwiinyanga ezininzi. Ukuba i-HBV yakho iya isiba mandundu, ugqirha wakho angakuqala kunyango lwe-HBV.

Ezinye izilumkiso

Ngaphambi kokuba uthathe i-Atripla, thetha nogqirha wakho malunga nembali yakho yezempilo. I-Atripla isenokungakulungeli ukuba uneemeko ezithile zonyango. Oku kubandakanya:

  • Hypersensitivity to Atripla okanye izithako zayo. Ukuba ngaba une-aleji engalunganga kwi-Atripla okanye nasiphi na isiyobisi esikuyo, kuya kufuneka uphephe ukuthatha i-Atripla. Ukuba ugqirha wakho ukumisela uAatripla, qiniseka ukubaxelela malunga nempendulo yakho yangaphambi kokuba uqale ukuthatha iyeza.

Phawula: Ngolwazi oluthe kratya malunga neziphumo ezibi ezinokubakho zeAtripla, jonga icandelo "Lweziphumo ebezingalindelekanga" apha ngasentla.

Libanda, Atripla

Ukuthatha kakhulu la mayeza kunokunyusa umngcipheko weziphumo ebezingalindelekanga ezibi.

Iimpawu libanda

Izifundo zonyango ze-Atripla khange zichaze ukuba kunokwenzeka ntoni ukuba kuthathwe kakhulu ichiza. Kodwa olunye uphononongo lubonakalisile ukuba ukuthatha i-efavirenz kakhulu, ichiza elifumaneka eAtripla, kunokunyusa iziphumo ebezingalindelekanga ezithile zeli chiza. Oku kubandakanya:

  • isiyezi
  • ingxaki yokulala
  • ukudideka
  • nemibono
  • ukuxhuma kwezihlunu

Kufuneka wenze ntoni xa uthe wagqithisa?

Ukuba uthatha ngaphezulu kwethebhulethi enye yeAtripla ngosuku, xelela ugqirha wakho. Kwaye qiniseka ukubaxelela malunga naluphi na utshintsho kwiziphumo zakho ebezingalindelekanga okanye kwindlela oziva ngayo ngokubanzi.

Ukuba ucinga ukuba uthathe iAtripla kakhulu, tsalela ugqirha wakho okanye ufune isikhokelo kuMbutho waseMelika wamaZiko oLawulo lweTyhefu ngo-800-222-1222 okanye ngesixhobo sazo esikwi-intanethi. Kodwa ukuba iimpawu zakho zinzima, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko.

Ukuphelelwa lixesha kuka-Atripla

Xa iAtripla ikhutshwa ekhemesti, usokhemesti uya kongeza umhla wokuphelelwa kwileyibhile esebhotileni. Lo mhla uqhele ukuba unyaka omnye ukusuka kumhla wokukhutshwa kwamayeza.

Injongo yale mihla yokuphelelwa lixesha kukuqinisekisa ukusebenza kweyeza ngeli xesha. Isimo sangoku soLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) kukuphepha ukusebenzisa amayeza aphelelwe lixesha.

Kuhlala ixesha elingakanani iyeza lihlala lilungile kunokuxhomekeka kwizinto ezininzi, kubandakanya nokuba ligcinwa njani kwaye liphi iyeza. Iipilisi ze-Atripla kufuneka zigcinwe kubushushu begumbi, malunga ne-77 ° F (25 ° C). Kuya kufuneka zigcinwe kwisikhongozeli sazo sokuqala, isiciko sivaliwe ngokuqinileyo.

Ukuba awusebenzisanga iyeza elidlulileyo kumhla wokuphelelwa kwalo, thetha nosokhemesti wakho malunga nokuba unganako na ukuyisebenzisa.

Ulwazi lobungcali lweAtripla

Olu lwazi lulandelayo lubonelelwe ngoochwephesha kunye nabanye abaqeqeshi bezempilo.

Indlela yokusebenza

I-Atripla yicwecwe lokudibanisa i-antiretroviral eline-efavirenz, eyi-non-nucleoside reverse transcriptase inhibitors (NNRTI), kunye ne-emtricitabine kunye ne-tenofovir disoproxil fumarate, zombini ezi zii-nucleoside analog reverse transcriptase inhibitors (NRTIs).

Ii-NNRTI kunye nee-NRTI zombini zibophelela kwi-HIV reverse transcriptase, eyeka ukuguqulwa kwe-HIV RNA ibe yi-HIV DNA. Nangona kunjalo, basebenza kwiindawo ezahlukileyo ezahlukileyo ze-HIV reverse transcriptase enzyme.

I-Pharmacokinetics kunye ne-metabolism

I-Atripla kufuneka ithathwe ngaphandle kwesisu. Omathathu la machiza eAtripla athathwe ngokukhawuleza. I-Efavirenz ithatha elona xesha lide ukufikelela kumanqanaba ombuso azinzileyo (iintsuku eziyi-6 ukuya kwezi-10) Ukupheliswa kwesiqingatha sobomi kuzo zontathu iziyobisi zezi zilandelayo:

  • I-efavirenz: iiyure ezingama-40-55
  • emtricitabine: iiyure ezili-10
  • i-tenofovir disoproxil fumarate: iiyure ezili-17

I-Atripla ayikhuthazwa ukuba isetyenziswe kubantu abanomonakalo wesibindi okanye obunzima. Ngenxa yokuba i-efavirenz idityaniswa zii-enzyme zesibindi (i-CYP P450), ukusetyenziswa kwe-Atripla kubantu abanomonakalo wesibindi kufuneka kwenziwe ngononophelo.

Ukusetyenziswa kwe-Atripla akukhuthazwa kubantu abanomodareyitha ukukhubazeka kwezintso (CrCl <50 mL / min).

Ukungqinelana

I-Atripla akufuneki isetyenziswe kubantu abane-erfavirenz, elinye lamachiza e-Atripla.

I-Atripla akufuneki isetyenziswe nakubantu abathatha i-voriconazole okanye i-elbasvir / grazoprevir.

Ukugcina

I-Atripla kufuneka igcinwe kubushushu begumbi i-77 ° F (25 ° C), ivalwe ngokuqinileyo kwisitya sayo sokuqala.

Iphepha elichazayo ukuba awusenanto oyifunayo: Iindaba zezoNyango namhlanje zenze zonke iinzame zokuqinisekisa ukuba zonke iinkcukacha zichanekile, zibanzi kwaye zihlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.

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