Uvavanyo lwe-BCR ABL yemvelo

Umxholo

• Yintoni uvavanyo lwe-BCR-ABL yemfuzo?
• Isetyenziselwa ntoni?
• Kutheni ndifuna uvavanyo lwe-BCR-ABL yemvelo?
• Kwenzeka ntoni ngexesha lovavanyo lwemfuzo lwe-BCR-ABL?
• Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?
• Ngaba bukhona ubungozi kuvavanyo?
• Zithetha ntoni iziphumo?
• Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lwemfuzo lwe-BCR-ABL?
• Izalathiso

Yintoni uvavanyo lwe-BCR-ABL yemfuzo?

Uvavanyo lwe-BCR-ABL yemfuza lujonga ukutshintsha kwemfuza (utshintsho) kwi-chromosome ethile.

IiChromosomes ngamalungu eeseli zakho aqukethe imfuza yakho. Imfuza ngamalungu e-DNA agqithiselwe kumama notata wakho. Baphethe ulwazi olumisela iimpawu zakho ezizodwa, ezinjengokuphakama nombala wamehlo.

Ngokwesiqhelo abantu banee-chromosomes ezingama-46, zahlulwe zangama-23 amabini, kwiseli nganye. Isibini esinye seekromosomes sivela kunyoko, kwaye esinye isibini sivela kuyihlo.

I-BCR-ABL lutshintsho olwenziwa ngokudityaniswa kwemfuza emibini, eyaziwa ngokuba yi-BCR kunye neABL. Ngamanye amaxesha kuthiwa yi-fusion gene.

• Uhlobo lwe-BCR luqhelekile kwinombolo ye-chromosome 22.
• Uhlobo lwe-ABL luqhele ukwenziwa kwinombolo ye-chromosome 9.
• Utshintsho lwe-BCR-ABL lwenzeka xa iziqwenga ze-BCR kunye ne-ABL zofuzo zishiya kwaye zitshintsha indawo.
• Utshintsho lubonakala kwi-chromosome 22, apho isiqwenga se-chromosome 9 sizincamathele khona.
• I-chromosome eguqulweyo engama-22 ibizwa ngokuba yi-chromosome yaseFiladelphia kuba sisixeko apho abaphandi baqala ukufumanisa khona.
• Uhlobo lwe-BCR-ABL ayilulo uhlobo lotshintsho olufunyenwe kubazali bakho. Luhlobo lwenguquko ye-somatic, oko kuthetha ukuba awuzalwanga nayo. Uyifumana kamva ebomini.

Uhlobo lwe-BCR-ABL lubonakala kwizigulana ezineentlobo ezithile ze-leukemia, umhlaza womongo wethambo kunye neeseli ezimhlophe zegazi. I-BCR-ABL ifunyanwa phantse kuzo zonke izigulana ezinoluhlobo lwe-leukemia ebizwa ngokuba yi-chronic myeloid leukemia (CML). Elinye igama le-CML lisisigxina zam Ileukemia. Omabini la magama abhekisa kwisifo esinye.

Uhlobo lwe-BCR-ABL lukwafunyanwa kwezinye izigulana ezinohlobo lwe-acute lymphoblastic leukemia (BONKE) kwaye kunqabile kwizigulana ezine-leukemia ye-myelogenous (AML).

Amayeza athile omhlaza asebenza ngokukodwa ekunyangeni abaguli abanesifo se-leukemia ngotshintsho lwe-BCR-ABL. La mayeza aneziphumo ebezingalindelekanga ezimbalwa kunezinye zonyango lomhlaza. La mayeza afanayo awasebenzi kunyango lweeukemia okanye eminye imihlaza.

Amanye amagama: i-BCR-ABL1, i-BCR-ABL1 fusion, i-chromosome yaseFiladelphia

Isetyenziselwa ntoni?

Uvavanyo lwe-BCR-ABL luhlala lusetyenziselwa ukuxilonga okanye ukukhupha i-leukemia engapheliyo (i-CML) okanye uhlobo oluthile lwe-leukemia ye-lymphoblastic leukemia (YONKE) ebizwa ngokuba yi-Ph-positive ALL. I-Ph-positive kuthetha ukuba i-chromosome yaseFiladelphia yafunyanwa. Uvavanyo alusetyenziswanga ukufumanisa ezinye iintlobo ze-leukemia.

Uvavanyo lunokusetyenziselwa:

• Jonga ukuba unyango lomhlaza luyasebenza na.
• Jonga ukuba ngaba isigulana sikhe samelana nonyango oluthile. Oko kuthetha ukuba unyango olwalukade lusebenza alusasebenzi.

Kutheni ndifuna uvavanyo lwe-BCR-ABL yemvelo?

Unokufuna uvavanyo lwe-BCR-ABL ukuba uneempawu ze-myeloid leukemia engapheliyo (i-CML) okanye i-Ph-positive acute lymphoblastic leukemia (BONKE). Oku kubandakanya:

• Ukudinwa
• Ifiva
• Ukuhla ukusinda
• Ukujuluka ebusuku (ukubila kakhulu xa ulele)
• Intlungu edibeneyo okanye yethambo

Abanye abantu abane-CML okanye i-Ph-positive BONKE abanazo iimpawu, okanye iimpawu ezinobulali, ngakumbi kumanqanaba okuqala esi sifo. Ke umboneleli wakho wezempilo unokuyalela olu vavanyo ukuba ubalo olupheleleyo lwegazi okanye olunye uvavanyo lwegazi lubonise iziphumo ebezingaqhelekanga. Kuya kufuneka ukwazise umboneleli wakho ukuba unazo naziphi na iimpawu ezikukhathazayo. I-CML kunye ne-Ph-positive ZONKE kulula ukuzinyanga xa zifunyenwe kwangethuba.

Unokulufuna olu vavanyo ukuba ngoku unyangwa i-CML okanye i-Ph-positive YONKE. Uvavanyo lunokunceda umboneleli wakho ukuba abone ukuba unyango lwakho luyasebenza na.

Kwenzeka ntoni ngexesha lovavanyo lwemfuzo lwe-BCR-ABL?

Uvavanyo lwe-BCR-ABL luhlala luvavanyo lwegazi okanye inkqubo ebizwa ngokuba ngumnqweno wethambo kunye ne-biopsy.

Ukuba ufumana uvavanyo lwegazi, Unonophelo lwempilo uyakuthatha isampulu yegazi kumthambo engalweni yakho, esebenzisa inaliti encinci. Emva kokuba inaliti ifakiwe, inani elincinci legazi liya kuqokelelwa kwityhubhu yovavanyo okanye igutyana. Unokuziva uluma kancinci xa inaliti ingena okanye iphuma. Oku kuhlala kuthatha imizuzu engaphantsi kwesihlanu.

Ukuba ufumana umnqweno wethambo kunye ne-biopsy, Inkqubo yakho inokubandakanya la manyathelo alandelayo:

• Uya kulala phantsi ngecala okanye kwisisu, kuxhomekeke kweliphi ithambo eliya kusetyenziswa kuvavanyo. Uninzi lweemvavanyo zomongo wethambo zithathwa kwithambo lesinqe.
• Umzimba wakho uya kugutyungelwa ngelaphu, ukuze kubonakale kuphela indawo ejikeleze indawo yovavanyo.
• Indawo izakucocwa ngesinqanda magciwane.
• Uya kufumana inaliti yesisombululo esindindisholo. Isenokuhlaba.
• Nje ukuba le ndawo ibe ndindisholo, umboneleli wezempilo uyakuthatha isampulu. Uya kudinga ukuxoka kakhulu ngexesha leemvavanyo.
  • Ukulungiselela umongo wethambo, oqhele ukwenziwa kuqala, umboneleli wezempilo uya kufaka inaliti ngethambo kwaye akhuphe umongo wethambo kunye neeseli. Unokuziva ubuhlungu obukrakra kodwa obufutshane xa kufakwa inaliti.
  • Ukulungiselela umongo wethambo i-biopsy, umboneleli wezempilo uya kusebenzisa isixhobo esikhethekileyo esiguqukayo sithambo ukuze athathe isampulu yomongo wethambo. Unokuziva uxinzelelo kwisiza ngelixa isampulu ithathwa.
• Kuthatha malunga nemizuzu eli-10 ukwenza zombini ezi mvavanyo.
• Emva kovavanyo, umboneleli wezempilo uya kuyigubungela indawo ngebhanti.
• Cwangcisa ukuba nomntu ekuqhubela ekhaya, kuba unganikwa into yokuthomalalisa ngaphambi kovavanyo, okunokukwenza wozele.

Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?

Ngokwesiqhelo awudingi malungiselelo akhethekileyo kuvavanyo lomongo wegazi okanye wethambo.

Ngaba bukhona ubungozi kuvavanyo?

Mncinci kakhulu umngcipheko wokuvavanywa kwegazi. Unokuba nentlungu encinci okanye ukrakra kwindawo apho inaliti yafakwa khona, kodwa uninzi lweempawu zihamba ngokukhawuleza.

Emva kovavanyo lomongo wethambo, unokuziva uqine okanye ukhathazekile kwindawo yenaliti. Oku kuhlala kuhamba kwiintsuku ezimbalwa. Umboneleli wakho wokhathalelo lwempilo unokucebisa okanye ukumisela umntu ophelisa iintlungu ukuba akuncede.

Zithetha ntoni iziphumo?

Ukuba iziphumo zakho zibonisa ukuba une-gene ye-BCR-ABL, kunye nenani elingaqhelekanga leeseli ezimhlophe zegazi, uya kufumanisa ukuba une-myeloid leukemia (CML) engapheliyo okanye i-Ph-positive, leukemia ebukhali ye-lymphoblastic (BONKE).

Ukuba okwangoku unyangelwa i-CML okanye i-Ph-positive YONKE, iziphumo zakho zingabonisa:

• Inani le-BCR-ABL egazini lakho okanye kumongo wethambo liyanda. Oku kunokuthetha ukuba unyango lwakho alusebenzi kwaye / okanye uye waxhathisa kunyango oluthile.
• Inani le-BCR-ABL egazini lakho okanye kumongo wethambo liyancipha. Oku kunokuthetha ukuba unyango lwakho luyasebenza.
• Isixa se-BCR-ABL egazini lakho okanye kumongo wethambo asonyukanga okanye sinciphile. Oku kunokuthetha ukuba isifo sakho sizinzile.

Ukuba unemibuzo malunga neziphumo zakho, thetha nomboneleli wakho wezempilo.

Funda ngakumbi malunga novavanyo lwelabhoratri, uluhlu lweereferensi, kunye neziphumo zokuqonda.

Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lwemfuzo lwe-BCR-ABL?

Unyango lwe-myeloid leukemia engapheliyo (i-CML) kunye ne-Ph-positive, i-lymphoblastic leukemia (YONKE) iphumelele kwizigulana ezinale ndlela ye-leukemia. Kubalulekile ukubona umboneleli wakho wezempilo rhoqo ukuqinisekisa ukuba unyango lwakho luyaqhubeka lusebenza. Ukuba uyaxhathisa kunyango, umboneleli wakho unokucebisa ngezinye iintlobo zonyango lonyango lomhlaza.

Izalathiso

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Ulwazi olukule ndawo akufuneki lusetyenziswe endaweni yonyango okanye iingcebiso. Nxibelelana nomboneleli wezempilo ukuba unemibuzo malunga nempilo yakho.